Evidence-Based Nutrition and Clinical Evidence of Bioactive Foods in Human Health and Disease
- 1st Edition - July 8, 2021
- Imprint: Academic Press
- Author: Asim K. Duttaroy
- Language: English
- Paperback ISBN:9 7 8 - 0 - 1 2 - 8 2 2 4 0 5 - 2
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 2 2 1 9 4 - 5
Evidence-Based Nutrition and Clinical Evidence of Bioactive Foods in Human Health and Disease explores a wide range of studies from clinical investigations to mechanistic research,… Read more
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Request a sales quoteEvidence-Based Nutrition and Clinical Evidence of Bioactive Foods in Human Health and Disease explores a wide range of studies from clinical investigations to mechanistic research, covering the actions of bioactives on specific tissues and cells in intestinal, neurological, immunological and cardiovascular health and disease, including cancers. The book also focuses on metabolism, mechanisms of actions, tissue-specific effects, and the structure–function relationships between clinical trial, ex vivo and in vitro data. Written for nutrition researchers, clinical researchers, dieticians, and others working in and studying health-related fields, this book highlights the concepts surrounding the preventive and therapeutic impacts of bioactive foods.
- Presents information on the prevention of disease using bioactive compounds
- Consolidates the research outcome from a variety of sources on specific bioactive foods
- Contains coverage of bioactive lipids and lipid mediators, bioactive phytochemicals, probiotics, bioactive proteins, peptides, polysaccharides, fibers and sphingolipids
Nutrition researchers, dieticians, and others working in and studying health-related fields
- Cover image
- Title page
- Table of Contents
- Copyright
- Preface
- Chapter 1. Bioactive lipids and their metabolism, function, and sources
- Abstract
- Introduction
- Fatty acids
- Conjugated linoleic acid
- Endocannabinoids
- Conclusion
- References
- Chapter 2. Bioactive lipids and their impacts on epigenetics
- Abstract
- Introduction
- Fatty acids and epigenetic modifications
- Saturated fatty acids and epigenetic modification
- Short-chain fatty acids and their impacts on epigenetics
- n−3 Polyunsaturated fatty acids and their impacts on epigenetics
- n−3 Fatty acids and their effects on the feto-placental epigenetics
- n−6 Polyunsaturated fatty acids and the epigenetics
- Monounsaturated fatty acids and their impacts on the epigenome
- Trans-fatty acids and their impacts on epigenetics
- Conclusion
- References
- Chapter 3. Bioactive lipids in cancers
- Abstract
- Introduction
- n−3 and n−6 fatty acids modulate cancers
- Lipids and their roles in cellular processes in cancer
- Lipids are signaling mediators in cancer biology
- Uptake of fatty acids and their intracellular transport in cancer biology
- Lipids in angiogenesis
- Lipids in cancer therapy
- Short-chain fatty acids and cancer
- Conclusion
- References
- Chapter 4. Bioactive lipids in immune cells function and immune disorders
- Abstract
- Abbreviations
- Introduction
- Fatty acids and their metabolites on the immune cell activity
- Prostaglandins and leukotrienes and their effects on immune function: modulation by dietary lipids
- Lysophospholipids and sphingolipids
- Endocannabinoids
- Synthesis of proresolving mediators and their functions in the immune system
- Human and animal studies with dietary fatty acids
- The Mediterranean diet and the immune function
- Conclusion
- Reference
- Chapter 5. Bioactive lipids in metabolic syndromes and hemostatic factors and fibrinolysis
- Abstract
- Abbreviations
- Introduction
- Long-chain fatty acids and metabolic syndromes
- Medium-chain fatty acids and metabolic syndromes
- Diacylglycerols and phospholipids and their effects on metabolic syndromes
- Effects of plant sterols and their derivatives on metabolic syndromes
- Effects of lipids on endothelium function
- Effects of lipids on the hemostatic and fibrinolytic factors
- Conclusion
- References
- Chapter 6. Bioactive lipids and brain function: from their mechanistic roles to clinical trials
- Abstract
- Abbreviations
- Introduction
- Structural and functional roles of DHA in the human brain
