Disease Pathways

An Atlas of Human Disease Signaling Pathways

1st Edition - October 18, 2019
Authors: Anastasia P. Nesterova, Anton Yuryev, Eugene A. Klimov, Maria Zharkova, Maria Shkrob, Natalia V. Ivanikova, Sergey Sozin, Vladimir Sobolev
Language: English
Paperback ISBN:
9 7 8 - 0 - 1 2 - 8 1 7 0 8 6 - 1
eBook ISBN:
9 7 8 - 0 - 1 2 - 8 1 7 0 8 7 - 8

Disease Pathways: An Atlas of Human Disease Signaling Pathways is designed to fill a void of illustrated reviews about the cellular mechanisms of human diseases. It covers 42 of… Read more

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Disease Pathways: An Atlas of Human Disease Signaling Pathways is designed to fill a void of illustrated reviews about the cellular mechanisms of human diseases. It covers 42 of the most common non-oncologic diseases and illustrates the connections between the molecular causes of the disease and its symptoms. This resource provides readers with detailed information about the disease molecular pathways, while keeping the presentation simple.

Pathway models that aggregate the knowledge about protein–protein interactions have become indispensable tools in many areas of molecular biology, pharmacology, and medicine. In addition to disease pathways, the book includes a comprehensive overview of molecular signaling biology and application of pathway models in the analysis of big data for drug discovery and personalized medicine.

This is a must-have reference for general biologists, biochemists, students, medical workers, and everyone interested in the cellular and molecular mechanisms of human disease.

1. Part One (A.Nesterova, E.Klimov)1.1. Introduction to the cell signaling biochemistry and proteomics1.2. System biology and signaling pathways1.3. Complexity of molecular mechanisms of human diseases

2. Part Two (the chapter will contain numerous images with disease pathways)2.1. Cardiovascular Diseases2.1.1. Arrhythmogenic Right Ventricular Dysplasia (A.Nesterova)2.1.2. Atherosclerosis (V.Sobolev)2.1.3. Hypertension (S.Sozin)2.2. Dermatological Diseases2.2.1. Acne Vulgaris (A.Nesterova)2.2.2. Atopic Dermatitis (V.Sobolev, A.Nesterova)2.2.3. Ichthyosis (V.Sobolev, A.Nesterova)2.3. Endocrine and Metabolic Diseases2.3.1. Diabetes Mellitus Type 1 (A.Nesterova)2.3.2. Diabetes Mellitus Type 2 (A.Nesterova, M.Zharkova)2.3.3. Phenylketonuria (A.Nesterova)2.4. Intestinal Diseases2.4.1. Crohn's Disease (A.Nesterova, V. Sobolev)2.4.2. Ulcerative Colitis (V.Sobolev)2.4.3. Celiac Disease (V.Sobolev, A.Nesterova)2.4. Hepatology/Liver Diseases2.4.1. Alpha 1-Antitrypsin Deficiency (S.Sozin)2.4.2. Non-Alcoholic Fatty Liver Disease (M.Zharkova)2.5. Musculoskeletal System Diseases2.5.1. Osteoarthritis (S.Sozin, A.Nesterova)2.5.2. Osteopetrosis (S.Sozin)2.5.3. Osteoporosis (S. Sozin, A.Nesterova)2.6. Neurological Diseases2.6.1. Alzheimer's Disease (A.Nesterova)2.6.2. Migraine, Familial Hemiplegic (E.Klimov)2.6.3. Sclerosis (S.Sozin)2.7. Obstetrics and Gynecology Diseases2.7.1. Polycystic Ovary Syndrome (M.Zharkova)2.8. Ophthalmology/Eye Diseases2.8.1. Age-Related Macular Degeneration (S.Sozin)2.8.2. Cataract (A.Nesterova)2.8.3. Glaucoma (S.Sozin)2.9. Otolaryngological Diseases2.9.1. Hearing Loss (S.Sozin)2.9.2. Otitis Media (S.Sozin)2.10. Respirator and Pulmonology Diseases2.10.1. Asthma (A.Nesterova)2.10.2. Chronic Obstructive Pulmonary Disease (S.Sozin, A.Nesterova)2.10.3. Cystic Fibrosis (A.Nesterova)2.11. Nephrology Diseases2.11.1. Cystic Kidney Disease (M.Zharkova)

3. Part Three3.1. Methods of using intracellular maps for diagnosis of diseases in personalized medicine (A.Nesterova)3.2. Conclusion (A.Nesterova)

Anastasia P. Nesterova

Dr. Nesterova is a senior scientist in the Life Science Research and Development Department at Elsevier with a focus on mammalian genetics and human diseases. For five years, her team compiled signaling pathways for over 250 diseases using the Elsevier Pathway Studio™ software and database.

Affiliations and expertise

Senior Scientist, Elsevier Inc., Rockville, MD, USA

Anton Yuryev

Dr. Anton Yuryev works as the Professional Services Director at Elsevier and is responsible for development of targeted bioinformatics solutions using Elsevier software and knowledge bases for areas of drug research, personalized medicine and agrobiology.

Affiliations and expertise

Elsevier Inc., Rockville, MD, USA

Eugene A. Klimov

Dr. Eugene A. Klimov is Head of the group of Medical and Veterinary Genetics in the Faculty of Biology and is the lecturer at Lomonosov Moscow State University. Dr. Klimov has 15 years of experience in structural and functional genomics, molecular biology, viral and neurological diseases.

Affiliations and expertise

Elsevier Inc. / Novel Software Systems, Moscow, Russia

Maria Zharkova

Dr. Maria Zharkova, Novel Software Systems employee, working as a scientist at the Life Science Research and Development Department at Elsevier with primary research interests in protein biology and biochemistry.

Affiliations and expertise

Scientist, Elsevier Inc. / Novel Software Systems, Moscow, Russia

Maria Shkrob

Dr. Maria Shkrob has 7 years of experience in the bioinformatics industry, working on the solutions for text and data mining. At Elsevier, she works as a Consultant for Elsevier Professional Services applying the rich R&D Solutions portfolio to address customers’ needs.

Affiliations and expertise

Elsevier Inc., Rockville, MD, USA

Natalia V. Ivanikova

Natalia Ivanikova, PhD, Novel Software Systems employee, works as a senior scientist at the Content and Innovation group at Elsevier's Operations division with a focus on the automated construction of biological knowledge bases using natural language processing technologies.

Affiliations and expertise

Scientist, Elsevier Inc. / Novel Software Systems, Saint-Petersburg, Russia

Sergey Sozin

Sergei Sozin, M.D., Novel Software Systems employee, works as a scientist at the Life Science Research and Development Department at Elsevier with a focus on internal medicine, hematology, cancer biology, oncogenomics, and clinical trials.

Affiliations and expertise

Scientist, Elsevier Inc. / Novel Software Systems, Saint-Petersburg, Russia

Vladimir Sobolev

Dr. Vladimir Sobolev is a senior scientist at the Mechnikov Research Institute of Vaccines and Sera, and at the Center for Theoretical Problems of Physicochemical Pharmacology, Russian Academy of Science. Dr. Sobolev specializes in cell biology and immunology.

Affiliations and expertise

Scientist, Elsevier Inc. / Novel Software Systems, Moscow, Russia

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Disease Pathways

An Atlas of Human Disease Signaling Pathways

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Institutional subscription on ScienceDirect

Anastasia P. Nesterova

Anton Yuryev

Eugene A. Klimov

Maria Zharkova

Maria Shkrob

Natalia V. Ivanikova

Sergey Sozin

Vladimir Sobolev