Clinical Chemistry
Fundamentals and Laboratory Techniques
- 1st Edition - December 12, 2015
- Imprint: Saunders
- Author: Donna Larson
- Language: English
- Paperback ISBN:9 7 8 - 1 - 4 5 5 7 - 4 2 1 4 - 1
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 2 9 2 5 3 - 5
Gain a clear understanding of pathophysiology and lab testing! Clinical Chemistry: Fundamentals and Laboratory Techniques prepares you for success as a medical lab technicia… Read more
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Request a sales quoteGain a clear understanding of pathophysiology and lab testing! Clinical Chemistry: Fundamentals and Laboratory Techniques prepares you for success as a medical lab technician by simplifying complex chemistry concepts and lab essentials including immunoassays, molecular diagnostics, and quality control. A pathophysiologic approach covers diseases that are commonly diagnosed through chemical tests — broken down by body system and category — such as respiratory, gastrointestinal, and cardiovascular conditions. Written by clinical chemistry educator Donna Larson and a team of expert contributors, this full-color book is ideal for readers who may have minimal knowledge of chemistry and are learning laboratory science for the first time.
- Full-color illustrations and design simplify complex concepts and make learning easier by highlighting important material.
- Case studies help you apply information to real-life scenarios.
- Pathophysiology and Analytes section includes information related to diseases or conditions, such as a biochemistry review, disease mechanisms, clinical correlation, and laboratory analytes and assays.
- Evolve companion website includes case studies and animations that reinforce what you’ve learned from the book.
- Laboratory Principles section covers safety, quality assurance, and other fundamentals of laboratory techniques.
- Review questions at the end of each chapter are tied to the learning objectives, helping you review and retain the material.
- Critical thinking questions and discussion questions help you think about and apply key points and concepts.
- Other Aspects of Clinical Chemistry section covers therapeutic drug monitoring, toxicology, transplantation, and emergency preparedness.
- Learning objectives in each chapter help you to remember key points or to analyze and synthesize concepts in clinical chemistry.
- A list of key words Is provided at the beginning of each chapter, and these are also bolded in the text.
- Chapter summaries consist of bulleted lists and tables highlighting the most important points of each chapter.
- A glossary at the back of the book provides a quick reference to definitions of all clinical chemistry terms.
- Cover image
- Title page
- Table of Contents
- Copyright
- Dedication
- Acknowledgments
- Contributors
- Reviewers
- Preface
- Part 1. Laboratory Principles
- 1. Laboratory Essentials
- Points to Remember
- Introduction
- History of Clinical Laboratories
- Types of Clinical Laboratories
- Regulation and Accreditation of Clinical Laboratories
- Laboratory Materials
- Chemistry Review
- Laboratory Mathematics
- Summary
- 2. Practical Laboratory Safety
- Case in Point
- Points to Remember
- Introduction
- Safety Regulations
- The Laboratory Safety Program
- Summary
- 3. Principles of Laboratory Instrumentation
- Points to Remember
- Introduction
- Properties of Light
- Spectrophotometry
- Fluorometry
- Luminometry
- Nephelometry and Turbidimetry
- Electrochemistry and Chemical Sensors
- Chromatography
- Mass Spectrometry
- Electrophoresis
- Colligative Properties
- Point-of-Care Testing
- Flow Cytometry
- Summary
- 4. Immunoassays
- Case in Point
- Points to Remember
- Introduction
- Antibodies, Antigens, and Analytes
- Immunochemical Methods
- Label Methods
- Particle Methods
- Light-Scattering Methods
- Factors Affecting Immunoassay Analytical Performance
- Summary
- 5. Molecular Diagnostics
- Points to Remember
- Introduction
- Nucleic Acid Structure and Function
- Laboratory Methods
- Diagnostic Applications
- Summary
- 6. Automation in the Laboratory
- Points to Remember
- Introduction
- Goal of Automation
- History of Automated Analyzers
- Automating Clinical Chemistry Tests
- Total Laboratory Automation
- Summary
- 7. Laboratory Quality Management Systems
- Case in Point
- Points to Remember
- Introduction
- Introduction to Quality
- Facilities and Safety Overview
- Purchasing and Inventory
- Process Control
- Assessment
- Personnel
- Customer Service
- Occurrence Management
- Process Improvement
- Documents and Records
- Organization
- Summary
- 8. Enzymes
- Case in Point
- Points to Remember
- Introduction
- The Nature of Enzymes
- Kinetics
- Enzyme Reaction Conditions
- Isoenzymes
- Specific Enzymes
- Summary
- Part 2. Pathophysiology and Analytes
- 9. Clinical Chemistry and Disease
- Case in Point
- Points to Remember
- Introduction
- Definition of Disease
- Pathology
- Disease Mechanisms
- Biochemistry of Disease
- Summary
- 10. Cell Injury and Its Relationship to Disease
- Case in Point
- Points to Remember
- Introduction
- Overview of Cellular Injury
- Causes of Cellular Injury
- Changes in Body Chemistry
- Laboratory Tests
- Summary
- 11. Inflammation
- Case in Point
- Points to Remember
- Introduction
- Defense Mechanisms
- The Inflammation Process
- Acute Inflammation
