
Emerging Paradigms in Delivery Systems for Antitubercular Therapy
- 1st Edition - April 23, 2025
- Imprint: Academic Press
- Editors: Rajeev Sharma, Neeraj Mishra, Laxmikant Gautam, S.P. Vyas
- Language: English
- Paperback ISBN:9 7 8 - 0 - 4 4 3 - 2 4 0 3 5 - 5
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 2 4 0 3 4 - 8
Emerging Paradigms in Delivery Systems for Antitubercular Therapy provides an up-to-date and thorough overview of the state-of-the-art of concepts, design, and recent advances… Read more

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Request a sales quoteEmerging Paradigms in Delivery Systems for Antitubercular Therapy provides an up-to-date and thorough overview of the state-of-the-art of concepts, design, and recent advances in nanomedicines and nanobiotechnology-based strategies for the treatment of tuberculosis. The book enables researchers to prepare a variety of nanotechnology-based strategies, investigate their properties, and discover their uses and applications in antitubercular therapy, focusing on advanced nanomaterials that are utilized for encapsulation of nucleic acid, mRNA, DNA, and tuberculosis vaccination.
This book covers all major topics that have shaped the development of nanomedicine and propelled it to its current place at the forefront of Nanotechnology based treatment innovation. It will be a welcomed resource for researchers and readers with more and more challenging therapy and biologicals with their possible modifications to be used for the effective therapy of tuberculosis.
- Focuses on advanced nanomaterials that are utilized for encapsulation of nucleic acid, mRNA, DNA, and tuberculosis vaccination
- Covers all major topics that have shaped the development of nanomedicine and propelled it to its current place at the forefront of nanotechnology based treatment innovation
- Provides assistance to researchers and readers with more and more challenging therapy and biologicals with their possible modifications to be used for effective therapies in tuberculosis
- Title of Book
- Cover image
- Title page
- Table of Contents
- Copyright
- List of contributors
- Chapter 1 Introduction: An overview of novel approaches for the treatment of tuberculosis
- Abstract
- 1.1 Introduction
- 1.2 Morbific of tuberculosis
- 1.3 Current therapies available for tuberculosis
- 1.4 Limitation of current therapies
- 1.5 Novel drug conveyance arrangements for tuberculosis
- 1.6 Novel delivery systems
- 1.7 Clinical trials involved in novel formulations for tuberculosis
- 1.8 Toxicity studies of novel formulation
- 1.9 Patents on novel formulation for tuberculosis
- 1.10 Conclusion
- References
- Chapter 2 Theragnostic approaches for the management of tuberculosis
- Abstract
- 2.1 Introduction
- 2.2 Tuberculosis: classification and therapeutic options
- 2.3 Conventional dosage forms for tuberculosis
- 2.4 Novel drug delivery systems for tuberculosis management
- 2.5 Theragnostic approaches for tuberculosis management
- 2.6 Conclusion and future perspectives
- References
- Chapter 3 Role of metallic nanoparticles in the treatment of tuberculosis
- Abstract
- 3.1 Introduction
- 3.2 Pathophysiology of tuberculosis
- 3.3 Challenges for drug delivery in drug-resistant tuberculosis
- 3.4 Metal nanoparticles-driven strategies for the treatment of tuberculosis
- 3.5 Regulatory overview and toxicity of metal nanoparticles
- 3.6 Conclusion and future prospects
- Acknowledgment
- References
- Chapter 4 Role of biodegradable polymeric nanoparticles for the treatment of tuberculosis
- Abstract
- 4.1 Introduction of nanomaterials
- 4.2 Advance methods for preparation of nanoparticles
- 4.3 Biodegradable polymeric nanocarriers for the delivery of antitubercular drugs
- 4.4 Conclusion
- References
- Chapter 5 Role of vesicular nanocarriers for the treatment of tuberculosis
- Abstract
- Abbreviations
- 5.1 Introduction
- 5.2 Barriers and strategies to overcome in tubercular disease
- 5.3 Conventional therapies
- 5.4 Limitations of conventional therapy
- 5.5 Need for nanocarriers-based drug delivery system in tuberculosis management
- 5.6 Various vesicular nanocarriers and targeting approaches in tuberculosis management
- 5.7 Advanced application of vesicular nanocarriers
- 5.8 Potential toxicity of vesicular nanocarrier and immune response
- 5.9 Current clinical status and regulatory translation
- 5.10 Future prospectives and challenges in commercialization
