Design, Characterization and Fabrication of Polymer Scaffolds for Tissue Engineering

1st Edition - October 9, 2024
Imprint: Woodhead Publishing
Authors: Dipankar Chattopadhyay, Beauty Das
Language: English
Paperback ISBN:
9 7 8 - 0 - 3 2 3 - 9 6 1 1 4 - 1
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 9 5 8 3 8 - 7

Design, Characterization and Fabrication of Polymer Scaffolds for Tissue Engineering covers core elements of scaffold design, from properties and characterization of polymeric… Read more

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Design, Characterization and Fabrication of Polymer Scaffolds for Tissue Engineering covers core elements of scaffold design, from properties and characterization of polymeric scaffolds to fabrication techniques and the structure-property relationship. Particular attention is given to the cell-scaffold interaction at the molecular level, helping the reader understand and adapt scaffold design to improve biocompatibility and function. The book goes on to discuss a range of tissue engineering applications for polymeric scaffolds, including bone, nerve, cardiac and fibroblast tissue engineering. This is an important, interdisciplinary work of relevance to materials scientists, polymer scientists, biomedical engineers, and those working regenerative medicine.

Cover image
Title page
Table of Contents
Copyright
Preface
Chapter 1. A brief introduction to tissue engineering
Abstract
1.1 Importance of tissue engineering
1.2 Progress in tissue engineering
1.3 Principle of tissue engineering
Acknowledgment
References
Chapter 2. Importance of scaffold in tissue engineering
Abstract
2.1 Scaffold: the most important triad of tissue engineering
2.2 Function of a scaffold
References
Chapter 3. Scaffold' properties and materials used in scaffold designing
Abstract
3.1 Properties of a scaffold
3.2 Materials used for scaffold fabrication: advantages and disadvantages
References
Chapter 4. Polymer in scaffold designing
Abstract
4.1 Inevitable role of polymers in tissue engineering
4.2 Types of polymer used in tissue engineering
4.3 Types of scaffold: implantable and injectable polymeric scaffold
References
Chapter 5. Fabrication of a polymeric scaffold
Abstract
5.1 Solvent casting and particulate leaching
5.2 Gas foaming
5.3 Phase separation
5.4 Melt molding
5.5 Freeze drying
5.6 Emulsion freeze drying
5.7 Rapid prototyping
5.8 Biomodification of a scaffold
References
Chapter 6. Role of the polymeric structure and nanocomposites in tissue engineering
Abstract
6.1 Structural aspects of the polymer in tissue engineering
6.2 Linear versus branched polymer at the biointerfacial interaction
6.3 Role of polymeric nanocomposites in tissue engineering
References
Chapter 7. Structure–property relationship in a polymer/nanocomposite-based scaffold
Abstract
7.1 Size
7.2 Shape
7.3 Charge
7.4 Surface topography
7.5 Molecular weight
7.6 Crystallinity
7.7 Wettability (hydrophobicity and hydrophilicity)
7.8 Mechanical properties
7.9 Flexibility
7.10 Porosity
7.11 Chemical functionality
7.12 Material stability
References
Chapter 8. Characterization of polymeric scaffolds
Abstract
8.1 Physicomechanical characterization
8.2 Chemical characterization
8.3 Morphological characterization
8.4 Surface characterization
8.5 Thermal characterization
8.6 Biological characterization: in vivo and in vitro studies
8.7 In vitro cytotoxicityand hematocompatibility assessment
8.8 Cell adhesion/spreading assay
8.9 In vitro immunocompatibility assay
8.10 In vivo assessment of biocompatibility and inflammatory response
References
Chapter 9. Tissue engineering approaches
Abstract
9.1 Introduction
9.2 Cell-seeded scaffold-based tissue engineering approach
9.3 Acellular scaffold-based tissue engineering approach
9.4 Conclusion
References
Chapter 10. Tissue engineering applications
Abstract
10.1 Introduction
10.2 Musculoskeletal tissue regeneration
10.3 Bone tissue engineering
10.4 Cartilage tissue engineering
10.5 Corneal tissue engineering
10.6 Nerve cell tissue engineering
10.7 Wound healing/skin tissue engineering
10.8 Cardiac tissue engineering
10.9 Hepatic tissue engineering
10.10 Tissue engineering based drug delivery
10.11 Conclusion
References
Chapter 11. Cell–polymeric scaffold interaction
Abstract
11.1 Introduction
11.2 Cell surface receptors for cell–extracellular matrix interaction
11.3 Biointerfacial interaction with the polymer
11.4 Biointerfacial interaction with nanocomposites
11.5 Conclusion
References
Chapter 12. Current research technology and practical applicability
Abstract
12.1 Current research technologies
12.2 Practical applicability
12.3 Conclusion
References
Chapter 13. Therapeutical and clinical approaches
Abstract
13.1 Introduction
13.2 Importance of clinical studies
13.3 Clinical advancements in tissue engineering
13.4 Basic consideration in clinical tissue engineering
13.5 Preclinical to clinical trial
Acknowledgement
References
Index

Dipankar Chattopadhyay

Prof. Dipankar Chattopadhyay is an eminent professor currently working in the Department of Polymer Science & Technology, University of Calcutta, India since 2006 and also a former HOD. Earlier, he worked as a lecturer at the Vidhyasagar University and Shahid Bhagat Singh College, Punjab, India. He obtained his B.Tech in Plastics & Rubber Technology from University of Calcutta, India and M.Tech in Polymer Science and Engineering, IIT, New Delhi with Ph.D. (Polymer Science) from the IACS, India. He is an experienced research professional with expertise in polymers nanocomposites, biomaterials, and nanomaterials. He has ~22 years of research experience with completed 10 research project and collaborative projects with industries. He is an active reviewer for various Journals and supervised >20 scholars and five post-doctorate students. He has 127 publications and has 3 patents. He is an Executive Member in the Society for Polymer Science, India; MRSI, Calcutta Chapter and many more.

Affiliations and expertise

Professor, Department of Polymer Science and Technology, University Colleges of Science and Technology, University of Calcutta, India

Beauty Das

Dr. Beauty Das completed her M.SC in Biotechnology from Utkal University, India and B.Sc in Zoology from Dibrugarh University, India with distinction. She completed her Ph.D in 2005 from Tezpur University on the topic of polymer nanocomposite based tissue engineering. She has more than 10 years of experience in this intriguing topic by employing polymers, hydrogels and nanocomposites. Currently she is working as a DST Inspire Faculty in University of Calcutta, India and conducting research on tissue engineering approaches to treat Alzheimer’s disease by enhancing neuro-regeneration. She has 6 years of post-doctoral experience on polymeric biomaterials. She has published more than 15 articles and has contributed several book chapters in this area.

Affiliations and expertise

DST Inspire Faculty, Department of Polymer Science and Technology, University Colleges of Science and Technology, University of Calcutta, India

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