Emerging Concepts in Ribosome Structure, Biogenesis, and Function
- 1st Edition - September 25, 2021
- Imprint: Academic Press
- Editor: Vijay Kumar
- Language: English
- Paperback ISBN:9 7 8 - 0 - 1 2 - 8 1 6 3 6 4 - 1
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 1 6 7 3 4 - 2
Ribosome biogenesis is the process of making ribosomes which are responsible for mRNA translation into proteins. It is a tightly regulated process closely linked to nearly all… Read more
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Request a sales quoteRibosome biogenesis is the process of making ribosomes which are responsible for mRNA translation into proteins. It is a tightly regulated process closely linked to nearly all biochemical and cellular processes, including cell division, growth, and development. Emerging Concepts in Ribosome Structure, Biogenesis, and Function provides a synthesized overview of all the parts engaged in this process. The book begins by providing an introduction to the ribosome factory, its origin, and its evolution of translation. It then goes on to describe ribosome structure including subunits, RNA, and protein components. Ribosome biogenesis and its emergence as a frontier research area for translational potential in cancer and other diseases are also discussed. In addition, the book explores current developments in ribosome research like the emergence of ribosomopathies, how deregulation of ribosome biogenesis can impact disease mechanisms and aging, and the discovery of specialized ribosomes that have specific functions that may translate differentially with consequences on normal and pathological processes. Emerging Concepts in Ribosome Structure, Biogenesis, and Function provides fundamental coverage and emerging research on ribosomes, biogenesis, and their structure and function and is a resourceful introduction for new researchers and those engaged in interdisciplinary ribosomal research.
- Provides an overview of ribosome biogenesis and examines its involvement in cell transformation and cancerous growth
- Covers disorders related to the ribosome (ribosomopathies) and explains the significance of ribosome dysfunction in human diseases
- Includes commonly used methods to study ribosomes, such as polysome preparation, RNA profiling and proteomics, CryoEM, and Cell-free assays along with proper illustrations
Researchers and academics in molecular and cell biology, cancer biology, and microbiology; doctors and clinicians active in ribosome disease research; graduate students, postdocs
- Cover image
- Title page
- Table of Contents
- Copyright
- Contributors
- Chapter 1: Introduction to ribosome factory, origin, and evolution of translation
- Abstract
- What are ribosomes?
- Basic components and structure of the ribosome
- Functions of ribosome
- Ribosome biogenesis and assembly
- Ribosomal gene mutations and ribosomopathies
- Inhibition of ribosome biogenesis
- Summary and conclusions
- Chapter 2: Ribosome structure
- Abstract
- Introduction
- Structure of prokaryotic ribosome
- Structure of eukaryotic ribosome
- Novel features of the 80S Ribosome’s structure
- Eukaryote-specific protein tails
- Expansion segments
- Intersubunit bridges
- Structure of mitochondrial ribosome
- Summary and conclusions
- Chapter 3: rDNA gene structure, transcription, and its coregulation
- Abstract
- Introduction
- Organization and regulation of ribosomal RNA genes
- Processing and maturation of pre-rRNA
- Organization and regulation of RNA pol III promoter
- Summary and conclusions
- Chapter 4: Ribosome proteins—Their balanced production
- Abstract
- Introduction
- Structure of ribosomes
- Ribosomal proteins
- Nomenclature of RPs
- The function of ribosomal proteins
- The 40S small subunit ribosomal proteins
- The 60S large subunit ribosomal proteins
- Eukaryotic mitochondrial ribosome or mitoribosomes
- Extra ribosomal functions of ribosomal proteins
- Balanced production of RPs
- Summary and conclusions
- Chapter 5: Ribosome diversity
- Abstract
- Introduction
- Variation in r-protein complement
- Paralogues of r-proteins
- R-protein posttranslational modifications
