Epigenetics and Metabolomics
- 1st Edition, Volume 28 - August 25, 2021
- Editors: Paban K. Agrawala, Trygve Tollefsbol, Poonam Rana
- Language: English
- Paperback ISBN:9 7 8 - 0 - 3 2 3 - 8 5 6 5 2 - 2
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 8 5 6 5 3 - 9
Epigenetics and Metabolomics, a new volume in the Translational Epigenetics series, offers a synthesized discussion of epigenetic control of metabolic activity, and systems-b… Read more
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Request a sales quoteEpigenetics and Metabolomics, a new volume in the Translational Epigenetics series, offers a synthesized discussion of epigenetic control of metabolic activity, and systems-based approaches for better understanding these mechanisms. Over a dozen chapter authors provide an overview of epigenetics in translational medicine and metabolomics techniques, followed by analyses of epigenetic and metabolomic linkage mechanisms likely to result in effective identification of disease biomarkers, as well as new therapies targeting the removal of the inappropriate epigenetic alterations. Epigenetic interventions in cancer, brain damage, and neuroendocrine disease, among other disorders, are discussed in-depth, with an emphasis on exploring next steps for clinical translation and personalized healthcare.
- Offers a synthesized discussion of epigenetic regulation of metabolic activity and systems-based approaches to power new research
- Discusses epigenetic control of metabolic pathways and possible therapeutic targets for cancer, neurodegenerative, and neuroendocrine diseases, among others
- Provides guidance in epigenomics and metabolomic research methodology
Human geneticists; human genomicists; translational researchers in genomic medicine, epigenetics, biochemistry, molecular biology, oncology, neurology, and bioinformatics; life science researchers; developmental biologists. Clinicians and graduate students in the biosciences
- Cover image
- Title page
- Table of Contents
- Copyright
- Contributors
- Preface
- Chapter 1: Metabolomics techniques: A brief update
- Abstract
- Acknowledgments
- Introduction
- NMR spectroscopy
- Mass spectrometry
- Chemometric analysis of metabolomics data
- Applications of metabolomics in various diseases
- Conclusions
- Chapter 2: Integration of epigenomics and metabolomics: From biomarkers discovery to personalized medicine
- Abstract
- Introduction
- Techniques and approaches
- P4 medicine and systems medicine: A proactive vision for personalized therapy
- Pharmaco-omics: Omics in personalized medicine
- Challenges
- Futuristic vision and conclusion
- Chapter 3: Aging-associated changes in metabolic regulation of epigenetic modifications and gene expression
- Abstract
- What is aging?
- How are aging and metabolism related?
- How is aging associated with changes in gene expression and epigenetic modifications?
- Metabolic activity, chromatin-based regulation of gene expression, and aging are all intricately entangled
- What factors contribute to premature aging?
- How can we rejuvenate or delay age-related processes?
