Disease Pathways
An Atlas of Human Disease Signaling Pathways
- 1st Edition - October 18, 2019
- Latest edition
- Authors: Anastasia P. Nesterova, Anton Yuryev, Eugene A. Klimov, Maria Zharkova, Maria Shkrob, Natalia V. Ivanikova, Sergey Sozin, Vladimir Sobolev
- Language: English
Disease Pathways: An Atlas of Human Disease Signaling Pathways is designed to fill a void of illustrated reviews about the cellular mechanisms of human diseases. It covers 42 of… Read more
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Description
Description
Disease Pathways: An Atlas of Human Disease Signaling Pathways is designed to fill a void of illustrated reviews about the cellular mechanisms of human diseases. It covers 42 of the most common non-oncologic diseases and illustrates the connections between the molecular causes of the disease and its symptoms. This resource provides readers with detailed information about the disease molecular pathways, while keeping the presentation simple.
Pathway models that aggregate the knowledge about protein–protein interactions have become indispensable tools in many areas of molecular biology, pharmacology, and medicine. In addition to disease pathways, the book includes a comprehensive overview of molecular signaling biology and application of pathway models in the analysis of big data for drug discovery and personalized medicine.
This is a must-have reference for general biologists, biochemists, students, medical workers, and everyone interested in the cellular and molecular mechanisms of human disease.
Key features
Key features
- Over 145 full-color illustrations of the molecular and cellular cascades underlying the disease pathology.
- Disease pathways are based on computational models from Elsevier’s Disease Pathway Collection, published for the first time outside of Pathway Studio® commercial software.
- Each relationship on the pathway models is supported by references to scientific articles and can be examined at freely available online resources.
Readership
Readership
Table of contents
Table of contents
1. Part One (A.Nesterova, E.Klimov)1.1. Introduction to the cell signaling biochemistry and proteomics1.2. System biology and signaling pathways1.3. Complexity of molecular mechanisms of human diseases
2. Part Two (the chapter will contain numerous images with disease pathways)2.1. Cardiovascular Diseases2.1.1. Arrhythmogenic Right Ventricular Dysplasia (A.Nesterova)2.1.2. Atherosclerosis (V.Sobolev)2.1.3. Hypertension (S.Sozin)2.2. Dermatological Diseases2.2.1. Acne Vulgaris (A.Nesterova)2.2.2. Atopic Dermatitis (V.Sobolev, A.Nesterova)2.2.3. Ichthyosis (V.Sobolev, A.Nesterova)2.3. Endocrine and Metabolic Diseases2.3.1. Diabetes Mellitus Type 1 (A.Nesterova)2.3.2. Diabetes Mellitus Type 2 (A.Nesterova, M.Zharkova)2.3.3. Phenylketonuria (A.Nesterova)2.4. Intestinal Diseases2.4.1. Crohn's Disease (A.Nesterova, V. Sobolev)2.4.2. Ulcerative Colitis (V.Sobolev)2.4.3. Celiac Disease (V.Sobolev, A.Nesterova)2.4. Hepatology/Liver Diseases2.4.1. Alpha 1-Antitrypsin Deficiency (S.Sozin)2.4.2. Non-Alcoholic Fatty Liver Disease (M.Zharkova)2.5. Musculoskeletal System Diseases2.5.1. Osteoarthritis (S.Sozin, A.Nesterova)2.5.2. Osteopetrosis (S.Sozin)2.5.3. Osteoporosis (S. Sozin, A.Nesterova)2.6. Neurological Diseases2.6.1. Alzheimer's Disease (A.Nesterova)2.6.2. Migraine, Familial Hemiplegic (E.Klimov)2.6.3. Sclerosis (S.Sozin)2.7. Obstetrics and Gynecology Diseases2.7.1. Polycystic Ovary Syndrome (M.Zharkova)2.8. Ophthalmology/Eye Diseases2.8.1. Age-Related Macular Degeneration (S.Sozin)2.8.2. Cataract (A.Nesterova)2.8.3. Glaucoma (S.Sozin)2.9. Otolaryngological Diseases2.9.1. Hearing Loss (S.Sozin)2.9.2. Otitis Media (S.Sozin)2.10. Respirator and Pulmonology Diseases2.10.1. Asthma (A.Nesterova)2.10.2. Chronic Obstructive Pulmonary Disease (S.Sozin, A.Nesterova)2.10.3. Cystic Fibrosis (A.Nesterova)2.11. Nephrology Diseases2.11.1. Cystic Kidney Disease (M.Zharkova)
3. Part Three3.1. Methods of using intracellular maps for diagnosis of diseases in personalized medicine (A.Nesterova)3.2. Conclusion (A.Nesterova)
Review quotes
Review quotes
"This is an excellent resource on the molecular pathways of the 42 most common on-oncologic diseases that illustrates the connection between the molecular causes of diseases and their symptoms. It is unique in the way it provides molecular disease pathways, which will assist readers in clearly understanding disease processes. It will serve as a reference for general biologists, biochemists, students, and medical workers."—Doody
"The BiochemistI would definitely recommend this book for anyone who works on disease pathology or cell biology as it is immensely useful both for deepening understanding and for quickly checking the role of a molecule in a specific disease. The writing is clear and concise and supported by beautiful diagrams; while the subjects are comprehensively covered, each section is a manageable chunk and it is very easy to quickly navigate the text. Overall, this book is a must-have for those interested in cell signalling and would make a great addition to an academic bookshelf!"—The Biochemist
Product details
Product details
- Edition: 1
- Latest edition
- Published: October 18, 2019
- Language: English
About the authors
About the authors
AN
Anastasia P. Nesterova
AY
Anton Yuryev
EK
Eugene A. Klimov
MZ
Maria Zharkova
MS
Maria Shkrob
NI
Natalia V. Ivanikova
SS
Sergey Sozin
VS