
Endocrine Hypertension
From Basic Science to Clinical Practice
- 1st Edition - October 26, 2022
- Imprint: Academic Press
- Editors: Joseph M. Pappachan, Cornelius James Fernandez
- Language: English
- Paperback ISBN:9 7 8 - 0 - 3 2 3 - 9 6 1 2 0 - 2
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 9 5 7 3 2 - 8
**Selected for Doody’s Core Titles® 2024 in Endocrinology/Metabolic Disease**Endocrine Hypertension: From Basic Science to Clinical Practice bridges the gap between scientists and… Read more

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Endocrine Hypertension: From Basic Science to Clinical Practice bridges the gap between scientists and practicing clinicians by providing a comprehensive overview on all forms of endocrine hypertension, covering epidemiological aspects, pathophysiology, clinical presentation, laboratory evaluation and practical management aspects of endocrine hypertension. This book is a great resource for endocrinologists, physicians, general practitioners and researchers who are eager to understand the complex facets of endocrine hypertension.
Endocrine hypertension is a term used to describe a group of endocrine pathologies that cause an elevation of blood pressure, estimated to account for up to 10% of all hypertension cases. Although common, this clinical condition is often overlooked. Patients with this condition are at risk of late diagnosis, delayed treatment and detrimental health consequences.
- Provides a comprehensive overview on all forms of endocrine hypertension
- Discusses molecular physiology and pathophysiology of various endocrine hypertension related conditions and offers guidance to diagnosis and management of endocrine hypertension
- Includes instructional overview figures, diagrams, flowcharts, scan images and tables to enhance understanding
- Cover image
- Title page
- Table of Contents
- Copyright
- Foreword
- Contributors
- Editors' brief resumes
- Invited senior authors' profiles
- Preface
- Chapter 1. Endocrine hypertension—an overview
- Introduction
- Individual chapters
- Recent trends/emerging concepts
- Genetic testing for familial PPGL
- Genetic testing for familial hyperaldosteronism especially GRA
- Conclusions
- Chapter 2. Catecholamines and blood pressure regulation
- Introduction
- Catecholamines and autonomic physiology
- Biologic effects
- Summary and conclusions
- Learning points
- Chapter 3. Adrenal cortical hormones and blood pressure regulation
- Introduction
- Physiological aspects
- Pathophysiological alterations in adrenocortical hormones and effects on cardiovascular homeostasis
- Emerging research questions
- Summary and conclusions
- Learning points
- Chapter 4. Hypothalamic–pituitary–adrenal axis and blood pressure regulation
- Introduction
- Physiology of blood pressure regulation and HPA axis
- Pathophysiology of hypertension and HPA axis
- Summary and conclusions
- Learning points
- Chapter 5. Renin–angiotensin–aldosterone system and blood pressure regulation
- Introduction
- Physiological aspects of RAAS
- RAAS, inflammation, and remodeling
- RAAS blocking agents and cardiovascular protection in hypertension
- ACE inhibitors
- ARBs
- Direct renin inhibitors
- Dual RAAS inhibition
- ACEI versus ARBs
- Mineralocorticoid receptor antagonists
- Conclusions
- Learning points
- Chapter 6. Monogenic hypertension: an overview
- Introduction
- Summary
- Learning points
- Chapter 7. Primary aldosteronism (Conn's syndrome)
- Introduction
- The renin–angiotensin–aldosterone system
- Who should be screened? (The epidemiology of primary aldosteronism)
- Aldosterone–renin ratio as screening test
- Confirmatory test after positive ARR
- Subtyping in primary aldosteronism: adrenal vein sampling or imaging?
