Drug-delivery systems of phytochemicals as therapeutic strategies in cancer therapy
- 1st Edition - November 7, 2023
- Imprint: Academic Press
- Authors: Akhileshwar Kumar Srivastava, Divya Singh, Rajesh Kumar Singh
- Language: English
- Paperback ISBN:9 7 8 - 0 - 4 4 3 - 1 5 9 6 0 - 2
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 1 5 9 6 1 - 9
Drug-delivery Systems of Phytochemicals as Therapeutic Strategies in Cancer Therapy elucidates the importance of various phytochemicals in cancer therapy and explains various r… Read more
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Request a sales quoteDrug-delivery Systems of Phytochemicals as Therapeutic Strategies in Cancer Therapy elucidates the importance of various phytochemicals in cancer therapy and explains various routes/methods to deliver phytochemicals for overcoming the problems associated with delivery systems in cancer treatment. Several nanotechnological methods are presented to enhance drug solubility, sustainability, bioavailability, and gastrointestinal permeability of these phytochemicals. Current understanding of the relevant information presented on therapeutic strategies in cancer therapy fulfils the requirements of oncologists, molecular biologists, pharmacologist and related researchers who want to work in the areas of drug development targeting phytochemicals for cancer therapy.
- Explains the significance of phytochemicals in cancer therapy, along with their pharmacologic action
- Elucidates the importance of various phytochemicals in cancer therapy
- Explains the emerging need of drug-delivery system for plant metabolites
- Deciphers the various drug-delivery systems for phytomedicines involved in cancer treatments
- Describes the crucial role of nanotechnology in the development of drug-delivery systems for anticancer phytochemicals
- Explores the challenges associated with developing drug-delivery systems for phytochemicals to cure cancer
Researchers as well as universities professors working in the areas of oncology, pharmaceutical sciences, biotechnology and drug-delivery systems in treatment of different cancers, pharmaceutical companies will be benefited in designing of delivery systems for phytochemicals targeting oncogenic factors
- Cover image
- Title page
- Table of Contents
- Copyright
- Dedication
- About the authors
- Preface
- Introduction
- Chapter 1. Significance of phytochemicals in cancer therapy
- Introduction
- Current challenges in cancer treatment and management
- Phytodrugs: A historical view
- Natural products
- Anticancer phytocomponents
- Molecular targets of phytochemicals
- Plants compounds targeting ROS and autophagy for cancer treatment
- Clinical trial of phytochemicals for cancer therapy
- Conclusion and future prospectives
- Chapter 2. Emerging need of delivery systems for plant metabolites
- Introduction
- Novel drug delivery methods
- Patterns of drug delivery
- Novel drug delivery systems for plants metabolites
- Conclusion and future prospectives
- Chapter 3. Phytosome: A promising drug delivery system for cancer therapy
- Introduction
- Principle for synthesis of phytosomes
- Composition of phytosomes
- Anticancer activity of phytosomes-formulated phytochemicals
- Challenges of phytosomal products to commercialization
- Conclusion and future prospect
- Chapter 4. Exosome-based delivery systems for natural compounds in cancer therapy
- Introduction
- Biogenesis of exosomes
- Role of exosomes in cancer
- Modification of exosome-based drug delivery system
- Modifications of exosome for target site
- Application of exosomes in delivery of phytochemicals for cancer treatment
- Current limitations and challenges
- Conclusions
- Chapter 5. Potential implications of ethosomes and transethosomes to deliver phytomedicine in cancer treatment
- Introduction
- Ethosomes
- Transethosomes
- Application of ethosomes and transethosomes in phytodrug delivery
- Advantages and disadvantages of ethosomes and transethosomes
- Conclusion and future perspectives
- Chapter 6. Chitosan-based drug delivery of plant metabolites for the treatment of breast cancer
- Introduction
- Chitosan
- Chitosan-based delivery system in oncotherapy
- Breast cancer drug delivery by chitosan-based system
- Conclusions
- Chapter 7. Sporopollenin-based targeted drug delivery system for gastrointestinal cancer
- Introduction
- Chemical structure of sporopollenin
- Sporopollenin-indomitable biopolymer for biomedical implications
- Sporopollenin-based drug delivery systems
- Impact of sporopollenin encapsulation on stability to digestion and gut microbes
- Conclusions
- Chapter 8. Nanotechnology-based delivery system for phytochemicals in cancer therapy
- Introduction
- Branches of nanotechnology
- Research breakthrough in nanotechnology for development of anticancer drugs
- Advancement in nanotechnology targeting cancer
- Nanodrug delivery systems of phytochemicals for cancer therapy
- Nanoformulation of phytochemicals for cancer treatments
- Nanocarrier-based codelivery of phytochemicals with conventional drugs for cancer treatment
- Clinical applications
- Conclusions and future perspective
- Chapter 9. Delivery system of phenolic compounds for the treatment of lung cancer
- Introduction
