
Eosinophil Ultrastructure
Atlas of Eosinophil Cell Biology and Pathology
- 1st Edition - May 2, 2022
- Imprint: Academic Press
- Authors: Rossana C.N. Melo, Ann M. Dvorak, Peter F. Weller
- Language: English
- Hardback ISBN:9 7 8 - 0 - 3 2 3 - 9 9 4 1 3 - 2
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 1 3 7 5 6 - 7
Eosinophil Ultrastructure: Atlas of Eosinophil Cell Biology and Pathology entirely focuses on eosinophils and their functional roles in inflammation, host defense, and normal ho… Read more
Purchase options

Eosinophil Ultrastructure: Atlas of Eosinophil Cell Biology and Pathology
entirely focuses on eosinophils and their functional roles in inflammation, host defense, and normal homeostatic activities. The book explores the ultrastructure of human eosinophils, highlighting biological processes observed under normal, experimental, and pathological conditions.Created to fill a void in the eosinophil literature, the book includes an extensive array of electron microscopic images that illustrate the diversity of eosinophil morphology. While the atlas is a learning and teaching tool, it is mainly a helpful resource for researchers to identify distinguishing features and structural changes that arise during studies of human eosinophils.
The book also covers the ultrastructure of mouse eosinophils under normal and activation conditions and in the context of representative diseases.
- Gives guidelines to understand the human eosinophils in studies focused on structural biology, cellular immunology, innate and adaptive immunity, immune responses to pathogens, immunopathology, and inflammatory responses
- Provides a core of essential knowledge to identify both immature and mature eosinophils
- Comprises a representative compilation of the eosinophil ultrastructure during biological processes, such as activation and degranulation, mostly under experimental conditions
- Highlights eosinophil biological processes found in vivo during human diseases, thus providing a link between basic science and clinical aspects
- Helps identify distinguishing features and structural changes that arise during studies of human eosinophils after isolation from body fluids, while in cultures, or biopsies
- Explains the ultrastructural organization of mature and immature mouse eosinophils, highlighting the similarities/differences between them and human eosinophils
SECTION I - THE CELL BIOLOGY OF HUMAN EOSINOPHILS
Chapter 1 Introduction
Chapter 2 Mature Eosinophils – General Morphology
2.1 Overview
2.2 Nucleus
2.3 Secretory Granules
2.4 Lipid Bodies
2.5 Eosinophil Sombrero vesicles (EoSVs)
2.6 Other Organelles and Structures
2.6.1 Endoplasmic Reticulum
Chapter 3 Eosinophils as Secretory Cells
3.1 Overview
3.2 Classical and Compound Exocytosis
3.3 Piecemeal Degranulation
3.4 Cytolysis
3.5 Extracellular Vesicles Production
Chapter 4 Eosinophil Activation
4.1 Overview
4.2 Ultrastructural Changes of Secretory Granules
4.3 EoSV Formation
4.4 Lipid Body Formation
4.5 Shape Changes
4.6 Extracellular Vesicle Production
Chapter 5 Subcellular Localization of Immune Mediators and other Proteins
5.1 Overview
5.2 Major Basic Protein
5.3 Cytokines
5.4 Receptors
5.5 Tetraspanins
5.6 Galectin-10
5.7 Enzymes Involved in the Formation of Leukotrienes
Chapter 6 Eosinophil Cell Death
6.1 Overview
6.2 Cytolytic Morphology – General Aspects
6.3 Cytolytic Morphology – ETosis
6.4 Apoptotic Morphology – General Aspects
Chapter 7 Immature Eosinophils
7.1 Overview
7.2 About Immature and Mature Eosinophil Granules
7.3 Maturation stages of human eosinophils characterized by TEM
SECTION II - EOSINOPHILS IN HUMAN DISEASES
Chapter 8 Eosinophil-associated diseases
8.1 Overview
8.2 Allergic Airway Diseases
8.3 Skin Disorders
8.4 Hypereosinophilic Syndrome (HES)
8.5 Eosinophilic Granulomatosis with Polyangiitis (EGPA)
8.6 Gastrointestinal Disorders
8.7 Infectious Diseases
8.8 Tumors
8.9 Charcot-Leyden Crystals (CLCs) Formation
SECTION III - THE CELL BIOLOGY OF MOUSE EOSINOPHILS
Chapter 9 Ultrastructure of Mouse Eosinophils
9.1 Overview
9.2 Mature Mouse Eosinophils: General Morphology
9.3 Immature Mouse Eosinophils
9.4 Activation and Degranulation of Mouse Eosinophils
9.5 Mice in the Context of EADs
- Edition: 1
- Published: May 2, 2022
- Imprint: Academic Press
- Language: English
RM
Rossana C.N. Melo
AD
Ann M. Dvorak
PW