- Laparoscopic surgery and peri-operative management
- Medical therapy of primary aldosteronism
- Familial forms of primary aldosteronism
- Conclusions
- Learning points
- Chapter 8. Familial hyperaldosteronism
- Introduction
- Pathophysiology of familial hyperaldosteronism
- Subtypes of familial hyperaldosteronism
- Summary and conclusions
- Learning points
- Chapter 9. Congenital adrenal hyperplasia and hypertension
- Introduction
- Genetics of CAH (in general—all forms)
- Pathophysiology of hypertension in CAH
- 11β-hydroxylase deficiency
- 17α-hydroxylase deficiency
- Overtreatment of CAH
- When to suspect of CAH in patients with hypertension
- Future research
- Summary and conclusions
- Learning points
- Chapter 10. Endocrine hypertension: discovering the inherited causes
- Introduction
- Inherited disorders of endocrine hypertension
- Monogenic hypertension associated with suppressed PAC and PRA
- Monogenic hypertension associated with normal PAC and low PRA
- Monogenic hypertension associated with high PAC and low PRA
- Monogenic hypertension associated with elevated PAC and PRA
- Monogenic hypertension associated with normal PAC and PRA
- Summary and conclusions
- Learning points
- Chapter 11. Pheochromocytomas and hypertension
- Introduction
- Molecular and genetic aspects of PCCs
- Clinical presentation
- Diagnostic workup
- Management
- Locoregional approaches
- Systemic therapy
- Follow-up
- Areas of uncertainty/emerging concepts
- Summary and conclusions
- Learning points
- Chapter 12. Paragangliomas and hypertension
- Introduction
- Epidemiology of paragangliomas and hypertension
- Pathophysiology of paraganglioma and hypertension
- Genetics of paragangliomas
- Clinical presentation
- Biochemical investigations
- Anatomical and functional imaging studies
- Perioperative medical management of paragangliomas
- Surgery for management of paragangliomas
- Radionuclide therapy
- Follow-up care of patients with paragangliomas
- Management in special populations
- Areas of uncertainty/emerging research
- Summary and conclusions
- Learning points
- Chapter 13. ACTH-dependent Cushing's syndrome
- Introduction
- Clinical presentation, screening, and diagnosis of Cushing's syndrome
- Localization testing: distinguishing between ACTH-dependent and ACTH-independent Cushing's syndrome
- Epidemiology of hypertension in Cushing's syndrome
- Pathophysiology of hypertension in Cushing's syndrome
- Antihypertensive therapy in Cushing's syndrome
- Role of medical therapy for CS in the treatment of hypertension
- Follow up of Cushing syndrome and hypertension
- Summary
- Learning points
- Chapter 14. Adrenal Cushing's syndrome
- Introduction
- Causes and epidemiology of adrenal Cushing syndrome
- Genetic syndromes associated with adrenal Cushing syndrome
- Genetics of ACTH -independent Cushing syndrome
- Clinical features
- Pathophysiology of hypertension in adrenal Cushing syndrome
- Investigations for adrenal CS
- Treatment of adrenal CS
- Long-term outcome of adrenal CS
- Autonomous cortisol secretion in adrenal incidentaloma
- Areas of uncertainty/emerging concepts
- Summary and conclusions
- Learning points
- Chapter 15. Hypertension in growth hormone excess and deficiency
- GH and IGF-1 physiological effects
- Acromegaly and hypertension
- Hypertension phenotype and cardiovascular comorbidities
- Screening for acromegaly in hypertensive patients
- Treatment
- Growth hormone deficiency and hypertension
- Phenotype of AGHD and characteristics of blood pressure profile
- Screening for AGHD
- Treatment
- Summary and closing remarks
- Learning points
- Chapter 16. Hypertension in thyroid disease and primary hyperparathyroidism
- Introduction
- Thyroid disease
- Parathyroid disease
- Summary and conclusions
- Learning points
- Chapter 17. Obesity, insulin resistance, and obstructive sleep apnea
- Introduction
- Epidemiology of OSA
- OSA and obesity
- Diagnosis of OSA
- Pathophysiology of OSA-related secondary hypertension
- OSA and insulin resistance
- Management of OSA
- Conclusions
- Learning points
- Chapter 18. Endocrine hypertension in children
- Introduction
- Primary versus secondary hypertension in children
- Endocrine hypertension in children
- Clinical presentation of endocrine hypertension in children
- Diagnostic approach to endocrine hypertension in children
- Management of endocrine hypertension in children
- Summary and conclusions
- Learning points
- Chapter 19. Endocrine hypertension in pregnancy
- Introduction
- Summary and conclusions
- Learning points
- Chapter 20. Imaging for patients with endocrine hypertension
- Introduction
- Summary and conclusions
- Learning points
- Chapter 21. Systematic approach to the diagnosis and management of endocrine hypertension
- Introduction
- Primary aldosteronism (PA)
- Other mineralocorticoid forms of hypertension
- Cushing's syndrome
- Acromegaly
- Thyroid disorders
- Primary hyperparathyroidism
- Renal artery stenosis and other rare forms of renin driven hypertension
- Conclusion
- Learning points
- Index
- Edition: 1
- Published: October 26, 2022
- Imprint: Academic Press
- No. of pages: 410
- Language: English
- Paperback ISBN: 9780323961202
- eBook ISBN: 9780323957328
JP
Joseph M. Pappachan
Professor Pappachan M Joseph is a senior consultant Endocrinologist in the UK and honorary professor at the Manchester Metropolitan University. He is an associate editor to Frontiers in Clinical Diabetes & Healthcare, the World Journal of Diabetes, and TouchREVIEWS in Endocrinology. He is also in the editorial board member of the American Endocrine Society Journal – JCEM Case Reports, has fully edited multiple journal issues in the past, and is the lead editor to the Elsevier Textbook “Endocrine Hypertension: From Basic Science to Clinical Practice”. He has 135 scientific publications in his credit in peer reviewed journals and has several multinational research collaborations. His academic h-index is 35 with more than 4200 citations of his works to date. His research special interests include obesity, metabolic disorders including MAFLD, neuroendocrinology & parathyroid disorders.
CF