Eosinophils in Health and Disease
- 1st Edition - November 2, 2012
- Latest edition
- Editors: James J. Lee, Helene F. Rosenberg
- Language: English
Written and edited by leaders in the field, Eosinophils in Health and Disease provides immunology researchers and students with a comprehensive overview of current thought a… Read more
Written and edited by leaders in the field, Eosinophils in Health and Disease provides immunology researchers and students with a comprehensive overview of current thought and cutting-edge eosinophil research, providing chapters on basic science, disease-specific issues, therapeutics, models for study and areas of emerging importance. Despite an explosion of discovery in this area over the last decade, this is the only up-to-date resource on eosinophils and eosinophilia exists. This full-color volume provides an essential collection of world class information that is a must-have for any immunologist’s workbench or bookshelf.
- The only updated, comprehensive source of information on eosinophils on the market
- Written by over 80 leaders in the field
- Holistic view of the subject, including basic science, disease-specific chapters, therapeutic options and emerging areas of research
Researchers, clinical investigators and advanced students in the fields of immunology, autoimmunity, asthma and allergy research and cell biology.
Dedication
Foreword
Preface
Acknowledgements
Contributors
Chapter 1. Historical Overview and Perspective on the Role of the Eosinophil in Health and Disease
Introduction
Paul Ehrlich and the Discovery of the Eosinophil
Early Days: The Eosinophil and Anaphylaxis
Eosinophil Granule Proteins and their Properties
Interleukin-5, Eotaxin, and Eosinophil-Derived Cytokines
Transgenic and Knockout Mice for the Investigation of Eosinophils
Eosinophil-Associated Diseases
Conclusion and Future Perspectives
Acknowledgements
References
Chapter 2. The Evolutionary Origins and Presence of Eosinophils in Extant Species
Introduction
Invertebrate Hemocytes
Vertebrate Eosinophil Granulocytes
Comparative Eosinophilopoiesis
So, why Eosinophil Granulocytes?
References
Chapter 3. Eosinophil Structure and Cell Surface Receptors
Chapter 3.1 Introduction
Chapter 3.2 Eosinophil Ultrastructure
Chapter 3.3 Eosinophil Receptor Profile
Chapter 4. Ex Vivo Models for the Study of Eosinophils
Chapter 4.1 Introduction
Chapter 4.2 Eosinophil Cell Lines
Chapter 4.3 Isolation and Manipulation of Eosinophils from Human Peripheral Blood
Chapter 4.4 Induction of Eosinophilia in Mice and the Isolation of Eosinophils for Ex Vivo Manipulations
Chapter 4.5 Culture and Characterization of Mouse Bone Marrow-Derived Eosinophils
Chapter 4.6 Modeling Eosinophil Development Ex Vivo from Human CD34+ Cells
Chapter 5. Eosinophilopoiesis
Chapter 5.1 Introduction
Chapter 5.2 Transcriptional Regulation of Eosinophil Lineage Commitment and Differentiation
Chapter 5.3 Eosinophil Lineage-Committed Progenitors
Chapter 5.4 Interleukin-5 and its Receptor Molecules
Chapter 5.5 Extramedullary Recruitment and Proliferation of Eosinophil Progenitors
Chapter 5.6 Mouse Models Manipulating Eosinophilopoiesis
Chapter 6. Eosinophil Trafficking
Chapter 6.1 Introduction
Chapter 6.2 Eosinophil Chemotaxis
Chapter 6.3 Adhesion Molecules
Chapter 6.4 Eosinophil-Endothelial Cell Interactions during Inflammation
Chapter 6.5 Eosinophils and Circulating Endothelial Progenitor Cells
Chapter 6.6 In Vivo Assessment of Eosinophil Trafficking by Intravital Microscopy
Chapter 7. Eosinophil Signal Transduction
Chapter 7.1 Introduction
Chapter 7.2 Priming: A Critical Step in the Control of Eosinophil Activation
Chapter 7.3 Eosinophil Receptor-Mediated Inhibition
Chapter 7.4 Apoptotic and Survival Signaling in Eosinophils
Chapter 7.5 Molecular Mechanisms Underlying Eosinophil Hematopoiesis
Chapter 7.6 Signaling and Degranulation
Chapter 7.7 Eosinophil Responses to Pathogen-Associated and Damage-Associated Molecular Patterns
Chapter 8. Eosinophil Secretory Functions
Chapter 8.1 Introduction
Chapter 8.2 Release of Cytokines and Chemokines from Eosinophils
Chapter 8.3 Release of Lipid Mediators: the Role of Lipid Bodies
Chapter 8.4 Gene-Knockout Mice: What Can They Teach Us about Sequelae Resulting from the Absence of Specific Eosinophil Cationic Proteins?
