Design and Applications of Theranostic Nanomedicines

1st Edition - September 10, 2022
Imprint: Woodhead Publishing
Editors: Somasree Ray, Amit Kumar Nayak
Language: English
Paperback ISBN:
9 7 8 - 0 - 3 2 3 - 8 9 9 5 3 - 6
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 8 8 5 9 8 - 0

Design and Applications of Theranostic Nanomedicines reviews the composition and design of various nanomedicines for theranostic applications, helping readers to make informed… Read more

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Design and Applications of Theranostic Nanomedicines reviews the composition and design of various nanomedicines for theranostic applications, helping readers to make informed decisions when exploring novel treatments for disease.

This book introduces readers to theranostic nanostructures as nanomedicines, beginning with a balanced look at the associated challenges, costs and benefits. The next section goes on to detail a range of different theranostic nanomedicines and their design, from nanodispersions and nanogels to exosomes and polymeric micelles. A variety of applications is covered, including in the treatment of pulmonary diseases, neurological disorders, cancers and more. The book also takes a look at the toxicological implications of nanotheranostics, an important aspect of any therapy or treatment.

Design and Applications of Theranostic Nanomedicines provides a snapshot of the state-of-the-art, and will be of use to materials scientists, biomedical engineers and pharmaceutical scientists with an interest in nanotechnology and theranostics.

Cover image
Title page
Table of Contents
Copyright
Dedication
List of contributors
Preface
Section I. Introduction
1. Theranostic nanostructures as nanomedicines: benefits, costs, and future challenges
1.1. Introduction
1.2. Nanotechnology, nanoscale, and nanostructures
1.3. Design of theranostic nanostructures as nanomedicines
1.4. Applications of theranostic nanostructures as nanomedicines
1.5. Benefits and costs of theranostic nanostructures as nanomedicines
1.6. Challenges of theranostic nanostructures as nanomedicines
1.7. Conclusion
Section II. Design
2. Theranostic nanogels: design and applications
2.1. Introduction
2.2. Nanogels
2.3. Theranostic nanogels
2.4. Designs of theranostic nanogels
2.5. Conclusion
3. Exosomes: a novel tool for diagnosis and therapy
3.1. Introduction
3.2. Exosomes
3.3. Biological functions of exosomes
3.4. Exosomes as biomarkers of diseases
3.5. Exosomes as therapeutic tools in other pathologies
3.6. Exosomes as a novel tool for diagnosis
4. Engineered liposomes as drug delivery and imaging agents
4.1. Introduction
4.2. Liposomes and their classifications
4.3. Preparation of liposomes
4.4. Rationale for the development of engineered liposomes
4.5. Engineered liposomes in drug delivery
4.6. Engineered liposomes in imaging
4.7. Theranostic engineered liposomes
4.8. Challenges and limitations of engineered liposomes as nanotheranostics
4.9. Conclusion and future perspective
5. Polymeric micelles for theranostic uses
5.1. Introduction
5.2. Advantages and disadvantages of polymeric micelle
5.3. Different types of polymer micelle as carrier systems used for the delivery of drugs
5.4. Mechanism of drug release from polymeric micelles
5.5. Pharmaceutical applications of polymeric micelle
5.6. Conclusion
6. Dendrimers: an effective drug delivery and therapeutic approach
6.1. Introduction
6.2. Synthesis procedure of dendrimer structure
6.3. Dendrimers in drug delivery
6.4. Advancement of dendrimer-based drug delivery in biomedical field
6.5. Conclusion
7. Nanocochleates: A novel lipid-based nanocarrier system for drug delivery
7.1. Introduction
7.2. History of the development of nanocochleates
7.3. Chemistry and mechanism of self-assembly of nanocochleates
7.4. Components of nanocochleates
7.5. Routes of administration
7.6. Advantages of nanocochleate-based drug delivery system
7.7. Limitations of nanocochleate-based drug delivery system
7.8. Mechanism of action of nanocochleate-based drug delivery system
7.9. Method of nanocochleates preparation
7.10. Stabilization of nanocochleates
7.11. Characterization of nanocochleates
7.12. Applications of nanocochleate-based drug delivery system
7.13. Commercial status of nanocochleates
7.14. Conclusions and future perspectives
Section III. Applications
8. Theranostic applications of nanoemulsions in pulmonary diseases
8.1. Introduction
8.2. Theranostic applications of NEs
8.3. NEs-based drug delivery systems
8.4. NEs-based diagnostics
8.5. Clearance of NEs
8.6. Advantages and disadvantages of NEs
8.7. Conclusion
9. Polymeric nanoparticles as tumor-targeting theranostic platform
9.1. Introduction
9.2. Definition of nanothranostics with some examples
9.3. Significance of nanotheranostic and comparison between nanotheranostic and nanotherapeutics
9.4. Advantages of polymeric nanoparticles for tumor targeting
9.5. Nanoparticles for imaging, diagnosis, and therapy
9.6. Different methods of tumor targeting
9.7. Polymeric nanomedicines in a clinical trial
9.8. Future prospect
9.9. Conclusion
10. Site-specific theranostic uses of stimuli responsive nanohydrogels
10.1. Introduction
10.2. Classification of nano hydrogel
10.3. Stimulus responsive nanogels
10.4. Applications of nanogels in drug delivery
10.5. Toxicity of stimulus sensitive nanogels
10.6. Conclusion
11. Ligand appended theranostic nanocarriers for targeted blood–brain barrier
11.1. Introduction
11.2. Blood–brain barrier
11.3. Ligand appended nanocarriers
11.4. Applications of ligand appended nanocarriers
11.5. Underlying challenges and future prospects
12. Nanotheranostics in CNS Malignancy
12.1. Introduction
12.2. Glioblastoma
12.3. Blood brain barrier (BBB)
12.4. Blood brain tumor barrier (BBTB)
12.5. Nanotheranostics
12.6. Conclusion
13. Application of nanotheranostics in cancer
13.1. Introduction
13.2. Nanomedicines as cancer theranostics
13.3. Emergence and scope of nanotheranostics
13.4. Conclusion
14. Self-assembled protein nanoparticles for multifunctional theranostic uses
14.1. Introduction
Section IV. Others
15. Nanotheranostics: The toxicological implications
15.1. Nanotheranostics: A tool for personifying medicine
15.2. Nanotheranostics: Bridging a therapeutic notch
15.3. Toxicity in nanotheranostics
15.4. Hazards associated with nanotheranostics
15.5. Factors influencing toxic responses to nanotheranostic agents
15.6. Toxic concern of materials commonly used in nanotheranostics
15.7. Silica
15.8. Toxicity in nanotheranostics: the mechanistic basis
15.9. Toxicity evaluation of nanotheranostic agents: testing systems in vitro and in vivo
15.10. Conclusion
Index

