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Diagnostic Immunohistochemistry
Theranostic and Genomic Applications
- 6th Edition - November 23, 2021
- Editor: David J Dabbs
- Language: English
- Hardback ISBN:9 7 8 - 0 - 3 2 3 - 7 2 1 7 2 - 1
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 7 2 1 7 4 - 5
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 7 2 1 7 3 - 8
Through five well-regarded editions, Dr. David Dabbs’ Diagnostic Immunohistochemistry has set the standard for concise, complete, guidance on the use and interpretation of i… Read more
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Request a sales quoteThrough five well-regarded editions, Dr. David Dabbs’ Diagnostic Immunohistochemistry has set the standard for concise, complete, guidance on the use and interpretation of immunohistochemical stains. The 6th Edition continues this tradition of excellence, bringing you fully up to date with all aspects of this dynamic field. Easy to use and understand, this practical resource distills the large body of information on immunohistochemistry into a single, convenient reference that is invaluable for today’s surgical pathologists.
Covers all aspects of the field, with an emphasis on the role of genomics in diagnosis and theranostic applications that will better inform treatment options.
Includes the latest grading schemes in several organs along with new antibodies to cover more genomic immunohistochemistry applications.
Contains current biomarker guidelines and up-to-date references throughout.
Offers a systematic approach to the diagnostic entities of each organ system, including detailed differential diagnoses, diagnostic algorithms, and immunohistograms that depict immunostaining patterns of tumors.
Contains numerous charts and tables, as well as 1,500 high-quality color histologic images that assist in making a definitive diagnosis.
Discusses diagnostic pitfalls through immunohistologic differential diagnosis wherever appropriate so you can provide the most accurate diagnoses.
Covers many more antigens than other texts, and discusses antibody specifications with tables that convey information on uses, clones, vendors, sources, antibody titers, and types of antigen retrieval.
Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.
General surgical pathologists in practice and in training (38,000).
- Instructions for online access
- Cover image
- Title page
- Table of Contents
- Copyright
- Dedication
- Contributors
- Preface
- How to Use This Book
- 1. Techniques of Immunohistochemistry: Principles, Pitfalls, and Standardization
- Overview
- Basic Principles of Immunohistochemistry
- Antibodies as Specific Reagents for Detection of Proteomic Targets
- Blocking Nonspecific Background
- Detection Systems
- Quality Control and Standardization
- Tissue Fixation, Processing, and Antigen Retrieval Techniques
- Techniques, Protocols, and Troubleshooting
- Future Directions: Companion Diagnostics Present New Challenges for Immunohistochemistry
- Conclusion
- 2. Quality Assurance in Immunohistochemistry in the Age of Precision Medicine
- Introduction
- Critical Definitions
- What Is Quality in Immunohistochemistry?
- Immunohistochemistry as a Qualitative Methodology in Precision Medicine
- The Importance of Purpose in Immunohistochemistry Biomarker Assays
- Validation of Immunohistochemistry Assays in Precision Medicine
- The Role of External Quality Assurance Proficiency Testing
- 3. Immunohistology of Infectious Disease
- Introduction
- Viral Infections
- Bacterial Infections
- Fungal Infections
- Protozoal Infections
- Emerging Infectious Diseases
- Pathologists, Immunohistochemistry, and Bioterrorism
- Beyond Immunohistology: Molecular Diagnostic Applications
- 4. Immunohistology of Neoplasms of Soft Tissue and Bone
- Overview
- Biology of Antigens and Antibodies
- Specific Soft Tissue and Bone Tumors
- Summary
- 5. Immunohistology of Bone Marrow, Spleen, and Histiocytic Disorders
- Overview
- Bone Marrow Antigens
- Normal Bone Marrow: Immunohistochemical Identification of Normal Components
- Myeloid Diseases
- Mastocytosis
- Spleen
- Histiocytic and Dendritic Neoplasms
- Summary
- 6. Immunohistology of Lymph Node and Lymph Node Neoplasms
- Antigens for Evaluation of Hematologic Disorders
- Establishing the Diagnosis of Lymphoma: Differential Diagnostic Considerations
- Immunohistochemical Evaluation of Small B-Cell Lymphomas
- Extranodal Marginal Zone Lymphoma
- Large B-Cell Lymphomas and Other Aggressive B-Cell Lymphomas
- Large B-Cell Lymphoma Subtypes
- T-Cell Lymphomas
- Hodgkin Lymphoma
- Pitfalls in the Diagnosis of Lymphoma: Mimicry
- Summary
- 7. Immunohistology of Melanocytic Neoplasms
- Overview
- Biology of Antigens and Antibodies
- Neuroendocrine Markers in Melanocytic Lesions
- Sentinel Lymph Node Biopsies for Metastatic Melanoma
- Application of Immunohistochemistry to Selected Differential Diagnoses
- Prognostic Markers and Targeted Therapy for Melanoma
- Summary
- 8. Immunohistology of Carcinoma of Unknown Primary Site
- Cancer of Unknown Primary Site: Clinical Aspects and Economic Considerations
- Diagnostic Approach to the Study of Cancer of Unknown Primary Site: Specimen Preparation
- Determining Site of Origin: Stepwise Approach
- Combined Antibody (Panel) Approach to Solving Diagnostic Problems
