Endogenous and Exogenous Opiate Agonists and Antagonists
Proceedings of the International Narcotic Research Club Conference, June 11-15, 1979, North Falmouth, Massachusetts, USA
- 1st Edition - January 1, 1980
- Imprint: Pergamon
- Editor: E. Leong Way
- Language: English
- Paperback ISBN:9 7 8 - 1 - 4 8 3 1 - 1 2 8 4 - 8
- eBook ISBN:9 7 8 - 1 - 4 8 3 1 - 4 5 2 6 - 6
Endogenous and Exogenous Opiate Agonists and Antagonists documents the proceedings of the International Narcotic Research Club Conference, held in North Falmouth, Massachusetts,… Read more
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Request a sales quoteEndogenous and Exogenous Opiate Agonists and Antagonists documents the proceedings of the International Narcotic Research Club Conference, held in North Falmouth, Massachusetts, USA, on 11-15 June 1979. The volume begins with a discussion of the programs of the World Health Organization, with an emphasis on the components of its drug dependence program. The 139 papers discussed at the conference are then presented. These papers are organized into 10 parts. The papers in Part I examine structure-activity relationships. Part II contains studies on receptor binding while Part III deals with the localization and characterization of active sites. Part IV focuses on ligands and receptor isolation. Part 5 examines neurochemical interactions. Part VI presents papers on disposition and metabolism. Parts VII and VIII take up analgetic mechanisms and neuroendocrine relationships, respectively. Part IX focuses on behavioral effects while the studies in Part X cover tolerance and physical dependence.
Preface
Who Role in Drug Addiction
I-Structure-Activity Relationships
Primary Structure and Specificity in Endogenous Opioid Peptides
Synthetic ßh-Endorphin Analogs Modified at the N-Terminal, Positions 2 and 5
Chemical Features for Opiate Agonist and Antagonist
The Synthesis and Agonist Activity of Some 14ß-Substituted Morphine and Codeine Derivatives
4-Aryl-4-Aminocyclohexanone Derivatives: a Chemically Novel Series of Analgesics including Opioid Antagonists and Extremely Potent Agonists
N-methylbenzomorphanalkanones. a Comparison of Their Structure-Activity Relationships and X-ray Crystal Structure with Those of the Bridged Thebaine Derivatives. An Opiate Receptor Proposal
Quantum Chemical Studies of Novel 4-Phenylpiperidine Opiates with Antagonist Activity
Structure-Function Studies in Peptides Related to the ß-LPH61-64 Sequence
Enkephalin Analogs and Physical Dependence
II-Receptor Binding
Interaction of a Model Opiate Anionic Receptor Site with N-Substituents of Rigid Opiates: Pcilo Energy Calculations
Effects of Monovalent Cations on Cerebroside Sulfate Binding to Opiate Agonists and Antagonists
Opiate Binding and Cerebroside Sulfates in Brain and Lung of Developing Chick
Opiate Receptor Binding Studies Influence of a Reversible Sulfhydryl Reagent
Ascorbate Destruction of Opioid Stereospecific Binding: Evidence for Receptor Regulation by Membrane Lipid
The Study of Enkephalin-Receptor Interaction Using Isosterically Modified Analogues
Seasonal Variation in the Apparent Number of H-naloxone Binding Sites
Evidence for Half-of-the-Sites Reactivity in the Binding of Opiate Agonists and Antagonists to the Opiate Receptor
Effects of Anesthetics In Vitro on Brain Receptors for Opiates, Spiroperidol and Ouabain
Opioid Agonists and Antagonists: Action on Multiple Opiate Receptors
Study of Opiate Receptor Multiplicity in Rats by In Vivo Binding Assays
Comparison of the Binding Characteristics of Opiates and Opioid Peptides
Type 1 and Type 2 Opiate Receptors: A Subclassification Scheme Based upon GTP's Differential Effects on Binding
Scatchard Analysis of Opiate Receptor Binding
Multiple Opiate Binding Sites in Rat Brain: Differential Displacement of 3h-Naloxone Binding by Different Opiate Ligands
Phenoxybenzamine, an Irreversible Ligand of Opioid Receptors In Vivo?
