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DiSaia and Creasman Clinical Gynecologic Oncology
- 10th Edition - June 17, 2022
- Editors: William T. Creasman, Robert S Mannel, David G Mutch, Krishnansu Tewari
- Language: English
- Hardback ISBN:9 7 8 - 0 - 3 2 3 - 7 7 6 8 4 - 4
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 2 8 4 1 4 - 4
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 7 7 6 8 5 - 1
For more than 40 years, DiSaia and Creasman Clinical Gynecologic Oncology has been the leading reference for diagnosis and treatment of gynecologic cancers, providing physi… Read more
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Request a sales quoteFor more than 40 years, DiSaia and Creasman Clinical Gynecologic Oncology has been the leading reference for diagnosis and treatment of gynecologic cancers, providing physicians and trainees alike with expert guidance on clinical presentations and management. The fully revised 10th Edition remains the most readable, most comprehensive text in the field. Under outstanding editorial leadership from Dr. William Creasman and featuring a “who’s who” list of expert contributing authors, this authoritative reference is a must-have resource for improving outcomes and providing effective patient care.
Emphasizes practical clinical presentations and management of commonly seen problems, making this text an excellent resource for daily decision making.
Provides in-depth explanations of major topics supplemented with up-to-date references.
Features a new chapter on Immunotherapy in Gynecologic Malignancies, updated information on invasive cervical cancer, and significantly revised content on vulvar cancer, with new guidance on micro-staging for sentinels.
Covers key topics such as precision medicine and new biomarker-driven targeted therapies, cancer staging, targeted therapy, and immunotherapy.
Includes quick-reference features such as key point boxes with bulleted lists, highlighted key text, enhanced chapter outlines, clinical algorithms that review recommended treatment and management options, and additional references online.
Contains useful appendices covering staging, screening, nutritional therapy, toxicity criteria, blood component therapy, and radiation therapy.
An ideal comprehensive resource for clinical practice, personal study, and exam review.
Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.
- Cover image
- Title page
- Table of Contents
- Copyright
- Contributors
- Preface
- List of Illustrations
- List of Tables
- 1. Preinvasive disease of the cervix
- Introduction
- Human papillomavirus natural history
- Epidemiology
- Human papillomavirus vaccination
- Screening
- Management of abnormal screening results
- Management of post-colposcopic results
- Management of abnormal screening results in pregnancy
- Future directions
- Bibliography
- 2. Preinvasive disease and dystrophies of the vagina and vulva and related disorders
- Embryology and diethylstilbestrol exposure
- Treatment of women exposed to diethylstilbestrol
- Nonneoplastic epithelial disorders of the vulva and vagina
- Vulvar intraepithelial neoplasia
- High-grade squamous intraepithelial lesion of the vagina
- Bibliography
- 3. Invasive cervical cancer
- General observations
- Clinical profile of invasive cancer
- Glandular tumors of the cervix
- Staging
- Treatment of early-stage disease
- Superficial carcinoma of the cervix
- Adenocarcinoma
- Treatment of locally advanced disease
- Neuroendocrine and other uncommon tumors of the cervix
- Glassy cell carcinoma, carcinosarcoma, lymphoma, and melanoma
- Survival results and prognostic factors for early-stage and locally advanced disease
- Recurrent and advanced carcinoma of the cervix
- Bibliography
- 4. Endometrial hyperplasia, estrogen therapy, and the prevention of endometrial cancer
- Introduction
- Endometrial hyperplasia: Pathologic diagnostic criteria
- Clinical presentation
- Management decisions for endometrial intraepithelial neoplasia
