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Epigenetics and DNA Damage
- 1st Edition, Volume 33 - August 14, 2022
- Editor: Miriam Galvonas Jasiulionis
- Language: English
- Paperback ISBN:9 7 8 - 0 - 3 2 3 - 9 1 0 8 1 - 1
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 9 1 0 8 2 - 8
Although scientists recognize the role of epigenetic mechanisms in DNA damage response, the complex, mechanistic interplay between chromatin regulation and DNA repair is still po… Read more
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Request a sales quoteAlthough scientists recognize the role of epigenetic mechanisms in DNA damage response, the complex, mechanistic interplay between chromatin regulation and DNA repair is still poorly understood. Comprehending how these processes are connected in time and space and play out in developmental processes may reveal novel directions for new research and disease treatment.
Epigenetics and DNA Damage, a new volume in the Translational Epigenetics series, offers a thorough grounding in the relationship between DNA Damage, epigenetic modifications, and chromatin regulation. Early chapters address the basic science of DNA damage and its association with various epigenetic mechanisms, including DNA methylation, post-translational histone modifications, histone variants, chromatin remodeling, miRNAs, and lncRNAs. This is followed by a close discussion of DNA damage and epigenetics in metabolism, aging, cellular differentiation, immune function, stem cell biology, and cancer, tying recent research to translational application in disease understanding. Later chapters examine possible epigenetic therapies combining DNA damage induction and epigenetic alteration, as well as instructive chapters on how to analyze DNA damage and epigenetic alterations in new research.
- Offers a thorough foundation in epigenetics and DNA damage research, as well as informed discussion of evolving research trends, disease findings, and early therapeutics
- Features chapter contributions from leading international contributors
- Empowers scientists to apply protocols in DNA damage and epigenetic alteration analysis and experimatation in their own research
Human geneticists; human genomicists; translational researchers in genomic medicine, epigenetics, biochemistry, molecular biology, oncology, and immunology; life science researchers; biotechnologists; developmental biologists. Clinicians and graduate students in the biosciences
- Cover image
- Title page
- Table of Contents
- Copyright
- Contributors
- Preface
- Section 1: Understanding the relationship between DNA damage and epigenetic mechanisms
- Chapter 1: DNA damage and DNA methylation
- Abstract
- Introduction
- Base modifications
- DNA methylation and DNA damageability
- Dynamics of DNA methylation
- DNA repair factors and DNA methylation
- DNA methylation upon DNA repair
- References
- Chapter 2: DNA damage and histone modifications
- Abstract
- Introduction
- Histone modifications in DNA double-stranded break repair
- Histone modifications in DNA excision repair
- Histone modifications in DNA mismatch repair
- Concluding remarks
- References
- Chapter 3: DNA damage and histone variants
- Abstract
- Introduction
- DDR mechanisms
- Histone variants
- Role of histone variants in DDR
- Conclusions
- References
- Chapter 4: DNA damage and miRNAs
- Abstract
- MicroRNA biogenesis and maturation
- Effects of DDR on miRNA biogenesis
- miRNAs and double-strand break (DSB) repair
- miRNAs and homologous recombination (HR) repair
- miRNAs and nonhomologous end-joining (NHEJ) repair
- miRNAs and base excision repair (BER)
- miRNAs and nucleotide excision repair (NER)
- miRNAs DNA mismatch repair (MMR)
- Role of miRNAs in cell cycle arrest and apoptosis
- DDR, miRNAs, and cancer development and treatment
- References
- Chapter 5: DNA damage and lncRNAs
- Abstract
- Introduction
- lncRNAs and their biogenesis
- lncRNAs in other signaling pathways
- lncRNAs and DNA repair
- The role of lncRNAs in the DDR regulation
- Conclusion
- References
- Chapter 6: DNA damage, sirtuins, and epigenetic marks
- Abstract
- Sirtuins
- Sirtuins and chromatin remodeling
- Sirtuins and epigenetic modifications
- Sirtuins and telomere maintenance
