Essentials of Clinical Neurophysiology
- 4th Edition - March 31, 2025
- Imprint: Elsevier
- Editors: Karl E. Misulis, Thomas C. Head
- Language: English
- Paperback ISBN:9 7 8 - 0 - 4 4 3 - 1 2 1 8 6 - 9
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 1 2 3 2 3 - 8
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 1 2 3 2 4 - 5
Up-to-date and easy to read, Essentials of Clinical Neurophysiology, Fourth Edition, details the basics of normal and abnormal neurologic function and provides authoritative… Read more
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Request a sales quoteUp-to-date and easy to read, Essentials of Clinical Neurophysiology, Fourth Edition, details the basics of normal and abnormal neurologic function and provides authoritative clinical guidance on performing and interpreting today's full range of neurophysiologic studies. Drs. Karl E. Misulis and Thomas C. Head cover recent advances in technology as well as changes in training and practice patterns for EEG, EMG, EP, intraoperative monitoring, sleep studies, and autonomic testing. Offering a practical overview of this complex field, this one-stop resource is an excellent tool for board review and preparation.
- Covers a wide variety of the studies used to evaluate epilepsy, coma, dementia, movement disorders, neuromuscular diseases, nerve dysfunction, sleep apnea, narcolepsy, and more
- Features numerous illustrations that highlight key content and promote visual understanding
- Includes a new Key Points section to begin each chapter and offers suggested readings for further study
- Discusses new technologies and explains their clinical implications
- An ideal resource for neurology residents, fellows in neurophysiology and EEG/EMG, those studying for recertification, and EEG/EMG technicians
- An eBook version is included with purchase. The eBook allows you to access all of the text, figures, and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud. Additional digital ancillary content may publish up to 6 weeks following the publication date
Neurology residents; fellows in neurophysiology and EEG and EMG
- Title of Book
- Cover image
- Title page
- Table of Contents
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- Copyright
- Preface
- List of Contributors
- Part 1: Basic Science
- 1. Neurophysiology
- Abstract
- Physiology of Excitable Tissue
- Action Potentials
- Neurotransmitters
- Electrical Activity of Nerve
- Neuromuscular Physiology
- What We Record During Electrophysiologic Studies
- Anatomy and Physiology for Clinical Neurophysiology
- 2. Technology
- Abstract
- Basic Science for Clinical Neurophysiology
- Basic Electronics for Neurophysiology
- Recording Instrumentation
- 3. Approach to Data Interpretation
- Abstract
- Data Analysis
- 4. Common Artifacts and Their Physics
- Abstract
- 5. Best Practices
- Abstract
- Elements of Optimal Practice
- Part 2: Electroencephalography
- 6. Physiology of Electroencephalography
- Abstract
- Generation of Cortical and Scalp Potentials
- Basic Electroencephalography Rhythms
- Generation of Epileptiform Activity
- 7. Technical Aspects of the Electroencephalography
- Abstract
- Guidelines
- Electroencephalography Equipment
- Electroencephalography Parameters
- Electrodes
- Electrode Position
- Montages
- Routine Electroencephalography
- Report
- 8. Normal Electroencephalography
- Abstract
- Normal Waking Electroencephalography
- Normal Drowsy and Sleep Electroencephalography
- Electroencephalography in Children
- Noncerebral Potentials
- Activation Methods
- 9. Abnormal Electroencephalography
- Abstract
- Slowing
- Spike and Sharp Waves
- Abnormal Frequency Composition
- Slow Activity
- Focal Loss of Electroencephalography Patterns
- Spikes and Sharp Waves
- Generalized Spikes and Generalized Epilepsy
- Periodic Patterns
- 10. Seizures
- Abstract
- Generalized Seizures
- Focal Seizures
- Status Epilepticus
- 11. Pediatric Electroencephalography
- Abstract
- Basics and Technical Requirements
- Guidelines for Interpretation
- Normal Neonatal Electroencephalograms
- Abnormal Neonatal Patterns
- 12. Electroclinical Syndromes
- Abstract
- Electroencephalography in Medical Conditions
- Epilepsies With Structural Cause
- Reflex Epilepsies
- Rasmussen Syndrome
- Conditions With Seizures Where Epilepsy Is Not Diagnosed
- 13. Nonepileptic Disorders
- Abstract
- Nonepileptic Events
- Factitious Illness
- Vasovagal Syncope
- Reflex Anoxic Seizures
- Breath-Holding Attacks
- Hyperventilation Syncope
- Compulsive Valsalva
- Orthostatic Intolerance or convulsive syncope
- Hallucinations in Psychiatric Disorders
- Migraine
- 14. Special Studies in Electroencephalography
- Abstract
- Brain Death
- Ambulatory Electroencephalogram Monitoring
- Quantitative Electroencephalogram
- Part 3: Nerve Conduction Studies and Electromyography
- 15. Physiology of Nerve Conduction Study and Electromyography
- Abstract
- Overview
- Neuromuscular Physiology
- Abnormal Neuromuscular Function
- 16. Methods
- Abstract
- Nerve Conduction Basics
- Evaluation of Individual Muscles
- Evaluation of Neuromuscular Transmission
- 17. Approach to Clinical Questions
- Abstract
- Overview
- 18. Neuropathies
- Abstract
- Overview
- 19. Myopathies
- Abstract
- Overview
- Muscular Dystrophies
- Inflammatory Myopathies
- Metabolic Myopathies