Chapter 8.5 The Eosinophil and Airways Hyperresponsiveness: the Role and Mechanisms of Cationic Proteins
Chapter 8.6 Cell-Free Granules are Functional Secretory Organelles
Chapter 9. Eosinophils and Anti-Pathogen Host Defense
Chapter 9.1 Introduction
Chapter 9.2 Eosinophil-Mediated Antibacterial Host Defense
Chapter 9.3 Interactions of Eosinophils with Respiratory Virus Pathogens
Chapter 9.4 Antifungal Immunity by Eosinophils: Mechanisms and Implications in Human Diseases
Chapter 10. Eosinophils: Mediators of Host-Parasite Interactions
Chapter 10.1 Introduction
Chapter 10.2 Eosinophil-Mediated Responses Toward Helminths
Chapter 10.3 Immune Responses in Helminth Infections
Chapter 10.4 Eosinophils as Facilitators of Helminth Infection
Chapter 11. Eosinophil Cell–Cell Communication
Chapter 11.1 Introduction
Chapter 11.2 Eosinophil and Nerve Interactions
Chapter 11.3 Eosinophils as Regulators of Gastrointestinal Physiological Homeostasis
Chapter 11.4 Eosinophil-Mediated Antigen Presentation
Chapter 11.5 Eosinophil Modulation of T Cell Activation and Recruitment
Chapter 11.6 Eosinophil–Mast Cell Interactions
Chapter 11.7 Plasma Cell/B Cell–Eosinophil Interactions
Chapter 11.8 Eosinophil–Airway Epithelial Cell Interactions
Chapter 11.9 The Eosinophil and the Thymus
Chapter 12. Eosinophil-Mediated Tissue Remodeling and Fibrosis
Chapter 12.1 Introduction
Chapter 12.2 Potential Role of Eosinophil Granule Proteins in Tissue Remodeling and Fibrosis
Chapter 12.3 Role of Eosinophils in Transforming Growth Factor β1-Mediated Remodeling
Chapter 12.4 Potential Role of Eosinophils and Tumor Necrosis Factor α in Tissue Remodeling
Chapter 12.5 Esophageal Remodeling and Pediatric Eosinophilic Esophagitis
Chapter 12.6 Remodeling and Disease Pathology: Adult Eosinophilic Esophagitis
Chapter 12.7 Human Studies of Remodeling and Fibrosis in Asthma and Allergic Inflammation
Chapter 13. Eosinophils in Human Disease
Chapter 13.1 Introduction
Chapter 13.3 Eosinophils and Skin Diseases
Chapter 13.4 The Evolving Role of Eosinophils in Asthma
Chapter 13.5 Eosinophil-Targeted Treatment of Asthma
Chapter 13.6 Eosinophils and Hemopoietic Processes in Allergic Asthma
Chapter 13.7 Eosinophil Activities and Virus-Induced Asthma
Chapter 13.8 Eosinophils and Gastrointestinal Disease
Chapter 13.9 Rare Hypereosinophilic Syndromes
Chapter 13.10 Eosinophils and Cancer
Chapter 13.11 Eosinophils and Chronic Rhinosinusitis
Chapter 13.12 Eosinophils and Vascular Healing
Chapter 13.13 Eosinophils and Allograft Rejection
Chapter 13.14 Eosinophils and Calpain-3 Mutation: A Genetic Cause Implicated in Idiopathic Eosinophilic Myositis
Chapter 14. Animal Models of Human Pathology
Chapter 14.1 Introduction: The Trials and Tribulations of Linking Cellular and/or Molecular Pathways and the Pathologies Associated with Inflammation using Animal Models
Chapter 14.3 Mouse Models of Esophageal Eosinophilia
Chapter 14.4 Models of Inflammatory Bowel Diseases
Chapter 14.5 Eosinophil-mediated Events in Mouse Models of Food Allergy
Chapter 14.6 Models of Eosinophilic Leukemia
Chapter 14.7 Eosinophils in Veterinary Medicine
Chapter 15. Antieosinophil Therapeutics
Chapter 15.1 Introduction
Chapter 15.2 Insights into the Pathogenesis of Asthma and Other Eosinophil-Mediated Diseases from Antagonists of Interleukin-5 and its Receptor
Chapter 15.3 Interleukin-5 Receptor-Directed Strategies
Chapter 15.4 Therapeutic Approaches Targeting Siglecs
Chapter 15.5 Targeting the FIP1L1–PDGFRα and Variant PDGFRα and PDGFRβ Fusion Kinases
Chapter 16. Emerging Concepts
Chapter 16.1 Introduction
Chapter 16.2 Understanding the Role of MicroRNA in Regulating Immune Responses: A New Approach to Treating Eosinophilic Disorders and Allergic Inflammation?
Chapter 16.3 Eosinophils in the Zebrafish
Chapter 16.4 Eosinophils as Immune Modulators: Roles of Indoleamine 2,3 Dioxygenase and Tryptophan Catabolites
Chapter 16.5 Regulation of Eosinophil Responses by the Epithelial-Derived Cytokines TSLP, IL-25, and IL-33
Conclusion
Eosinophil Activities Are Complex and Diverse
Anti-Eosinophil Strategies May Not Be the Only Answer
Index
- Edition: 1
- Latest edition
- Published: November 2, 2012
- Language: English
JL
James J. Lee
Affiliations and expertise
Consultant, Division of Pulmonary Medicine, Associate Professor, Department of Biochemistry and Molecular Biology , Distinguished Mayo Clinic Investigator, Mayo Clinic, Scottsdale, Arizona, USAHR
Helene F. Rosenberg
Affiliations and expertise
Senior Investigator and Section Chief, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USARead Eosinophils in Health and Disease on ScienceDirect