- Sirtuins and genomic stability
- Sirtuins and diseases
- Concluding remarks
- References
- Section 2: DNA damage and epigenetics—Their impact in the onset of diseases
- Chapter 7: DNA damage, metabolism, and epigenetic regulation
- Abstract
- Acknowledgments
- Introduction
- Crosstalk between epigenetics and metabolism in cancer
- Metabolic dysfunction, epigenetic modification, and genomic instability
- Epigenetics and steroid hormone metabolism in endocrine-driven cancer
- Conclusions and perspectives
- References
- Chapter 8: DNA damage, epigenetics, and aging
- Abstract
- Introduction
- Epigenetic modifications versus DNA damage
- DNA damage causes cellular senescence and aging
- Epigenetic marks that prevent DNA damage and aging: Youth-associated genome-stabilizing epigenetic marks
- How epigenetic modifications prevent DNA damage and the aging process: DNA Protection vs. DNA repair
- IRS hypomethylation drives the molecular pathogenesis of age-related noncommunicable diseases
- Youth-DNA-GAPs
- The fountain of youth
- References
- Chapter 9: DNA damage signaling, cell reprogramming, and differentiation
- Abstract
- Introduction
- DNA damage signaling in cell reprogramming and differentiation
- iPS cells derived from DNA repair-deficient disease
- NHEJ factors (DNA-PKcs, LIG IV, and Artemis)
- Conclusion
- References
- Chapter 10: The interplay between DNA damage and epigenetics in cancer
- Abstract
- Introduction
- Genetic factors
- Environmental exposures
- The cancer epigenome and DNA damage
- Susceptibility of the cancer epigenome to DNA damage
- Targeting DNA damage and epigenetic changes in cancer diagnosis and treatment
- Conclusion
- References
- Chapter 11: Oncometabolites, epigenetic marks, and DNA repair
- Abstract
- Oncometabolite biology
- Oncometabolites and DNA repair
- References
- Section 3: Therapeutic strategies inducing DNA damage and epigenetic alterations
- Chapter 12: Cancer therapies inducing DNA damage
- Abstract
- Acknowledgments
- Introduction
- Mechanisms of DNA damage by radiotherapy
- DNA damage-inducing chemotherapies
- Conclusions
- References
- Chapter 13: Epigenetic therapy and DNA damage response
- Abstract
- Introduction
- Commonly altered epigenetic regulatory proteins implicated in cancer and their implication for therapy
- Targeting the epigenetics of the DNA damage response in cancer: The concept of synthetic lethality
- Conclusion: Implications of epigenetic regulation for improved cancer treatment
- References
- Section 4: Experimental approaches to study DNA damage and epigenetic modifications
- Chapter 14: Useful protocols to study DNA damage
- Abstract
- Acknowledgments
- Introduction
- Alkaline comet assay
- DNA lesions immunodetection
- Final remarks
- References
- Chapter 15: Useful methods to study epigenetic marks: DNA methylation, histone modifications, chromatin structure, and noncoding RNAs
- Abstract
- Introduction
- Methods used to study DNA methylation
- Methods used to study histone modifications
- Methods used to study chromatin accessibility
- Methods used to identify chromatin-associated proteins
- Methods used to study noncoding RNAs (ncRNA)
- Conclusions
- References
- Index
- No. of pages: 336
- Language: English
- Edition: 1
- Volume: 33
- Published: August 14, 2022
- Imprint: Academic Press
- Paperback ISBN: 9780323910811
- eBook ISBN: 9780323910828
MJ
Miriam Galvonas Jasiulionis
Dr. Miriam Galvonas Jasiulionis is a Professor at the Department of Pharmacology, in the Laboratory of Ontogeny and Epigenetics, at the Universidade Federal de São Paulo, Brazil. Her lab has investigated the role of epigenetic alterations in the relationship between sustained stressful conditions and malignant transformation, especially in melanocytes, to contribute to better comprehension of mechanisms involved in melanoma genesis and open avenues to develop novel therapeutic approaches. Dr. Jasiulionis has published widely in such peer reviewed journals as Clinical Epigenetics, Molecular Oncology, Frontiers in Immunology, Oncotarget, Epigenetics, and Neoplasia.
Affiliations and expertise
Professor, Department of Pharmacology and Scientist, Laboratory of Ontogeny and Epigenetics, Escola Paulista de Medicina, Universidade Federal de Sao Paulo, Brazil