Diagnostic, Prognostic, and Therapeutic Role of MicroRNAs in Head and Neck Cancer
- 1st Edition - July 25, 2024
- Imprint: Academic Press
- Editors: Ashok Kumar, Neha Arya, Shikha Tiwari, Raju Khan
- Language: English
- Paperback ISBN:9 7 8 - 0 - 4 4 3 - 1 5 9 6 8 - 8
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 1 5 9 6 9 - 5
Diagnostic, Prognostic and Therapeutic Role of MicroRNAs in Head and Neck Cancer provides detailed information on various miRNA-based approaches for the diagnosis, progno… Read more
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Request a sales quoteDiagnostic, Prognostic and Therapeutic Role of MicroRNAs in Head and Neck Cancer provides detailed information on various miRNA-based approaches for the diagnosis, prognosis, and treatment of HNSCC. The book encompasses various miRNA-based point-of-care diagnostics and drug delivery systems for HNSCC, along with information on clinical trials for improved clinical outcomes in HNSCC patients. In addition, it provides a comprehensive overview of currently available miRNAs associated with HNSCC and their extensive application for early diagnosis, prognosis, and treatment. Scientists and clinicians looking to win the battle against HNSCC will benefit from the book's sections on early diagnosis to improve treatment, increase treatment response rates, and reduce mortality rates. Recently, miRNA-based diagnostics and therapeutics have gained considerable attention among the scientific community. MiRNAs are known to have great potential as biomarkers for early diagnosis, prediction, and prognosis of HNSCC, and play a role in development of targeted gene therapy.
- Covers the role of the tumor microenvironment in head and neck cancer
- Provides information on oncogenic and tumor suppressor miRNAs dysregulated in HNSCC patients
- Elucidates the role of miRNAs in metastasis, recurrence, and chemoresistance in HNSCC
- Includes the current state-of-art in miRNA-based clinical trials for head
Clinicians, biochemists, molecular biologists, pathologists, medical oncologists, radiation oncologists, pharmacologists, medical practitioners, bioengineers, academic institutes, etc. Pharmaceutical companies for the development of novel diagnostic and therapeutic technologies for the management of HNSCC
- Cover image
- Title page
- Table of Contents
- Copyright
- List of contributors
- Chapter 1. Epidemiology, pathology, and genomic topography of head and neck cancers
- Abstract
- 1.1 Introduction
- 1.2 Epidemiology of head and neck cancer
- 1.3 Risk factors
- 1.4 Squamous cell carcinoma
- 1.5 Genetic landscape of head and neck cancer
- 1.6 Signaling pathway associated with head and neck squamous cell carcinoma
- 1.7 Genetic heterogeneity
- 1.8 Management
- 1.9 Conclusion
- Acknowledgment
- References
- Chapter 2. Association of human papillomavirus with head and neck cancers
- Abstract
- 2.1 Head and neck cancers: pathogenesis, incidence, and mortality
- 2.2 Risk factors for head and neck cancers
- 2.3 Human papillomavirus: history, genome, and mode of infection
- 2.4 Epidemiology and regional differences in incidence of human papillomavirus-positive head and neck cancer
- 2.5 Differences in mutational signatures between human papillomavirus-positive and human papillomavirus-negative head and neck cancer
- 2.6 Clinical implications of human papillomavirus positivity in head and neck cancers
- 2.7 Conclusion
- References
- Chapter 3. MicroRNA regulation of different subtypes of head and neck malignancies
- Abstract
- 3.1 Introduction
- 3.2 MicroRNAs: biogenesis and role in cancer
- 3.3 miRNA regulation of head and neck malignancies
- 3.4 Role of miRNAs in different subtypes of head and neck malignancies
- 3.5 Conclusion
