Coeliac Disease and Gluten-Related Disorders
- 1st Edition - October 12, 2021
- Imprint: Academic Press
- Editors: Annalisa Schiepatti, David S. Sanders
- Language: English
- Paperback ISBN:9 7 8 - 0 - 1 2 - 8 2 1 5 7 1 - 5
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 2 1 5 7 2 - 2
Coeliac Disease and Gluten-Related Disorders provides an updated and comprehensive overview on the crucial aspects and clinical management of gluten-related disorders. It provid… Read more
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Request a sales quoteCoeliac Disease and Gluten-Related Disorders provides an updated and comprehensive overview on the crucial aspects and clinical management of gluten-related disorders. It provides an overview of the scientific background, mechanisms involved, and emphasizes the translational effect of research on clinical practice. Highlighted throughout are insights into future research areas likely to have a crucial impact in the clinical management of these common conditions. The book is perfect for researchers and gastroenterologists involved in Coeliac Disease and other gluten-related disorders.
- Presents both research and clinically based perspectives on the most relevant issues of gluten-related disorders
- Provides a wide-ranging discussion and the most updated opinions by international experts in the field of coeliac disease and gluten-related disorders
- Translates the latest research insights into practical suggestions for specialists
Gastroenterology and Health Science Researchers, General Practitioners, Gastroenterologists
- Cover Image
- Title Page
- Copyright
- Table of Contents
- Contributors
- Chapter 1 Epidemiology and clinical features of celiac disease in adults
- Abstract
- 1.1 Introduction
- 1.2 Initial epidemiological studies based on clinical symptoms
- 1.3 Modern epidemiological study based on the serological test
- 1.4 Global prevalence of CeD
- 1.5 Global seroprevalence of CeD
- 1.6 Global prevalence of biopsy-confirmed CeD
- 1.7 Prevalence of CeD by gender and age
- 1.8 Continent wise prevalence of CeD
- 1.9 Extra-intestinal manifestations of CeD (Table 1.2 and Table 1.3)
- 1.10 Mortality in celiac disease
- References
- Chapter 2 Pediatric coeliac disease
- 2.1 Introduction: Distinct features of pediatric coeliac disease
- 2.2 Clinical presentation
- 2.3 Diagnosis
- 2.4 Screening of children for coeliac disease
- 2.5 Treatment and monitoring of paediatric coeliac disease
- 2.6 Toward primary prevention of coeliac disease?
- 2.7 Summary
- References
- Chapter 3 Pathogenesis of coeliac disease – a disorder driven by gluten-specific CD4+ T cells
- Abstract
- 3.1 Inductive and effector sites within the gut immune system
- 3.2 Induction of adaptive immune response to gluten
- 3.3 Gluten-specific CD4+ T cells
- 3.4 Functional role of gluten-specific CD4+ T cells
- 3.5 Concluding remarks
- References
- Chapter 4 Seronegative villous atrophy
- Abstract
- 4.1 Introduction
- 4.2 Seronegative coeliac disease
- 4.3 Immunomediated non-coeliac enteropathies
- 4.4 Enteropathies due to infectious causes
- 4.5 Lymphoproliferative disorders causing villous atrophy
- 4.6 Villous atrophy due to inflammatory disorders
- 4.7 Idiopathic villous atrophy
- 4.8 Methodological approach to differential diagnosis and management of seronegative villous atrophy
- 4.9 Conclusions
- References
- Chapter 5 Nonresponsive and complicated coeliac disease
- Abstract
- 5.1 Introduction
- 5.2 Dietary indiscretion and mucosal healing
- 5.3 An alternative pathology
- 5.4 Refractory coeliac disease
- 5.5 Other complications of coeliac disease
- 5.6 Clinical approach
- 5.7 Concluding remarks
- Supplementary materials
- Acknowledgments
- Author contributions
- Conflicts of interest
- References
- Chapter 6 New perspectives on the diagnosis of adulthood coeliac disease
- Abstract
- 6.1 Introduction
- 6.2 Neoepitopes
- 6.3 Gluten tetramers
- 6.4 Point-of-care tests
- 6.5 Detection of CeD autoantibodies in saliva and feces
- 6.6 Detection of CeD-specific VOC biomarkers in urine and feces
- 6.7 No biopsy strategy
- 6.8 Empowering the intestinal biopsy
- 6.9 Conclusions
- References
- Chapter 7 Non-dietary therapies for celiac disease
- Abstract
- 7.1 Introduction
- 7.2 Aims of research and therapy
- 7.3 Therapeutic targets and drugs
- 7.4 Clinical trial endpoints
- 7.5 Clinical trial pitfalls
- 7.6 Summary
- References
- Chapter 8 Dermatitis herpetiformis -- a cutaneous manifestation of coeliac disease
- Abstract
- 8.1 Epidemiology of dermatitis herpetiformis
- 8.2 Pathogenesis of dermatitis herpetiformis: from gut to skin
- 8.3 Clinical features of dermatitis herpetiformis
- 8.4 Diagnosis of dermatitis herpetiformis
- 8.5 Treatment of dermatitis herpetiformis
- 8.6 Long-term prognosis of dermatitis herpetiformis
- 8.7 Concluding remarks
- References
- Chapter 9 Noncoeliac gluten sensitivity
- Abstract
- 9.1 Introduction
- 9.2 The clinical picture
- 9.3 IBS – NCGS – or both? What can be learned from RCTs?
