Colorectal Neoplasia and the Colorectal Microbiome
Dysplasia, Probiotics, and Fusobacteria
- 1st Edition - August 15, 2020
- Imprint: Academic Press
- Editor: Martin H. Floch
- Language: English
- Paperback ISBN:9 7 8 - 0 - 1 2 - 8 1 9 6 7 2 - 4
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 2 2 5 6 1 - 5
Colorectal Neoplasia and the Microbiome: Dysplasia, Probiotics, and Fusobacteria provides foundational knowledge on the gut microbiome and evidence for an association with colo… Read more
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Request a sales quoteColorectal Neoplasia and the Microbiome: Dysplasia, Probiotics, and Fusobacteria provides foundational knowledge on the gut microbiome and evidence for an association with colorectal neoplasia. It covers the role of microbiota in causing adenomatous polyps and colorectal cancer as well as the modulatory effect of diet and probiotics. Chapters explain a foundational history of microbiology in the colon, the epidemiology of colon polyps and cancer, dysbiosis, the role of immunology and bacteria, and the diet. The book combines medical and scientific aspects to show mechanistic aspects between microbiota and hosts, clearly presenting the association between microbiota, colonic lesions and possible causal links.
The book is essential reading for everyone working with human microbiota including basic scientists, physiologists of the intestine, experts in intestinal microbiota, gastroenterologists, oncologists and surgeon.
- Provides foundational background on the complete history of microbiology in the colon
- Offers thorough coverage of the connection between fusobacterium nucleatum, diet and bacteria on colon health
- Presents the connection between immunology and bacteria in the colon
Gastroenterology basic researchers, physiologists of the intestine, experts in intestinal microbiota, gastroenterologists
- Cover image
- Title page
- Table of Contents
- Copyright
- Dedication
- List of Contributors
- Preface
- Chapter 1. History of bacteriology in the intestine
- Abstract
- Leeuwenhoek and Koch
- Anaerobes
- References
- Chapter 2. Epidemiology of colorectal cancer
- Abstract
- Key points
- Introduction
- Epidemiology
- Risk factors for colorectal cancer
- Screening for colorectal cancer
- Colorectal cancer treatment
- Summary
- References
- Chapter 3. Streptococcus gallolyticus and its implication in colorectal cancer
- Abstract
- General characteristics of the Streptococcus spp. group
- Streptococcus bovis group: identification/classification
- Streptococcus bovis/equinux complex group pathogenesis
- Streptococcus gallolyticus and its relationship with colorectal cancer
- Screening methods and clinical treatments for Stretococcus gallolyticus
- References
- Chapter 4. Bacteroides fragilis
- Abstract
- Enterotoxgenic Bacteroides fragilis in colorectal cancer
- In vitro and in vivo studies of enterotoxigenic Bacteroides fragilis in colorectal cancer
- References
- Chapter 5. Colorectal cancer and the microbiome: dysplasia, probiotics, and Fusobacterium nucleatum
- Abstract
- Introduction
- The gut microbiota
- Lifestyle changes and carcinogenesis
- Role of inflammation in colorectal cancer
- The role of dysbiosis in colorectal cancer
- Specific microbiota involved in cancer
- Role of colonic biofilms in malignancy
- Mechanisms of action of microbes and their secretions in colorectal cancer
- Treatment of colorectal cancer
- Summary
- References
- Further reading
- Chapter 6. Fusobacteria: physiology, form, and function
- Abstract
- Fusobacterial phylogeny
- Fusobacterial growth and metabolism
- Fusobacterial isolation and culture
- Fusobacterial stress responses
- Fusobacterial cell wall–associated virulence determinants
- Fusobacterial genomes
- Fusobacterial plasmids and the development of genetic tools
- Fusobacterial bacteriophages
- Interactions between Fusobacterium spp. and other human gastrointestinal microorganisms
- Interactions between F. nucleatum and gastrointestinal mucosae
- References
- Chapter 7. Dysbiosis of the intestinal microbiota and colorectal cancer
- Abstract
- Intestinal microbiota: the good, the bad, and the ugly
- Dysbiosis and colorectal cancer: a dynamic play of cause and consequence
- Dysbiosis and colorectal cancer: updates on human studies and mouse models
- Is there hope in the hype about the intestinal microbiota?
- Concluding remarks
- References
- Chapter 8. Microbiota, mucosal immunity, and Colon cancer
- Abstract
- Introduction
- Mucosal immunity and intestinal barrier integrity
- Intestinal microbiota, chronic inflammation, and colon carcinogenesis
- Conclusion: Immunomicrobiologic signatures of carcinogenic bacteria for prevention and treatment of colorectal cancer
- References
- Chapter 9. Diet—microbiome interaction in colorectal cancer: a potentially discriminatory role for Fusobacterium nucleatum
- Abstract
- Introduction
- General concepts on diet and risk for disease
- Gut microbiome and diet processing
- Evolutionary effects on modern days gut microbiota–diet relationships and potential links to colorectal cancer
- Diet, gut microbiota, and colorectal cancer
- Therapeutic strategies targeting the microbiome
- Conclusion
- Funding and acknowledgments
- Conflicts of interest statement
- References
- Chapter 10. Colorectal cancer screening
- Abstract
- References
- Index
- Edition: 1
- Published: August 15, 2020
- No. of pages (Paperback): 270
- No. of pages (eBook): 270
- Imprint: Academic Press
- Language: English
- Paperback ISBN: 9780128196724
- eBook ISBN: 9780128225615
MF
Martin H. Floch
Dr. Floch is a Clinical Professor of Medicine at Yale University where he recently formed the Fellow’s Clinic in the Digestive Disease Section supervising all gastrointestinal trainees in consultation on problem cases. He is a Master of the American College of Gastroenterology (MACG) and an American Gastroenterology Association Fellow (AGAF) as well as a Fellow of the American College of Physicians (FACP). He formerly was Chairman of Medicine at Norwalk Hospital and the Founding Chief of Gastroenterology and Nutrition in Norwalk. He is Editor-in-Chief of Journal of Clinical Gastroenterology and has written five books including the 2nd edition of the textbook “Netter’s Gastroenterology”.
Dr. Floch is renowned for his work in gastric and intestinal diseases and probiotics. He lectures nationally and internationally, haven given Grand Rounds at Harvard, Brown, UMass, and UConn among others. He is a consultant to Pfizer, Proctor & Gamble, Dannon, Shire and Biocodex.
His research has been extensive in gastroenterology having had grants from the Armed Forces and National Institute of Health.
Dr. Floch has a FWCI of 1.18 and has the majority (76%) of his content published in gastroenterology journals. 8.7% of his work appears in the top 10% most cited journals worldwide.
Dr. Floch has experience with national, international, institutional and single authorship.
Affiliations and expertise
Clinical Professor of Medicine, Section of Gastroenterology and Nutrition, Yale University School of Medicine, Norwalk Hospital, Norwalk, CT, USARead Colorectal Neoplasia and the Colorectal Microbiome on ScienceDirect