- Conclusion
- Chapter 4: Epigenetic and metabolic changes in traumatic brain injury
- Abstract
- Introduction
- Perturbed metabolism during TBI
- Interplay between epigenetics and metabolism
- Role of mitoepigenetics
- Future directions and conclusion
- Chapter 5: Metabolic regulation in urological tumors: Interplay with epigenetics and epitranscriptomics
- Abstract
- Introduction
- Epigenetics and metabolic reprograming interplay
- RNA modifiers and metabolic regulation cross-talk
- Epigenetic and epitranscriptomics crosslinks with metabolic reprogramming in urological tumors
- Clinical applications
- Conclusion
- Chapter 6: Multiomics approach for precision wellness
- Abstract
- Precision wellness
- What is omics
- Analytical platforms for omics
- Integromics and systems medicine
- Chapter 7: Oncogene: An epigenetic regulation
- Abstract
- Introduction
- Epigenetics of the tumor suppressor gene
- Epigenetics of proto-oncogene
- Conclusion and future perspective
- Chapter 8: Epigenetic regulations in gastrointestine: Implications on sensitivity to ionizing radiation, inflammatory diseases, and cancer development
- Abstract
- Introduction
- Basic epigenetic modifications
- Adverse epigenomic programs in different cancer types
- Cellular responses to ionizing radiation: Genomic instability, bystander effects, and radiation carcinogenesis
- Epigenetic regulations following IR exposure
- The gastrointestinal system
- Therapies to treat epigenetic defects
- Conclusions and future directions
- Chapter 9: Epigenetics of epithelial to mesenchymal transition (EMT) in cancer
- Abstract
- Introduction
- Processes governing EMT—Cellular models of EMT induction
- EMT induction by TGFβ
- EMT induction by TNF-α
- Hypoxia-induced EMT
- Epigenetic modifications during EMT
- Histone acetyl transferases (HATs) and histone deacetylases (HDACs)
- EMT in metabolic reprogramming and metabolic plasticity
- Conclusion
- Chapter 10: Nutrients seminal role in the development and epigenetic reprogramming during the first 1000 days of life
- Abstract
- Acknowledgments
- Development is a genetic program
- Epigenetic reprogramming and the global epigenetic erasure in the embryogenesis
- Early 1000 days in development are a critical period with irreversible milestones
- Diet is an essential abiotic factor for the development
- Diet as a conduit for gut microbiome: The emerging frontier in health research
- Dietary and microbial metabolites as the catalyzers for epigenetic programming
- The implication of dietary status on epigenetics: The phenomenon of the double and triple burden
- Future perspectives: Healthy nutrition for healthy living and reduce disease burden
- Chapter 11: Epigenetic mechanisms of hepatocellular carcinoma progression: Potential therapeutic opportunities
- Abstract
- Introduction
- Epigenetic alterations in HCC
- Challenges and future prospects
- Concluding remarks
- Chapter 12: Translational epigenetics in neurodegenerative diseases
- Abstract
- Introduction
- Epigenetic regulation of chromatin in the brain
- DNA methylation
- Histone acetylation
- Histone methylation
- Histone phosphorylation
- Histone variants
- Chromatin positioning/remodeling
- Histone chaperones
- DNA methylation
- miRNA and lncRNA
- Conclusion
- Chapter 13: Host-epigenetics-microbiota: A tripartite interaction in health and disease
- Abstract
- Introduction
- Microbiota, epigenetics, and homeostasis
- Microbiota, epigenetics, and immune system
- Microbiota, epigenetics, and disorders
- Future perspective
- Chapter 14: Epigenetics in cardiovascular complications
- Abstract
- Atherosclerosis: Disease characteristics and Molecular basis
- Epigenetic mechanisms in atherosclerosis
- Chapter 15: Epigenetics and viral infectious diseases
- Abstract
- Introduction
- Discussion of epigenetic modification during DNA viruses infection
- Discussion of epigenetic modification during RNA viruses infection
- Epigenetic regulation of immune cells during viral infection
- Epigenetic targeted therapy for viral infections
- Chapter 16: Metabolic profiling leading to clinical phenomics: From bench to bedside
- Abstract
- Introduction
- Metabolic profiling techniques
- Clinical metabolomics
- Clinical phenomics
- Big-data and phenomics
- Future directions and limitations
- Chapter 17: Epigenetic insights for wound healing mechanism
- Abstract
- Introduction
- Overview of epigenetic mechanism
- Epigenetic and wound healing
- Dynamic expression of epigenetic regulators in wound healing