Somasree Ray

Dr Somasree Ray is Professor at the Department of Pharmaceutics, Gupta College of Technological Sciences, Asansol, West Bengal, India. She completed her B.Pharm ,M.Pharm and PhD Degree from Jadavpur University. Her research interests are centered on design and physicochemical characterization of advanced drug delivery systems based on natural polymers. She has received ‘Teacher of the year 2018’ award from Maulana Abul Kalam Azad University of Technology, West Bengal, India. She has over 10 years of research experience, and has mentored 40 master’s theses based on the development and characterization of sustained release drug delivery systems, nanostructured drug delivery systems and the development of hydrogel films for wound healing applications.

Affiliations and expertise

Professor, Department of Pharmaceutics, Gupta College of Technological Sciences, Asansol, West Bengal, India

Amit Kumar Nayak

Dr. Amit Kumar Nayak (MPharm, PhD) is working as a professor, at the Department of Pharmaceutics, School of Pharmaceutical Sciences, Siksha ‘O' Anusandhan (Deemed to be University), Odisha, India. He has earned his PhD from IFTM University, Moradabad, Uttar Pradesh, India. He has over 14 years of research experiences in the field of pharmaceutics, especially in the development and characterization of novel biopolymeric and nanostructured drug delivery systems. Till date, he has authored more than 138 research and review publications in various high-impact peer-reviewed journals and 135 book chapters. He has edited/authored 23 international books to his credit. Dr. Nayak has presented his research work at several conferences. He has received University Foundation Day Research Award, 2019 and 2022 by Biju Patnaik University of Technology, Odisha. Dr. Nayak is a life member of the Association of Pharmaceutical Teachers of India (APTI) and a registered pharmacist.

Affiliations and expertise

Professor, Department of Pharmaceutics, School of Pharmaceutical Sciences, Siksha 'O' Anusandhan (Deemed to be University), Bhubaneswar, Odisha, India

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