- Acknowledgment
- References
- Chapter 4. Oncogenic and tumor suppressor microRNAs in head and neck cancer
- Abstract
- 4.1 Introduction
- 4.2 miRNA deregulation in head and neck cancer
- 4.3 Conclusion
- References
- Chapter 5. Epigenetic regulation of head and neck cancer by microRNAs
- Abstract
- 5.1 Introduction
- 5.2 MicroRNAs: a distinct class of noncoding RNAs
- 5.3 Epigenetics: an epicenter in the regulation of gene expression
- 5.4 Epigenetics and methylomics of head and neck cancer
- 5.5 Role of microRNAs in head and neck cancer
- 5.6 Conclusion
- Acknowledgments
- References
- Chapter 6. Association of genetic variations in microRNAs with susceptibility to head and neck cancer
- Abstract
- 6.1 Introduction
- 6.2 miR-146a role in head and neck cancer susceptibility
- 6.3 miR-149 role in head and neck cancer susceptibility
- 6.4 miR-196a2 role in head and neck cancer susceptibility
- 6.5 miR-605 and its role in head and neck cancer susceptibility
- 6.6 miR-608 and its role in head and neck cancer susceptibility
- 6.7 miR-499 and its role in head and neck cancer susceptibility
- 6.8 Conclusion and future perspectives
- References
- Chapter 7. Role of microRNAs in metastasis, recurrence, and chemoradiation resistance of head and neck cancer
- Abstract
- 7.1 Introduction
- 7.2 Head and neck squamous cell carcinomas and miRNAs
- 7.3 Role of miRNAs in metastasis of head and neck squamous cell carcinomas
- 7.4 Role of miRNAs in the recurrence of head and neck squamous cell carcinomas
- 7.5 The role of microRNAs in radioresistance and chemoresistance in head and neck squamous cell carcinomas
- 7.6 Conclusion
- References
- Chapter 8. Regulation of head and neck tumor microenvironment by microRNAs
- Abstract
- 8.1 Introduction
- 8.2 Role of miRNA in regulating various cell types in tumor microenvironment
- 8.3 Regulation of tumor microenvironments by various miRNAs
- 8.4 miRNAs in head and neck squamous cell carcinoma metabolism
- 8.5 Regulation of cancer stemness by miRNAs
- 8.6 Role of hypoxia in regulating malignancy
- 8.7 Exosomal miRNA and the tumor microenvironment: intercellular communication and disease pathogenesis
- 8.8 MicroRNAs in targeting molecular pathways in head and neck squamous cell carcinoma
- 8.9 Therapeutic avenue to target head and neck squamous cell carcinoma using microRNA
- 8.10 Conclusion
- References
- Chapter 9. Genome-wide discovery and prediction of microRNA-based biomarkers in head and neck squamous cell carcinoma
- Abstract
- Abbreviations
- 9.1 Introduction
- 9.2 Overview of miRNA biomarkers
- 9.3 Genome-wide discovery of miRNA biomarkers
- 9.4 Toward personalized therapy in head and neck squamous cell carcinoma using next-generation sequencing – future perspective
- 9.5 Conclusion
- Acknowledgments
- References
- Chapter 10. Computational modeling for identification of microRNAs as diagnostic and prognostic biomarkers for head and neck cancer
- Abstract
- 10.1 Introduction
- 10.2 microRNA databases
- 10.3 Types of computational models
- 10.4 Pros and cons of different models
- 10.5 Conclusion
- References
- Chapter 11. Development of microRNA as prognostic markers in head and neck cancer
- Abstract
- Abbreviations
- 11.1 Introduction
- 11.2 miRNAs in head and neck cancer
- 11.3 miRNA as a prognostic biomarker in head and neck cancer
- 11.4 MicroRNA as a biomarker in head and neck cancer
- 11.5 Human papillomavirus and role of miRNA in head and neck cancer
- 11.6 Conclusion
- References
- Chapter 12. Development of microRNA as diagnostic markers in head and neck cancer
- Abstract
- 12.1 Introduction
- 12.2 microRNAs: biogenesis and transcriptional regulation
- 12.3 microRNAs as diagnostic tools
- 12.4 microRNA in head and neck cancer diagnostics