- References
- Chapter 6 Role of carbon nanotubes for the treatment of tuberculosis
- Abstract
- 6.1 Introduction
- 6.2 Macrophage: the cellular tropics of Mycobacterium tuberculosis
- 6.3 Challenges with current tuberculosis chemotherapy
- 6.4 Need for engineered nanoconstructs
- 6.5 Role of carbon nanomaterials in the treatment of tuberculosis
- 6.6 In vivo toxicity of carbon nanomaterials
- 6.7 Role of carbon nanotubes for the treatment of tuberculosis
- 6.8 Conclusions
- References
- Chapter 7 Role of the gut lung axis and microbiota based approaches in the treatment of tuberculosis
- Abstract
- 7.1 Introduction
- 7.2 Tuberculosis
- 7.3 Microbiota and tuberculosis
- 7.4 The gut–lung axis in tuberculosis
- 7.5 Microbiota-based therapeutic approaches used for the treatment of tuberculosis
- 7.6 Conclusion
- References
- Chapter 8 Mucoadhesive polymeric nanocarriers for the treatment of tuberculosis
- Abstract
- 8.1 Introduction
- 8.2 Current approaches to tuberculosis treatment and their limitations
- 8.3 Mucoadhesion in drug delivery: an overview
- 8.4 Applications of mucoadhesive drug delivery systems
- 8.5 Mucoadhesion
- 8.6 Applications of mucoadhesives in the treatment of tuberculosis
- 8.7 Conclusion
- References
- Chapter 9 Recent gene therapy approaches for the treatment of tuberculosis
- Abstract
- 9.1 Introduction
- 9.2 Gene delivery mechanisms: viral and nonviral vectors
- 9.3 Characteristics of viral vectors used in gene therapy treatment of tuberculosis
- 9.4 Recent advances in tuberculosis gene therapy
- 9.5 Challenges and considerations
- 9.6 Conclusion
- References
- Chapter 10 Novel targets and drugs for the treatment of tuberculosis
- Abstract
- 10.1 Introduction
- 10.2 Cell wall biosynthesis
- 10.3 Peptidoglycans synthesis
- 10.4 Mycolic acid
- 10.5 Arabinogalactan biosynthesis
- 10.6 Amino acid biosynthesis
- 10.7 Branched-chain amino acid biosynthesis
- 10.8 Cofactor biosynthesis
- 10.9 Pantothenic acid biosynthesis
- 10.10 Coenzyme A biosynthesis
- 10.11 Riboflavin biosynthesis
- 10.12 Mycothiol biosynthesis
- 10.13 Terpenoid biosynthesis
- 10.14 Glyoxylate shunt pathway
- 10.15 Targeting regulatory proteins
- 10.16 Menaquinone biosynthesis
- 10.17 DNA synthesis
- 10.18 Methionine aminopeptidase
- 10.19 Toward enlarging the target space for oxidative phosphorylation
- 10.20 Role of nanotechnology
- 10.21 Passive targeting
- 10.22 Passive targeting of antitubercular
- 10.23 Active targeting
- 10.24 Mannose receptor targeting
- 10.25 Folate receptor targeting
- 10.26 Hyaluronic acid receptor targeting
- 10.27 Tuftsin receptor targeting
- 10.28 Formyl peptide receptor
- 10.29 Other receptors
- 10.30 Challenges associated with the development of antitubercular candidates with novel targets
- 10.31 Current and future perspective
- 10.32 Conclusion
- Acknowledgment
- Declaration of interest
- References
- Chapter 11 Multidrug resistance complexity of Mycobacterium tuberculosis and oxidative stress: the need for innovative drug delivery strategies
- Abstract
- 11.1 Introduction
- 11.2 Challenges in treatment of tuberculosis
- 11.3 Classification
- 11.4 Unique features
- 11.5 Evolution
- 11.6 Epidemiology of tuberculosis
- 11.7 Global and national epidemiology
- 11.8 The challenges of drug resistance
- 11.9 Drug resistance and fitness
- 11.10 Mutation rate
- 11.11 Treatment of tuberculosis
- 11.12 Multidrug resistant and extensively drug resistant tuberculosis
- 11.13 Susceptibility testing
- 11.14 Alternatives to antibiotics
- 11.15 Nanoparticles
- 11.16 Oxidative stress contribution to antituberculosis drug resistance
- 11.17 Development of new antituberculous drugs
- 11.18 Innovative drug delivery strategies
- 11.19 Nanoantimicrobials
- 11.20 New drugs or new chemical entities
- 11.21 Herbal drugs
- 11.22 Recent trials of new tuberculosis drugs and regimens
- 11.23 Conclusion
- References
- Chapter 12 Role of biosensors as an alternative approach for the treatment of tuberculosis
- Abstract
- 12.1 Introduction
- 12.2 Types of biosensor
- 12.3 Biosensors development for the treatment of tuberculosis
- 12.4 Challenges in the development of biosensor
- 12.5 Application of biosensor in tuberculosis
- 12.6 Conclusion
- References
- Chapter 13 Recent approaches for the treatment of multidrug resistance tuberculosis
- Abstract
- 13.1 Introduction
- 13.2 Global extent of multidrug resistance tuberculosis
