Electrocardiography of Channelopathies

A Primer for the Clinical Cardiologist

1st Edition - November 27, 2024
Imprint: Academic Press
Editor: Manlio F. Márquez-Murillo
Language: English
Paperback ISBN:
9 7 8 - 0 - 4 4 3 - 2 2 3 4 4 - 0
eBook ISBN:
9 7 8 - 0 - 4 4 3 - 2 2 3 4 5 - 7

Electrocardiography of Channelopathies: A Primer for the Clinical Cardiologist introduces readers to the inherited arrhythmia syndromes that are a leading cause of sudden cardiac d… Read more

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Electrocardiography of Channelopathies: A Primer for the Clinical Cardiologist introduces readers to the inherited arrhythmia syndromes that are a leading cause of sudden cardiac death. As the ECG is the cornerstone of identifying inherited arrhythmia syndromes, this cutting-edge book is a critical resource to guide cardiologists in using the technology for optimum diagnosis and treatment of their patients. It clearly delineates the differences between each syndrome to improve accuracy and health outcomes. Its easy portability belies a vast knowledge base for use by clinicians in the moment as well as by researchers in the laboratory.

This book illuminates diseases such as Short and Long QT Syndromes, Andersen-Tawil Syndrome, Brugada Syndrome, Polymorphic Ventricular Tachycardia, and Early Repolarization syndrome. Electrocardiography of Channelopathies: A Primer for the Clinical Cardiologist will no doubt become a go-to reference for experienced clinicians seeking confirmation of their diagnoses, as well as those newer to the field seeking guidance in ECG interpretation.

