Current Topics in Cellular Regulation
- 1st Edition, Volume 22 - April 28, 1983
- Imprint: Academic Press
- Editors: Bernard L. Horecker, Earl R. Stadtman
- Language: English
- Paperback ISBN:9 7 8 - 1 - 4 8 3 2 - 0 3 7 8 - 2
- eBook ISBN:9 7 8 - 1 - 4 8 3 2 - 1 7 2 1 - 5
Current Topics in Cellular Regulation: Volume 22 is a collection of papers that deals with eukaryotic protein synthesis, lysosomal thiol proteinases, and the properties of… Read more
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Request a sales quoteCurrent Topics in Cellular Regulation: Volume 22 is a collection of papers that deals with eukaryotic protein synthesis, lysosomal thiol proteinases, and the properties of adenylosuccinate synthetase. Other papers discuss the regulation of acetyl-CoA carboxylase, ornithine cycle, and seminal vesicle development and function. One paper investigates the poly ADP-ribosylation of protein, particularly in quantifying synthesis and in the function of the polymer. Another paper observes the construction of a reconstituted cell-free system in which there is for the first time a catalytic use, followed by a recycling of eIF-2. A eukaryotic regulatory factor or eukaryotic recycling factor (eRF) is a prerequisite factor in the in the control of the rate of initiation. One paper reviews the properties, structures, and functions of thiol endopeptidases in mammalian lysosomes and the characteristics of the endogenous inhibitor. Another paper explains the regulatory, kinetic, and genetic aspects of adenylosuccinate synthetase from a variety of systems. One paper discusses the short-term regulation of the carboxylase from animal tissues, with emphasis on the covalent modification of the carboxylase, and its relationship to the allosteric control mechanism. Molecular biologists, general biologists, and microbiologists will find the articles in this collection invaluable.
Contributors
Poly ADP-Ribosylation of Protein
I. Perspectives and Summary
II. Poly(ADP-Ribose): Historical Aspects and Characterization
III. Quantification of Poly(ADP-Ribose)
IV. Poly(ADP-Ribose) Synthetase
V. Degradation of Poly(ADP-Ribose)
VI. Physiological Functions of Poly(ADP-Ribose)
References
The Control of the Rate of Initiation of Eukaryotic Protein Synthesis
I. Introduction
II. Purification and Characterization
III. The Mode of Action of the Regulatory Factor, eRF
IV. The Effect of HRI
V. Complex Formation Between eIF-2 and eRF
VI. Discussion
References
Structures and Functions of Lysosomal Thiol Proteinases and Their Endogenous Inhibitor
I. Introduction
II. Properties of Lysosomal Thiol Proteinases
III. Structures of Lysosomal Thiol Proteinases
IV. Control of Lysosomal Thiol Proteinases
V. Endogenous Thiol Proteinase Inhibitor
VI. Functions of Lysosomal Thiol Proteinases
VII. Concluding Remarks
References
Regulation, Genetics, and Properties of Adenylosuccinate Synthetase: A Review
I. Introduction
II. Measurement of Enzyme Activity
III. Isolation and Properties
IV The Isozymes of Adenylosuccinate Synthetase
V. Substrate Specificity
VI. Inhibitors
VII. Mechanism of Action
VIII. Adenylosuccinate Synthetase Regulation in E. coli
IX. Regulation and Metabolic Roles of Eukaryotic Adenylosuccinate Synthetase
X. Genetic Considerations
References
Regulation of Acetyl-CoA Carboxylase
I. Introduction
II. Allosteric Control Mechanism
III. Covalent Modification Mechanism
IV. Relationship Between Covalent Phosphorylation and the Quaternary Structure of Acetyl-CoA Carboxylase
V. Regulation of Covalent Phosphorylation of Acetyl-CoA
VI. Concluding Remarks
References
The Evolutionary History of the Ornithine Cycle as a Determinant of Its Structure and Regulation
I. Introduction
II. Problematical Aspects of the Ornithine Cycle
III. Evolutionary Origin of the Ornithine Cycle
IV. Evaluation of the Postulated Evolutionary Relationships
V. Conclusion
References
Regulatory Features of Seminal Vesicle Development and Function
I. Introduction
II. Occurrence and Functions of Seminal Vesicles
III. Male Reproductive Tract Differentiation and the Molecular Biology of Steroid Hormone Action
IV. Embryonic Differentiation of Seminal Vesicles
V Hormonal Regulation of Adult Seminal Vesicle Growth and Secretory Functions
VI. Formation and Functions of Vesicular Secretion Constituents
VII. Participation of Vesicular Secretion Constituents in Semen Coagulation
References
Index
Cumulative Contributors Index
Contents of Previous Volumes
- Edition: 1
- Volume: 22
- Published: April 28, 1983
- Imprint: Academic Press
- No. of pages: 304
- Language: English
- Paperback ISBN: 9781483203782
- eBook ISBN: 9781483217215
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