
De Novo Peptide Design
Principles and Applications
- 1st Edition - September 17, 2022
- Imprint: Academic Press
- Editors: Vibin Ramakrishnan, Kirti Patel, Ruchika Goyal
- Language: English
- Paperback ISBN:9 7 8 - 0 - 3 2 3 - 9 9 9 1 7 - 5
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 9 8 5 4 3 - 7
De novo Peptide Design: Principles and Applications presents the latest developments in the fields of therapeutic peptides and bio-nanotechnology. The title focuses on the desig… Read more

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Request a sales quoteDe novo Peptide Design: Principles and Applications presents the latest developments in the fields of therapeutic peptides and bio-nanotechnology. The title focuses on the design of peptides, particularly how peptides may be tailored to specific functions. It includes computational and experimental protocols to assist in the design of peptides. Sections cover the basics of protein and peptide structure, modeling and simulation, solid phase peptide synthesis, peptide-based antibiotics, drug delivery, peptide nanomaterials, aromatic interactions directing nano-assembly, protein/peptide aggregation, therapeutic interventions against protein/peptide aggregation diseases, peptide based hydrogels, computational tools and algorithms for peptide design, and experimental protocols in peptide chemistry.
In addition, the book covers key aspects in peptide design, providing a solution for researchers working within the 'peptidic universe' to create new therapeutic agents.
- Gives comprehensive coverage, including peptide design, modeling, synthesis and applications
- Presents emerging topics in the design of peptide-based therapeutics
- Details the latest developments in the fields of therapeutic peptides and bio-nanotechnology
- Considers peptide design and the tailoring of peptides to specific functions
- Offers computational tools and algorithms for peptide design and experimental protocols for peptide chemistry
- Cover image
- Title page
- Table of Contents
- Copyright
- Dedication
- List of contributors
- Chapter 1. Structural organization of peptides
- Abstract
- 1.1 Molecular interactions for protein folding
- 1.2 Poly-alanine models and the energetics of protein folding
- 1.3 De novo protein design and stereochemical logic of protein folding
- 1.4 Shape-specific design of heterochiral proteins
- 1.5 Enzymes: functional proteins
- References
- Chapter 2. Modeling and simulation of peptides
- Abstract
- 2.1 Introduction
- 2.2 Peptide design
- 2.3 Prediction of peptide structure
- 2.4 In silico validation of design by molecular dynamic simulations
- 2.5 Conclusion
- References
- Chapter 3. Solid phase peptide synthesis
- Abstract
- 3.1 Introduction
- 3.2 Principles of solid phase peptide synthesis
- 3.3 Resins
- 3.4 Linkers
- 3.5 Side-chain protecting groups
- 3.6 Coupling reaction
- 3.7 Fmoc deprotection
- 3.8 Final cleavage
- 3.9 Side reactions
- References
- Chapter 4. Peptide-based Antibiotics
- Abstract
- 4.1 Introduction
- 4.2 Antimicrobial peptides
- 4.3 De novo design of antimicrobial peptides
- 4.4 Antimicrobial peptides: Strategy to combat antimicrobial resistance
- 4.5 Mechanism of action and selectivity of antimicrobial peptides
- 4.6 Strengths and weakness of antimicrobial peptides
- 4.7 Conclusion
- References
- Chapter 5. Cell-penetrating peptides
- Abstract
- 5.1 Cell-penetrating peptides: a brief history
- 5.2 Classification of cell-penetrating peptides
- 5.3 Mechanism of uptake
- 5.4 Strengths, limitations, and opportunities
- 5.5 Cell-type specificity: to be or not to be
- 5.6 Cell-penetrating peptides for anticancer drug delivery
- 5.7 Cell-penetrating peptide prediction
- 5.8 Designing cell-penetrating peptides
- 5.9 Conclusion
- References
- Chapter 6. Peptide-based nanomaterials: applications and challenges
- Abstract
- Graphical abstract
- 6.1 Introduction to molecular self-assembly
- 6.2 Protein and peptide self-assembly
- 6.3 Peptide-based nanomaterials
- 6.4 Applications of peptide-based nanomaterials
- 6.5 Conclusion, challenges, and future directions
- References
- Chapter 7. Peptide nanocatalysts
- Abstract
- 7.1 Introduction
- 7.2 Types of catalysts
- 7.3 Enantioselectivity in catalytic reactions
- 7.4 Enzyme catalysis
- 7.5 Enzyme mimetics
- 7.6 Structural design of the artificial peptide-based enzyme
- 7.7 Self-assembling peptide catalysts
- 7.8 Peptide mimics with enhanced catalytic efficiency
- 7.9 Peptide-based artificial metalloenzyme
- 7.10 Exploring unnatural amino acids for de novo peptide-based metalloenzymes
- 7.11 Aldolase mimic
- 7.12 Hydrolase mimic
- 7.13 Oxidase mimic
- 7.14 Conclusions and future prospects
- References
- Chapter 8. Bioinspired functional molecular constructs
- Abstract
- 8.1 Introduction
- 8.2 Peptide-based functional materials
- 8.3 De novo designed peptide nano-assemblies
- 8.4 Properties of self-assembled nanostructures
- 8.5 Factors affecting nanoassemblies
- 8.6 Applications of de novo designed peptide constructs
- 8.7 Conclusion and future directions
- References
- Chapter 9. Patents in peptide science
- Abstract
- 9.1 Introduction
- 9.2 Basics of protein and peptide structure
- 9.3 Modeling and simulation of peptides
- 9.4 Glucagon-like peptide-1 analogs
- 9.5 Peptide-based antibiotics
- 9.6 Drug delivery vehicles
- 9.7 Protein aggregation
- 9.8 Peptide nanomaterials
- 9.9 Peptide-based hydrogels
- 9.10 Therapeutic interventions against protein/peptide aggregation diseases
- 9.11 Computational tools and algorithms in peptide design
- References
- Index
- Edition: 1
- Published: September 17, 2022
- Imprint: Academic Press
- No. of pages: 296
- Language: English
- Paperback ISBN: 9780323999175
- eBook ISBN: 9780323985437
VR
Vibin Ramakrishnan
KP
Kirti Patel
RG