- 12.5 Future challenges
- 12.6 Conclusion
- References
- Chapter 13. Exosomal microRNA for diagnosis and prognosis of head and neck cancer
- Abstract
- 13.1 Introduction
- 13.2 Exosomal microRNAs as diagnostic biomarkers for head and neck squamous cell carcinoma
- 13.3 Exosomal microRNA as a prognostic biomarker for head and neck squamous cell carcinoma
- 13.4 Conclusion
- Acknowledgments
- References
- Chapter 14. MicroRNA expression profiling for disease progression assessment
- Abstract
- 14.1 Introduction
- 14.2 Origin and progression of head and neck cancer
- 14.3 Expression profile of miRNAs in premalignant oral lesions
- 14.4 The role of miRNAs in local recurrence
- 14.5 miRNA expression profiling of head and neck squamous cell carcinoma metastasis
- 14.6 Conclusion
- References
- Chapter 15. MicroRNA-based point-of-care devices for diagnosis and prognosis of head and neck cancer
- Abstract
- 15.1 Introduction
- 15.2 MicroRNA
- 15.3 Potential application of microRNAs in diagnosis
- 15.4 Role of microRNAs in head and neck cancer prognosis
- 15.5 Summary
- Acknowledgments
- References
- Chapter 16. Therapeutic role of microRNAs in management of head and neck cancer
- Abstract
- 16.1 Introduction
- 16.2 Synthesis and processing of miRNA
- 16.3 Detection of miRNAs
- 16.4 miRNA and head and neck squamous cell carcinoma
- 16.5 Management of head and neck squamous cell carcinoma patients
- 16.6 Conclusion
- Author’s contributions
- Acknowledgments
- Conflict of interest
- References
- Chapter 17. Role of microRNA in nutritional deficiencies and cachexia associated with head and neck cancer: current status and future research directions
- Abstract
- 17.1 Introduction
- 17.2 Nutritional deficiencies and implications in head and neck cancers
- 17.3 Head and neck cancer-associated cachexia and its mediators
- 17.4 miRNAs in the development of head and neck cancers and cancer-related cachexia
- 17.5 Treatment of cancer-associated cachexia and its clinical implications in head and neck cancers
- 17.6 Nutritional support and management in nutritional deficiencies in head and neck cancer
- 17.7 Conclusion
- Acknowledgments
- References
- Chapter 18. MicroRNA-based nanomedicine for the treatment of head and neck cancer
- Abstract
- 18.1 Introduction
- 18.2 Types of nanoparticles used in nanomedicines
- 18.3 MicroRNAs in cancer therapy
- 18.4 MicroRNA-based therapeutics
- 18.5 Delivery of microRNA-based therapeutics into cancer cells
- 18.6 Conclusion
- References
- Chapter 19. MicroRNA-based clinical trials for head and neck cancer
- Abstract
- 19.1 Introduction
- 19.2 MicroRNA regulation and editing as cancer therapy
- 19.3 Cancer therapy with microRNA
- 19.4 MicroRNA in preclinical studies for head and neck cancer therapy
- 19.5 MicroRNA-based clinical trials
- 19.6 Conclusions and future directions
- References
- Index
- Edition: 1
- Published: July 25, 2024
- No. of pages (Paperback): 362
- No. of pages (eBook): 270
- Imprint: Academic Press
- Language: English
- Paperback ISBN: 9780443159688
- eBook ISBN: 9780443159695
AK
Ashok Kumar
Dr. Ashok Kumar is currently working as an Associate Professor in the Department of Biochemistry of All India Institute of Medical Sciences Bhopal. His current research interest is understanding the role of non-coding RNAs and sphingosine-1-phosphate signaling in Head and Neck Cancer. He received his PhD degree from Sanjay Gandhi Postgraduate Institute of Medical Sciences (SGPGIMS) Lucknow, India. Then, he received postdoctoral training from UCSFBenioff’s Children’s Hospital Oakland & Research Centre, Oakland, CA, USA. Dr. Ashok Kumar’s major area of research work are Cell & Molecular Biology, Cancer Biology, Immunology & Sphingolipid signaling. He has more than 15 years of research experience. He has published more than 50 research articles and 10 book chapters and he has edited two books. He is a member of several international professional societies including American Association of Cancer Research and Fellow of Royal Society of Biology
