Experimental Chemotherapy V4

Contributors

Preface

Contents of Volume I

Contents of Volume II

Contents of Volume III

Contents of Volume V

Chemotherapy of Neoplastic Diseases I

1. Approaches to Cancer Chemotherapy

Text

References

2. Methods of Drug Evaluation

I. Introduction

II. Screening Systems in Cancer Chemotherapy

III. Design of Screening Procedures

IV. Design of Comparative Investigations

V. Mechanism of Drug Action

VI. Toxicological Investigations

References

3. Antimetabolites

I. Introduction

II. Aminopterin and Related Compounds

III. Some Other Folic Acid Antagonists

IV. 6-Mercaptopurine

V. 6-Thioguanine

VI. Some Other Substituted Purines, with Particular Reference to Derivatives of 6-Mercaptopurine and 6-Thioguanine

VII. 8-Azaguanine

VIII. 5-Fluoropyrimidines and Their Ribosides

IX. Iodo- and Bromopyrimidine Deoxyribosides

X. 6-Azauracil and 6-Azauridine

XI. Some Other Pyrimidine Derivatives and Analogs

XII. 1-Aminocyclopentanecarboxylic Acid (ACP)

XIII. Other Amino Acid Analogs

References

4. Antitumor Antibiotics

I. Introduction

II. The Actinomycins

III. Mitomycin C

IV. Azaserine

V. DON (6-Diazo-5-oxo-L-norleucine)

VI. Puromycin

VII. Sarkomycin

VIII. Cycloheximide, E73, and the Streptovitacins

IX. Carzinophilin

X. Chromomycin A3 (Toyomycin)

XI. Antibiotic 6270

XII. Streptonigrin

XIII. Fumagillin and Fumagillin Alcohol

XIV. Psicofuranine

XV. Hadacidin

XVI. Actinogan and Peptinogan

XVII. Miscellaneous Antibiotics

References

Appendix: Survey of Recent Developments in Experimental Chemotherapy: Supplements to Volumes I, II, and III

Supplement to Volume I

Toxicity in Chemotherapy

Statistical Evaluation in Chemotherapy

Drug Resistance in Chemotherapy

Chemotherapy of Trypanosomiasis

Chemotherapy of Trichomoniasis

Chemotherapy of Histomoniasis

Chemotherapy of Giardiasis

Chemotherapy of Amebiasis

Chemotherapy of Coccidiosis

Chemotherapy of Malaria. Part 2. The Antimalarial Drugs

Chemotherapy of Babesiasis

Chemotherapy of Theileriasis and Anaplasmosis

Chemotherapy of Toxoplasmosis

Chemotherapy of Balantidiasis

Chemotherapy of Spirochetal Infections

Chemotherapy of Miscellaneous Infections

Chemotherapy of Filariasis

Chemotherapy of Myiasis

Supplement to Volume II

Chemotherapy with Antibacterial Dyestuffs

Acridine Dye Action at Cellular and Molecular Levels

Microbial Resistance to Harsh and Destructive Environmental Conditions

Antibacterial Chemotherapy with Sulfonamides

The Nitrofurans—Chemotherapeutic Properties

Antibacterial Agents of Limited Action

Experimental Chemotherapy of Leprosy

Supplement to Volume III

The Tetracyclines

The Macrolides (Erythromycin Group)

The Polypeptides of the Polymyxin Group

Novobiocin

Antibiotics Used in the Chemotherapy of Bacterial and Fungal Infections

Chemotherapy of Rickettsial Infections

Experiences with Experimental Chemotherapy of Viral Diseases

Bibliographic List of Recent Publications Not Discussed in This Supplement

Author Index

Subject Index