Current Topics in Developmental Biology
Fertilization and Activation of Development
- 1st Edition, Volume 162 - April 18, 2025
- Imprint: Academic Press
- Editors: Paul Wassarman, Eveline Litscher
- Language: English
- Hardback ISBN:9 7 8 - 0 - 3 2 3 - 9 1 2 4 1 - 9
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 9 1 2 4 6 - 4
Fertilization and Activation of Development, Volume 162 in the Current Topics in Developmental Biology series, highlights new advances in the field, with this new volume presen… Read more
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Request a sales quoteFertilization and Activation of Development, Volume 162 in the Current Topics in Developmental Biology series, highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors.
Chapters in this new release include Fertilization and the fast block to polyspermy in the African Clawed Frog, Xenopus laevis: A historical perspective, The Mammalian Egg's Zona Pellucida, Fertilization, and Fertility, Function, structure, and regulation of the broadly conserved gamete membrane fusion protein, HAP2, Gamete activation for fertilization and seed development in flowering plants, Paternal contributions to mammalian zygote, and much more.
Additional sections cover Ovarian follicle formation and activation, Cytoskeletal dynamics in gamete (pro)nuclear migration across flowering plants, animals, and yeast, and Luteinizing hormone-induced changes in the structure of mammalian preovulatory follicles.
Chapters in this new release include Fertilization and the fast block to polyspermy in the African Clawed Frog, Xenopus laevis: A historical perspective, The Mammalian Egg's Zona Pellucida, Fertilization, and Fertility, Function, structure, and regulation of the broadly conserved gamete membrane fusion protein, HAP2, Gamete activation for fertilization and seed development in flowering plants, Paternal contributions to mammalian zygote, and much more.
Additional sections cover Ovarian follicle formation and activation, Cytoskeletal dynamics in gamete (pro)nuclear migration across flowering plants, animals, and yeast, and Luteinizing hormone-induced changes in the structure of mammalian preovulatory follicles.
- Presents a comprehensive exploration of the fertilization process, including gamete interaction, fusion, and early embryonic development
- Provides in-depth analysis of the molecular mechanisms underlying fertilization, sperm-egg recognition, and activation of embryonic development
- Examines the key events and signaling pathways involved in activating embryonic development post-fertilization
Professors, researchers, and students in biology, Medical students, clinicians
- Cover image
- Title page
- Table of Contents
- Series Page
- Copyright
- Contributors
- Preface
- References
- Chapter One: Gamete activation for fertilization and seed development in flowering plants
- Abstract
- 1 Introduction
- 2 Sperm cell activation
- 3 Egg cell activation
- 4 Initiation of endosperm proliferation
- 5 Conclusion
- Acknowledgment
- References
- Chapter Two: Cytoskeletal dynamics of gamete nuclear migration in flowering plants, animals, and yeast
- Abstract
- 1 Introduction
- 2 Sperm nuclear migration in flowering plants
- 3 Pronuclear migration in animals
- 4 Nuclear migration in yeast
- 5 Conclusion
- References
- Chapter Three: Fertilization mechanisms in hermaphroditic ascidians and nematodes: Common mechanisms with mammals and plants
- Abstract
- 1 Introduction
- 2 Fertilization mechanisms in ascidians: Comparison with echinoderms, mammals and plants
- 3 Fertilization mechanisms in nematodes: Comparison with mammals
- 4 Conclusions and perspectives
- Acknowledgments
- References
- Chapter Four: Activating the C. elegans egg: Molecular players, current knowledge, and unanswered questions
- Abstract
- 1 Introduction
- 2 List of key genes
- 3 Calcium waves and zinc fluxes
- 4 Completion of meiosis
- 5 Localization of the EGG complex
- 6 The C. elegans eggshell
- 7 Block to polyspermy
- 8 Cortical granule exocytosis in C. elegans
- 9 Regulation of maternal RNAs and proteins
- 10 Conclusions
- References
- Chapter Five: Fertilization and the fast block to polyspermy in the African Clawed Frog, Xenopus laevis: A historical perspective
- Abstract
- 1 Introduction
- 2 Mating system
- 3 Sperm and egg interaction
- 4 Polyspermy is embryonic lethal for most animals
- 5 Fast block to polyspermy
- 6 Fast block mechanism
- 7 Signaling pathway of the fast block in X. laevis
- 8 Concluding remarks
- References
- Chapter Six: No transcription, no problem: Protein phosphorylation changes and the transition from oocyte to embryo
- Abstract
- 1 Background, outstanding questions, and emerging research
- 2 Post-translational modifications as regulators of egg activation
- 3 Conserved events related to phospho-regulation during egg activation
