DNA Damage and Double Strand Breaks
- 1st Edition, Volume 51 - October 19, 2022
- Imprint: Academic Press
- Editors: Fuyuhiko Tamanoi, Kenichi Yoshikawa
- Language: English
- Hardback ISBN:9 7 8 - 0 - 3 2 3 - 9 9 3 9 7 - 5
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 9 9 4 0 5 - 7
DNA Damage and Double Strand Breaks, Volume 51 in The Enzymes series, highlights new advances in the field, with this new volume presenting interesting chapters that provide an upd… Read more
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Request a sales quoteDNA Damage and Double Strand Breaks, Volume 51 in The Enzymes series, highlights new advances in the field, with this new volume presenting interesting chapters that provide an update on female and male genital schistosomiasis and a call to integrate efforts to escalate diagnosis, treatment and awareness in endemic and non-endemic settings, vertebrates as uninfected disseminators of helminth eggs and larvae, and combatting anthelmintic resistance in ruminants.
- Provides the authority and expertise of leading contributors from an international board of authors
- Presents the latest release in The Enzymes series
Specialists in the field of Enzymes
- Cover
- Title page
- Table of Contents
- Copyright
- Contributors
- Preface
- Chapter One: Overview of DNA damage and double-strand breaks
- Abstract
- 1: DNA damages involving base modifications
- 2: DNA strand breaks
- 3: Assays to detect DNA double-strand breaks
- 4: Effect of DNA structure, nucleosomes, and reactive oxygen species
- 5: Repair of DNA double-strand breaks
- References
- Chapter Two: Quantitative evaluation of DNA double-strand breaks (DSBs) through single-molecule observation
- Abstract
- 1: Introduction
- 2: Single-molecule observation on DNA DSBs
- 3: DSBs caused by γ-ray
- 4: Real-time observation of DSBs
- 5: DNA compaction exhibits marked protective effect against DSBs
- 6: How to reduce DSBs caused by mechanical mixing
- 7: Protective effect of antioxidant against various damage sources
- 8: Future prospective
- Acknowledgments
- References
- Chapter Three: Chromatin organization and DNA damage
- Abstract
- 1: Introduction
- 2: Chromatin compaction and radiation damage
- 3: Regulation of chromatin organization to cope with DNA damage
- 4: Conclusion and clinical implications
- References
- Chapter Four: Mechanical force induced DNA double-strand breaks: Ultrasound
- Abstract
- 1: Introduction
- 2: Different ultrasound induced DNA damages
- 3: Experimental system for ultrasound exposure
- 4: Summary
- Acknowledgment
- References
- Chapter Five: DNA damage and biological responses induced by Boron Neutron Capture Therapy (BNCT)
- Abstract
- 1: Introduction
- 2: DNA damage and repair mechanism induced by BNCT
- 3: Biological effects of BNCT
- 4: Closing remarks
- Reference
- Chapter Six: Core level ionization or excitation and Auger relaxation induce clustered DNA damage
- Abstract
- 1: Introduction: Radiation damage to DNA
- 2: Clustered DNA damage
- 3: Nucleobase excision repair enzymes as probes to detect nucleobase lesions and AP sites
- 4: DSBs arising from treatment with base excision enzymes
- 5: Core level ionization or excitation by collision with swiftly moving high-LET charged particles or irradiation with low-LET radiations
- 6: Synchrotron radiation providing monochromatic soft X-rays induce Auger relaxation of particular elements in DNA
- 7: Model of clustered damage induced after Auger relaxation of DNA constituent atoms
- 8: Pre-thermalized Auger electrons are highly localized by the Coulomb potential of the cation ion of the parent atom
- 9: Novel method to examine the repairability of various types of DNA damage, and future prospects of studies on Auger relaxation and clustered DNA damage
- 10: Conclusion
- References
- Chapter Seven: Auger electrons and DNA double-strand breaks studied by using iodine-containing chemicals
- Abstract
- 1: Introduction
- 2: Iododeoxyuridine
- 3: Iodine containing DNA binding chemicals
- 4: Nanoparticles containing iodine
- 5: Our experiments using monochromatic X-rays and tumor spheroids incubated with iodine nanoparticles
- 6: Experiments with gadolinium-loaded nanoparticles
- 7: Summary
- Acknowledgment
- References
- Chapter Eight: Carbon ion radiation and clustered DNA double-strand breaks
- Abstract
- 1: Introduction
- 2: Clustered DSB formation visualized by high-resolution imaging
- 3: Repair and mutations after high LET carbon ion irradiation
- 4: Summary
- Acknowledgment
- References
- Chapter Nine: Damages of DNA in tritiated water
- Abstracts
- 1: Introduction
- 2: Double-strand breaks in tritiated water by β-rays irradiation and other factors
- 3: Image processing method for single-molecular imaging
- 4: In silico simulation of DNA damage by tritium β decay
- 5: Summary and future outlook
- References
- Edition: 1
- Volume: 51
- Published: October 19, 2022
- Imprint: Academic Press
- No. of pages: 164
- Language: English
- Hardback ISBN: 9780323993975
- eBook ISBN: 9780323994057
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Fuyuhiko Tamanoi
Fuyu Tamanoi is a biochemist who has served on the UCLA School of Medicine and UCLA College faculty since he joined the Department of Microbiology, Immunology & Molecular Genetics in 1993. He became a full professor in 1997.
Affiliations and expertise
Biochemist, Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, USAKY
Kenichi Yoshikawa
Kenichi Yoshikawa works in Doshisha University and Kyoto University in Japan
Affiliations and expertise
Doshisha University/Kyoto University, JapanRead DNA Damage and Double Strand Breaks on ScienceDirect