- Docosahexaenoic acid, 22:6n−3 and its metabolites
- The function of DHA and its metabolites in the brain
- DHA and its roles in neurocognitive function in the developmental stage
- DHA deficiency and human brain function
- DHA and dementia
- DHA and Parkinson’s disease
- DHA and behavioral consequences
- Clinical trials of DHA supplementation and brain function
- Arachidonic acid and brain function
- Conclusion
- References
- Chapter 7. Bioactive lipids on platelet function and platelet–vessel-wall interactions
- Abstract
- Introduction
- Human blood platelets and their roles in the cardiovascular system
- Effects of dietary fatty acids and their metabolites on human blood platelets
- Platelets and vessel-wall interactions: effects of lipids
- Clinical trials with n−3 fatty acids
- Dietary recommendation and sources of n−3 fatty acids
- Conclusion
- References
- Chapter 8. Polysaccharide on diabetes, obesity, and other cardiovascular disease risk factors
- Abstract
- Abbreviations
- Introduction
- Gut microbiota and their roles in the metabolism of polysaccharides
- Effects of polysaccharides on insulin resistance and diabetes
- Effects of polysaccharides on obesity and other cardiovascular disease factors
- Conclusion
- References
- Chapter 9. Polysaccharides on the gut microbiome and epigenome
- Abstract
- Introduction
- The gut microbiota and their effects on the epigenome
- The gut microbiota and the epigenetic regulation of disease
- Conclusion
- References
- Chapter 10. Polysaccharides and their bioactivity and biomedical applications
- Abstract
- Introduction
- Physicochemical characteristics of polysaccharides and their impacts on biology
- Microbial fermentation of polysaccharides
- Polysaccharides from different sources
- Bioactive polysaccharides of different sources
- Polysaccharides as an antimicrobial agent
- Antitumor activity of polysaccharides
- Antiobesity and hypocholesterolemic effects of polysaccharides
- Antidiabetic effects of polysaccharides
- Protective effects of polysaccharides on the gastrointestinal tract
- Roles of polysaccharides in the immune response and inflammation
- Polysaccharides and brain function
- Antioxidant activity of polysaccharides
- Tissue repairing
- Wound healing and polysaccharides
- Polysaccharides and drug delivery
- Conclusion
- References
- Chapter 11. Polysaccharides and immune function
- Abstract
- Introduction
- Immunomodulatory function of polysaccharides
- Effect of polysaccharides on the production of cytokines and NO by macrophages
- Effects of polysaccharides on the activation of macrophages
- Polysaccharides regulate the immune system
- A metaanalysis of polysaccharides effects on the immune system
- Conclusion
- References
- Chapter 12. Polysaccharides on metabolic syndromes and dyslipidemia
- Abstract
- Introduction
- Effects of polysaccharides on metabolic syndromes
- Polysaccharides: their source and biological activity
- Effects of polysaccharides and lipid metabolism
- Gut microbiota and their impacts on metabolic syndromes and hyperlipidemia
- Conclusion
- References
- Chapter 13. Polysaccharides and cancer
- Abstract
- Introduction
- Effects of polysaccharides on cancer cells
- Depolarization of mitochondrial membrane and reactive oxygen species: effects of polysaccharides
- Effects of polysaccharides on nitric oxide pathway
- Immunomodulation by polysaccharides
- Anticancer effects of polysaccharides and their classifications
- Selective cytotoxicity
- Polysaccharides in cancer trials
- Conclusion
- References
- Chapter 14. Polyphenols and their antioxidant and nonantioxidant effects in health and disease
- Abstract
- Introduction
- Biochemistry of free radicals in the body
- Oxidative stress and human diseases
- The antioxidant system in the body
- Antioxidant and nonantioxidant of activities of dietary polyphenols
- Polyphenols, their source, and bioavailability
- Effects of polyphenols as an antioxidant and their impacts on human diseases
- Effects of polyphenols on obesity
- Cardioprotective effects of polyphenols
- Effects of polyphenols on diabetes mellitus
- Effects of polyphenols on cancers
- Antiaging effects of polyphenols
- Polyphenols and neurodegenerative disorders
- Conclusion
- References
- Chapter 15. Polyphenols in neuroprotection and brain disorders
