Copper in N-Heterocyclic Chemistry
- 1st Edition - November 13, 2020
- Imprint: Elsevier
- Editor: Ananya Srivastava
- Language: English
- Paperback ISBN:9 7 8 - 0 - 1 2 - 8 2 1 2 6 3 - 9
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 2 1 5 4 7 - 0
Copper in N-Heterocyclic Chemistry provides an overview of copper-catalyzed synthesis and functionalization of N-heterocyclic compounds, covering all recent developments in a way… Read more
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Request a sales quoteCopper in N-Heterocyclic Chemistry provides an overview of copper-catalyzed synthesis and functionalization of N-heterocyclic compounds, covering all recent developments in a way that is ideal for researchers and students working in the area of synthetic organic chemistry and medicinal chemistry. The book explores N-heterocyclic compounds as unique structural units in the development of natural products and pharmaceuticals, along with the remarkable progress made in the area of high atom economic strategies, and more recently, copper-catalyzed C-H activation and its applications in organic synthesis. Readers will find troubleshooting protocols, as well as the advantages and limitations of each method discussed.
As copper catalysts show versatile chemical reactivity in many aspects, including their oxidation states 0–3 are accessible and their ability to facilitate bond formations due to their ability to serve as Lewis acids, oxidizing agents and catalysts, this book is an ideal resource on the topics explored.
- Discusses novel synthetic methods developed over the past decade for copper-catalyzed synthesis of N-heterocyclic compounds
- Covers the most recent methodologies adapted in synthetic chemistry for applications in natural products and pharmaceuticals
- Includes troubleshooting protocols, as well as the advantages and limitations of each method discussed in detail
Researchers and students working in the area of synthetic organic chemistry and medicinal chemistry. Pharmaceutical scientists
- Cover image
- Title page
- Table of Contents
- Copyright
- Contributors
- About the editor
- Preface
- Chapter 1: Copper-catalyzed synthesis of aziridines
- Abstract
- Acknowledgments
- 1: Introduction
- 2: Asymmetric nucleophilic addition to 2H-azirines
- 3: Reaction of aziridines and oxaziridines
- 4: Cycloaddition reactions
- 5: Cyclization reaction/Baldwin rearrangement
- 6: Copper-catalyzed C–H amination reaction
- 7: Aziridination via intramolecular SN2 substitution
- 8: Aziridination of imines via carbene transfer
- 9: Aziridination of olefins via nitrene transfer
- Chapter 2: Copper catalysis for imidazoles and pyrazoles
- Abstract
- 1: Introduction
- 2: Synthesis of imidazole and its congener using copper catalyst
- 3: Synthesis of benzimidazole and its congener by using copper catalyst
- 4: Synthesis of pyrazole and its congener by using copper catalyst
- 5: Conclusion
- Chapter 3: Copper catalysis in the synthesis of 1,2,3-triazoles and tetrazoles
- Abstract
- 1: Introduction
- 2: Properties of 1,2,3-triazoles and tetrazoles
- 3: Synthetic strategies for the synthesis of 1,2,3-triazole and tetrazole nucleus
- 4: Recent developments in copper catalysis in the synthesis of 1,2,3-triazoles and tetrazoles
- Chapter 4: Copper catalysis for pyridines and pyrimidines
- Abstract
- 1: Introduction
- 2: Conclusion
- Chapter 5: Copper catalysis for triazines
- Abstract
- Acknowledgment
- 1: Introduction
- 2: Synthesis
- 3: Modification of triazines
- 4: Conclusion
- Chapter 6: Copper catalysis for pyrazines and quinoxalines
- Abstract
- Acknowledgment
- 1: Introduction
- 2: Synthesis of quinoxaline and its congener using copper catalyst
- 3: Synthesis of pyrazine and its congener using copper catalyst
- 4: Conclusion
- Chapter 7: Copper catalysis for the synthesis of quinolines and isoquinolines
