Drugs in Pregnancy, An Issue of Obstetrics and Gynecology Clinics

1st Edition, Volume 50-1 - February 25, 2023
Editor: Catherine Stika
Language: English
Hardback ISBN:
9 7 8 - 0 - 3 2 3 - 9 3 9 8 9 - 8
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 9 3 9 9 0 - 4

In this issue of Obstetrics and Gynecology Clinics of North America, guest editor Dr. Catherine Stika brings her considerable expertise to the topic of Drugs in Pregnancy. The use… Read more

Drugs in Pregnancy, An Issue of Obstetrics and Gynecology Clinics

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In this issue of Obstetrics and Gynecology Clinics of North America, guest editor Dr. Catherine Stika brings her considerable expertise to the topic of Drugs in Pregnancy. The use of medications during pregnancy can be difficult to manage because not only is research lagging in this area, but typically drugs are not studied for use in pregnant women. In this issue, key experts provide a state-of-the-art review on clinical pharmacology in pregnancy, with a look at commonly prescribed medications as well as over-the-counter medications.

Cover image
Title page
Table of Contents
Copyright
Contributors
Forthcoming Issues
Introduction
Foreword
Preface
Principles of Obstetric Pharmacology: Maternal Physiologic and Hepatic Metabolism Changes
Key points
Impact of physiologic changes in pregnancy on pharmacology
Hepatic metabolism overview
PHASE I drug metabolizing enzymes and pregnancy
PHASE II drug metabolizing enzymes and pregnancy
Summary
Clinical Care Points
Disclosure
Inclusion of Pregnant and Lactating People in Clinical Research: Lessons Learned and Opportunities
Key points
Pregnant and lactating people as a vulnerable population
Food and Drug Administration and National Institutes of Health initiatives
PRGLAC task force recommendations
Pregnancy labeling
Summary
Clinics care points
Over-The-Counter Drugs and Pregnancy
Key points
Introduction
Principles of educating pregnant patients
Advice about over-the-counter drugs for specific conditions
Summary
Clinics care points
Antihypertensives in Pregnancy
Key points
Case
Diagnosis and treatment of hypertension outside of pregnancy
Case, continued
Diagnostic and treatment thresholds for hypertension in pregnancy
Case, continued
Review of antihypertensive safety in pregnancy
Antihypertensive selection for nonsevere hypertension in pregnancy
Case, continued
Antihypertensive selection for acute severe hypertension in pregnancy
Case, continued
Antihypertensive selection in the postpartum period
Summary
Disclosure
Aspirin and Pravastatin for Preeclampsia Prevention in High-Risk Pregnancy
Key points
Introduction and pathogenesis of preeclampsia
Aspirin
Clinical data and implications
Pravastatin
Summary
Clinics care points
Disclosure
Magnesium Sulfate Use in Pregnancy for Preeclampsia Prophylaxis and Fetal Neuroprotection: Regimens in High-Income and Low/Middle-Income Countries
Key points
Introduction
Summary
Clinics care points
Disclosures
Obstetric Indications for Progestin Therapy
Key points
Introduction
Progestin pharmacology
Prevention of recurrent first trimester pregnancy loss
Prevention of preterm birth in singleton pregnancies
Prevention of preterm birth in twin pregnancies
Other indications
Clinics care points
Funding
Antenatal Steroids and Tocolytics in Pregnancy
Key points
Antenatal corticosteroids
Tocolytics
Summary
Clinics care points
Disclosure
Medications for Managing Preexisting and Gestational Diabetes in Pregnancy
Key points
Introduction
Summary
Clinics care points
Disclosure
Antibiotics in Labor and Delivery
Key points
Introduction
Treatment of peripartum infections
Other obstetric infections
Pyelonephritis
Summary
Clinics care points
Analgesia in Pregnancy
Key points
Introduction
Pathophysiology of pain
Neuraxial analgesia
Parenteral (intravenous, intramuscular, subcutaneous) analgesics
Nitrous oxide
Unplanned cesarean delivery
Postdelivery considerations
Summary
Clinics care points
COVID-19 Therapeutics and Considerations for Pregnancy
Key points
Introduction
Summary
Clinics care points
An Overview of Antiviral Treatments in Pregnancy
Key points
Introduction
Cytomegalovirus
Ebola virus
Hepatitis B
Influenza virus
Simplex virus
Zika virus
Summary
Clinics care points
Antiretrovirals for Human Immunodeficiency Virus Treatment and Prevention in Pregnancy
Key points
Introduction
Historical Perspective on Antiretrovirals in Pregnancy
Pharmacokinetic Data During Pregnancy
Preexposure Prophylaxis
Therapies on the Horizon
Summary
Clinics care points
Funding
A Clinical Review of the Use of Common Psychiatric Medications in Pregnancy: Guidelines for Obstetrical Providers
Key points
Introduction
Antidepressants
Sedatives and hypnotics
Mood stabilizers
Antipsychotics
Summary
Clinics care points
Disclosure
Opioids and Opioid Use Disorder in Pregnancy
Key points
Introduction
Opioids and opioid use disorder
Management of analgesia for people with opioid use disorder in labor and postpartum
Summary
Clinics care points
Disclosure
Anticoagulation Regimens in Pregnancy
Key points
Introduction
Clinics care points
Antiseizure Medications in Pregnancy
Key points
Introduction
Summary
Clinics care points
Disclosure

Life sciences

Physical sciences & Engineering

Social sciences & Humanities

Health

Drugs in Pregnancy, An Issue of Obstetrics and Gynecology Clinics

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Catherine Stika