- Abstract
- Introduction
- Epidemiology of neurodegenerative diseases and the underlying causes
- Polyphenols and their source, bioavailability, and their neuroprotection activity
- Polyphenols and brain health
- Studies on the potency of the mixture of polyphenols
- Effects of polyphenols: in vitro studies
- Studies on neuroprotection of polyphenols in cell models
- Studies on neuroprotection of polyphenols in the animal model
- Clinical trials
- Polyphenols and blood–brain barrier
- Conclusion
- References
- Chapter 16. Polyphenols and their impacts on the host epigenome and the gut microbiome
- Abstract
- Introduction
- Epigenome and gut microbiota in health and diseases
- Dietary polyphenols
- Gut microbiota and polyphenols
- The interplay between polyphenols and the gut microbiota and impacts on disease
- Conclusion
- References
- Chapter 17. Polyphenols and cancer
- Abstract
- Introduction
- Polyphenols
- Epidemiological observation of the anticancer effects of polyphenols
- Chemopreventive effects of polyphenols
- Various polyphenols and their specific anticancer actions
- Phenolic acids
- Lignans
- Anticancer effects of mixtures of polyphenols
- Effects of polyphenols in cancer metastasis
- Conclusion
- References
- Chapter 18. Polyphenols and their effects on metabolic syndromes and other CVD risk factors
- Abstract
- Introduction
- Metabolic syndromes
- Effects of polyphenol intake on the features of metabolic syndrome
- Epidemiological studies on the association between the intake of polyphenols and MetS and CVD risk factors
- Association between polyphenol intake and insulin resistance
- Association between polyphenol intake and the incidence of hypertension
- Association between polyphenol intake and other CVD risk factors
- Clinical trials with polyphenols
- Long-term interventions with polyphenols in patients with MetS
- Gut microbiota, polyphenols, and metabolic syndrome
- Conclusion
- References
- Chapter 19. Gut microbiota on human health and disease
- Abstract
- Introduction
- Development and establishment of the human gut microbiota
- Dysbiosis of gut microbiota and human diseases
- The microbiota and brain diseases
- Probiotics and gastroenteritis
- Cardiovascular disease and the gut microbiota
- Clinical trials of probiotics
- Infants and probiotics
- Healthy adults and probiotics
- Conclusion
- References
- Chapter 20. Gut microbiota and lipid metabolism and metabolic syndrome
- Abstract
- Introduction
- The human gut microbiome and lipid metabolism
- Gut microbiota and lipid metabolic diseases
- Gene factors of the host
- The gut microbiota as a therapeutic target
- Conclusion
- References
- Chapter 21. Gut microbiota and their effects on atherosclerosis, platelet function, and hypertension
- Abstract
- Abbreviations
- Introduction
- Atherosclerosis and the gut microbiota
- Gut microbiota and TMAO metabolism
- Human blood platelets and CVD
- Platelet activation pathways
- Platelet hyperactivity and the development of CVD
- Hypertension and gut microbiota
- Conclusion
- References
- Chapter 22. Gut microbiota and the immune system and inflammation
- Abstract
- Introduction
- Establishment of the gut microbiome in early life: impact on the immune system
- The immune system and the gut microbiota
- The innate Immunity and the gut microbiota
- Adaptive immunity and gut microbiota
- Importance of the gut microbiota in autoimmune response
- Autoimmune diseases and the gut microbiota
- Inflammatory bowel disease
- Rheumatoid arthritis
- Type 1 diabetes
- Alteration in microbiota composition
- Conclusion
- References
- Chapter 23. Gut microbiota and brain function and pathophysiology
- Abstract
- Abbreviations
- Introduction
- The central nervous system and blood–brain barrier: roles of the microbiota
- Impacts of microbiota on the microglia and astrocytes
- Immune cells and the central nervous system: the microbiota
- Gut–brain axis and microbiota
- Brain signaling systems and the microbiota
- The gut microbiota, depression, and stress
- The gut microbiota and behavior
- Possible pathways and mediators involved in the microbiota–brain–gut–brain axis
- Role of the microbiota in human mental health
- Multiple sclerosis
- Parkinson’s disease
- Alzheimer’s disease
