Endophytic Fungi

The Full Story of the Untapped Treasure

1st Edition - August 7, 2024
Editors: Ahmed M. Abdel Azeem, Ajar Nath Yadav, Neelam Yadav
Language: English
Paperback ISBN:
9 7 8 - 0 - 3 2 3 - 9 9 3 1 4 - 2
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 9 9 3 1 5 - 9

Endophytic Fungi: The Full Story of the Untapped Treasure covers the developments in endophytic fungal research from beginning to the end by the eminent researchers involved in the… Read more

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Endophytic Fungi: The Full Story of the Untapped Treasure covers the developments in endophytic fungal research from beginning to the end by the eminent researchers involved in the field. It sheds light on the endophytic fungal current research, challenges, and future possibilities, the trending recent topics in the plant-fungal endophytes' biodynamics for sustainable development of bioproducts and its applications are supported in large-scale biosynthesis of industrially and pharmaceutical important biomolecules.

Endophytic Fungi: The Full Story of the Untapped Treasure highlights the bioprospecting and applied aspects of endophytic fungal communities from diverse hosts and discusses the practical applications of such endophytes in detail. It also reviews recent strategies on alternative sustainable sources of medicines such as secondary metabolites of fungi instead of over collection of plants under prohibiting of biodiversity conventions. The uniqueness of this book is the inclusion of updated bioinformatics-based strategies and its importance in bioactive molecules produced by endophytic fungi. The book addresses one of the most eminent issues in this field: how to translate the potential that endophytic fungi hold in stable practical application.