- Management of endometrial hyperplasia without atypia
- Prevention of endometrial cancer
- Benefits and risks of menopausal hormone therapy
- Risk modification with hormone therapy: Options and opportunities
- Nonhormone therapies for menopausal symptoms
- Menopausal hormone therapy for endometrial and breast cancer survivors
- Bibliography
- 5. Adenocarcinoma of the uterine corpus and sarcomas of the uterus
- Incidence
- Epidemiology
- Diagnosis
- Prognostic factors
- Treatment
- Antiangiogenic therapy in endometrial cancer
- Uterine sarcoma
- Incidence and epidemiology
- Leiomyosarcoma
- Endometrial stromal sarcoma
- Other sarcomas
- Bibliography
- 6. Invasive cancer of the vulva
- Invasive squamous cell carcinoma
- Technique of inguinofemoral lymphadenectomy
- Very early vulvar carcinoma
- Paget disease
- Melanoma
- Sarcoma
- Bartholin gland carcinoma
- Basal cell carcinoma
- Bibliography
- 7. Gestational trophoblastic disease
- Epidemiology
- Hydatidiform mole
- Gestational trophoblastic neoplasia
- Other considerations
- Bibliography
- 8. Adnexal masses
- Adnexal masses
- Extraovarian adnexal masses
- Ovarian masses
- Management of adnexal masses
- Special circumstances
- Bibliography
- 9. Epithelial ovarian cancer
- Classification
- Incidence, epidemiology, and etiology
- Signs and symptoms
- Staging
- Other considerations
- Surveillance and follow-up techniques
- Palliative/end of life support
- Conclusions on management
- Current areas of research
- Bibliography
- 10. Germ cell, stromal, and other ovarian tumors
- Germ cell tumors
- Tumors of germ cell and sex cord derivation
- Tumors derived from special gonadal stroma
- Tumors derived from nonspecific mesenchyme
- Small cell carcinoma of the ovary, hypercalcemic type
- Malignant lymphoma
- Metastatic tumors to the ovary
- Malignant ovarian tumors in children
- Bibliography
- 11. Breast diseases
- Introduction
- Anatomy of the breast
- Embryology and development of the breast
- Pregnancy and breast feeding
- Benign breast conditions
- History and physical examination
- Breast imaging
- Breast ultrasound and magnetic resonance imaging
- Diagnostic evaluation
- Epidemiology of breast cancer
- Risk factors and assessment
- Pathology
- Metastases from extramammary tumors
- Biologic markers and prognostic factors
- Staging of breast cancer using the tumor–node–metastasis system
- Treatment of breast cancer
- Special issues
- Conclusions
- Bibliography
- 12. Cancer in pregnancy
- Background and epidemiology of cancer
- The more common solid tumors
- Evaluation and therapeutic modalities
- Hematologic malignancies
- Other tumors
- Bibliography
- 13. Complications of disease and therapy
- Disease–oriented complications
- Treatment-related complications
- Bibliography
- 14. Basic principles of chemotherapy and other systemic therapies
- Historical overview
- General principles
- Cell cycle control and growth kinetics
- Dynamics of chemotherapy
- Pharmacologic principles
- Categories of drugs in current use (Table 14.7)
- Drug toxicity
- Evaluation of new agents
- Bibliography
- 15. Targeted therapy and molecular genetics
- Targeted therapy
- Foundation of targeted therapy
- Targeted agents
- Angiogenesis
- Vascular endothelial growth factors and vascular endothelial growth factor receptors
- Ofranergene obadenovec (VB-111)
- Phosphatidylinositol-3-kinase/AKT pathway
- Ras/Raf pathway
- Poly (ADP-ribose) polymerase pathway
- Epidermal growth factor receptor pathway
- Multipathway targeted agents
- Other targets of interest
- Unique toxicities of targeted therapy
- Special considerations for targeted therapies
- Conclusions
- Acknowledgments
- Bibliography
- 16. Molecular hallmarks of cancer
- Biology of gynecologic cancers
- Molecular changes in gynecologic malignancies
- Cell cycle
- Agents
- Targets
- Conclusions
- Bibliography
- 17. Immunotherapy in gynecologic malignancies
- Cytokines
- Monoclonal antibodies
- Clinical use of antibody drug conjugates