- Biological function of polyphenols in cancer
- Bioavailability of phenolic compounds
- Polyphenolics drug delivery systems
- Drug delivery
- Methyl gallate@ZIF-L hybrid as drug delivery system for lung cancer treatment
- Curcumin-loaded solid lipid nanoparticles (Cur-SLNs) as drug delivery system for the lung cancer therapy
- Conclusion and future perspective
- Chapter 10. Advancement in drug delivery systems of curcumin for cancer chemoprevention
- Introduction
- Drug delivery vehicle for curcumin
- Drug delivery systems for synergistic application of curcumin with anticancer regimens
- Conclusions and future prospective
- Chapter 11. Drug delivery system for saponins in cancer treatments
- Introduction
- Classification of saponins
- Anticancer event of saponin
- Drug delivery system for saponins
- Release of nanofiber membrane loaded with saponin
- Saponin-loaded chitosan nanoparticles
- Saponin-loaded montmorillonite–human serum albumin nanocomposites in cancer therapy
- A novel saponin liposome based on the couplet medicines
- Conclusions and future perspectives
- Chapter 12. Administration of plant-derived terpenoids in cancer management
- Introduction
- Mechanism of action of terpenoids against cancer development
- Terpene-based therapeutic deep eutectic systems against colorectal cancer
- Coencapsulation and sustained release of terpenes from injectable PELGE nanoparticles
- The combination of nanomicelles with terpenoids for skin drug delivery
- Development of enhanced drug delivery vehicles for three cannabis-based terpenes
- Patents of some terpenoids as an anticancer compound
- Conclusions and future perspectives
- Chapter 13. Therapeutic role of essential oils in malignancies through drug delivery mechanisms
- Introduction
- Activity of essential oils/their constituents on cancer cell lines
- Major issues in clinical use of essential oils
- Effective essential oil delivery in living systems
- Problems of current technology
- Nanoencapsulation approach
- Targeted nanodelivery systems for cancer treatment
- Conclusion and future perspectives
- Chapter 14. Development of codelivery systems for phytochemicals and targeted siRNA in treatment of cancer
- Introduction
- Event of siRNA action
- Implication of siRNA in cancer therapy
- Phytochemicals–siRNA codelivery
- Conclusions
- Chapter 15. Future challenges of drug-delivery systems for phytochemicals in cancer management
- Introduction
- Challenges of phytochemicals in cancer treatment
- Challenges of nanotechnology for phytochemicals in cancer treatment
- Major issues in nano-formulation of drugs
- Associated challenges of chitosan-based nanoparticles
- Combination of phytochemicals with conventional chemotherapeutics
- Conclusions
- Index
- Edition: 1
- Published: November 7, 2023
- No. of pages (Paperback): 264
- No. of pages (eBook): 320
- Imprint: Academic Press
- Language: English
- Paperback ISBN: 9780443159602
- eBook ISBN: 9780443159619
AS
Akhileshwar Kumar Srivastava
Dr. Akhileshwar Kumar Srivastava works as a Research Associate (ICMR) in CSIR-Central Food Technological Research Institute, Mysore, India. In his eight years of research, he has published approximately 20 research articles and book chapters in international and national journals of repute. His research specialization is primarily in the area of pharmacognosy with genetics, metabolomics, bioinformatics, and molecular biology-associated targeting cancer diseases. In addition, he has studied at Augusta University (formerly, Georgia Regents University) in Augusta, GA, United States on a J-1 Exchange Scholar Visa and at Ben-Gurion University, Israel. He is also a life member fellow in Indian Science Congress and Agriculture, Nutrition and Health Academy, United Kingdom.
Affiliations and expertise
CSIR-Central Food Technological Research Institute, Mysore, IndiaDS
Divya Singh
Divya Singh is presently working as Scientist-B in Department of Mulberry Physiology, CSRTI, Mysore, India. Her research specialization is primarily in genetics, proteomics, metabolomics, toxicology, bioinformatics and molecular biological evaluation in various in vivo and in vitro plant models to elucidate the physiological changes and evaluate the DNA damage potency. In her 11 years of research experiences, she has published 8-peer reviewed publications, two books (1 edited and 1 authored) including 6 book chapters and several meeting presentations at local and international scientific meetings.
Affiliations and expertise
CSRTIRS
Rajesh Kumar Singh
Dr. Rajesh Kumar Singh is currently working as a Research Associate in Banaras Hindu University. His research focus is pharmacognosy, reverse pharmacology, drug design and discovery, extraction & isolation of natural products, cell culture, and handling of different rodents. He has published several research articles in reputable journals over the course of his career. At present, he is involved in developing an Indian origin cell line and screening drugs of natural origin for the treatment of gallbladder cancer.
Affiliations and expertise
Research Associate, Centre of Experimental Medicine and Surgery at Banaras Hindu University, IndiaRead Drug-delivery systems of phytochemicals as therapeutic strategies in cancer therapy on ScienceDirect