Conformation in Fibrous Proteins and Related Synthetic Polypeptides
- 1st Edition - January 1, 1973
- Imprint: Academic Press
- Editor: R Fraser
- Language: English
- Hardback ISBN:9 7 8 - 0 - 1 2 - 2 6 6 8 5 0 - 0
- Paperback ISBN:9 7 8 - 0 - 1 2 - 4 1 2 4 8 4 - 4
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 1 4 3 9 9 - 8
Conformation in Fibrous Proteins: And Related Synthetic Polypeptides provides a comprehensive and critical account of conformation in fibrous proteins and synthetic polypeptides in… Read more
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Request a sales quoteConformation in Fibrous Proteins: And Related Synthetic Polypeptides provides a comprehensive and critical account of conformation in fibrous proteins and synthetic polypeptides in the solid state. Physical methods of determining conformation are discussed, and relevant results from studies of synthetic polypeptides and fibrous proteins are presented. Comprised of 18 chapters divided into three sections, this book opens with a discussion on the theory and technique of X-ray diffraction applicable to the study of conformation in fibrous materials, along with electron diffraction, electron microscopy, optical diffraction, and infrared spectrophotometry. The procedures used for conformation analysis and prediction are also outlined. The following chapters consider optimization techniques and other methods for elucidating conformation in fibrous proteins and synthetic polypeptides; the use of synthetic polypeptides as models of fibrous proteins; and conformation in fibrous proteins such as silks, collagens, myofibrillar proteins, and keratins. This monograph will be a valuable source of information for molecular biologists.
Preface
Acknowledgments
Abbreviations for Amino Acid Residues
Methods of Determining Conformation
Chapter 1 X-Ray Diffraction
List of Symbols
A. Theory of X-Ray Diffraction
B. Experimental Methods
C. Processing of Observed Data
D. Refinement of Model Structures
E. Summary
Chapter 2 Electron Diffraction
List of Symbols
A. Theory of Electron Diffraction
B. Experimental Techniques
C. Summary
Chapter 3 Electron Microscopy
List of Symbols
A. Contrast
B. Radiation Damage
C. Specimen Preparation
D. Interpretation of Micrographs
E. Summary
Chapter 4 Optical Diffraction
List of Symbols
A. Experimental Arrangement
B. Tests of Model Structures
C. Optical Processing of Electron Micrographs
D. Summary
Chapter 5 Infrared Spectrophotometry
List of Symbols
A. Vibrational Modes of Fibrous Proteins
B. Dichroism
C. Intensity Measurements
Chapter 6 Analysis and Prediction of Conformation
List of Symbols
A. Description of Conformation
B. "Allowed" Conformations
C. Calculation of Potential Energies
D. Intermolecular Interactions
E. Energy Minimization
F. Summary
Chapter 7 Optimization Techniques
List of Symbols
A. Direct Search Methods
B. Gradient Methods
C. Least Squares Methods
D. Constrained Optimization
E. Searches for Global Minima
Chapter 8 Other Methods of Studying Conformation
List of Symbols
A. Ultraviolet Absorption Spectra
B. Optical Rotatory Disperison and Circular Dichroism
C. Birefringence
D. Light Scattering
E. Raman Spectra
F. Mechanical and Thermal Properties
Synthetic Polypeptides as Models of Fibrous Proteins
Chapter 9 The Alpha Helix
A. Introduction
B. Diffraction Studies
C. Infrared Studies
D. Factors Affecting Helix Sense and Geometry
Chapter 10 The Beta Conformation
A. Introduction
B. Homopolymers
C. Sequential Polypeptides
D. Summary
Chapter 11 Poly(Glycine) II, Poly(L-Proline) II, and Related Conformations
A. Introduction
B. Poly(Glycine) II
C. Poly(L-Proline)
D. Poly(L-Hydroxyproline)
E. Polytripeptides
F. Polyhexapeptides
G. Summary
Chapter 12 The Influence of Composition on Conformation
A. Introduction
B. Conformational Effects of Some Individual Residues
C. Classification of Residues
Conformation in Fibrous Proteins
Chapter 13 Silks
A. Introduction
B. Beta Silks
C. Alpha Silks
D. Other Silks
Chapter 14 Collagens
A. Introduction
B. Chemical Nature of Collagen
C. Physical Studies of Chain Conformation
D. Models of Chain Conformation
E. Molecular Structure and Packings
Chapter 15 Myofibrillar Proteins
A. Introduction
B. Actin
C. Tropomyosin
D. Myosin
E. Paramyosin
Chapter 16 Keratins
A. Introduction
B. Mammalian Hard Keratin
C. Soft Mammalian Keratins
D. Beta-Keratin
E. Feather Keratin
F. Other Keratins
Chapter 17 Conformation in Other Fibrous Proteins
A. Fibrin and Fibrinogen
B. Flagellins
C. Elastin and Resilin
Chapter 18 Some General Observations on Conformation
References
Author Index
Subject Index
- Edition: 1
- Published: January 1, 1973
- Imprint: Academic Press
- No. of pages: 648
- Language: English
- Hardback ISBN: 9780122668500
- Paperback ISBN: 9780124124844
- eBook ISBN: 9780323143998
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