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Epigenetics and Dermatology
1st Edition - February 16, 2015
Editors: Qianjin Lu, Christopher Chang, Bruce C. Richardson
Hardback ISBN:9780128009574
9 7 8 - 0 - 1 2 - 8 0 0 9 5 7 - 4
eBook ISBN:9780128012727
9 7 8 - 0 - 1 2 - 8 0 1 2 7 2 - 7
Epigenetics and Dermatology explores the role of epigenetics in the pathogenesis of autoimmune-related skin diseases and skin cancer. Leading contributors cover common and… Read more
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Epigenetics and Dermatology explores the role of epigenetics in the pathogenesis of autoimmune-related skin diseases and skin cancer. Leading contributors cover common and uncommon skin conditions in which extensive epigenetic research has been done. They explain how environmental exposures (chemicals, drugs, sunlight, diet, stress, smoking, infection, etc.) in all stages of life (from a fetus in-utero to an elderly person) may result in epigenetic changes that lead to development of some skin diseases in life. They also discuss the possibilities of new and emergent epigenetic treatments which are gradually being adopted in management of various skin diseases. Chapters follow a conventional structure, covering fundamental biology of the disease condition, etiology and pathogenesis, diagnosis, commonly available treatments, and epigenetic therapy where applicable.
Discusses the basic biology of skin diseases and skin cancers induced or aggravated by aberrant epigenetic changes
Evaluates how to approach autoimmune-related skin diseases from a therapeutic perspective using the wealth of emergent epigenetic clinical trials
Offers a coherent and structured table of contents with basic epigenetic biology followed by discussion of the spectrum of rheumatologic through neoplastic skin diseases, finally ending with a discourse on epigenetic therapy
Basic biologists working on skin-related diseases, and translational researchers interested in further exploration of epigenetic therapies. Some oncologists.
Dedication
List of Contributors
Preface
Acknowledgments
Section 1: Biological and Historical Aspects of Epigenetics
Chapter 1. Introduction to Epigenetics
References
Chapter 2. Laboratory Methods in Epigenetics
2.1 Introduction
2.2 DNA Methylation Analysis
2.3 Techniques Used for 5hmC Mark Detection
2.4 Histone Modification Analysis
2.5 miRNA Analysis
2.6 Conclusion
References
Chapter 3. Keratinocyte Differentiation and Epigenetics
3.1 Introduction
3.2 Gene Expression in Keratinocyte Differentiation
3.3 Epigenetic Modulation in Keratinocyte Differentiation
3.4 Epigenetics and Skin Diseases
3.5 Conclusion
References
Chapter 4. Epigenetics and Fibrosis: Lessons, Challenges, and Windows of Opportunity
