
Epigenetics and Neuroplasticity - Evidence and Debate
- 1st Edition, Volume 128 - November 5, 2014
- Imprint: Academic Press
- Editors: Schahram Akbarian, Farah Lubin
- Language: English
- Hardback ISBN:9 7 8 - 0 - 1 2 - 8 0 0 9 7 7 - 2
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 0 1 0 8 5 - 3
The ‘epi-(Greek for ‘over’, ‘above’)genome’, with its rich cache of highly regulated, structural modifications—including DNA methylation, histone modifications and histone… Read more

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Request a sales quote- Topics cover the entire lifespan of the brain, from transgenerational epigenetics to neurodevelopmental disease to disorders of the aging brain.
- All chapters are written with dual intent, to provide the reader with a timely update on the field, and a discussion of provocative or controversial findings in the field with the potential of great impact for future developments in the field.
- Preface
- Chapter One: The Epigenetic Basis of Memory Formation and Storage
- Abstract
- 1 Introduction to the Neurobiology of Learning and Memory
- 2 Epigenetic Mechanisms of Memory Consolidation
- 3 Epigenetic Mechanisms of Memory Reconsolidation
- 4 Epigenetic Mechanisms of Memory Extinction
- 5 Future Directions and Conclusions
- Acknowledgments
- Chapter Two: Epigenetics in Posttraumatic Stress Disorder
- Abstract
- 1 Introduction
- 2 Epigenetic Evidences in PTSD
- 3 Epigenetic Mechanisms in Gene by Environment Interactions in PTSD
- 4 Conclusions
- Chapter Three: Histone-Mediated Epigenetics in Addiction
- Abstract
- 1 Introduction
- 2 General Overview of Histone-Mediated Epigenetics
- 3 Learning Processes Involved in the Development of Addiction
- 4 Histone-Mediated Epigenetic Mechanisms
- 5 Histone-Mediated Actions in Drug Addiction
- 6 Debates and Considerations
- 7 Considerations for Histone-Mediated Treatment of Addiction
- Acknowledgments
- Chapter Four: Modeling the Molecular Epigenetic Profile of Psychosis in Prenatally Stressed Mice
- Abstract
- 1 The Epigenetic Hypothesis of Psychosis
- 2 Prenatal or Early-Life Stress and Impaired Epigenetic Profile
- 3 The Epigenetic Modifications of GABAergic and Glutamatergic Genes Induced by Prenatal Stress in Mice Are Also Detected in SZ and BP Disorder Patients
- 4 PRS Mice Are a Promising Model for Studies of the Natural Course of SZ and BP Disorders
- Acknowledgment
- Chapter Five: Epigenetics of Depression
- Abstract
- 1 Introduction
- 2 Genetics of Major Depression
- 3 Epigenetics of Major Depression
- Acknowledgments and Disclosures
- Chapter Six: Epigenetic Factors in Intellectual Disability: The Rubinstein–Taybi Syndrome as a Paradigm of Neurodevelopmental Disorder with Epigenetic Origin
- Abstract
- 1 Intellectual Disability and Chromatin-Modifying Enzymes
- 2 Molecular Genetics of RSTS
- 3 Lessons from Mouse Models
- 4 From Mouse Models to Patients: Therapy Prospects
- 5 Standing Questions and Controversies in RSTS Research
- 6 Concluding Remarks
- Acknowledgments
- Chapter Seven: The Intergenerational Effects of Early Adversity
- Abstract
- 1 Introduction
- 2 Intergenerational Studies of Malnutrition: Human
- 3 Long-Term and Intergenerational Effects of Postnatal Malnutrition: The Barbados Nutrition Study
- 4 Intergenerational Studies of Malnutrition: Animal Studies
- 5 Intergenerational Studies of Early Adversity and Trauma: Human and Animal Studies
- 6 Other Intergenerational Studies: Chemical Exposures
- 7 Intergenerational Transmission: Epigenetic Mechanisms
- 8 Conclusion
- Acknowledgments
- Chapter Eight: The Future of Neuroepigenetics in the Human Brain
- Abstract
- 1 Introduction
- 2 Challenges for Epigenetic Approaches in the (Human) Brain
- 3 Evidence and Debate
- 4 Synopsis and Outlook
- Conflict of Interest
- Acknowledgment
- Index
- Edition: 1
- Volume: 128
- Published: November 5, 2014
- Imprint: Academic Press
- No. of pages: 250
- Language: English
- Hardback ISBN: 9780128009772
- eBook ISBN: 9780128010853
SA
Schahram Akbarian
Dr. Akbarian has been a principal investigator on National Institutes of Health-funded research projects since 2001and published close to 100 articles in scientific journals and book chapters. He is a member of professional societies such as the American College of Neuropsychopharmacology and presently serves on the Scientific Advisory Board of the Brain & Behavior Research Foundation and on Editorial Boards of various journals in the field
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Farah Lubin
Dr. Akbarian has been a principal investigator on National Institutes of Health-funded research projects since 2001and published close to 100 articles in scientific journals and book chapters. He is a member of professional societies such as the American College of Neuropsychopharmacology and presently serves on the Scientific Advisory Board of the Brain & Behavior Research Foundation and on Editorial Boards of various journals in the field