Cover image
Title page
Table of Contents
Copyright
Contributors
About the editors
Foreword by Davinder Singh
Foreword by Amrik Singh Ahluwalia
Preface
Acknowledgments
Chapter 1 Exploring endophytic fungal diversity: Review of traditional and molecular techniques
Abstract
1.1 Introduction
1.2 Significance of the endophytic fungi diversity
1.3 Collecting, isolation, and cultivation
1.4 Taxonomy and morphological identification of endophytic fungi
1.5 Molecular identification of isolated endophytic fungi
1.6 Assessing endophytic fungal biodiversity
1.7 Challenges and perspectives of modern methods for identification of endophytic fungi
1.8 Conclusions
References
Chapter 2 Endophytic fungi: A natural tool for plant growth promotion and sustainable agriculture
Abstract
2.1 Introduction
2.2 Emergence of interest in endophytic fungi
2.3 Plant growth-enhancing traits of endophytic fungi
2.4 Role of endophytic fungi in abiotic and biotic stress alleviation
2.5 Safety and necessary care for using endophytic fungi as pgp inoculant
2.6 Conclusion
References
Chapter 3 Molecular approaches to screen bioactive compounds from endophytic fungi
Abstract
3.1 Introduction
3.2 Activation of biosynthetic gene clusters
3.3 Bioassay-guided fractionation
3.4 Biotransformation
3.5 Genome mining for the discovery of novel metabolites
3.6 Omics approaches
3.7 Prospects
References
Chapter 4 In silico prediction and characterization of secondary metabolites from endophytic fungi
Abstract
4.1 Introduction
4.2 Secondary metabolites produced by endophytic fungi
4.3 Characterization of endophytic fungal secondary metabolites
4.4 In silico methods for secondary metabolite selection and activity prediction
4.5 Conclusion and future prospects
References
Chapter 5 The insecticidal activity of endophytic fungi for sustainable agriculture
Abstract
5.1 Introduction
5.2 Biodiversity and distribution of endophytic fungi exhibiting insecticidal activity
5.3 Disease management mechanism of endophytic fungi
5.4 Applications of endophytic fungi
5.5 Commercialized mycoinsecticides
5.6 Limitations and challenges
5.7 Conclusion and future prospects
References
Further reading
Chapter 6 Exploration of fungal endophytes for the untouched treasure within
Abstract
6.1 Introduction
6.2 Types of endophytic fungi
6.3 The association between plant and endophytic fungi
6.4 Factors affecting the production of bioactive compounds in endophytes
6.5 The need for research on endophytes
6.6 Endophytes a quintessential reservoir of bioactive compounds
6.7 Bioprospecting fungal endophytes for its application in therapeutics
6.8 Conclusion
References
Chapter 7 Industrially important enzymes of endophytic fungi
Abstract
7.1 Introduction
7.2 Various endophytic enzymes in industry: A background
7.3 Molecular mining of endophytes
7.4 Fungal endophyte-host plant interaction
7.5 Biotransformation, the way toward green chemistry and sustainability
7.6 Functional role of endophytic enzymes
7.7 Fungal endophytic enzymes industrial applications
7.8 Selection criteria of industrial endophytic enzymes
7.9 Conclusion and future aspects
References
Chapter 8 The alpha-amylase inhibitors of endophytic fungal's metabolites
Abstract
8.1 Introduction
8.2 Structure of alpha amylase
8.3 Microorganisms producing amylase
8.4 Diabetes and antidiabetics
8.5 Extraction of endophytic fungi’ metabolites
8.6 Screening of antiglycemic activity
References
Chapter 9 Antimycobacterial compounds produced by endophytic fungi: An overview
Abstract
9.1 Introduction
9.2 Mycobacterial infection and epidemiology
9.3 Treatment of TB
9.4 Endophytic fungi for the treatment of mycobacterial infection
9.5 Future prospective
References
Chapter 10 Secondary metabolites production by endophytic fungi
Abstract
10.1 Introduction
10.2 Distribution Of endophytic fungi in nature
10.3 Does climate affect fungal endophyte communities?
10.4 Role of endophytes in the ecosystem
10.5 Ecological role of endophytes
10.6 Fungal endophytes associated with medicinal plants
10.7 Secondary metabolites of microorganisms
10.8 Ecological role of secondary metabolites
10.9 Applications of secondary metabolites
10.10 Conclusion and future aspects
References
Chapter 11 Endophytic fungi—An alternative source of cytotoxic compounds
Abstract
11.1 Introduction
11.2 Contribution of endophytic fungi to the discovery of novel anticancer molecules
11.3 Natural products from endophytic fungi as source of cytotoxic compounds
11.4 Conclusion
References
Chapter 12 Volatile organic compounds from endophytic fungi
Abstract
12.1 Introduction
12.2 How VOCs mediate plant-endophytic fungi interactions
12.3 Bioactivity of VOCs produced by endophytic fungi
12.4 Highlights of methods used in the analysis of VOCs produced by endophytic fungi
12.5 Conclusion and future prospects
References
Chapter 13 Anticancer and antimicrobial potential of fungal endophytes from medicinal plants
Abstract
13.1 Introduction
13.2 EF classification
13.3 The pharmacological effects of fungal metabolites’ bioactive compounds
References
Chapter 14 Fungal endophytes as novel sources of antirheumatoid compounds
Abstract
Acknowledgment
14.1 Introduction
14.2 Antiinflammatory and antioxidant activity of mushrooms
14.3 Endophytic fungi as a source of natural products
14.4 Antiinflammatory and antioxidant activity of endophytic fungi
14.5 Conclusion
References
Chapter 15 Endophytic fungi: The budding source of natural antioxidants
Abstract
15.1 Introduction
15.2 Oxidative stress: Causes and side effects
15.3 Fungal endophyte-host plant interaction
15.4 Fungal endophytes secret producers of bioactive plant metabolite
15.5 Natural antioxidant and their production from endophytic fungi
15.6 Glutahione content and endophytic fungi
15.7 Marine fungal endophyte and their produced antioxidant
References
Chapter 16 Fungal endophytes’ secondary metabolism: Regulation, function and drug discovery
Abstract
16.1 Introduction
16.2 The ecological aspect of endophyte fungi and distribution
16.3 Fungal endophyte and plant–host interaction
16.4 Classes of the fungal endophyte
16.5 Genomics of microbial endophytes and gene cluster
16.6 Spectrum of bioactive compounds produced by fungal endophytes
16.7 Secondary metabolism
16.8 Regulation of fungal SM
16.9 Drug discovery from fungal secondary metabolites
16.10 Fungal secondary metabolite used as antiparasitic
16.11 Bioactive metabolites from endophyte fungi as novel drug candidates
References
Chapter 17 Endophytic fungi from the lab to the factory: Biostimulants’ recent developments
Abstract
Acknowledgment
17.1 Introduction
17.2 Endophytic fungi isolation and characterization
17.3 Endophytic fungi as biostimulants and relationships with the host
17.4 Factors affecting the performance of endophytic fungi as a biostimulant
17.5 Application of endophytic fungi in agriculture: Advances and hindrances
17.6 Application of endophytic fungi in pharmaceutical: Advances and hindrances
17.7 Prospects and limitations
17.8 Conclusion
References
Chapter 18 Global scenario of endophytic fungal research: Biodiversity and biotechnological applications
Abstract
Acknowledgments
18.1 Introduction
18.2 Biodiversity of endophytic fungi
18.3 Taxonomy and molecular phylogeny of endophytic fungi
18.4 Methods for diversity analysis of culturable endophytic fungi
18.5 Application of omics approaches in endophytic fungi
18.6 Biotechnological applications
18.7 Conclusion and future perspective
References
Chapter 19 Fungi as an unseen heritage and wealth: Conclusion and future challenges
Abstract
Acknowledgments
19.1 Introduction
19.2 Biodiversity of endophytic fungi
19.3 Natural compounds of fungal endophytes
19.4 Biotechnological applications
19.5 Conclusion
References
Index