- Syndromes of Continuous Muscle Fiber Activity
- Other Disorders of Muscle
- 20. Neuromuscular Junction Defects
- Abstract
- Overview
- Myasthenia Gravis
- Lambert-Eaton Myasthenic Syndrome
- Botulism
- Neonatal Myasthenia and Congenital Myasthenia
- Part 4: Evoked Potentials and Intraoperative Neurological Monitoring
- 21. Overview
- Abstract
- Evoked Potentials
- Intraoperative Neurological Monitoring
- 22. Visual Evoked Potentials
- Abstract
- Stimulus
- Testing Parameters
- Responses
- Clinical Applications
- 23. Brainstem Auditory Evoked Potential
- Abstract
- Stimulus
- Recording Parameters
- Brainstem Auditory Evoked Potential Waveforms and Generators
- Patterns of Abnormalities
- Clinical Application
- Brainstem Auditory Evoked Potential and IONM
- 24. Somatosensory Evoked Potential
- Abstract
- Stimulus
- Waveforms and Localization
- Recording Parameters
- Interpretation
- Clinical Applications
- 25. Motor Evoked Potential
- Abstract
- Components of Transcranial Motor Evoked Potential—D Waves and M Waves
- Stimulus
- Interpretation
- Clinical Applications
- 26. Electromyography and Cranial Nerve Monitoring in IONM
- Abstract
- Electromyography Monitoring in Intraoperative Neurological Monitoring (IONM)
- Electromyography Setup and Stimulation
- Spontaneous Electromyography Monitoring
- Types of Electromyography Activity Specific to IONM
- 27. Electroencephalography, Cortical Mapping, and Anesthetic Considerations in IONM
- Abstract
- Electroencephalography Monitoring in Intraoperative neurological monitoring (IONM)
- Electroencephalography Changes in Ischemia
- Cortical Mapping
- Anesthetic Considerations in IONM
- Part 5: Polysomnography
- 28. Sleep Physiology
- Abstract
- Normal Sleep
- Sleep-Wake Regulation
- Function of Sleep
- 29. Polysomnography Methods
- Abstract
- Introduction
- Types of Sleep Studies and Their Indications
- Physiologic Measurements and Electrode placement
- Airflow Signals
- Body Position
- Electrocardiogram
- Audiovisual Monitoring
- Recording Protocol for a Standard Nocturnal Study
- Scoring Rules
- Sleep staging
- Event Scoring
- Artifact Identification
- Tabulation and Reporting of Sleep Parameters
- Interpretation and Diagnosis
- 30. Polysomnography in Sleep Disorders
- Abstract
- Overview of Sleep Disorders
- Sleep-Related Breathing Disorders
- Central Disorders of Hypersomnolence
- Sleep-Related Movement Disorders
- Circadian Rhythm Sleep-Wake Disorders
- Parasomnias and Sleep-Related Epilepsy
- Part 6: Autonomic Testing
- 31. Neuroanatomy of the Autonomic Nervous System
- Abstract
- The Sympathetic Nervous System
- The Parasympathetic Nervous System
- Cerebral Control of Autonomic Function
- The Baroreflex
- Thermoregulation
- Conclusion
- 32. Autonomic Testing
- Abstract
- Introduction
- Equipment
- Cardiovascular Tests
- Heart Rate Response to Cyclic Deep Breathing
- Valsalva Maneuver
- Head-up Tilt Table Testing
- Other Sympathetic Tests
- Sudomotor Testing
- Summary
- Glossary
- Appendix
- Abbreviations
- References
- Index
- Confidence is ClinicalKey
- Edition: 4
- Published: March 31, 2025
- Imprint: Elsevier
- Language: English
- Paperback ISBN: 9780443121869
- eBook ISBN: 9780443123238
- eBook ISBN: 9780443123245
KM
Karl E. Misulis
Dr. Misulis is a neurologist at Vanderbilt University Medical Center, specializing in hospital neurology. After a fellowship in neurophysiology, he joined the Vanderbilt faculty practicing general neurology and researching nerve regeneration and brain tumor biology. He moved to West Tennessee Healthcare where he was a hospital neurologist and Chief Medical Information Officer, while retaining his faculty appointment at Vanderbilt. Dr. Misulis has returned to full-time practice at Vanderbilt University Hospital as Professor of Clinical Neurology and Director of the Neurology Hospitalist service. He has a secondary appointment as Professor of Clinical Biomedical Informatics. Dr. Misulis is board certified in neurology and recently completed his 10-year recertification. He is also certified in Clinical Informatics by the American Board of Preventative Medicine and certified in EEG by the American Board of Clinical Neurophysiology. Dr. Misulis has received numerous awards including being listed in Best Doctors for many years. He has published numerous books, including a co-authorship on “Neurologic Localization and Diagnosis” to publish with Elsevier this year. He has taught medicine around the world, working directly with physicians on three continents and lecturing on six.
Affiliations and expertise
Professor of Clinical Neurology,Vanderbilt University Medical Center,Nashville, TN, USATH
Thomas C. Head
Dr. Head received his medical degree from University of Alabama School of Medicine and has been in practice for more than 20 years. He is board certified in neurology as well as in clinical neurophysiology (American Board of Psychiatry and Neurology), with a focus on neuromuscular. Dr. Head served as co-author with Dr. Misulis for the previous edition of this text as well as on Netter’s Concise Neurology Updated Edition.
Affiliations and expertise
Assistant Professor of Neurology, Neuromuscular, University of Alabama at Birmingham, Heersink School of Medicine, Birmingham, Alabama, USARead Essentials of Clinical Neurophysiology on ScienceDirect