- 13.3 Obstacle to the management of multidrug resistance tuberculosis
- 13.4 Recent treatment approaches for multidrug resistance tuberculosis
- 13.5 Conclusion
- Acknowledgment
- References
- Chapter 14 Targeted drug delivery to the macrophagic cellular tropics in tuberculosis
- Abstract
- 14.1 Introduction
- 14.2 Macrophage and its role in tuberculosis pathogenesis
- 14.3 Drug resistance: a major challenge in tuberculosis treatment
- 14.4 Targeting macrophages for enhanced drug delivery: a potential solution
- 14.5 Macrophage-targeted drug delivery
- 14.6 Challenges associated with macrophage targeting
- 14.7 Conclusion and future prospectives
- Acknowledgment
- References
- Chapter 15 Tuberculosis vaccines: advancements and on-going clinical trials
- Abstract
- 15.1 Introduction
- 15.2 Pathogenesis of tuberculosis
- 15.3 Nucleic acid vaccine
- References
- Chapter 16 Impact of socioeconomic factors on the treatment of tuberculosis
- Abstract
- Abbreviations
- 16.1 Introduction
- 16.2 Impact of social and economic factors on tuberculosis
- 16.3 Barriers to accessing the tuberculosis treatment programs
- 16.4 Potential actions for overcoming barriers to access tuberculosis healthcare services
- 16.5 Harnessing resources to deliver tuberculosis treatment
- 16.6 Conclusion and future perspectives
- Acknowledgments
- References
- Chapter 17 Future prospects and clinical aspects for the management of tuberculosis
- Abstract
- 17.1 Introduction
- 17.2 Present status of clinical research for tuberculosis treatment
- 17.3 Present diagnostic tests for tuberculosis infection
- 17.4 New diagnostics in tuberculosis
- 17.5 Initiatives to shorten the duration and effectiveness of tuberculosis treatment
- 17.6 Summary and conclusion
- References
- Index
- Edition: 1
- Published: April 23, 2025
- Imprint: Academic Press
- No. of pages: 416
- Language: English
- Paperback ISBN: 9780443240355
- eBook ISBN: 9780443240348
RS
Rajeev Sharma
Rajeev Sharma is an Assistant Professor at the Amity Institute of Pharmacy, Amity University, Madhya Pradesh, Gwalior, India. He earned his B.Pharm, M.Pharm, and Ph.D. in Pharmaceutical Sciences from Dr. H. S. Gour Central University, Sagar, India. Dr. Sharma has approximately 13 years of experience in both teaching and industry. He has served as a Junior Research Fellow under AICTE, an ICMR-SRF, and a CSIR-RA Fellow during his research career, and has worked as an Assistant Professor in academia and as a Senior Formulation Development Scientist in the R&D industry. Dr. Sharma has edited two international and two national books and has authored over 30 publications and 21 book chapters in international reference books. His work focuses on recent concepts in immunology, nanobiotechnology, novel drug delivery systems, and targeted and controlled drug delivery of bioactives for the treatment of diseases such as cancer and diabetes. He is a life member of the Association of Pharmaceutical Teachers of India (APTI). Dr. Sharma's work has been cited approximately 1,200 times, and he has an h-index of 17. The cumulative impact factor of his published papers is around 120, according to SCOPUS. He is currently working on a research project funded by the Madhya Pradesh Council of Science and Technology (MPCST). Dr. Sharma has received several awards for his research, including the Young Research Scholar award and various awards for best oral and poster presentations at national and international conferences. His current research interest is in nanocarrier-based targeted approaches for the effective delivery of bioactives.
NM
Neeraj Mishra
Dr. Neeraj Mishra is a Professor and Head of the Department of Pharmaceutics at Amity Institute of Pharmacy, India, a position he has held since July 2019. With nearly two decades of teaching and research experience, Dr. Mishra has authored over 100 publications on novel drug delivery systems, focusing on nanocarriers and microparticles for treating breast and colon cancer, as well as neurodegenerative disorders. He has written several books and book chapters, and holds three international and two Indian patents. Dr. Mishra has received numerous accolades, including the "Distinguished Professor Award" (2019, 2021) and the "Outstanding Scientist Award" (2020). He has served as a guest editor for Bentham Sciences and is recognized in Stanford University's World Scientists Rankings for 2022 and 2024.
LG
Laxmikant Gautam
SV