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Davidson's Principles and Practice of Medicine
- 23rd Edition
- Editors: Stuart H. Ralston, Ian D Penman, Mark W J Strachan, Richard Hobson
- Language: English
More than two million medical students, doctors and other health professionals around the globe have owned a copy of Davidson’s Principles and Practice of Medicine since it was fir… Read more
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More than two million medical students, doctors and other health professionals around the globe have owned a copy of Davidson’s Principles and Practice of Medicine since it was first published. Now in its 23rd Edition, this textbook describes the pathophysiology and clinical features of the most frequently encountered conditions in the major specialties of adult medicine and explains how to recognise, investigate, diagnose and manage them. Taking its origins from Sir Stanley Davidson’s much-admired lecture notes, Davidson’s has endured because it keeps pace with how modern medicine is taught and provides a wealth of information in an easy-to-read, concise and beautifully illustrated format. This book will serve readers everywhere as a core text that integrates medical science with clinical medicine, conveying key knowledge and practical advice in a highly accessible and readable format.
- The opening section describes the fundamentals of genetics, immunology, infectious diseases and population health, and discusses the core principles of clinical decision-making and good prescribing.
- A new second section on emergency and critical care medicine encompasses poisoning, envenomation and environmental medicine, and introduces a new chapter on acute medicine and critical illness.
- The third section covers the major medical specialties, each thoroughly revised and brought fully up to date. Two new chapters on maternal and adolescent/transition medicine complement the one on ageing and disease. A new chapter on medical ophthalmology has been included.
- Clinical Examination overviews summarise the main elements for each system and now feature in the biochemistry, nutrition and dermatology chapters.
- Presenting Problems sections provide a clear pathway for the assessment of and approach to the most common complaints in each specialty.
- Practice Point summaries detail the practical skills that medical students and junior doctors must acquire.
- Emergency boxes emphasise the core knowledge needed to manage acutely ill patients.
- In Old Age , In Pregnancy and In Adolescence boxes highlight differences in the practice of medicine in these patient groups, and illustrate the interfaces between medical, obstetric and paediatric services.
- The text is extensively illustrated, with over 1000 diagrams, clinical photographs, and radiology and pathology images.
- The global perspective is enhanced by an International Advisory Board of experts from 17 countries, and by authors from around the world.
Medical students / undergraduates; Junior doctors; MRCP candidates; nurses / nurse practitioners; physician assistants
- Cover image
- Title Page
- Disclaimer
- Table of Contents
- Sir Stanley Davidson (1894–1981)
- Copyright
- Preface
- Contributors
- International Advisory Board
- Acknowledgements
- Introduction
- Clinical examination overviews
- Presenting problems
- Boxes
- Terminology
- Units of measurement
- Finding what you are looking for
- Part 1 Fundamentals of Medicine
- 1 Clinical decision-making
- Introduction
- The problem of diagnostic error
- Clinical reasoning: definitions
- Clinical skills and decision-making
- Use and interpretation of diagnostic tests
- Dealing with uncertainty
- Cognitive biases
- Reducing errors in clinical decision-making
- Patient-centred evidence-based medicine and shared decision-making
- Clinical decision-making: putting it all together
- Answers to problems
- Further information
- 2 Clinical therapeutics and good prescribing
- Principles of clinical pharmacology
- Adverse outcomes of drug therapy
- Drug regulation and management
- Prescribing in practice
- Further information
- 3 Clinical genetics
- The fundamental principles of genomics
- Genomics, health and disease