Ahmed M. Abdel Azeem

Professor Azeem PhD is currently working as a Professor at the Department of Botany and Microbiology, Faculty of Science, Suez Canal University, Ismailia 41522, Egypt. He completed his Ph.D. degree from Suez Canal University, Ismailia, Egypt. Prof. Abdel-Azeem is a mycologist with particular interest in the ecology, taxonomy, biology, and conservation of fungi, especially on the members of the phylum Ascomycota. His research includes isolation, identification, and taxonomic assessments of these fungi with particular emphasis on those which produce bioactive materials from different ecological habitats especially endophytes. He is the editor in chief of Microbial Biosystems Journal (MBJ) and a reviewer of more than seven international journals. He has published more than 70 research paper journals, 27 book chapters in books published by international publishers, and 5 books

Affiliations and expertise

Professor, Department of Botany and Microbiology, Faculty of Science, Suez Canal University, Ismailia, Egypt

Ajar Nath Yadav

Dr. Ajar Nath Yadav is currently working as an Assistant Professor (Sr. Scale) and Assistant Controller of Examinations at Eternal University, Baru Sahib, Himachal Pradesh, in India. He has eight years of teaching and 12 years of research experience in the field of microbial biotechnology, microbial diversity, and plant-microbe interactions. He has over 301 publications, with h-index of 55, i10-index of 155, and 15180 citactions. Dr. Yadav has published three books in Elsevier, five books in Taylor & Francis, one book in Wiley, and 21 books in Springer-nature. Dr. Yadav has published 123 research communications in different international and national conferences, and obtained 12 Best Paper Presentation Awards, and 01 Young Scientist Award (NASI-Swarna Jyanti Purskar). He has been serving as an editorial board member and reviewer for 35 different national and international peer-reviewed journals. He has lifetime membership in the Association of Microbiologist in India, and Indian Science Congress Council.

Affiliations and expertise

Assistant Professor, Department of Biotechnology, KSG Akal College of Basic Sciences, Eternal University, Himachal Pradesh, India

Neelam Yadav

Ms. Neelam Yadav PhD is currently working microbial diversity from diverse sources and its applications in agriculture, industry, medicine and related sectors. She obtained her Post graduation degree in Food and Nutrition in 2015 from Gopi Nath P.G. College, Veer Bahadur Singh Purvanchal University, Deoli–Salamatpur, Ghazipur, Uttar Pradesh, India. She has research interest in the area of Probiotics microbes, Human microbiota, and beneficial microbiomes for human health. In her credit 10 Publications in different reputed international, national journals and publishers. She has published 19 abstracts in different conferences/symposiums/workshops. She has presented 9 papers presentation in national and international conferences/symposiums and got 02 best paper presentations Award, and 01 certificates of excellence in reviewing Award. In her credit >1700 microbes (Archaea, bacteria and fungi) isolated from diverse sources and >115 potential and efficient microbes deposited at culture collection. She has deposited 295 nucleotide sequences to NCBI GenBank databases: in public domain. She is Editor/associate editor/reviewer of different international and national journals including. She has the lifetime membership of Association of microbiologist in India, Indian Science Congress Council, India and National Academy of Sciences, India.

Affiliations and expertise

Veer Bahadur Singh Purvanchal University, Uttar Pradesh, India

Life Sciences

Physical Sciences & Engineering

Social Sciences & Humanities

Health

Endophytic Fungi

The Full Story of the Untapped Treasure

Purchase options

Institutional subscription on ScienceDirect

Ahmed M. Abdel Azeem

Ajar Nath Yadav

Neelam Yadav