
Diabetes Mellitus in Cats and Dogs, An Issue of Veterinary Clinics of North America: Small Animal Practice
- 1st Edition, Volume 53-3 - April 11, 2023
- Imprint: Elsevier
- Editors: Thomas K. Graves, Chen Gilor
- Language: English
- Hardback ISBN:9 7 8 - 0 - 3 2 3 - 9 4 0 2 3 - 8
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 9 4 0 2 4 - 5
In this issue of Veterinary Clinics: Small Animal Practice, guest editors Drs. Thomas K. Graves and Chen Gilor bring their considerable expertise to the topic of Diabetes Mellitus… Read more

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Contains 14 relevant, practice-oriented topics including diabetic ketoacidosis and hyperosmolar hyperglycemic syndrome in dogs and cats; diabetes mellitus and the kidneys; continuous glucose monitoring in dogs and cats: applying new technology to an old problem; the role of nutrition in diabetes mellitus therapy; the future of diabetes therapies: ultra-long-acting insulin, smart insulin, novel GLP-1 analogs, SGLT-2 inhibitors and beta cell replacement therapy; and more.
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Provides in-depth clinical reviews on diabetes mellitus in cats and dogs, offering actionable insights for clinical practice.
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Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.
- Cover image
- Title page
- Table of Contents
- Copyright
- Contributors
- Forthcoming Issues
- Preface
- Etiology and Pathophysiology of Diabetes Mellitus in Dogs
- Key points
- Introduction
- Classification and description
- Underlying risk factors
- Pathophysiology
- Future perspectives on precision diabetes management
- Summary
- Clinics care points
- Disclosures
- Pathophysiology of Prediabetes, Diabetes, and Diabetic Remission in Cats
- Key points
- Introduction
- Diabetes mellitus in cats
- Factors contributing to diabetes mellitus development in cats
- Prediabetes in cats
- Diabetic remission in cats
- Glucose tolerance in diabetic remission
- Disclosure
- Supplementary data
- Diabetes Ketoacidosis and Hyperosmolar Hyperglycemic Syndrome in Companion Animals
- Key points
- Definitions
- Demographics
- Ketogenesis
- Predisposition and pathogenesis of diabetes ketoacidosis and euglycemic diabetes ketoacidosis
- Predisposition and pathogenesis of hyperosmolar hyperglycemic state
- Predisposition and pathogenesis of hyperosmolar diabetes ketoacidosis
- Clinical history of diabetes ketoacidosis in dogs and cats
- Physical examination findings
- Clinical diagnosis of diabetes ketoacidosis
- Other diagnostic tests
- Clinical management of diabetes ketoacidosis
- Outcome of dogs and cats with diabetes ketoacidosis
- Clinics care points
- Disclosure
- Glucose Counterregulation: Clinical Consequences of Impaired Sympathetic Responses in Diabetic Dogs and Cats
- Key points
- Introduction
- Frequency of insulin-induced hypoglycemia in diabetic dogs and cats
- Clinical signs of insulin-induced hypoglycemia in diabetic dogs and cats
- Glucagon responses to hypoglycemia are largely mediated by activation of the autonomic nervous system
- Impaired counterregulatory responses to hypoglycemia in diabetes mellitus
- The “Somogyi effect”: time to let it go
- Summary
- Clinics care points
- Disclosure
- Diabetes Mellitus and the Kidneys
- Key points
- Introduction
- Summary
- Clinics care points
- Declaration of Interests
- Anesthetic Considerations in Dogs and Cats with Diabetes Mellitus
- Key points
- Introduction
- Anesthetic considerations and management
- Disclosure
- Continuous Glucose Monitoring in Dogs and Cats: Application of New Technology to an Old Problem
- Key points
- Introduction
- Continuous glucose monitoring systems
- Flash Glucose Monitoring Systems
- New Technologies
- Continuous Glucose Monitoring Systems in Routine Clinical Practice: Published Evidence
- Future perspective
- Summary
- Clinics care points
- Disclosure
- Supplementary data
- Insulin Therapy in Small Animals, Part 1: General Principles
- Key points
- Introduction
- The choice of insulin depends on the specific clinical scenario
- Pathophysiology: insulin requirements on the diabetes spectrum
- Principles of insulin pharmacology
- Compliance, adherence, convenience, and cost
- Goals of therapy for the specific patient
- Clinics care points
- Declaration of Interests
- Insulin Therapy in Small Animals, Part 2: Cats
- Key points
- Introduction
- Pathophysiology: insulin requirements on the diabetes spectrum
- Timing of insulin injection in conjunction with feeding
- Glucose variability in different strategies of insulin therapy
- Goals of therapy for the specific patient
- Guidelines for choosing insulin formulations
- Clinics care points
- Disclosure
- Insulin Therapy in Small Animals, Part 3: Dogs
- Key points
- Introduction
- Insulin physiology and pathophysiology
- Managing Inappetence and Gastrointestinal Signs
- Goals of therapy for the specific patient
- Formulation-specific considerations
- KeyPoints
- Clinics care points
- Disclosure
- Nutritional Management of Cats and Dogs with Diabetes Mellitus
- Key points
- Introduction
- Summary
- Declaration of Interests
- The Future of Diabetes Therapies: New Insulins and Insulin Delivery Systems, Glucagon-Like Peptide 1 Analogs, Sodium-Glucose Cotransporter Type 2 Inhibitors, and Beta Cell Replacement Therapy
- Key points
- Introduction
- Ultra-long-acting insulins
- Glucagon-like peptide 1-based therapies
- Sodium-glucose cotransporter type 2 inhibitors
- Non-injectable insulins
- Continuous insulin infusion
- Smart insulin
- Beta cell replacement therapy
- Summary
- Clinics care points
- Disclosure
- Hypersomatotropism and Other Causes of Insulin Resistance in Cats
- Key points
- Introduction
- Lack of glucose response to insulin-true insulin resistance
- Hypersomatotropism
- Prevalence and cause
- Clinical presentation
- Characteristics of diabetes mellitus secondary to hypersomatotropism
- Diagnosis
- Insulin-like growth factor-1 dynamics and impact on diagnosis
- Imaging
- Treatment
- Prognosis
- Hypercortisolism
- Prevalence and etiology
- Clinical presentation and characteristics of diabetes mellitus secondary to hypercortisolism
- Diagnosis
- Imaging
- Treatment options for hypercortisolism
- Medical treatment (pituitary-dependent hyperadrenocorticism and adrenal-dependent hyperadrenocorticism)
- Hypophysectomy (pituitary-dependent hyperadrenocorticism)
- Unilateral or bilateral adrenalectomy (adrenal-dependent hyperadrenocorticism or pituitary-dependent hyperadrenocorticism)
- Radiation therapy (pituitary-dependent hyperadrenocorticism)
- Quality of life and prognosis
- Clinics care points
- Disclosure
- Cushing’s Syndrome and Other Causes of Insulin Resistance in Dogs
- Key points
- Insulin resistance
- Cushing syndrome
- The effect of Cushing-associated dysglycemia in diabetic dogs
- Diagnosis of canine hypercortisolism
- Diestrus
- Obesity
- Summary
- Clinics care points
- Disclosure
- Edition: 1
- Volume: 53-3
- Published: April 11, 2023
- Imprint: Elsevier
- No. of pages: 240
- Language: English
- Hardback ISBN: 9780323940238
- eBook ISBN: 9780323940245
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Thomas K. Graves
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