- Immune checkpoint inhibitors
- Clinical use of anti-CTLA-4 antibodies
- Clinical use of anti-PD-(L)1 antibodies
- Clinical use of combined immune checkpoint inhibition
- Resistance mechanisms to immune checkpoint inhibition
- Therapeutic cancer vaccines
- Adoptive cell therapy
- Immune-related adverse events
- Therapy of immune-related adverse events
- Special patient populations
- Obstacles to immunotherapy
- Summary
- Bibliography
- 18. Genes and cancer: Genetic counselling and clinical management
- Introduction
- Genetic alterations in cancer
- Mechanisms of human gene mutation
- Cancer epigenetics
- Genomic imprinting and cancer
- Genetic alterations that cause cancer
- Hereditary cancer risk assessment: Genetic counseling and genetic testing
- Genetic counseling and genetic testing for hereditary cancers
- Referral of gynecologic cancer patients for hereditary cancer risk assessment
- Genetic testing
- Legal aspects of genetic testing
- Long-term contact for patients and families with hereditary risk for cancer
- DNA banking
- Conclusion
- Glossary
- Bibliography
- 19. Palliative care and quality of life
- Evolution of palliative care
- Quality of life in gynecologic cancers
- Management of common physical symptoms
- Psychosocial and spiritual needs of patients and families
- Management of psychosocial and spiritual distress
- Quality of life issues in advanced and recurrent ovarian cancer
- Quality of life issues in advanced and recurrent uterine and cervical cancer
- End-of-life decision making
- Bibliography
- 20. Role of minimally invasive surgery in gynecologic malignancies
- Laparoscopic surgery in gynecologic oncology
- Laparoscopic surgical staging of gynecologic malignancies
- Robotic surgery in gynecologic malignancies
- Length of stay
- Minimally invasive surgery learning curve
- Minimally invasive surgical technique
- Surgery in the overweight and underweight patient
- Applications of minimally invasive surgery in gynecologic oncology
- Complications of laparoscopic surgery
- Conclusions
- Bibliography
- 21. Epidemiology of commonly used statistical terms, and analysis of clinical studies
- Epidemiology
- Evidence-based medicine
- Measures in epidemiology
- Analysis of clinical trials
- Graphical displays of complex statistical data
- Types of clinical trials
- Evaluation of clinical trials
- Bibliography
- 22. Basic principles in gynecologic radiotherapy
- Introduction to electromagnetic radiation
- Radiation units
- Radiation physics
- Radiobiology
- Radiosensitizers, hypoxic cell sensitizers, and radioprotectors
- Principles of clinical radiation therapy
- New radiation modalities
- New radiation delivery technology
- Glossary
- Bibliography
- Appendix A: Staging
- Appendix B: Modified from common terminology criteria for adverse events (CTCAE)
- Appendix C: Blood component therapy
- Appendix D: Suggested recommendations for routine cancer screening
- Appendix E: Normal nutrition
- Index
- No. of pages: 744
- Language: English
- Edition: 10
- Published: June 17, 2022
- Imprint: Elsevier
- Hardback ISBN: 9780323776844
- eBook ISBN: 9780443284144
- eBook ISBN: 9780323776851
WC
William T. Creasman
Affiliations and expertise
Sims-Hester Professor and Chairman, Department of Obstetrics and Gynecology, Medical University of South Carolina, Charleston, South CarolinaRM
Robert S Mannel
Affiliations and expertise
Professor, Division of Gynecologic Oncology, Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OklahomaDM
David G Mutch
Affiliations and expertise
Ira C. and Judith Call Professor of Obstetrics and Gynecology, Department of Obstetrics and Gynecology, Vice Chair of Gynecology, Washington University School of Medicine, St. Louis, MissouriKT
Krishnansu Tewari
Affiliations and expertise
Professor & Division Director, Division of Gynecologic Oncology, University of California, Irvine, Irvine, CaliforniaRead DiSaia and Creasman Clinical Gynecologic Oncology on ScienceDirect