Drug Discovery
From Bedside to Wall Street
- 1st Edition - December 15, 2005
- Latest edition
- Authors: Tamas Bartfai, Graham V. Lees
- Language: English
Everyone expects something from the drug industry. Physicians and patients, investors, regulators and administrators all have an active interest. Everyone wants to know what ma… Read more
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Description
Description
Everyone expects something from the drug industry. Physicians and patients, investors, regulators and administrators all have an active interest. Everyone wants to know what makes drugs ‘work’ medically and economically. Why are drugs so expensive? Is it the drug companies or investors who demand high profits? What governs the pharmacoeconomics? Why are so few diseases treatable?
Drug Discovery opens the windows and doors of the industry telling the story of drug development by using real stories from inside the process.
Key features
Key features
- Co-written by Graham Lees and Tamas Bartfai who has been involved in the development of drugs taken by more that 20 million people every day
- Opens the windows and doors of the most regulated industry in the world, the pharmaceutical industry
- Tells the story of drug development by using real examples based on current research and events
- Provides an objective, lucid account of the successes and failures, shortcomings and constraints of the pharmaceutical and biotech industries
- Gives insights into the development of new drugs to combat multiple conditions including cancer and pain
- Balanced, unbiased account of how better to translate basic science into drug discovery
Readership
Readership
Table of contents
Table of contents
1. The Art of Putting a Molecule Into Man
2. Raising & Rising Expectations
3. History is good to know
4. The "Better Betablocker Barrier"
5. Why Some Good Drugs Do Not Get a Chance & Why
6. About the Economics of Target and Clinical Candidate Selection
7. Target Based Drug Discovery: Part I
8. Changes Need to be Made
9. Target Based Drug Discovery, Part II
10. "Drugable" Targets
11. So Many Drugs, So Few Entities
12. How to Find a Candidate
13. Practicalities: The Hoops & Hurdles of Big Pharma
14. Practical Trials for a Balanced Portfolio
15. How to Improve the Odds of Finding a Safe Drug that Works
16. The Tribulations of Clinical Trials
17. Linking Putative Targets to Disease States
18. More Ways to Look for Targets
19. The Business Basics
20. Adding Value in a Growth of Industry
21. What's the Most Profitable Approach?
22. Pharmacoeconomics for Biotech
23. Shrinking Value of Targets
24. Assessing Company Assets? Look in the Library
25. To Merge or Not to Merge?
26. Working with the Food & Drug Administration (FDA)
27. Regulating Regulatory Regimens Reliably
28. The Hypothesis Is: There is a Better Way
29. What are "We" all Working on?
30. More Tablets Taken per Day than Meals Served
Review quotes
Review quotes
"Doody's 3 Star Review: It was refreshing reading about these matters from a different perspective. The critical nature of the book, I would imagine, was intentional to play the proverbial "devil's advocate". This book truly caused me to rethink some attitudes and opinions I have had about pharmaceutical company behavior in the marketplace. It's nice that once in a while such a refreshing publication comes along."—Albert Wertheimer, B.S., MBA, PhD, Temple University School of Pharmacy for DOODY'S
"[This book] is very readable and insightful. I am hopeful that many people will pick it up, and develop a better appreciation for what goes into making the treatments that everyone wants!"—Dennis W. Choi, M.D., Sr. VP Merck (2006)
"Anyone who thinks solutions to drug development are just around the corner would be well-advised to get this insider's views as to where the real problems lie."—Floyd Bloom, CEO Neurome, former Editor of Science magazine (2006)
"...a very informative and exciting book filling an important niche. Very easy to read, it encouraged me to think about several things."—Richard Nass, Vanderbilt University (2006)
Product details
Product details
- Edition: 1
- Latest edition
- Published: December 15, 2005
- Language: English
About the authors
About the authors
TB
Tamas Bartfai
Dr. Bartfai has held many prestigious academic positions. He is a member of Academia Europae and the Hungarian Academy of Sciences, a fellow of AAAS for pioneering work on neuropeptides, and a member of the Royal Swedish Academy of Sciences, which awards the Nobel Prizes in Chemistry and Physics. He was professor of the Karolinska Institute, which awards the Nobel Prize in Medicine or Physiology. He has been awarded a number of prestigious prizes including Eötvös Medal for mathematics in 1966, Budapest, Hungary; Royal Swedish Academy’s Svedberg Prize for biochemistry in 1985 and Ericsson Prize in 1996; and the Ellison Medical Foundation Senior Scholar Award 2002.
GL
Graham V. Lees
The authors’ previous book Drug Discovery: from Bedside to Wall Street, Elsevier/Academic Press, 2006, has been published in Japanese (Chem-Bio Informatics Society) and Mandarin (Science Press). Their later book’s Japanese and Mandarin editions are in preparation.