- Interrogating the genome: the changing landscape of genomic technologies
- Genomics and clinical practice
- Further information
- 4 Clinical immunology
- Functional anatomy and physiology
- The inflammatory response
- Presenting problems in immune disorders
- Immune deficiency
- Periodic fever syndromes
- Amyloidosis
- Autoimmune disease
- Allergy
- Angioedema
- Transplantation and graft rejection
- Tumour immunology
- Further information
- 5 Population health and epidemiology
- Global burden of disease and underlying risk factors
- Social determinants of health
- Principles of screening
- Epidemiology
- Health data/informatics
- Further information
- 6 Principles of infectious disease
- Infectious agents
- Normal microbial flora
- Host–pathogen interactions
- Investigation of infection
- Epidemiology of infection
- Infection prevention and control
- Antimicrobial stewardship
- Treatment of infectious diseases
- Further information
- Part 2 Emergency and Critical Care Medicine
- 7 Poisoning
- Comprehensive evaluation of the poisoned patient
- General approach to the poisoned patient
- Poisoning by specific pharmaceutical agents
- Drugs of misuse
- Chemicals and pesticides
- Environmental poisoning
- Food-related poisoning
- Plant poisoning
- Further information
- 8 Envenomation
- Comprehensive evaluation of the envenomed patient
- Geographical distribution of venomous snakes
- Bedside tests in the envenomed patient
- Overview of envenomation
- General approach to the envenomed patient
- Envenomation by specific animals
- Further information
- 9 Environmental medicine
- Radiation exposure
- Extremes of temperature
- High altitude
- Under water
- Humanitarian crisis
- Further information
- Telephone numbers
- 10 Acute medicine and critical illness
- Clinical examination in critical care
- Monitoring
- Acute medicine
- Presenting problems in acute medicine
- Identification and assessment of deterioration
- Common presentations of deterioration
- Disorders causing critical illness
- Critical care medicine
- Stabilisation and institution of organ support
- Daily clinical management in intensive care
- Complications and outcomes of critical illness
- Further information
- Part 3 Clinical Medicine
- 11 Infectious disease
- Clinical examination of patients with infectious disease
- Presenting problems in infectious diseases
- Viral infections
- Prion diseases
- Bacterial infections
- Protozoal infections
- Infections caused by helminths
- Ectoparasites
- Fungal infections
- Further information
- 12 HIV infection and AIDS
- Clinical examination in HIV disease
- Epidemiology
- Virology and immunology
- Diagnosis and investigations
- Clinical manifestations of HIV
- Presenting problems in HIV infection
- Prevention of opportunistic infections
- Antiretroviral therapy
- Further information
- 13 Sexually transmitted infections
- Clinical examination in men
- Clinical examination in women
- Approach to patients with a suspected STI
- Presenting problems in men
- Presenting problems in women
- Prevention of STI
- Sexually transmitted bacterial infections
- Sexually transmitted viral infections
- Further information
- 14 Clinical biochemistry and metabolic medicine
- Clinical examination in biochemical and metabolic disorders
- Biochemical investigations
- Water and electrolyte homeostasis
- Sodium homeostasis
- Water homeostasis
- Potassium homeostasis
- Acid–base homeostasis
- Calcium homeostasis
- Magnesium homeostasis
- Phosphate homeostasis
- Disorders of amino acid metabolism
- Disorders of carbohydrate metabolism
- Disorders of complex lipid metabolism
- Lipids and lipoprotein metabolism
- The porphyrias
- Further information
- 15 Nephrology and urology
- Clinical examination of the kidney and urinary tract
- Functional anatomy and physiology
- Investigation of renal and urinary tract disease
- Presenting problems in renal and urinary tract disease
- Glomerular diseases
- Tubulo-interstitial diseases
- Genetic renal diseases
- Renal vascular diseases
- Renal involvement in systemic conditions
- Acute kidney injury
- Chronic kidney disease
- Renal replacement therapy
- Renal disease in pregnancy
- Renal disease in adolescence
- Drugs and the kidney
- Infections of the urinary tract
- Urolithiasis