- 9.4 The gluten-free market
- 9.5 Immunobiology of gluten in NCGS (and CD)
- 9.6 The possible culprits
- 9.7 Serological and genetic markers
- 9.8 Clinical investigation – the view of the clinical dietician
- 9.9 The FODMAP approach
- 9.10 Summary
- References
- Chapter 10 Pediatric noncoeliac gluten sensitivity
- Abstract
- 10.1 Introduction
- 10.2 Definition and epidemiology of NCGS/NCWS in children
- 10.3 Clinical features and diagnosis of NCGS/NCWS in children
- 10.4 Histological features of NCGS/NCWS in children
- 10.5 Therapeutic approach to NCGS/NCWS in children
- 10.6 Conclusion
- References
- Chapter 11 Neurological manifestations of gluten-related disorders
- Abstract
- 11.1 Introduction
- 11.2 Gluten ataxia
- 11.3 Gluten neuropathy
- 11.4 Gluten encephalopathy
- 11.5 Epilepsy
- 11.6 Gluten myopathy
- 11.7 Pathophysiology
- 11.8 Conclusions
- References
- Chapter 12 The role of gluten in multiple sclerosis, psoriasis, autoimmune thyroid diseases and type 1 diabetes
- Abstract
- 12.1 Introduction
- 12.2 Gluten
- 12.3 Multiple sclerosis
- 12.4 Psoriasis
- 12.5 Autoimmune thyroid diseases
- 12.6 Type 1 diabetes
- 12.7 Concluding remarks
- References
- Chapter 13 Irritable bowel syndrome
- Abstract
- 13.1 Introduction
- 13.2 Gluten free diet
- 13.3 Low FODMAP diet
- 13.4 Traditional dietary advice
- 13.5 Challenges of dietary studies
- 13.6 Choice of dietary therapy
- 13.7 Conclusion
- References
- Index
- Edition: 1
- Published: October 12, 2021
- Imprint: Academic Press
- No. of pages: 278
- Language: English
- Paperback ISBN: 9780128215715
- eBook ISBN: 9780128215722
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Annalisa Schiepatti
Annalisa Schiepatti is a researcher with the faculty of Medicine and Surgery at the University of Pavia, Pavia Italy. Her major areas of research include coeliac disease and its complications, Whipple’s Disease and other rare enteropathies causing severe malabsorption.
Affiliations and expertise
Researcher, Faculty of Medicine and Surgery, University of Pavia, Pavia, ItalyDS
David S. Sanders
Professor David Sanders is Professor of Gastroenterology at The University of Sheffield and an NHS consultant based in The Academic Unit of Gastroenterology, Royal Hallamshire Hospital. He is the current Chair of the Coeliac UK Health Advisory Council, BSG Council Member and President of the International Society for the Study of Coeliac Disease (ISSCD). He is a medical doctor, international researcher and author with a longstanding clinical and research experience in the field of coeliac disease and gluten-related disorders.
Affiliations and expertise
Professor of Gastroenterology, The University of Sheffield; NHS Consultant, The Academic Unit of Gastroenterology, Royal Hallamshire Hospital, UKRead Coeliac Disease and Gluten-Related Disorders on ScienceDirect