Tolerance, Cross-Tolerance and Dependence to µ and k Agonists In Vivo and In Vitro
Specific Protection of µ-and δ Binding Sites in Guinea-Pig Brain, Against the Inhibitory Effect of Phenoxybenzamine, by Agonists Preferentially Interacting with µ-or δ-Sites
Ligand Specificity of Opioid Binding Sites in Brain and Peripheral Tissues
Multiple Opiate Receptors: Evidence for Mediation of Analgesia by a Subpopulation of Receptors
Abnormal Brain Opiate Mechanisms in Schizophrenia
III-Localization and Characterization of Active Sites
Characterization of 3H-ß-Endorphin Binding in Rat Brain
α-MSH in Brain ß-Endorphin Neurons, and Other Neurons as Well
Opioid Receptor Autoradiography in Brains of Humans and Animals
Development of Opiate Tolerance/Dependence in the Guinea-Pig Myenteric Plexus and the Mouse Vas Deferens
Iontophoretically Applied Morphine and Met-Enkephalin May Interact with Different Receptors in the Brain
Local and CNS-Mediated Effects of Morphine and Narcotic Antagonists on Gastrointestinal Propulsion in Rats
Central Effects of ß-Endorphin on Intestinal Transit
Effects of 6-Hydroxydopamine and 5,7-Dihydroxytryptamine Brain-Stem Lesions on Morphine Analgesia in the Rat
Opioid-Induced Hypermotility in Rats
Differences between the Mechanism of Action of Morphine Antinociception in Mice and Rats
Actions of Opioid Peptides on the Responsiveness of Reticular Neurones to Tooth-Pulp Stimulation
Inhibition of Glutamate Induced Cortical Release of Adenine Derivatives by Opiates and Enkephalin
Intrastriatal Injection of Morphine: Effect on EMG-Recorded Activity of the Gastrocnemius-Soleus Muscle of Rats
EEG Alterations Induced in Rats by Ethylketocyclazocine, Cyclazocine, and Morphine: the Differential Effects of Naloxone
Ontogenesis of Enkephalinergic Systems in Rat Brain
Immunohistochemical Localization of Methionine Enkephalin in Old World Primates: Preliminary Observations
Endorphin and Corticotropin Regulate the Activity of Septal-Hippocampal Cholinergic Neurons
Naloxone Excitation of Spinal Dorsal Horn Units Shows Diurnal Variation
IV-Ligands and Receptor Isolation
Partial Purification of Endorphins from Human Cerebrospinal Fluid from Chronic Back Pain and Elective Surgery Patients
Identification of a New Opioid Peptide from the Bovine Brain and its Mechanism of Action
Acupuncture Tolerance in Rats: Anti-Opiate Substrates Implicated
Studies on Possible Precursors for the Enkephalins
Enkephalin Precursors from Guinea-Pig Myenteric Plexus
Characterization of High Molecular Weight Enkephalin Immuno-Reactivity in Rat Brain and Bovine Adrenal Medulla
Tentative Subunit Composition of Enkephalin-Macromolecule Complexes
Characterization of a High Affinity 3h-ßh-Endorphin Receptor in Rat Brain Crude Synaptosomal Fraction
Endorphin-Regulated Protein Phosphorylation as a Functional Entity of the Opiate-Receptor Complex
ß-Casomorphins-Novel Opioid Peptides Derived from Bovine Casein-Isolation and Structure
V—Neurochemical Interactions
The Effect of Opioids on the Phosphorylation 'In Vitro' of Synaptic Membrane Proteins
ß-Lipotropin, Corticotropin and ß-Endorphin: Phosphorylation by Cyclic AMP-Dependent and Independent Protein Kinases