- Special Clinical Presentations
- Molecular Approach for Determining Site of Origin
- Summary
- 9. Immunohistology of Head and Neck Lesions
- Introduction
- Squamoproliferative Lesions
- Nasal Cavity and Paranasal Sinuses
- Nasopharynx
- Oral Cavity
- Larynx/Hypopharynx
- Salivary Glands
- Ear and Temporal Bone
- Metastatic Tumors
- Summary
- 10. Immunohistology of Endocrine and Neuroendocrine Neoplasms
- Overview
- Biology of Antigens and Antibodies
- Tumors of Specific Sites
- Neuroendocrine Tumors in Other Sites
- Summary
- 11. Immunohistology of the Mediastinum
- Introduction
- The Normal Thymus
- Thymic Tumors
- Thymic Epithelial Tumors
- Thymic Carcinoma
- Germ Cell Tumors
- Mediastinal Sarcomas
- Neurogenic and Neuroectodermal Neoplasms
- Lymphoproliferative Tumors
- Summary
- 12. Immunohistology of Pulmonary and Pleural Neoplasms
- Malignant Epithelial Neoplasms of the Lung
- Biphasic Neoplasms of the Lung
- Neuroendocrine Tumors of the Lung
- Mesenchymal Tumors of the Lung
- Primary Vascular Neoplasms of the Lung
- SMARC—Deficient Neoplasms
- Unusual Primary Tumors of the Lung
- Lymphoproliferative Tumors of the Lung
- Tumors of the Pleura
- 13. Immunohistology of Skin Tumors
- Overview
- Epithelial Tumors of the Skin
- Cutaneous Lymphohematopoietic Disorders
- Mesenchymal Tumors of The Skin
- Special Topics in Cutaneous Immunohistochemistry
- 14. Immunohistology of the Gastrointestinal Tract
- Biology of Antigens and Antibodies: General and Tissue Specific
- Diagnostic Immunohistochemistry: Epithelial Lesions of the Gastrointestinal Tract
- Diagnostic Immunohistochemistry: Neuroendocrine Neoplasms of the Gastrointestinal Tract
- Diagnostic Immunohistochemistry: Mesenchymal Lesions of the Gastrointestinal Tract
- Beyond Immunohistochemistry: Theranostic and Genomic Applications
- Summary
- 15. Immunohistology of Pancreas and Hepatobiliary Tract
- Pancreas
- Extrahepatic Biliary Tract (Extrahepatic Bile Ducts and Gallbladder)
- Ampulla
- Liver
- Summary
- 16. Immunohistology of the Prostate
- Overview
- Biology of Antigens and Antibodies
- Diagnostic Immunohistochemistry of Specific Prostate Lesions
- Beyond Immunohistochemistry: Theranostic and Genomic Applications
- Summary
- 17. Immunohistology of the Bladder, Kidney, and Testis
- Overview
- Immunohistology of the Urinary Bladder
- Immunohistology of Renal Neoplasms
- Immunohistology of Testicular Tumors
- Summary
- 18. Immunohistology of the Female Genital Tract
- Biology of Antigens and Antibodies
- Lower Female Genital Tract and Uterus
- Upper Female Genital Tract
- Summary
- 19. Immunohistology of the Breast
- Introduction
- Myoepithelial Cells and Assessment of Stromal Invasion
- Immunohistochemistry of Papillary Lesions
- Proliferative Ductal Epithelial Lesions and In Situ Carcinoma
- Tumor Type Identification by Immunohistochemistry
- Immunohistochemistry for Identifying Special Types of Breast Carcinomas
- Paget Disease of the Breast
- Detection of Lymphatic Space Invasion
- Sentinel Lymph Node Examination
- Systemic Metastasis of Breast Carcinoma
- Fibroepithelial Tumors
- Theranostic Applications
- Genomic Applications of Immunohistochemistry: Breast Cancer Molecular Classification and Immunogenomics
- Other Tumor Markers
- Summary
- 20. Immunohistology of the Nervous System
- Overview
- Clinical and Radiologic Perspective of Lesions
- Nonneoplastic Brain Lesions
- Tumors of the Nervous System
- Cysts of the Nervous System
- Dementias
- Demyelination
- Epilepsy
- Cortical Malformations
- Pitfalls in Diagnosis
- Summary
- 21. Immunocytology
- Use of Immunocytology
- Diagnostic Immunocytochemistry: Techniques
- Diagnostic Immunocytochemistry: Applications
- Pitfalls in Immunocytochemistry
- Beyond Immunocytochemistry: Theranostic and Genomic Applications
- Summary
- 22. Immunohistology of Pediatric Neoplasms
- Overview
- Biology of Antigens and Antibodies: Principal Antibodies
- Specific Tumors
- Summary
- 23. Imaging and Quantitative Immunohistochemistry
- Overview
- Imaging Systems
- Software Algorithms
- Strengths and Limitations
- Clinical Guidelines
- Clinical Applications
- Summary
- 24. Molecular Anatomic Pathology: Principles, Techniques, and Application to Immunohistologic Diagnosis
- General Principles of Molecular Biology
- Genetic Polymorphism and Mutations (Sequence Variants)
- Specimen Requirements for Molecular Testing
- Technologies for Molecular Analysis
- Genetic Alteration Detection Strategies
- DNA-Based Tissue Identity Testing
- Summary
- INDEX
- No. of pages: 1000
- Language: English
- Edition: 6
- Published: November 23, 2021
- Imprint: Elsevier
- Hardback ISBN: 9780323721721
- eBook ISBN: 9780323721745
- eBook ISBN: 9780323721738
DD
David J Dabbs
Dr Dabbs has twenty years of experience in the surgical pathology of solid tumors, with additional subspecialty-focused interest in the study of tumors of unknown origin, breast carcinoma, gynecologic pathology and tumor cytopathology. He served as Member of Medical & Scientific Advisory Board of US LABS, Inc. He offers national workshops in breast pathology and immunohistochemistry and has presented more than 100 papers in peer-reviewed journals and at national meetings
Affiliations and expertise
Professor of Pathology, University of Hawaii, John A Burns School of Medicine, Honolulu, Hawaii