- Ribosome-associated factors
- Contribution of rRNA alternatives in ribosome diversity
- Modifications of rRNA contribute to ribosome diversity
- Special ribosomes of mitochondria
- Congenital anomalies and mutations of ribosomal proteins
- Summary and conclusions
- Chapter 6: Ribosome cycle—Assembly, degradation, and recycling
- Abstract
- Introduction
- Ribosome assembly
- Degradation of the ribosome and ribosomal proteins
- Ribosome recycling
- Summary and conclusions
- Chapter 7: Ribosomal biogenesis in eukaryotes
- Abstract
- Introduction
- Yeast as an eukaryotic model to study ribosome biogenesis
- Preinitiation complex formation
- Control of rDNA transcription
- Processing of pre-rRNA
- Coordination of folding and processing of pre-rRNA
- Roles of the ribosomal proteins
- Role of ribosome assembly factors
- Maturation of ribosomal subunits
- Modifications of pre-RNA
- Summary and conclusions
- Chapter 8: Ribosome biogenesis in prokaryotes
- Abstract
- Introduction
- Escherichia coli as a model organism to study ribosome biogenesis
- r-RNA gene structure, transcription, and posttranscriptional processing
- Regulation of rrn expression
- Structure of the ribosomal protein-coding genes, the operons and regulation of expression
- Modification of RPs
- Assembly of ribosome
- Association and dissociation of ribosomal subunits
- Ribosome degradation, modifications, and recycling
- Ribosome biogenesis in archaebacteria
- Summary and conclusions
- Chapter 9: Translation—Process and control
- Abstract
- The process of translation
- Translation initiation
- Translation elongation
- Termination of translation
- Control of translation
- Ribosome profiling
- Chapter 10: Inhibitors of ribosome biogenesis in prokaryotes and eukaryotes
- Abstract
- Introduction
- Prokaryotic ribosome biogenesis and inhibitors
- Eukaryotic ribosome biogenesis and inhibitors
- Conclusions
- Chapter 11: Ribosomopathies—A tree of pathologies with many roots and branches!
- Abstract
- Introduction
- Diamond-Blackfan anemia
- Other ribosomopathies
- Suspected ribosomopathies
- Is cancer a ribosomopathy?
- Conclusions
- Chapter 12: Ribosomal profiling—Diversity and applications
- Abstract
- Introduction
- Tools and techniques of ribosome profiling
- Quality control of mRNA
- Understanding the mechanism and regulation of translation
- Diversity and applications of ribosome profiling
- Summary and conclusions
- Index
- Edition: 1
- Published: September 25, 2021
- Imprint: Academic Press
- No. of pages: 296
- Language: English
- Paperback ISBN: 9780128163641
- eBook ISBN: 9780128167342
VK
Vijay Kumar
Dr. Vijay Kumar is currently Professor and J.C. Bose National Fellow in the Department of Molecular and Cellular Medicine at the Institute of Liver and Biliary Sciences (ILBS) in New Delhi, India. He received his PhD in Medical Sciences at All India Institute of Medical Sciences in New Delhi, India and pursued his post-doctoral studies in Molecular Biology at the Université Louis-Pasteur in Strasbourg, France. He has been working in the area of cancer biology for over three decades. His work has focused on signaling mechanisms, cell cycle, DNA replication, ribosomal RNA, and protein synthesis, and he has extensive knowledge of ribosome biogenesis and its involvement in cell transformation and cancerous growth. He has done pioneering work in the area of steroid hormone receptors, regulation of RNA polymerase I-dependent transcription and ribosome biogenesis, cell cycle regulation, hepatitis B virus and hepatocellular carcinoma, and hepatoprotective mechanisms of medicinal plants. His current research interest includes the role of microRNA in health and disease. Dr. Kumar is a recipient of several national awards and is a fellow of National Academy of Sciences, National Academy of Medical Sciences, and the National Academy of Agricultural Sciences of India.
Affiliations and expertise
Professor and J.C. Bose National Fellow, Department of Molecular and Cellular Medicine, Institute of Liver and Biliary Sciences, New Delhi, IndiaRead Emerging Concepts in Ribosome Structure, Biogenesis, and Function on ScienceDirect