De Novo Peptide Design
Principles and Applications
- 1st Edition - September 17, 2022
- Imprint: Academic Press
- Editors: Vibin Ramakrishnan, Kirti Patel, Ruchika Goyal
- Language: English
- Paperback ISBN:9 7 8 - 0 - 3 2 3 - 9 9 9 1 7 - 5
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 9 8 5 4 3 - 7
De novo Peptide Design: Principles and Applications presents the latest developments in the fields of therapeutic peptides and bio-nanotechnology. The title focuses on the desig… Read more
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Request a sales quoteDe novo Peptide Design: Principles and Applications presents the latest developments in the fields of therapeutic peptides and bio-nanotechnology. The title focuses on the design of peptides, particularly how peptides may be tailored to specific functions. It includes computational and experimental protocols to assist in the design of peptides. Sections cover the basics of protein and peptide structure, modeling and simulation, solid phase peptide synthesis, peptide-based antibiotics, drug delivery, peptide nanomaterials, aromatic interactions directing nano-assembly, protein/peptide aggregation, therapeutic interventions against protein/peptide aggregation diseases, peptide based hydrogels, computational tools and algorithms for peptide design, and experimental protocols in peptide chemistry.
In addition, the book covers key aspects in peptide design, providing a solution for researchers working within the 'peptidic universe' to create new therapeutic agents.
- Gives comprehensive coverage, including peptide design, modeling, synthesis and applications
- Presents emerging topics in the design of peptide-based therapeutics
- Details the latest developments in the fields of therapeutic peptides and bio-nanotechnology
- Considers peptide design and the tailoring of peptides to specific functions
- Offers computational tools and algorithms for peptide design and experimental protocols for peptide chemistry
Advanced students in biotechnology, pharmacy, chemistry and chemical engineering; Researchers working in the broad area of medicinal chemistry and peptides
- Cover image
- Title page
- Table of Contents
- Copyright
- Dedication
- List of contributors
- Chapter 1. Structural organization of peptides
- Abstract
- 1.1 Molecular interactions for protein folding
- 1.2 Poly-alanine models and the energetics of protein folding
- 1.3 De novo protein design and stereochemical logic of protein folding
- 1.4 Shape-specific design of heterochiral proteins
- 1.5 Enzymes: functional proteins
- References
- Chapter 2. Modeling and simulation of peptides
- Abstract
- 2.1 Introduction
- 2.2 Peptide design
- 2.3 Prediction of peptide structure
- 2.4 In silico validation of design by molecular dynamic simulations
- 2.5 Conclusion
- References
- Chapter 3. Solid phase peptide synthesis
- Abstract
- 3.1 Introduction
- 3.2 Principles of solid phase peptide synthesis
- 3.3 Resins
- 3.4 Linkers
- 3.5 Side-chain protecting groups
- 3.6 Coupling reaction
- 3.7 Fmoc deprotection
- 3.8 Final cleavage
- 3.9 Side reactions
- References
- Chapter 4. Peptide-based Antibiotics
- Abstract
- 4.1 Introduction
- 4.2 Antimicrobial peptides
- 4.3 De novo design of antimicrobial peptides
- 4.4 Antimicrobial peptides: Strategy to combat antimicrobial resistance
- 4.5 Mechanism of action and selectivity of antimicrobial peptides
- 4.6 Strengths and weakness of antimicrobial peptides
- 4.7 Conclusion
- References
- Chapter 5. Cell-penetrating peptides
- Abstract
- 5.1 Cell-penetrating peptides: a brief history
- 5.2 Classification of cell-penetrating peptides
- 5.3 Mechanism of uptake
- 5.4 Strengths, limitations, and opportunities
- 5.5 Cell-type specificity: to be or not to be
- 5.6 Cell-penetrating peptides for anticancer drug delivery
- 5.7 Cell-penetrating peptide prediction
- 5.8 Designing cell-penetrating peptides
- 5.9 Conclusion
- References
- Chapter 6. Peptide-based nanomaterials: applications and challenges
- Abstract
- Graphical abstract
- 6.1 Introduction to molecular self-assembly
- 6.2 Protein and peptide self-assembly
- 6.3 Peptide-based nanomaterials
- 6.4 Applications of peptide-based nanomaterials
- 6.5 Conclusion, challenges, and future directions
- References
