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Chronobiology: Biological Timing in Health and Disease
- 1st Edition, Volume 119 - July 27, 2013
- Editor: Martha Gillette
- Language: English
- Hardback ISBN:9 7 8 - 0 - 1 2 - 3 9 6 9 7 1 - 2
- eBook ISBN:9 7 8 - 0 - 1 2 - 3 9 7 2 8 0 - 4
This special volume of Progress in Molecular Biology and Translational Science focuses on chrono… Read more
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Request a sales quoteThis special volume of Progress in Molecular Biology and Translational Science focuses on chronobiology.
- Contributions from leading authorities
- Informs and updates on all the latest developments in the field
Researchers in molecular biology and translational science
Contributors
Introduction to Biological Timing in Health and Disease
References
Chapter One. The Suprachiasmatic Nucleus and the Circadian Timing System
1 Introduction
2 The Emergence of a Circadian Neurobiology
3 Anatomical Organization of the SCN
4 Afferent and Efferent Connections
5 Conclusions
6 Reprise
References
Chapter Two. Epigenetic Regulation of the Molecular Clockwork
1 Introduction to Epigenetics and the Circadian Clock
2 Circadian Epigenetics and Synaptic Plasticity in the Brain
3 Linking the Circadian Metabolome and Metabolism to Epigenetics
4 Conclusions
References
Chapter Three. Diversity of Human Clock Genotypes and Consequences
1 Introduction
2 BMAL1
3 Clock
4 NPAS2
5 PER1
6 PER2
7 PER3
8 CRY1
9 CRY2
10 REV-ERBα
11 CK1ε
12 CK1δ
13 CUL1
14 β-TrCP
15 DEC1
16 DEC2
17 TIMELESS
18 Concluding Remarks
References
Chapter Four. Peripheral Circadian Oscillators: Time and Food
1 Introduction
2 The SCN as Master Clock
3 The Peripheral Oscillators and Their Relationship with Clock Genes
4 The SCN as the Driving Force Behind the Oscillators
5 Synchronization of the Circadian System by the SCN
6 Timing by Food?
7 Energy Oscillation in the Cell
8 Heme as Another Metabolic Clock Connection Possibility
9 The Link Between Clock Genes and Metabolic Genes
10 Conclusions
Acknowledgments
References
Chapter Five. Circadian Clocks, Food Intake, and Metabolism
1 Introduction
2 Physiology
3 Pathology
4 Chronotherapeutics
5 Conclusion
Acknowledgments
References
Chapter Six. Control of Sleep and Wakefulness in Health and Disease
1 The Brain Stem
2 The Hypothalamus
3 The Cortex
4 The Endocrine System
5 The Rest
References
Chapter Seven. Circadian Rhythms, Sleep Deprivation, and Human Performance
1 Introduction
2 Sleep–Wake and Circadian Regulation: Two-Process Model
3 Circadian Rhythms of Performance
4 Protocols to Assess Circadian Variation in Neurobehavioral Functions
5 Interindividual Variability in Circadian Rhythms
6 Sleep Deprivation and Performance
7 Conclusions
Acknowledgments
References
Chapter Eight. Timing, Sleep, and Respiration in Health and Disease
1 Introduction
2 Normal Breathing
3 Circadian Rhythms and Breathing
4 Sleep and Breathing
5 Implications for Human Disease
6 Conclusions
References
Chapter Nine. The Circadian Clock in Cancer Development and Therapy
1 Introduction
2 Circadian Dysfunction Promotes Cancer Development in Humans
3 Circadian Disruption Promotes Cancer Development in Animal Models
4 The Role of the Mammalian Circadian Clock in Tumor Suppression
5 Anticancer Chronotherapy
6 Conclusions
Acknowledgments
References
Chapter Ten. Health Consequences of Circadian Disruption in Humans and Animal Models
1 Introduction
2 Circadian Regulation
3 Types of Circadian Disruption in Humans and Animal Models
4 Health Consequences of Circadian Disruption
5 Future Research Questions
References
Chapter Eleven. Sleep and Circadian Rhythm Disruption in Social Jetlag and Mental Illness
1 The Biology of Sleep
2 Sleep and Circadian Rhythm Disruption Arising from Social Timing
3 SCRD and Psychoses
4 A Conceptual Framework for SCRD in Psychiatric Illness
5 Conclusions
References
Index
- No. of pages: 376
- Language: English
- Edition: 1
- Volume: 119
- Published: July 27, 2013
- Imprint: Academic Press
- Hardback ISBN: 9780123969712
- eBook ISBN: 9780123972804
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