- Chronic Inflammation
- Laboratory Procedures and Limitations
- Summary
- 12. Body Fluids and Electrolytes
- Case in Point
- Points to Remember
- Introduction
- Fluid Balance and Body Fluid Compartments
- Electrolytes
- Colligative Properties
- Fluid Imbalances
- Summary
- 13. Blood Gases and Acid-Base Balance
- Case in Point
- Points to Remember
- Introduction
- Blood Gases
- Acid-Base Theory
- Acid-Base Disorders
- Interpreting Blood Gas Analyses
- Summary
- 14. Blood Diseases
- Case in Point
- Points to Remember
- Introduction
- Hematopoiesis
- White Blood Cells
- Red Blood Cells
- Summary
- 15. Proteins
- Case in Point
- Points to Remember
- Introduction
- Biochemistry of Proteins
- Plasma Proteins
- Proteins in Other Body Fluids
- Summary
- 16. Cancer and Tumor Markers
- Case in Point
- Points to Remember
- Introduction
- Cancer and Tumor Markers
- Clinical Correlations
- Summary
- 17. Blood Vessel Diseases
- Case in Point
- Points to Remember
- Introduction
- Lipids
- Lipoproteins
- Normal Lipoprotein Metabolism
- Abnormal Lipoprotein Metabolism
- Laboratory Procedures and Limitations
- Lipoproteins and Clinical Vascular Disease
- Summary
- 18. Heart Disease
- Case in Point
- Points to Remember
- Introduction
- Heart Structure and Blood Flow
- Myocardial Infarction
- Congestive Heart Failure
- Congenital Heart Defects
- Endocarditis, Myocarditis, and Pericarditis
- Summary
- 19. Respiratory Diseases
- Case in Point
- Points to Remember
- Introduction
- Structure and Function of the Respiratory System
- Respiratory Diseases and Pathophysiology
- Summary
- 20. Gastrointestinal Disease
- Case in Point
- Points to Remember
- Introduction
- Gastrointestinal System
- Gastrointestinal Function Tests
- Summary
- 21. Diseases of the Liver
- Case in Point
- Points to Remember
- Introduction
- Liver and Biliary Tract
- Liver Diseases
- Summary
- 22. Pancreatic Diseases and Disorders
- Case in Point
- Points to Remember
- Introduction
- Overview of the Pancreas
- Pancreatitis
- Diabetes
- Cystic Fibrosis
- Malabsorption and Maldigestion
- Summary
- 23. Endocrinology
- Case in Point
- Points to Remember
- Introduction
- Overview of the Endocrine System
- Anatomy, Pathophysiology, and Laboratory Testing
- Summary
- 24. Kidney and Urinary Tract Diseases
- Case in Point
- Points to Remember
- Introduction
- Kidney Anatomy
- Normal Physiology
- Disease States
- Laboratory Procedures
- Summary
- 25. Reproductive Diseases and Disorders
- Case in Point
- Points to Remember
- Introduction
- Reproductive System Structure and Function
- Diseases and Disorders
- Laboratory Procedures and Limitations
- Summary
- 26. Pregnancy
- Case in Point
- Points to Remember
- Introduction
- Pregnancy
- Complications of Pregnancy
- Fetal Complications
- Laboratory Diagnosis of Fetal Abnormalities
- Summary
- 27. Bone, Joint, and Skeletal Muscle Diseases
- Case in Point
- Points to Remember
- Introduction
- Normal Anatomy and Physiology of Bones
- Bone Diseases
- Normal Anatomy and Physiology of Joints
- Joint Diseases
- Normal Anatomy and Physiology of Muscles
- Muscle Diseases
- Summary
- 28. Nervous System Diseases
- Case in Point
- Points to Remember
- Introduction
- Nervous System Anatomy and Physiology
- Nervous System Diseases
- Cerebrospinal Fluid Analysis
- Summary
- 29. Skin, Hair, and Nail Diseases
- Case in Point
- Points to Remember
- Introduction
- Skin Diseases
- Effects of Systemic Disease on Skin
- Hair Diseases
- Nail Diseases
- Summary
- 30. Eye and Ear Diseases
- Case in Point
- Points to Remember
- Introduction
- Eyes
- Ears
- Summary
- 31. Nutritional and Metabolic Diseases
- Case in Point
- Points to Remember
- Introduction
- General Concepts of Health and Disease
- Cold Injuries
- Heat Illnesses
- Nutritional Conditions
- Metabolic Diseases
- Inborn Errors of Metabolism
- Summary
- 32. Immune System Diseases
- Case in Point
- Points to Remember
- Introduction
- Normal Immune System
- Disease States
- Summary
- Part 3. Other Aspects of Clinical Chemistry
- 33. Therapeutic Drug Monitoring
- Case in Point
- Points to Remember
- Introduction
- Drug Disposition
- Administration of Drugs
- Drug Levels
- Cardiovascular Drugs
- Antibiotics
- Antiepileptic Drugs
- Psychoactive Drugs
- Bronchodilators
- Immunosuppressant Drugs
- Summary
- 34. Toxicology
- Case in Point
- Points to Remember
- Introduction
- Routes of Exposure
- Dose-Response Relationship
- Acute and Chronic Toxicity
- Specimen Collecting and Handling
- Conditions Caused by Pollutants
- Toxic Agents
- Household Products
- Toxic Metals
- Drugs of Abuse
- Summary
- 35. Transplantation
- Case in Point
- Points to Remember
- Introduction
- Overview of Transplantation
- Role of Medical Laboratories in Transplantation
- Overview of the Immune System
- Role of the Immune System in Transplantation
- Immunosuppression
- Exceptional Cases in Transplantation
- Future of Transplantation
- 36. Emergency Preparedness
- Case in Point
- Points to Remember
- Introduction
- Emergency Preparedness
- Emergency Response
- Laboratory Response Network
- Summary
- Glossary
- Answer Key
- Index
- Edition: 1
- Published: December 12, 2015
- Imprint: Saunders
- No. of pages: 736
- Language: English
- Paperback ISBN: 9781455742141
- eBook ISBN: 9780323292535
DL
Donna Larson
Affiliations and expertise
Dean of Allied Health
Mt Hood Community College
Gresham, Oregon