4.1 Introduction
4.2 Incidence and Prevalence of Fibrosis
4.3 Biology of Epigenetics
4.4 Epigenetics and Fibrosis
4.5 Autoimmunity and Fibrosis
4.6 Conclusion
Acknowledgments
References
Chapter 5. Epigenetic Modulation of Hair Follicle Stem Cells
5.1 Introduction
5.2 Epigenetic Regulation
5.3 Prospects
References
Chapter 6. Epigenetics and the Regulation of Inflammation
6.1 Introduction
6.2 Epigenetic Mechanisms During T-Cell Differentiation
6.3 Epigenetic Regulation of the Immune-Modulatory Cytokine IL-10
6.4 DNA Contraction During Antigen Receptor Arrangement in T and B Cells
6.5 Posttranscriptional Regulation of Inflammation Through miRNAs
6.8 Epigenetic Modifications Function as Autoantigens in Autoimmune Disease
6.9 Conclusion
References
Chapter 7. Malignant Transformation and Epigenetics
7.1 Introduction
7.2 Regulation of DNA Methylation
7.3 Histone Modifications
7.4 SNF Factors of Chromatin Remodeling
7.5 Epigenetic Therapy for Cancer
7.6 Conclusion
Acknowledgments
References
Chapter 8. Epigenetic Mechanisms of Sirtuins in Dermatology
8.1 Introduction
8.2 Background
8.3 Epigenetic Mechanisms of Sirtuin Function
8.4 Sirtuin Modification of Chromatin Structure and Function Impacts Gene Expression
8.5 Sirtuin Function in Cellular Processes Common to Skin Diseases
8.6 Sirtuins in Skin Aging
8.7 Sirtuins in Skin Inflammation, Inflammatory Diseases, and Autoimmune Diseases
8.8 Sirtuins in Hyperproliferative Skin Disease
8.9 Sirtuins in Skin Repair and Scarring
8.10 Sirtuins in Skin Cancer
8.11 Modulators of Sirtuin Function
8.12 Conclusion
References
Chapter 9. MicroRNAs in Skin Diseases
9.1 Introduction
9.2 MicroRNAs
9.3 miRNAs in Inflammatory Skin Diseases
9.4 miRNAs in Malignant Skin Diseases
9.5 The Clinical Applications of miRNAs
9.6 Conclusion
References
Section 2: Immunologic Skin Diseases
Chapter 10. Systemic Lupus Erythematosus
10.1 Introduction
10.2 Background
10.3 DNA Methylation, Gene Expression, and T-Cell Function
10.4 DNA Methylation and Lupus
10.5 Environmental Causes of T-Cell DNA Demethylation
10.6 Genetic/Epigenetic Interactions in Lupus
10.7 Histone Modifications and Lupus
10.8 miRNAs and Lupus
10.9 Summary/Conclusions
References
Chapter 11. Epigenetics in Psoriasis
11.1 Epidemiology of Psoriasis
11.2 Environmental Factors of Psoriasis
11.3 Epigenetics and Genetics in Psoriasis
11.4 DNA Methylation
11.5 Histone Modification
11.6 Noncoding RNAs
11.7 Conclusion
References
Chapter 12. Epigenetics and Systemic Sclerosis
12.1 Introduction
12.2 Pathogenesis of SSc
12.3 Genetic Factors in SSc
12.4 Epigenetic Aberrancies in SSc
12.5 What Might Trigger Epigenetic Dysregulation in SSc?
12.6 Clinical Relevance of Epigenetic Aberrancies in SSc
12.7 Conclusion
References
Chapter 13. Epigenetics of Allergic and Inflammatory Skin Diseases
13.1 Introduction
13.2 Atopic Dermatitis
13.3 Psoriasis
13.4 Mastocytosis
13.5 Urticaria
13.6 Conclusion
References
Chapter 14. Epigenetics and Other Autoimmune Skin Diseases
14.1 Epigenetics in Vitiligo
14.2 Epigenetics in Alopecia Areata
14.3 Epigenetics in Dermatomyositis
14.4 Epigenetics in Pemphigus
14.5 Conclusion
References
Section 3: Nonimmunologic Skin Diseases
Chapter 15. Epigenetics and Infectious Skin Disease
15.1 Herpes Simplex Viruses
15.2 HSV1 and -2 and VZV
15.3 Human Papilloma Virus
15.4 Conclusion
References
Chapter 16. Epigenetics of Melanoma
16.1 Introduction to the Disease Condition
16.2 Diagnosis of Melanoma
16.3 Etiology and Pathogenesis of Melanoma
16.4 Common Treatments and Epigenetic Therapy
16.5 Conclusion
References
Chapter 17. Cutaneous T-Cell Lymphoma: Mycosis Fungoides and Sézary Syndrome
17.1 Introduction
17.2 MF/SS Clinical Overview
17.3 Molecular Immunopathology of MF/SS
17.4 Molecular Gene Expression Differences in MF/SS
17.5 Potential Genetic and Epigenetic Mechanisms in MF/SS
17.6 Summary
Acknowledgments
References
Chapter 18. Epigenetics and Aging
18.1 Introduction
18.2 Senescence and Aging
18.3 Changes Associated with Aging Skin
18.4 Epigenetic Changes in Cellular and Structural Components of Skin
18.5 Photoaging of Skin
18.6 DNA Methylation and Overall Aging in Skin
18.7 Chromatin and Aging Skin
18.8 MicroRNAs
18.9 Reversing Aging
18.10 Epigenetic Therapeutics in Prevention or Treatment of Aged Skin
18.11 Conclusion
References
Section 4: Applications of Epigenetics
Chapter 19. Targeting Epigenetics in the Development of New Diagnostic Applications—Lessons from Autoimmune Diseases
19.1 Introduction
19.2 The Molecular Basis of Epigenetics
19.3 Epigenetic Perturbations in Autoimmune Diseases—Potential Targets for the Development of Diagnostic Markers and Novel Therapeutic Interventions
19.4 Clinical Applications
19.5 Future Perspectives
19.6 Take-Home Messages
References
Chapter 20. Principles of Epigenetic Treatment
20.1 Introduction
20.2 DNA Methylation
20.3 Epigenetic Therapy in Dermatology
20.4 Discussion
20.5 Conclusion
References
Chapter 21. How the Environment Influences Epigenetics, DNA Methylation, and Autoimmune Diseases
21.1 Introduction
21.2 Environmental Factors
21.3 Epigenetics
21.4 Mechanism of Action
21.5 Conclusion
References
Index
No. of pages: 520
Language: English
Published: February 16, 2015
Imprint: Academic Press
Hardback ISBN: 9780128009574
eBook ISBN: 9780128012727
QL
Qianjin Lu
Affiliations and expertise
Director, Institute of Dermatology at Central South University, Director of Hunan Key Laboratory of Medical Epigenomics, Changsha, China
CC
Christopher Chang
Dr Chang is the current Medical Director for Pediatric Immunology, Allergy and Rheumatology at Joe DiMaggio Children’s Hospital in Florida. At the same time, he serves as Associate Program Director for the Allergy Immunology Fellowship program at the University of California at Davis. Dr. Chang has previously been Chief of the Division of Allergy and Immunology at Thomas Jefferson University and Nemours Children’s Hospital in Philadelphia, PA and Wilmington, DE, respectively. He is a fellow of the American Academy of Allergy, Asthma and Immunology (AAAAI) and the American College of Allergy, Asthma and Immunology (ACAAI), and a member of the Clinical Immunology Society (CIS) and the American Association of Immunologists (AAI). He is Chair of the Core Curriculum, Education and Residency Review Committee of the AAAAI and Vice-chair of the Training Program Directors Committee of the ACAAI. He has over 100 original publications and has authored over 20 chapters in immunology, rheumatology and allergy books, and has also edited 2 books with a third on the way. He has over 30 years’ experience in the practice of Immunology and Allergy and has been involved in the education of future allergists and immunologists at the levels of the medical student, resident and fellow.
Affiliations and expertise
Professor of Medicine and Associate Director, Allergy and Immunology Fellowship Program, Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis, California, USA
BR
Bruce C. Richardson
Affiliations and expertise
Professor of Internal Medicine, University of Michigan, Chief Section of Rheumatology, Veterans Affairs Hospital, Ann Arbor, MI, USA