Current Topics in Cellular Regulation

Contributors

Poly ADP-Ribosylation of Protein

I. Perspectives and Summary

II. Poly(ADP-Ribose): Historical Aspects and Characterization

III. Quantification of Poly(ADP-Ribose)

IV. Poly(ADP-Ribose) Synthetase

V. Degradation of Poly(ADP-Ribose)

VI. Physiological Functions of Poly(ADP-Ribose)

References

The Control of the Rate of Initiation of Eukaryotic Protein Synthesis

I. Introduction

II. Purification and Characterization

III. The Mode of Action of the Regulatory Factor, eRF

IV. The Effect of HRI

V. Complex Formation Between eIF-2 and eRF

VI. Discussion

References

Structures and Functions of Lysosomal Thiol Proteinases and Their Endogenous Inhibitor

I. Introduction

II. Properties of Lysosomal Thiol Proteinases

III. Structures of Lysosomal Thiol Proteinases

IV. Control of Lysosomal Thiol Proteinases

V. Endogenous Thiol Proteinase Inhibitor

VI. Functions of Lysosomal Thiol Proteinases

VII. Concluding Remarks

References

Regulation, Genetics, and Properties of Adenylosuccinate Synthetase: A Review

I. Introduction

II. Measurement of Enzyme Activity

III. Isolation and Properties

IV The Isozymes of Adenylosuccinate Synthetase

V. Substrate Specificity

VI. Inhibitors

VII. Mechanism of Action

VIII. Adenylosuccinate Synthetase Regulation in E. coli

IX. Regulation and Metabolic Roles of Eukaryotic Adenylosuccinate Synthetase

X. Genetic Considerations

References

Regulation of Acetyl-CoA Carboxylase

I. Introduction

II. Allosteric Control Mechanism

III. Covalent Modification Mechanism

IV. Relationship Between Covalent Phosphorylation and the Quaternary Structure of Acetyl-CoA Carboxylase

V. Regulation of Covalent Phosphorylation of Acetyl-CoA

VI. Concluding Remarks

References

The Evolutionary History of the Ornithine Cycle as a Determinant of Its Structure and Regulation

I. Introduction

II. Problematical Aspects of the Ornithine Cycle

III. Evolutionary Origin of the Ornithine Cycle

IV. Evaluation of the Postulated Evolutionary Relationships

V. Conclusion

References

Regulatory Features of Seminal Vesicle Development and Function

I. Introduction

II. Occurrence and Functions of Seminal Vesicles

III. Male Reproductive Tract Differentiation and the Molecular Biology of Steroid Hormone Action

IV. Embryonic Differentiation of Seminal Vesicles

V Hormonal Regulation of Adult Seminal Vesicle Growth and Secretory Functions

VI. Formation and Functions of Vesicular Secretion Constituents

VII. Participation of Vesicular Secretion Constituents in Semen Coagulation

References

Index

Cumulative Contributors Index

Contents of Previous Volumes