- Diseases of the collecting system and ureters
- Tumours of the kidney and urinary tract
- Urinary incontinence
- Prostate disease
- Testicular tumours
- Erectile dysfunction
- Further information
- 16 Cardiology
- Clinical examination of the cardiovascular system
- Functional anatomy and physiology
- Investigation of cardiovascular disease
- Presenting problems in cardiovascular disease
- Cardiac arrhythmias
- Principles of management of cardiac arrhythmias
- Coronary artery disease
- Peripheral arterial disease
- Diseases of the aorta
- Diseases of the heart valves
- Congenital heart disease
- Diseases of the myocardium
- Diseases of the pericardium
- Further information
- 17 Respiratory medicine
- Clinical examination of the respiratory system
- Functional anatomy and physiology
- Investigation of respiratory disease
- Presenting problems in respiratory disease
- Obstructive pulmonary diseases
- Infections of the respiratory system
- Tumours of the bronchus and lung
- Interstitial and infiltrative pulmonary diseases
- Occupational and environmental lung disease
- Pulmonary vascular disease
- Diseases of the upper airway
- Pleural disease
- Diseases of the diaphragm and chest wall
- Further information
- 18 Endocrinology
- Clinical examination in endocrine disease
- An overview of endocrinology
- The thyroid gland
- The reproductive system
- The parathyroid glands
- The adrenal glands
- The endocrine pancreas and gastrointestinal tract
- The hypothalamus and the pituitary gland
- Disorders affecting multiple endocrine glands
- Further information
- 19 Nutritional factors in disease
- Clinical examination in nutritional disorders
- Clinical assessment and investigation of nutritional status
- Nutritional factors and disease
- Disorders of altered energy balance
- Micronutrients, minerals and their diseases
- Further information
- 20 Diabetes mellitus
- Clinical examination of the patient with diabetes
- Functional anatomy and physiology
- Investigations
- Aetiology and pathogenesis of diabetes
- Presenting problems in diabetes mellitus
- Management of diabetes
- Complications of diabetes
- Further information
- 21 Gastroenterology
- Clinical examination of the gastrointestinal tract
- Functional anatomy and physiology
- Investigation of gastrointestinal disease
- Presenting problems in gastrointestinal disease
- Diseases of the mouth and salivary glands
- Diseases of the oesophagus
- Diseases of the stomach and duodenum
- Diseases of the small intestine
- Inflammatory bowel disease
- Irritable bowel syndrome
- HIV/AIDS and the gastrointestinal tract
- Ischaemic gut injury
- Disorders of the colon and rectum
- Diseases of the peritoneal cavity
- Other disorders
- Diseases of the pancreas
- Further information
- 22 Hepatology
- Clinical examination of the abdomen for liver and biliary disease
- Functional anatomy and physiology
- Investigation of liver and hepatobiliary disease
- Presenting problems in liver disease
- Cirrhosis
- Portal hypertension
- Infections and the liver
- Alcoholic liver disease
- Non-alcoholic fatty liver disease
- Autoimmune liver and biliary disease
- Liver tumours and other focal liver lesions
- Drugs and the liver
- Inherited liver diseases
- Vascular liver disease
- Pregnancy and the liver
- Liver transplantation
- Cholestatic and biliary disease
- Further information
- Websites
- 23 Haematology and transfusion medicine
- Clinical examination in blood disease
- Functional anatomy and physiology
- Investigation of diseases of the blood
- Presenting problems in blood disease
- Principles of management of haematological disease
- Anaemias
- Haemoglobinopathies
- Haematological malignancies
- Aplastic anaemias
- Myeloproliferative neoplasms
- Bleeding disorders
- Thrombotic disorders
- Further information
- 24 Rheumatology and bone disease
- Clinical examination of the musculoskeletal system
- Functional anatomy and physiology
- Investigation of musculoskeletal disease
- Presenting problems in musculoskeletal disease
- Principles of management
- Osteoarthritis
- Crystal-induced arthritis
- Fibromyalgia
- Bone and joint infections
- Rheumatoid arthritis
- Juvenile idiopathic arthritis
- Spondyloarthropathies
- Autoimmune connective tissue diseases