Phosphorylation of Endogenous ß-Lipotropin and Other Peptides by Slices of Pituitary, Adult Brain and Neonate Brain of the Rat
The Role of Na+ and GTP in NG108-15 Opiate Receptor Function
Growth Inhibition Induced by Methadone: Prevention by Dibutyryl Cyclic Adenosine Monophosphate
Calcium Ions and Opioid Action in Neuroblastoma X Glioma Hybrid Cells
Calcium Antagonism of Opiate Action in the Non-Tolerant and Tolerant Guinea Pig Ileum
Opioid-Induced Changes in Cell Surface Composition of Neurotumor Cell Lines
A Role of Lipid in Opiate-Receptor Interaction
Potentiation of Opiate Effects in the Neuroblastoma Cell Line N18tg-2 by Sulfatide Incorporation
Search for a "Sodium Effect" in the Action of Opiates on Human Plasma Cholinesterase
VI-Disposition and Metabolism
Release of Endorphins and their Modulation from Rat Brain In Vitro
In Vitro Biosynthesis and Chemical Characterization of ACTH and ACTH Fragments by the Rat Pars Intermedia
Maturation of the Common Precursor for Beta-Endorphin and Alpha-MSH in the Rat Pars Intermedia
Pain Threshold and Brain Endorphin Levels in Genetically Obese (ob/ob) and Opiate Receptor Deficient (CXBK) Mice
Specific Processing of Endorphins in Rat Brain
Plasma Levels of ß-Endorphin/ß-Lipotropin in Humans under Stress
The Occurrence of ß-Endorphin and of Alpha-Melanotropin in the Secretory Granules of Anterior Pituitary Corticotropin/Endorphin Cells May be Coupled
Corticotropin, ß-Lipotropin/ß-Endorphin and the Non-Corticotropin/ß-Lipotropin Portion of Their Common Precursor Are Present in the Same Secretory Granules
Humoral Endorphin: Endogenous Opiate in Blood Cerebrospinal Fluid and Brain
Demonstration of Placental Endorphins by Radioimmunoassay and Radioreceptor Techniques
Increased Biosynthesis of ß-Endorphin in the Pars Intermedia of Rat Pituitaries after Long-term Treatment with Haloperidol
Biosynthesis of Beta-Endorphin and Alpha-MSH in the Pars Inter-Media of Rat Pituitaries
Endorphin Levels in the Rat Brain after the Tooth Pulp Stimulation
In Vitro Evidence for an Involvement of Intestinal Endorphins in the Control of Peristalsis in the Guinea Pig Ileum. Comparison to Rabbit, Rat, Cat and Dog Small Intestine
Using HPLC and Fluorometric Methods in Studying Endogenous Peptides
Characterization of Enkephalinases
Further Characterization and Kinetics of Appearance of Hydrolysis Products of Met-Enkephalin
Degradation of Enkephalin by Two Brain Enzymatic Activities
Enkephalinase: Preliminary Characterization and Comparison with Angiotensin Converting Enzyme
VII-Analgetic Mechanisms
Antagonism of Morphine Action by Cerebroside Sulfate Antibody
One Way Cross Tolerance from Morphine to Nantradol-A Potent, Non-Opioid Analgetic
Oral Tryptophan as a Potential Adjunctive Therapy in Chronic Pain Patients
Dietary Supplementation with L-Tryptophan Reverses Tolerance to Analgesia Induced by Periaqueductal Gray Stimulation in Humans
Further Studies on the Analgesic Activity of D-Phenylalanine (DPA) in Mice and Humans
The Antipeptidases Increase Electroacupuncture Analgesia and Show Predictable HYP Algesic Effects on Mice with Congenitally Abnormal Endorphin Systems
Biphasic Dose Response to Buprenorphine in the Rat Tail Flick Assay: Effect of Naloxone Pretreatment
Is ß-Endorphin Involved in the Analgesia Generated by Stress?