Title of Book
Cover image
Title page
Table of Contents
Copyright
Dedication
Contributors
Preface
Chapter 1. Introduction: An historical perspective
1 Introduction
Chapter 2. How to measure the QT interval in your office. Pitfalls to avoid
1 Introduction
2 Correction of the QT interval. Why is it important?
3 QT interval correction formulas. Where did it come from?
4 QT interval measurement. Is there a possibility for error?
4.1 End of QT interval: It can get complicated
5 A list of common pitfalls to avoid in the measurement of QT/QTc interval
6 Specific considerations in measuring the QT interval in children
7 Conclusions
Chapter 3. Clinical applicability of QT formulae to correct QT interval
1 Introduction
2 Methods for QT interval correction
3 Clinical implications of QTc intervals
4 Conclusion
Chapter 4. Usefulness of digital health devices for QT measurement and as an aid for diagnosis of channelopathies
1 Introduction
2 Handheld ECGs for QT measurement
3 Smartwatch ECGs for QT measurement
4 Tips for the busy clinician
Chapter 5. Brief review of maneuvers to unmask the LQTS
1 Introduction
2 Stand up test (Passive orthostatic challenge or Viskin's test)
2.1 Abnormal QT hysteresis
2.2 QT stunning
3 Exercise stress test
3.1 Which patients should undergo an exercise stress test?
3.2 What are the limitations of provocative exercise testing?
4 The epinephrine infusion challenge
4.1 Mayo Clinic protocol
4.2 Shimizu protocol
4.3 Effects of epinephrine in the QT interval
5 Adenosine test
6 Tips for the busy clinician
Chapter 6. Drug-induced Torsades de Pointes and other forms of “acquired LQTS”
1 What is the difference between congenital and acquired LQTS?
2 What is the mechanism behind an acquired LQTS?
3 Risk assessment for drug-induced prolonged QT and risk of ventricular arrhythmias
4 Acquired long QT interval in the recent COVID-19 pandemic
5 Polypharmacy as a risk factor for acquired LQTS
6 Acute coronary syndromes and acquired long QT
6.1 Ischemic VT versus acquired LQTS in the setting of ischemia and the role of quinidine
7 Tips for the busy clinician
Chapter 7. ECG findings of isolated long QT syndrome 1
1 Introduction
2 Why we should know about LQTS subtypes?
3 Representative ECG traces of LQT1
4 Alternative maneuvers
5 Tips for the busy clinician
Chapter 8. ECG findings of long QT syndrome type 2
1 Introduction
2 Representative ECG tracings
3 Provocative maneuvers (Viskin's test)
4 Tips for the busy clinician
Chapter 9. ECG findings in long QT syndrome type 3 (LQT3)
1 Definition
2 Clinical findings
2.1 NaV1.5 gain-of function phenotype
3 NaV1.5 mixed gain and loss-of function phenotype
Chapter 10. Andersen-Tawil syndrome (LQT7): A focus on ECG alterations
1 Background1
2 Pathophysiology
2.1 What is the role of the Kir 2.1 channel?
2.2 How is the KCNJ2 gene affected by ATS-1?
2.3 How does the abnormality of the Kir2.1 channel affect the heart?
2.4 Could there be other factors behind ATS?
3 Cardiac manifestations
3.1 Q-T interval or Q-U interval prolongation?
3.2 Characteristics of premature ventricular contractions and ventricular bigeminy in ATS-1
3.3 Ventricular arrhythmias
4 Future perspectives
Chapter 11. The electrocardiographic spectrum of the long QT syndrome in pediatric patients
1 Introduction
2 Representative ECG tracings (could be a 12-lead ECG, a stress-treadmill test, a holter monitoring rhythm strip, or all in some cases)
3 Alternative maneuvers (Viskin's test, lidocaine test)
4 Typical and atypical ECG patterns
5 Tips in four steps for the busy clinician
Chapter 12. ECG of short QT syndrome
1 Introduction
1.1 Genetic background and pathophysiology
1.2 Clinical manifestations
1.3 Diagnosis
2 Representative ECG tracings—ECG findings
3 Description of main ECG diagnostic findings of representative tracings
4 Alternative maneuvers
5 Tips for the busy clinician
Chapter 13. High-risk electrocardiographic markers for sudden death in Brugada syndrome
1 Introduction
2 Electrocardiographic diagnosis
3 Sudden cardiac death risk stratification
4 Brugada phenocopy
4.1 Introduction
4.2 Definition and mechanisms
4.3 Causes of Brugada phenocopy
4.4 Diagnosis
5 Conclusions
Chapter 14. ECG in Brugada syndrome beyond ST-segment elevation: Application of the beta angle and the base of the triangle
1 Introduction
2 Brugada ECG patterns
3 Recognizing high-risk ECG features in patients with BrS ECG pattern
4 The β-angle and the base of the triangle in clinical practice
5 Association between the β-angle and the base of the triangle with the ajmaline inducibility test
6 Clinical vignette
7 Conclusion
8 Tips for the busy clinician
Chapter 15. Electrocardiography of polymorphic ventricular tachycardia
1 Introduction
2 Polymorphic VT associated with long QT
3 Polymorphic VT associated with primary electric diseases without QT prolongation
3.1 Brugada syndrome
3.2 Short QT syndrome
3.3 CPVT
4 Polymorphic VT/VF associated with early repolarization syndrome
5 Idiopathic VF and short-coupled related VT/VF
6 Polymorphic VT/VF in structural heart diseases
7 Tips for the busy clinician
Abbreviations
Chapter 16. Electrocardiographic diagnostics in catecholaminergic polymorphic ventricular tachycardia: ECG, Holter, and stress testing
1 Introduction1
2 Clinical diagnosis
3 Pathophysiology
4 Genetics of CPVT
5 ECG features
6 Holter monitoring and loop recorders
7 Treadmill stress testing: The cornerstone of diagnosis
8 Conclusions
9 Tips for the busy clinician
Chapter 17. ECG diagnosis of early repolarization pattern
1 Introduction
1.1 Original definitions
1.2 Early repolarization syndrome
2 Current definition of early repolarization
2.1 Relevance of the slope of the ST segment
3 Representative examples
4 Population studies (epidemiology)
4.1 Is there an association of early repolarization with sudden death?
5 Debate: Early repolarization or delayed depolarization?
6 Tips for the busy clinician
Index

Life Sciences

Physical Sciences & Engineering

Social Sciences & Humanities

Health

Electrocardiography of Channelopathies

A Primer for the Clinical Cardiologist

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World Book Day Celebration!

Institutional subscription on ScienceDirect

Manlio F. Márquez-Murillo

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