Affiliations and expertise
Associate Professor, Department of Biochemistry, All India Institute of Medical Sciences (AIIMS), Bhopal, MP, IndiaNA
Neha Arya
Dr. Neha Arya is currently working as an Assistant Professor at the Translational Medicine Centre, AIIMS Bhopal. Her major interests include design and fabrication of biomaterials for tissue engineering and drug delivery applications with a special focus on in vitro disease models and nanotechnology in cancer therapeutics. She received her Bachelor’s degree from Gargi College, University of Delhi, India and her Master’s degree from South Campus, University of Delhi. She earned her Ph.D degree from Department of Biological Sciences and Bioengineering, Indian Institute of Technology (IIT), Kanpur following which she went to University of Freiburg, Germany as a Post Doctoral Researcher. She then worked as a DST INSPIRE Faculty Fellow at the Department of Biochemistry, AIIMS, Bhopal, India followed by working at the Department of Medical Devices, NIPER Ahmedabad as an Assistant Professor. She has several International publications, book chapters and served as a co-inventor in 2 patents. She has also received several awards and research grants from the Government of India for her research
Affiliations and expertise
Assistant Professor at the Translational Medicine Centre, AIIMS Bhopal.ST
Shikha Tiwari
Dr. Shikha Tiwari is currently working as Women Scientist in the Department of Biochemistry, All India Institute of Medical Sciences Bhopal. Her current research interest is understanding the role of single nucleotide polymorphism in miRNAs to genetic susceptibility towards oral squamous cell carcinomas. She received his PhD degree from Maulana Azad National Institute of Technology, Bhopal, India. Thereafter, she worked as an Assistant Professor in MGMM Jabalpur, India. Dr. Shikha Tiwari’s major area of research work is Cancer diagnosis, Bioinformatics and molecular biology. She has published 11 research articles in referred journals
Affiliations and expertise
DHR-Women Scientist, Department of Biochemistry, All India Institute of Medical Sciences Bhopal, IndiaRK
Raju Khan
Raju Khan is a Senior Principal Scientist and Professor, at CSIR-Advanced Materials and Processes Research Institute, Bhopal. He did his PhD in Chemistry in 2005 from Jamia Millia Islamia, Central University, New Delhi, and Postdoctoral researcher at the “Sensor Research Laboratory” University of the Western Cape, Cape Town. His current research involved synthesizing novel materials to fabricate electrochemical and fluorescence-based biosensors integrated with microfluidics to detect target disease risk biomarkers for health care monitoring. He has published over 150 papers in SCI journal, which attracted over 5500 citations as per Google Scholar, published 45 book chapters in the reputed book Elsevier and Taylor Francis, editing of 28 books from Elsevier and Taylor Francis, and his research has been highlighted in Nature India. He has supervised 5 PhD and 30 undergraduate/postgraduate theses and has supervised 4 numbers of postdoctoral fellows under the scheme of N-PDF, CSIR-Nehru Fellowship, and DST-Women Scientist Projects.
Affiliations and expertise
Senior Principal Scientist & Professor, CSIR-Advanced Materials & Processes Research Institute, Bhopal, Madhya Pradesh, IndiaRead Diagnostic, Prognostic, and Therapeutic Role of MicroRNAs in Head and Neck Cancer on ScienceDirect