- 4 Kinases and phosphatases that regulate maternal phospho-proteins during egg activation
- 5 Summary and future directions
- Acknowledgments
- References
- Chapter Seven: The mammalian egg’s zona pellucida, fertilization, and fertility
- Abstract
- 1 Introduction to the ZP
- 2 Mammalian oogenesis
- 3 Features of ZP matrix
- 4 ZP proteins and genes
- 5 Assembly of ZP proteins
- 6 ZP domain
- 7 Primary structure of ZP proteins
- 8 Three-dimensional structure of ZP proteins
- 9 Evolution of ZP proteins
- 10 Mammalian fertilization and the ZP
- 11 Inactivation and mutation of ZP genes
- 12 Final comments
- Acknowledgments
- References
- Further reading
- Chapter Eight: Luteinizing hormone-induced changes in the structure of mammalian preovulatory follicles
- Abstract
- 1 Introduction
- 2 Structure of mammalian preovulatory follicles
- 3 Luteinizing hormone receptor localization and signaling
- 4 Methods for inducing and observing ovulation
- 5 Cumulus expansion and follicular enlargement, interrelated events
- 6 Apical thinning, a multistep process
- 7 Invagination and contraction of the follicular surface
- 8 Increases in vascular permeability, capillary diameter, and angiogenesis
- 9 Conclusions
- Acknowledgments
- References
- Chapter Nine: Cellular and molecular regulations of oocyte selection and activation in mammals
- Abstract
- 1 Introduction
- 2 Oocyte selection and arrest before the establishment of female reproductive reserve in fetal ovaries
- 3 Oocytes in PF: a balance of dormancy and activation
- 4 Oocyte maturation: an orchestration between nucleus and cytoplasm
- 5 Conclusions and future perspective
- Acknowledgements
- References
- Chapter Ten: The characteristics of the calcium signals that activate mammalian eggs at fertilization
- Abstract
- 1 The sperm-induced Ca2+ signals that cause egg activation
- 2 The importance of multiple Ca2+ transients in egg activation
- 3 PLCζ induced Ca2+ oscillations in eggs
- 4 The mechanism of PLCζ induced Ca2+ oscillations
- 5 Other soluble sperm factors and Ca2+ release in eggs
- 6 The sensitivity of Ca2+ release to different stimuli
- 7 Changes in ATP concentration at fertilization
- 8 Unresolved problems
- Acknowledgments
- References
- Chapter Eleven: Ion channels and transporters involved in calcium flux regulation in mammalian sperm
- Abstract
- 1 Introduction
- 2 Evaluating the evidence for the role of an ion transporter in calcium homeostasis
- 3 Calcium regulation in cells and sperm
- 4 Plasma membrane calcium entry mechanisms
- 5 Plasma membrane calcium extrusion mechanisms
- 6 Intracellular calcium storage
- 7 Organellar calcium uptake in mammalian sperm
- 8 Molecular basis of organellar calcium release in mammalian sperm
- 9 Final remarks
- Acknowledgments
- References
- Chapter Twelve: Paternal contributions to mammalian zygote – Beyond sperm-oocyte fusion
- Abstract
- 1 Introduction – fertilization beyond sperm-oolemma fusion
- 2 Perinuclear theca cargo
- 3 Sperm contributions to early zygotic development
- 4 Paternal mitochondria and post-fertilization sperm mitophagy
- 5 Accessory sperm structures
- 6 Ribonucleic acids
- 7 Conclusions
- Acknowledgments
- References
- Edition: 1
- Volume: 162
- Published: April 18, 2025
- Imprint: Academic Press
- No. of pages: 464
- Language: English
- Hardback ISBN: 9780323912419
- eBook ISBN: 9780323912464
PW
Paul Wassarman
Paul M. Wassarman, the Series Editor of CTDB since 2007, is Professor in the Dept. Developmental and Regenerative Biology at the Icahn School of Medicine at Mount Sinai in New York City. He received a Ph.D. in biochemistry from Brandeis University where he carried out thesis research in the Graduate Dept. Biochemistry with Professor Nathan O. Kaplan. In 1967 Wassarman joined the Division of Structural Studies at the MRC, Laboratory of Molecular Biology in Cambridge, England as a Helen Hay Whitney Foundation Fellow with Sir John C. Kendrew. In 1972 he joined the faculty of the Dept. Biological Chemistry at Harvard Medical School and in 1986 moved to the Roche Institute of Molecular Biology where he was Chair of the Dept. Cell and Developmental Biology and Adjunct Professor in the Dept. Cell Biology, New York University School of Medicine. In 1996 he moved to the Icahn School of Medicine at Mount Sinai where he was the Lillian and Henry M. Stratton Professorial Chair of the Dept. Molecular, Cell, and Developmental Biology. Wassarman has published more than 200 research papers and reviews, dealing primarily with mammalian oogenesis, fertilization, and early embryogenesis.
Affiliations and expertise
Icahn School of Medicine, Mount Sinai, USAEL
Eveline Litscher
Eveline Litscher is at Icahn School of Medicine at Mount Sinai, USA
Affiliations and expertise
Icahn School of Medicine, Mount Sinai, USARead Current Topics in Developmental Biology on ScienceDirect