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Elsevier

Clinical Ethics at the Crossroads of Genetic and Reproductive Technologies

Clinical Ethics at the Crossroads of Genetic and Reproductive Technologies offers thorough discussions on preconception carrier screening, genetic engineering and the use of CRISPR… Read more

Description

Clinical Ethics at the Crossroads of Genetic and Reproductive Technologies offers thorough discussions on preconception carrier screening, genetic engineering and the use of CRISPR gene editing, mitochondrial gene replacement therapy, sex selection, predictive testing, secondary findings, embryo reduction and the moral status of the embryo, genetic enhancement, and the sharing of genetic data. Chapter contributions from leading bioethicists and clinicians encourage a global, holistic perspective on applied challenges and the moral questions relating the implementation of genetic reproductive technology. The book is an ideal resource for practitioners, regulators, lawmakers, clinical researchers, genetic counselors and graduate and medical students.

As the Human Genome Project has triggered a technological revolution that has influenced nearly every field of medicine, including reproductive medicine, obstetrics, gynecology, andrology, prenatal genetic testing, and gene therapy, this book presents a timely resource.

Key features

  • Provides practical analysis of the ethical issues raised by cutting-edge techniques and recent advances in prenatal and reproductive genetics
  • Contains contributions from leading bioethicists and clinicians who offer a global, holistic perspective on applied challenges and moral questions relating to genetic and genomic reproductive technology
  • Discusses preconception carrier screening, genetic engineering and the use of CRISPR gene editing, mitochondrial gene replacement therapy, ethical issues, and more

Readership

Active researchers, basic and translational scientists, clinicians, and students in the areas of human genetics, medical genetics, genomics, reproductive medicine, gynecology, obstetrics, andrology, embryology, prenatal testing, and genetic testing; genetic counselors; bioethicists; fertility specialists; lawmakers and regulators; medical students and residents; pharmacologists

Table of contents

1. Genomic Editing—From Human Health to the “Perfect Child”

2. Ethics of Mitochondrial Gene Replacement Therapy

3. Reproductive Technologies Used by Same Gender Couples

4. Ethical Issues Raised by Multiparents

5. Revisiting the Nondirective Principle of Genetic Counseling in Prenatal Screening

6. Sex Selection, Gender Selection, and Sexism

7. The Impact of Big Data on Beginning of Life Issues

8. The Moral Status of the Embryo From the Standpoint of Social Perceptions

9. Fetal Reduction

10. Stem Cell Therapies for Neurodegenerative Disorders. An Ethical Analysis

11. Predictive Genetic Testing in Multifactorial Disorders

12. Whole-Genome Sequencing as a Method of Prenatal Genetic Diagnosis

13. Noninvasive Prenatal Genetic Diagnosis

14. Prenatal Testing in Low-Risk Populations: A US Perspective

15. Using Genetics for Enhancement (Liberal Eugenics)

16. Should Incidental Findings Arising From Prenatal Testing be Reported Indiscriminately to Patients?

17. Third Party Sharing of Genetic Information

Product details

About the editor

SH

Sorin Hostiuc

Sorin Hostiuc, MD, PhD, is Professor in the Department of Legal Medicine and Bioethics at Carol Davila University of Medicine and Pharmacy, Bucharest, Romania, and Senior Physician at the National Institute of Legal Medicine, Bucharest, Romania. Dr. Hostiuc has written extensively on topics such as informed consent, research ethics, history of medical ethics, and reproductive ethics, with more than 200 published articles in The Lancet, New England Journal of Medicine, PLOS ONE, Journal of Translational Medicine, and Frontiers in Neuroscience, among other journals. He has also published four monographs in Romanian dealing with bioethical issues: A Treaty of Medical and Dental Bioethics, Ethics of Scientific Research, Ethics of Scientific Publishing, and Informed Consent as well as a book about the history of informed consent in Europe. Dr. Hostiuc received his PhD in medicine and MD from Carol Davila University of Medicine and Pharmacy.
Affiliations and expertise
Professor, Department of Legal Medicine and Bioethics, Department 2, Faculty of Dentistry, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania, Medical Manager, National Institute of Legal Medicine, Bucharest, Romania

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