- Epigenetic regulation in hemostasis phase after injury
- Epigenetic regulation in inflammatory phase
- Epigenetic changes during proliferation phase
- Epigenetic regulation in angiogenesis
- Epigenetic regulation in re-epithelialization phase
- Epigenetic regulations in remodeling phase
- Chapter 18: Role of metabolomics to investigate combined effect of radiation and burn
- Abstract
- Acknowledgment
- Introduction
- Metabolomics—From biomarkers to mechanism
- Metabolic alteration after burn injury
- Metabolic alterations after radiation injury
- Biochemical and metabolic alterations caused by radiation and burn combined injuries
- Conclusion and future directions
- Chapter 19: Advances and prospects of epigenetics in plants
- Abstract
- Introduction
- Molecular mechanisms
- The triangle of interactions of epigenetic mechanisms
- Methods of studying epigenetic mechanisms
- Biological phenomenon involving plant epigenetics
- Implications in plant breeding
- Future perspective
- Epigenetic markers as a bio-tool
- Conclusion: Epigenetics could alter the way we breed crops for drought and climate change
- Index
- No. of pages: 476
- Language: English
- Edition: 1
- Volume: 28
- Published: August 25, 2021
- Imprint: Academic Press
- Paperback ISBN: 9780323856522
- eBook ISBN: 9780323856539
PA
Paban K. Agrawala
Dr. Paban K. Agrawala Ph.D is a Scientist in the Radiation Epigenetics Division at the Institute of Nuclear Medicine and Allied Sciences in New Delhi, India, and previously was a Post doctoral Research Associate at Brookhaven National Lab, New York, USA. Dr. Agrawala is a member of the Indian Society for Radiation Biology, as well the Flowcytometry Society of India. He has published widely in such peer reviewed journals as the International Journal of Radiation Biology; Frontiers in Immunology; Current Topics in Medicinal Chemistry; and the Journal of Environmental Pathology, Toxicology, and Oncology. His current research focuses on understanding the epigenetic changes, especially histone acetyltion status, following exposure to ionizing radiation.
Affiliations and expertise
Radiation Epigenetics Division, Institute of Nuclear Medicine and Allied Sciences, New Delhi, IndiaTT
Trygve Tollefsbol
Dr. Tollefsbol is a Distinguished Professor of Biology and a Senior Scientist in the O’Neal Comprehensive Cancer Center, Integrative Center for Aging Research, Nutrition Obesity Research Center, University Wide Microbiome Center, and the Comprehensive Diabetes Center at the University of Alabama at Birmingham (UAB). He is Director of the UAB Cell Senescence Culture Facility which he established in 1999. Dr. Tollefsbol trained as a Postdoctoral Fellow and Assistant Research Professor with members of the National Academy of Science at Duke University and the University of North Carolina. He earned doctorates in molecular biology and osteopathic medicine from the University of North Texas Health Sciences Center and his bachelor’s degree in Biology from the University of Houston. He has received prior funding from the NCI, NHLBI, NIMH and other federal institutes as well as the Glenn Foundation for Medical Research, Susan G. Komen for the Cure, the American Federation for Aging Research (AFAR), and the American Institute for Cancer Research (AICR) among many other sources.
Affiliations and expertise
Distinguished Professor of Biology
Senior Scientist, O’Neal Comprehensive Cancer Center
Senior Scientist, Integrative Center for Aging Research
Senior Scientist, Comprehensive Diabetes Center
Senior Scientist, Nutrition Obesity Research Center
Senior Scientist, University Wide Microbiome Center
Director, Cell Senescence Culture Facility
University of Alabama at Birmingham, AL, USAPR
Poonam Rana
Dr. Poonam Rana Phd is a Senior Scientist at the Institute of Nuclear Medicine & Allied Sciences, under Ministry of Defence, Delhi, India. She received her PhD at the CCS Haryana Agricultural University in Hisar, India. Her focus of research is applications of metabolomics and imaging in identification of biomarkers for traumatic brain injury and radiation exposure during combat emergencies. She has published widely in such peer reviewed journals as the Scientific Reports, Metabolomics, Journal of Neuroendocrinology, International Journal of Radiation Biology, Journal of Neuroscience Research, and Chemical Biological Interactions.
Affiliations and expertise
Nuclear Medicine and Allied Sciences, Ministry of Defence, Timarpur, New Delhi, IndiaRead Epigenetics and Metabolomics on ScienceDirect