- Conclusion
- References
- Chapter 24. Gut microbiota and obesity and the body weight regulation
- Abstract
- Introduction
- Microbiota and its role in obesity
- The gut microbiota and its impact on obesity
- Inflammation obesity and the gut microbiota
- Probiotics used for obesity treatments
- Mechanisms involving the effects of microbiota on obesity
- Conclusion
- References
- Chapter 25. Gut microbiota and hypertension, diabetes, and other cardiovascular risk factors
- Abstract
- Introduction
- Hypertension
- The gut microbiota and diabetes mellitus
- Impacts of diets and the gut microbiota in diabetes
- Mechanism of actions of the gut microbiota
- Conclusion
- References
- Chapter 26. Bioactive peptides and proteins on hypertension and endothelium function
- Abstract
- Introduction
- The renin–angiotensin–aldosterone system
- Proteins and peptides, and hypertension
- Endothelium function, and proteins and peptides
- Inflammation and endothelial dysfunction
- Antiinflammatory bioactive peptides
- Conclusion
- References
- Chapter 27. Bioactive alkaloids
- Abstract
- Introduction
- Alkaloids
- Alkaloids and their bioactivities
- Neurodegenerative diseases and alkaloids
- Antiviral activity of alkaloids
- Alkaloids and diabetes
- Autoimmune disease and alkaloids
- Safety issues with alkaloids
- Conclusion
- References
- Chapter 28. Health effects of terpenoids
- Abstract
- Introduction
- Terpenes and terpenoids: their structure–function and bioactivities
- Clinical applications of terpenoids
- Antiviral activity of terpenes and terpenoids
- Anticancer activities of terpenes and terpenoids
- Antidiabetic effects of terpenes and terpenoids
- Antidepressant and terpenes and terpenoid
- Conclusion
- References
- Chapter 29. Clinical use of curcumin
- Abstract
- Introduction
- Curcumin and bioactivities
- Antiinflammatory effects of curcumin
- Effects of curcumin on metabolic syndrome, diabetes mellitus, and other cardiovascular disease risk factors
- Curcumin and its effects on cancer
- Curcumin effects on the reproductive system
- Effects of curcumin in healthy people
- Side effects of consuming curcumin and its bioavailability
- Conclusion
- References
- Chapter 30. Volatile bioactive compounds: source and activity
- Abstract
- Introduction
- Plant volatile organic compounds
- The bioactivity of volatile compounds: effects on human health
- The gut microbiota and the volatile organic compounds
- Conclusion
- References
- Chapter 31. Cardioprotective properties of water-soluble compounds of tomato
- Abstract
- Abbreviations
- Introduction
- In vitro studies with water-soluble tomato extract on human blood platelet aggregation
- Human trials
- Comparing the dietary antiplatelet Fruitflow with the antiplatelet drug aspirin
- Hypotensive effects of Fruitflow
- European Food Safety Authority approval of Fruitflow
- Conclusion
- References
- Index
- Edition: 1
- Published: July 8, 2021
- No. of pages (Paperback): 472
- No. of pages (eBook): 472
- Imprint: Academic Press
- Language: English
- Paperback ISBN: 9780128224052
- eBook ISBN: 9780128221945
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Asim K. Duttaroy
Dr. Asim K. Duttaroy is a professor at the Faculty of Medicine, University of Oslo, Oslo, Norway. His research programs focus on the roles of food components on growth and development, as well as in the prevention of diseases such as diabetes and cardiovascular disease. He is also investigating the roles of the antiplatelet and antihypertensive properties of fruits and vegetables. His discoveries of antithrombotic factors in tomatoes and kiwifruits are patented internationally, and three companies (Provexis Limited in the United Kingdom, IDIA AS in Norway, and Genimen Pharmacon in India) are working to commercialize these discoveries. He has published over 265 original contributions and reviews, 6 books, and several book chapters and editorials, and he is the Editor-in-Chief of the journal Food & Nutrition Research, as well as a guest editor of several journals such as Nutrients and Frontiers in Physiology.
Affiliations and expertise
Faculty of Medicine, University of Oslo, Oslo, NorwayRead Evidence-Based Nutrition and Clinical Evidence of Bioactive Foods in Human Health and Disease on ScienceDirect