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Emerging Concepts in Ribosome Structure, Biogenesis, and Function
- 1st Edition - September 25, 2021
- Editor: Vijay Kumar
- Language: English
- Paperback ISBN:9 7 8 - 0 - 1 2 - 8 1 6 3 6 4 - 1
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 1 6 7 3 4 - 2
Ribosome biogenesis is the process of making ribosomes which are responsible for mRNA translation into proteins. It is a tightly regulated process closely linked to nearly all… Read more
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Request a sales quoteRibosome biogenesis is the process of making ribosomes which are responsible for mRNA translation into proteins. It is a tightly regulated process closely linked to nearly all biochemical and cellular processes, including cell division, growth, and development. Emerging Concepts in Ribosome Structure, Biogenesis, and Function provides a synthesized overview of all the parts engaged in this process. The book begins by providing an introduction to the ribosome factory, its origin, and its evolution of translation. It then goes on to describe ribosome structure including subunits, RNA, and protein components. Ribosome biogenesis and its emergence as a frontier research area for translational potential in cancer and other diseases are also discussed. In addition, the book explores current developments in ribosome research like the emergence of ribosomopathies, how deregulation of ribosome biogenesis can impact disease mechanisms and aging, and the discovery of specialized ribosomes that have specific functions that may translate differentially with consequences on normal and pathological processes. Emerging Concepts in Ribosome Structure, Biogenesis, and Function provides fundamental coverage and emerging research on ribosomes, biogenesis, and their structure and function and is a resourceful introduction for new researchers and those engaged in interdisciplinary ribosomal research.
- Provides an overview of ribosome biogenesis and examines its involvement in cell transformation and cancerous growth
- Covers disorders related to the ribosome (ribosomopathies) and explains the significance of ribosome dysfunction in human diseases
- Includes commonly used methods to study ribosomes, such as polysome preparation, RNA profiling and proteomics, CryoEM, and Cell-free assays along with proper illustrations
Researchers and academics in molecular and cell biology, cancer biology, and microbiology; doctors and clinicians active in ribosome disease research; graduate students, postdocs
1. Introduction to ribosome factory, origin and evolution of translation
2. Ribosome structure
3. rDNA gene structure, transcription and their co-regulation
4. Ribosomal proteins - their balanced production
5. Ribosome diversity
6. Ribosome cycle - Assembly, degradation, and recycling
7. Ribosomal biogenesis in eukaryotes
8. Protein biogenesis in prokaryotes
9. Translation - Process and control
10. Inhibitores of ribosome biogenesis in prokaryotes and eukaryotes
11. Ribosomopathies - A tree of pathologies with many roots and branches!
12. Ribosomal profiling - Diversity and applications
2. Ribosome structure
3. rDNA gene structure, transcription and their co-regulation
4. Ribosomal proteins - their balanced production
5. Ribosome diversity
6. Ribosome cycle - Assembly, degradation, and recycling
7. Ribosomal biogenesis in eukaryotes
8. Protein biogenesis in prokaryotes
9. Translation - Process and control
10. Inhibitores of ribosome biogenesis in prokaryotes and eukaryotes
11. Ribosomopathies - A tree of pathologies with many roots and branches!
12. Ribosomal profiling - Diversity and applications
- No. of pages: 296
- Language: English
- Edition: 1
- Published: September 25, 2021
- Imprint: Academic Press
- Paperback ISBN: 9780128163641
- eBook ISBN: 9780128167342
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Vijay Kumar
Dr. Vijay Kumar is currently Professor and J.C. Bose National Fellow in the Department of Molecular and Cellular Medicine at the Institute of Liver and Biliary Sciences (ILBS) in New Delhi, India. He received his PhD in Medical Sciences at All India Institute of Medical Sciences in New Delhi, India and pursued his post-doctoral studies in Molecular Biology at the Université Louis-Pasteur in Strasbourg, France. He has been working in the area of cancer biology for over three decades. His work has focused on signaling mechanisms, cell cycle, DNA replication, ribosomal RNA, and protein synthesis, and he has extensive knowledge of ribosome biogenesis and its involvement in cell transformation and cancerous growth. He has done pioneering work in the area of steroid hormone receptors, regulation of RNA polymerase I-dependent transcription and ribosome biogenesis, cell cycle regulation, hepatitis B virus and hepatocellular carcinoma, and hepatoprotective mechanisms of medicinal plants. His current research interest includes the role of microRNA in health and disease. Dr. Kumar is a recipient of several national awards and is a fellow of National Academy of Sciences, National Academy of Medical Sciences, and the National Academy of Agricultural Sciences of India.
Affiliations and expertise
Professor and J.C. Bose National Fellow, Department of Molecular and Cellular Medicine, Institute of Liver and Biliary Sciences, New Delhi, IndiaRead Emerging Concepts in Ribosome Structure, Biogenesis, and Function on ScienceDirect