Central 5-Hydroxytryptamine, Opiate-like Substances and Acupuncture Analgesia
Ultraviolet Radiation-Induced Nociception: Basis for a Novel Analgesic Test in Mice
VIII-Neuroendocrine Relationships
Estrogen Treatment Alters Narcotic Disposition in the Rat
Effects of Morphine on Serum Prolactin Levels and Dopamine Turnover in the Median Eminence: Acute and Chronic Effects
The Effect of Acute Administration of Morphine and Opiate Antagonists on the Indole Content of the Rat Pineal Gland
Changes Induced by an Opioid on Blood Glucose and Insulin in the Rat
Narcotic Antagonists Increase Serum Luteinizing Hormone Levels by a Nontestosterone-Dependent Mechanism
IX—Behavioral Effects
Naloxone's Effects on a Variety of Motivated Behaviors
The Activation of Endorphin(s) by Reward
Discrimination of the Interoceptive Stimuli Produced by Phenyl-Quinone. A Measure of the Affective Component of Pain in the Rat
Generalization Study with Some Narcotic and Nonnarcotic Psychoactive Drugs in Rats Trained to Discriminate between Cyclazocine and Saline
Discriminative and Reinforcing Effects of Some Systematically Active Enkephalin Analogues
Naloxone Antagonism of Morphine-Withdrawal Body Shakes by an Auditory Conditional Stimulus
Possible Gaba Involvement in the Mediation of Narcotic Antagonist-Induced Aversions
Endogenous Opiates as Mediators of Activation and Coping
Similarity between Behavioral Effects of Des-Tyrosine-Y-Endorphin and Haloperidol and of A-Endorphin and Amphetamine
Diurnal Differences in Enkephalin Levels Correlated with Nociceptive Sensitivity
Endorphin-like Responses Provoked by Intracerebroventricular Peptidase Inhibitors in Mildly Stressed Rats
Actions of Hyperalgesic Substances (-) Naloxone, Theophylline and 5-Methoxy-N, N-Dimethyltryptamine on Nociceptive Learning
The Effect of Prototype Opiate Receptor Agonists and Opioid Peptides on Body Temperature and Behavior after Central Administration to Cats
Naloxone Improvement of Shock Pathophysiology: Evidence for Opiate Receptor Involvement
Naloxone Reversal of Hypotension Caused by Spinal Transection
Electroconvulsive Shock (ECS) in Rats: Naloxone Modification of Post-ECS Behaviors Provides Evidence for Functional Endorphin Release
X-Tolerance and Physical Dependence
Evidence for Biochemical Adaptation in Morphine Tolerance Dependence
Serotonin-Substance-P Pathway in the Manifestation of Gut Withdrawal
Development of Tolerance to and Dependence of Opioids in the Isolated Longitudinal Muscle Strips of Guinea Pig Ileum
Lack of Dependence Liability of Dezocine (WY-16225) in the Myenteric Plexus-Longitudinal Muscle Strip of Guinea Pig Ileum
Tolerance, Dependence and Quasi-Dependence in the Guinea-Pig Isolated Ileum
Interactions between Clonidine and a Withdrawal-Inducing Benzazocine upon the Isolated Mouse Vas Deferens and Guinea Pig Ileum
An Eexamination of Tolerance to the Antinociceptive Effects of Morphine, Clonidine and Their Combination in the Mouse Tail Immersion Test
Differential Effects of Leu- and Met-Enkephalin on Narcotic-Induced Enhancement of Naloxone Efficacy
Exaggerated Weight Loss in Genetically Obese (ob/ob) Mice by Withdrawal from Morphine
N-Dealkylation in the CNS: Effect of Tolerance and Opiate Antagonists
Electroacupuncture Hypalgesia is Enhanced in Morphine Dependent Mice; Showing No Cross-Tolerance and Reducing Signs of Withdrawal
Study of Cross-Tolerance to the Effects of Morphine and Methadone on the EEG and Behavior of the L-Alpha-Acetylmethadol (LAAM)-Maintained Rat
Development of Tolerance to Opiates in Explants of Mouse Spinal Cord with Attached Dorsal Root Ganglia
The Effects of Melanocyte-Stimulating Hormone Release Inhibiting Factor and Synthetic Analogs on Tolerance to and Physical Dependence on Morphine
Modification of Development of Physical Dependence on Morphine by Thyrotropin-Releasing Hormone
Inhibition of Tolerance to Morphine by DPHE7-ACTH(1-10)-NH2
Dependence in Non-Addict Humans after a Single Dose of Morphine
Opiates and Social Dependence
Reversal of Clonidine-Induced Hypotension by Opioid Antagonists in Man
Author Index
- Edition: 1
- Published: January 1, 1980
- No. of pages (eBook): 592
- Imprint: Pergamon
- Language: English
- Paperback ISBN: 9781483112848
- eBook ISBN: 9781483145266
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