- Vasculitis
- Diseases of bone
- Bone and joint tumours
- Rheumatological involvement in other diseases
- Miscellaneous conditions
- Further information
- 25 Neurology
- Clinical examination of the nervous system
- Functional anatomy and physiology
- Investigation of neurological disease
- Presenting problems in neurological disease
- Functional symptoms
- Headache syndromes
- Epilepsy
- Vestibular disorders
- Disorders of sleep
- Neuro-inflammatory diseases
- Paraneoplastic neurological disorders
- Neurodegenerative diseases
- Infections of the nervous system
- Intracranial mass lesions and raised intracranial pressure
- Disorders of cerebellar function
- Disorders of the spine and spinal cord
- Diseases of peripheral nerves
- Diseases of the neuromuscular junction
- Diseases of muscle
- Further information
- 26 Stroke medicine
- Clinical examination in stroke disease
- Functional anatomy and physiology
- Investigations
- Presenting problems
- Stroke
- Subarachnoid haemorrhage
- Cerebral venous disease
- Further information
- 27 Medical ophthalmology
- Functional anatomy and physiology
- Investigation of visual disorders
- Presenting problems in ophthalmic disease
- Specialist ophthalmological conditions
- Further information
- 28 Medical psychiatry
- Clinical examination
- Functional anatomy and physiology
- Presenting problems in psychiatric illness
- Principles of management of psychiatric disorders
- Psychiatric disorders
- Psychiatry and the law
- Further information
- 29 Dermatology
- Clinical examination in skin disease
- Functional anatomy and physiology
- Investigation of skin disease
- Presenting problems in skin disease
- Principles of management of skin disease
- Skin tumours
- Common skin infections and infestations
- Acne and rosacea
- Eczemas
- Psoriasis and other erythematous scaly eruptions
- Lichenoid eruptions
- Urticaria
- Bullous diseases
- Pigmentation disorders
- Hair disorders
- Nail disorders
- Skin disease in general medicine
- Further information
- 30 Maternal medicine
- Clinical examination in pregnancy
- Clinical evaluation in maternal medicine
- Planning pregnancy in patients with medical conditions
- Functional anatomy and physiology
- Investigations
- Presenting problems in pregnancy
- Medical disorders in pregnancy
- Further information
- 31 Adolescent and transition medicine
- Transition from paediatric to adult health services
- Functional anatomy and physiology
- Investigations
- Clinical assessment
- Presenting problems in transition medicine
- Clinical presentations
- Summary
- Further information
- 32 Ageing and disease
- Comprehensive Geriatric Assessment
- Demography
- Functional anatomy and physiology
- Investigations
- Presenting problems in geriatric medicine
- Rehabilitation
- Further information
- 33 Oncology
- Clinical examination of the cancer patient
- The 10 hallmarks of cancer
- Environmental and genetic determinants of cancer
- Investigations
- Presenting problems in oncology
- Emergency complications of cancer
- Metastatic disease
- Therapeutics in oncology
- Specific cancers
- Multidisciplinary teams
- Further information
- 34 Pain and palliative care
- Pain
- Palliative care
- Death and dying
- Further information
- 35 Laboratory reference ranges
- Notes on the international system of units (SI units)
- Laboratory reference ranges in adults
- Laboratory reference ranges in childhood and adolescence
- Laboratory reference ranges in pregnancy
- Further information
- Index
- Language: English
- Edition: 23
- Published:
- Imprint: Elsevier
SR
Stuart H. Ralston
Affiliations and expertise
Arthritis Research UK Professor of Rheumatology, University of Edinburgh; Honorary Consultant Rheumatologist, Western General Hospital, Edinburgh, UKIP
Ian D Penman
Affiliations and expertise
Consultant Gastroenterologist, Royal Infirmary of Edinburgh; Honorary Senior Lecturer, University of Edinburgh, UKMS
Mark W J Strachan
Affiliations and expertise
Consultant Endocrinologist, Metabolic Unit, Western General Hospital, Edinburgh; Honorary Professor, University of Edinburgh, UKRH
Richard Hobson
Affiliations and expertise
Consultant Microbiologist, Harrogate and District NHS Foundation Trust; Honorary Senior Lecturer, University of Leeds, UK