- Chapter 7. Peptide nanocatalysts
- Abstract
- 7.1 Introduction
- 7.2 Types of catalysts
- 7.3 Enantioselectivity in catalytic reactions
- 7.4 Enzyme catalysis
- 7.5 Enzyme mimetics
- 7.6 Structural design of the artificial peptide-based enzyme
- 7.7 Self-assembling peptide catalysts
- 7.8 Peptide mimics with enhanced catalytic efficiency
- 7.9 Peptide-based artificial metalloenzyme
- 7.10 Exploring unnatural amino acids for de novo peptide-based metalloenzymes
- 7.11 Aldolase mimic
- 7.12 Hydrolase mimic
- 7.13 Oxidase mimic
- 7.14 Conclusions and future prospects
- References
- Chapter 8. Bioinspired functional molecular constructs
- Abstract
- 8.1 Introduction
- 8.2 Peptide-based functional materials
- 8.3 De novo designed peptide nano-assemblies
- 8.4 Properties of self-assembled nanostructures
- 8.5 Factors affecting nanoassemblies
- 8.6 Applications of de novo designed peptide constructs
- 8.7 Conclusion and future directions
- References
- Chapter 9. Patents in peptide science
- Abstract
- 9.1 Introduction
- 9.2 Basics of protein and peptide structure
- 9.3 Modeling and simulation of peptides
- 9.4 Glucagon-like peptide-1 analogs
- 9.5 Peptide-based antibiotics
- 9.6 Drug delivery vehicles
- 9.7 Protein aggregation
- 9.8 Peptide nanomaterials
- 9.9 Peptide-based hydrogels
- 9.10 Therapeutic interventions against protein/peptide aggregation diseases
- 9.11 Computational tools and algorithms in peptide design
- References
- Index
- Edition: 1
- Published: September 17, 2022
- Imprint: Academic Press
- No. of pages: 296
- Language: English
- Paperback ISBN: 9780323999175
- eBook ISBN: 9780323985437
VR
Vibin Ramakrishnan
Dr. Vibin Ramakrishnan is a Professor of Biosciences and Bioengineering at IIT Guwahati. Dr. Vibin earned his Master’s in Applied Chemistry from Cochin University of Science and Technology and Ph.D. from School of Biosciences and Bioengineering, IIT Bombay. He worked as a Postdoctoral Research Associate at Rennsselaer Polytechnic Institute, New York and a Faculty scientist at IBAB Bangalore, before joining Department of Biosciences & Bioengineering at IITG. He has more than 50 research papers in reputed international journals and 10 patents, including an international patent to his credit. He is the principal scientific advisor of two biotech companies. Vibin is the editorial board member of two reputed journals, the Journal of Controlled Release of Elsevier and Scientific Reports of Nature publishing group. The Department of Biotechnology, Govt. of India has awarded Vibin the Innovative Young Biotechnologist Award (IYBA) in the year 2007-08 to recognize his contributions and innovative approach in biotechnology research.
Affiliations and expertise
Professor of Biosciences and Bioengineering, IIT Guwahati, IndiaKP
Kirti Patel
Dr. Kirti Patel is Assistant Professor of Chemistry at N. B. Mehta Science College, affiliated to University of Mumbai. Dr. Patel earned his Master’s in Organic Chemistry from University of Pune and Ph.D. from Department of Chemistry, IIT Bombay. He worked as an Assistant Professor at Bytco College, Nashik before joining N. B. Mehta Science College, Mumbai University. His research work is mostly concentrated in developing peptide-based biomaterials, and he has already published 10 research papers in this area.
Affiliations and expertise
Assistant Professor of Chemistry at N. B. Mehta Science College, affiliated to University of Mumbai, IndiaRG
Ruchika Goyal
Dr. Ruchika Goyal is a Postdoctoral Fellow at University of Strathclyde, Glasgow. She completed her B. Tech (Biotechnology) from G. B. Pant University of Agriculture and Technology, Pantnagar and M. Tech (Biotechnology) from Graphic Era University, Dehradun before joining her doctoral research at IIT Guwahati. In her entire career, she have been associated with many prestigious institutes like NIPER Guwahati, RGCB Trivandrum, BBCI Guwahati, AIIMS New Delhi, JNU New Delhi, etc. She has half a dozen publications and a patent in drug delivery vehicles. She was also selected for the award of prestigious D. S. Kothari Postdoctoral Fellowship 2021 and Marie Curie Postdoctoral Fellowship 2021.
Affiliations and expertise
Post-doctoral researcher, presently associated with IIT Guwahati, IndiaRead De Novo Peptide Design on ScienceDirect