Current Topics in Cellular Regulation

1st Edition, Volume 22 - April 28, 1983

Editors: Bernard L. Horecker, Earl R. Stadtman

eBook ISBN:

9 7 8 - 1 - 4 8 3 2 - 1 7 2 1 - 5

Current Topics in Cellular Regulation: Volume 22 is a collection of papers that deals with eukaryotic protein synthesis, lysosomal thiol proteinases, and the properties of… Read more

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Current Topics in Cellular Regulation: Volume 22 is a collection of papers that deals with eukaryotic protein synthesis, lysosomal thiol proteinases, and the properties of adenylosuccinate synthetase. Other papers discuss the regulation of acetyl-CoA carboxylase, ornithine cycle, and seminal vesicle development and function. One paper investigates the poly ADP-ribosylation of protein, particularly in quantifying synthesis and in the function of the polymer. Another paper observes the construction of a reconstituted cell-free system in which there is for the first time a catalytic use, followed by a recycling of eIF-2. A eukaryotic regulatory factor or eukaryotic recycling factor (eRF) is a prerequisite factor in the in the control of the rate of initiation. One paper reviews the properties, structures, and functions of thiol endopeptidases in mammalian lysosomes and the characteristics of the endogenous inhibitor. Another paper explains the regulatory, kinetic, and genetic aspects of adenylosuccinate synthetase from a variety of systems. One paper discusses the short-term regulation of the carboxylase from animal tissues, with emphasis on the covalent modification of the carboxylase, and its relationship to the allosteric control mechanism. Molecular biologists, general biologists, and microbiologists will find the articles in this collection invaluable.

Contributors

Poly ADP-Ribosylation of Protein

I. Perspectives and Summary

II. Poly(ADP-Ribose): Historical Aspects and Characterization

III. Quantification of Poly(ADP-Ribose)

IV. Poly(ADP-Ribose) Synthetase

V. Degradation of Poly(ADP-Ribose)

VI. Physiological Functions of Poly(ADP-Ribose)

References

The Control of the Rate of Initiation of Eukaryotic Protein Synthesis

I. Introduction

II. Purification and Characterization

III. The Mode of Action of the Regulatory Factor, eRF

IV. The Effect of HRI

V. Complex Formation Between eIF-2 and eRF

VI. Discussion

References

Structures and Functions of Lysosomal Thiol Proteinases and Their Endogenous Inhibitor

I. Introduction

II. Properties of Lysosomal Thiol Proteinases

III. Structures of Lysosomal Thiol Proteinases

IV. Control of Lysosomal Thiol Proteinases

V. Endogenous Thiol Proteinase Inhibitor

VI. Functions of Lysosomal Thiol Proteinases

VII. Concluding Remarks

References

Regulation, Genetics, and Properties of Adenylosuccinate Synthetase: A Review

I. Introduction

II. Measurement of Enzyme Activity

III. Isolation and Properties

IV The Isozymes of Adenylosuccinate Synthetase

V. Substrate Specificity

VI. Inhibitors

VII. Mechanism of Action

VIII. Adenylosuccinate Synthetase Regulation in E. coli

IX. Regulation and Metabolic Roles of Eukaryotic Adenylosuccinate Synthetase

X. Genetic Considerations

References

Regulation of Acetyl-CoA Carboxylase

I. Introduction

II. Allosteric Control Mechanism

III. Covalent Modification Mechanism

IV. Relationship Between Covalent Phosphorylation and the Quaternary Structure of Acetyl-CoA Carboxylase

V. Regulation of Covalent Phosphorylation of Acetyl-CoA

VI. Concluding Remarks

References

The Evolutionary History of the Ornithine Cycle as a Determinant of Its Structure and Regulation

I. Introduction

II. Problematical Aspects of the Ornithine Cycle

III. Evolutionary Origin of the Ornithine Cycle

IV. Evaluation of the Postulated Evolutionary Relationships

V. Conclusion

References

Regulatory Features of Seminal Vesicle Development and Function

I. Introduction

II. Occurrence and Functions of Seminal Vesicles

III. Male Reproductive Tract Differentiation and the Molecular Biology of Steroid Hormone Action

IV. Embryonic Differentiation of Seminal Vesicles

V Hormonal Regulation of Adult Seminal Vesicle Growth and Secretory Functions

VI. Formation and Functions of Vesicular Secretion Constituents

VII. Participation of Vesicular Secretion Constituents in Semen Coagulation

References

Index

Cumulative Contributors Index

Contents of Previous Volumes