- Abstract
- 1: Introduction
- 2: Copper-catalyzed synthesis of quinolines
- 3: Copper-catalyzed synthesis of isoquinolines
- 4: Summary
- Chapter 8: Copper-mediated synthesis of quinazolines and related benzodiazines
- Abstract
- 1: Introduction
- 2: Synthesis of quinazoline derivatives by Cu-mediated condensation/oxidation
- 3: Synthesis of quinazoline derivatives via Ullmann-Goldberg reaction
- 4: Synthesis of quinazoline derivatives using miscellaneous methods
- 5: Synthesis of polycyclic quinazoline derivatives
- 6: Cu-mediated synthesis of other benzodiazines
- 7: Modification of quinazoline and quinoxaline scaffolds
- 8: Conclusion
- Chapter 9: Copper catalysis for large rings
- Abstract
- 1: Introduction
- 2: Copper-catalyzed “click” reaction for the construction of aza-macrocycles
- 3: Copper-catalyzed N-arylation for the construction of aza-large ring
- 4: Copper-catalyzed atom transfer radical cyclization reactions
- 5: Conclusions and outlook
- Chapter 10: Copper catalysis for saturated N-heterocycles via C–H functionalization
- Abstract
- 1: Introduction
- 2: Four-membered saturated N-heterocycles
- 3: Five-membered saturated N-heterocycles
- 4: Six-membered saturated N-heterocycles
- 5: Seven-membered saturated N-heterocycles
- 6: Summary
- Chapter 11: Pursuit for simple and efficient ligands promoting copper-catalyzed Ullmann type reactions for N-aryl heterocycles and aromatic amines
- Abstract
- Acknowledgments
- 1: Introduction
- 2: Ligands in Ullmann reaction: Mechanism for CN bond formation
- 3: Ligands in CN bond formation
- 4: Ligands for promoting Cu-catalyzed CN bond formation in material and drug development
- 5: Conclusions
- Chapter 12: Solid supported copper for N-heterocycles
- Abstract
- Acknowledgments
- 1: Supported nanocatalysts
- 2: Catalysis by Cu-MOFs
- 3: Supported copper salts and complexes
- Chapter 13: Copper catalysis for biologically active N-heterocycles*
- Abstract
- 1: Introduction
- 2: Synthesis of N-heterocycles and their biological activities
- 3: Conclusion
- Index
- Edition: 1
- Published: November 13, 2020
- No. of pages (Paperback): 504
- No. of pages (eBook): 504
- Imprint: Elsevier
- Language: English
- Paperback ISBN: 9780128212639
- eBook ISBN: 9780128215470
AS
Ananya Srivastava
Dr Ananya Srivastava has done her Ph.D. in Synthetic Organic Chemistry at the Department of Chemistry, Indian Institute of Technology Delhi, India. Prior to this, she earned her master of science in chemistry with a gold medal from D.D.U. Gorakhpur University, Gorakhpur, India. Currently, she is employed as a Scientific officer at the National Institute of Pharmaceutical Education and Research, Guwahati, India. Her research contributions are highly interdisciplinary, spanning a wide range in synthetic organic chemistry, nano-catalysis, material characterization, and nanobiosensor. She has published her research work in the leading and representative journals of her research area. She has also presented her research work in various conferences and symposium including 2nd International Symposium on C-H Bond Activation, Rennes, France. She is the recipient of many prestigious awards and fellowships, including JRF and SRF from Council of Scientific & Industrial Research (CSIR), Government of India, invited visiting scholar under NRF fellowship, South Korea to work at Pusan National University, South Korea. She is also the editor of the journal Modern Chemistry & Applications, U.S.A. She has also worked as visiting scientist with Professor Yoon Bo Shim at Department of Chemistry, PNU, South Korea. She has also completed the Patent Law course from the Nalsar University of Law, Hyderabad, India.
Affiliations and expertise
National Institute of Pharmaceutical Education and Research, GuwahatiRead Copper in N-Heterocyclic Chemistry on ScienceDirect