Clinical and Experimental Toxicology of Organophosphates and Carbamates

ForewordPrefaceList of ContributorsAbbreviations Used in the TextPart 1 Basic Science 1 Overview of the Biological and Clinical Aspects of Organophosphates and Carbamates 2 Biochemical Determination of Cholinesterase Activity in Biological Fluids and Tissues 3 Histochemical Localization of Cholinesterase in Anticholinesterase Poisoning 4 Pharmacology and Toxicology of Organophosphates 5 Pharmacology and Toxicology of Carbamates 6 Structure-Activity Relationships and Anticholinesterase ActivityPart 2 Neurotoxicity 7 Neurobehavioural Toxicology of Anticholinesterases 8 Central Neurotoxicity and Behavioural Effects of Anticholinesterases 9 Acute and Subchronic Neurotoxicity and Cardiotoxicity of Anticholinesterases 10 Molecular Events in Delayed Neuropathy: Experimental Aspects of Neuropathy Target Esterase 11 Validation of a Rodent Model of Organophosphorus-Induced Delayed Neuropathy 12 Intermediate Syndrome in Anticholinesterase NeurotoxicityPart 3 Specific Organ and Long-Term Toxicology 13 Cardiac Effects of Anticholinesterase Agents 14 Effects of Organophosphates on the Heart 15 Effects of Anticholinesterases on Airway Smooth Muscle 16 Pulmonary Toxicity of Anticholinesterases 17 Anticholinesterase-Induced Myonecrosis 18 Ophthalmic Toxicology of Anticholinesterases 19 Nephrotoxicity of Anticholinesterases 20 Immunotoxicology of Anticholinesterase Agents 21 Immunotoxic Effects of Anticholinesterases 22 Genotoxic and Carcinogenic Potential of Anticholinesterases 23 Developmental and Reproductive Toxicity of AnticholinesterasesPart 4 Environmental Aspects 24 Agricultural and Veterinary Toxicology of Anticholinesterases 25 Avian Toxicology of Anticholinesterases 26 Ecotoxicological Consequences of Interactions between Avian Esterases and Organophosphorus Compounds 27 Toxicity of Anticholinesterases to Aquatic OrganismsPart 5 Exposure Patterns 28 Cutaneous Absorption of Anticholinesterases 29 Respiratory Tract Absorption of Anticholinesterases 30 Exposure of Agricultural Workers to Anticholinesterases 31 Greenhouse Exposure to Anticholinesterases 32 Commercial and Residential Poisoning with Anticholinesterases 33 Residues of Anticholinesterases in Foodstuffs 34 Organophosphorus Compounds as Chemical Warfare Agents 35 Combustion Toxicology of AnticholinesterasesPart 6 Protection and Monitoring 36 General Considerations on Workplace Safety for Anticholinesterases 37 Physical Protection Against Anticholinesterases 38 Screening of Agricultural Workers for Exposure to Anticholinesterases 39 Monitoring for Exposure to Anticholinesterase-Inhibiting Organophosphorus and Carbamate Compounds by Urine Analysis 40 Neurophysiological Monitors of Anticholinesterase ExposurPart 7 Clinical Toxicology by Geographical Regions 41 Organophosphate Poisoning in the UK: The National Poisons Information Service Experience during 1984-1987 42 Incidence, Presentation and Therapeutic Attitudes to Anticholinesterase Poisoning in the USA 43 Incidence, Presentation and Therapeutic Attitudes to Anticholinesterase Poisoning in Asia 44 Incidence, Presentation and Therapeutic Attitudes to Anticholinesterase Poisoning in Egypt 45 Anticholinesterases used in the USSR: Poisoning, Treatment and Preventative Measures 46 Acute Anticholinesterase Poisoning in ChinaPart 8 Clinical and Therapeutic Aspects 47 Clinical Presentation and Diagnosis of Acute Organophosphorus Insecticide and Carbamate Poisoning 48 Pseudocholinesterase Deficiency and Anticholinesterase Toxicity 49 Clinical Management of Acute Organophosphate Poisoning: an Overview 50 Anticholinesterase Poisoning: an Overview of Pharmacotherapy 51 Atropine in the Management of Anticholinesterase Poisoning 52 Efficacy, Toxicity and Clinical use of Oximes in Anticholinesterase Poisoning 53 Anticonvulsants in Anticholinesterase Poisoning 54 Calcium Channel Blocking Agents in the Management of Acute Anticholinesterase Poisoning 55 Acetylcholinesterase Sequestration of Organophosphate Intoxicants 56 Prophylaxis Against Anticholinesterase Poisoning 57 Role of Poison Control Centres in the Recognition and Management of Anticholinesterase Poisoning 58 Forensic Aspects of Acute Anticholinesterase Poisoning 59 Aerial Application and Spray Drift of Anticholinesterases: Protective MeasuresIndex