Chromatin Remodelling and Immunity

Chapter One: Chromatin Remodeling in Monocyte and Macrophage Activation

• Abstract
• 1 Introduction
• 2 The Multidimensional Model of Monocyte and Macrophage Activation
• 3 Epigenetics of Tissue Macrophages in Homeostasis
• 4 Epigenetic Regulation During Stress Signal-Induced Activation
• 5 Evidence for Epigenetic Regulation During Trained Immunity and Tolerance
• 6 Conclusion
• Acknowledgments

Chapter Two: Roles of SMC Complexes During T Lymphocyte Development and Function

• Abstract
• 1 Overview of Chromatin Dynamics During T Cell Development and Activation
• 2 Epigenetic Phenomena in T Cell Development and Function
• 3 Structure of SMC Complexes
• 4 Classical Functions of SMC Complexes
• 5 Involvement of SMC Complexes in T Cell Development
• 6 Roles of SMC Complexes in Peripheral T Cell Biology
• 7 Regulation of Gene Expression in T Cells by SMC Complexes
• 8 Regulation of SMC Complexes
• 9 Conclusions and Outlook

Chapter Three: The Role of Epigenetic Regulation in Transcriptional Memory in the Immune System

• Abstract
• 1 Introduction
• 2 Chromatin Structure and Function
• 3 Epigenetic Mechanisms as a Basis for Cellular Memory
• 4 Epigenetic Mechanisms as a Basis for Transcriptional Memory
• 5 Conclusions
• Acknowledgments

Chapter Four: Histone Acetylation and the Regulation of Major Histocompatibility Class II Gene Expression

• Abstract
• 1 Introduction
• 2 Histone Acetylation Correlates with Active MHC Class II Transcription
• 3 Interplay Between CIITA Chromatin Remodeling Factors
• 4 Regulation of MHC Class II Gene Expression by Long-Range Chromatin Remodeling
• 5 Epigenetic Regulation of CIITA Expression
• 6 Epigenetic Immune Escape by Mycobacterial Infection
• 7 Tumor Immunosurveillance Escape and Antitumor Therapy with HDAC Inhibitors
• 8 Conclusion

Chapter Five: Mechanisms of Chromatin Remodeling and Repurposing During Extracellular Translocation

• Abstract
• 1 Introduction
• 2 Chromatin Translocation In Vitro
• 3 Release of Microparticles
• 4 In Vitro Systems for Chromatin Translocation
• 5 In Vivo Systems for Chromatin Translocation
• 6 Immune Activities of Chromatin Components
• 7 Remodeled Chromatin as a Biomarker
• 8 Remodeled Chromatin as a Target of Therapy
• 9 Conclusion

Chapter Six: Epigenetic Changes in Chronic Inflammatory Diseases

• Abstract
• 1 Introduction
• 2 Epigenetic Processes
• 3 Epigenetic Modification Influence Mediators of Inflammation
• 4 Epigenetics in Chronic Inflammatory Diseases
• 5 Conclusions
• Acknowledgments

Chapter Seven: Regulation of Cellular Immune Responses in Sepsis by Histone Modifications

• Abstract
• 1 Introduction
• 2 Histone Modifications: Potent Tools for Epigenetic Control
• 3 Histone Modifications and Postseptic Innate Immune Responses
• 4 Histone Modifications and Postseptic Adaptive Immune Responses
• 5 Conclusions and Future Perspectives
• 6 Summary

Chapter Eight: A New Molecular Mechanism Underlying the Antitumor Effect of DNA Methylation Inhibitors via an Antiviral Immune Response

• Abstract
• 1 Introduction
• 2 Chromatin Remodeling Mediated by DNA Methylation and Histone Modification
• 3 Activation of Tumor-Suppressor miRNAs by Chromatin-Modifying Drugs in Cancer Cells
• 4 Induction of Immune Response by Chromatin-Modifying Drugs in Cancer Cells
• 5 Activation of ERVs by Chromatin Remodeling
• 6 Inhibition of DNA Methylation Suppresses Cancer Cells by Inducing an Antiviral Immune Response
• Acknowledgments

Chapter Nine: Chromatin Remodeling and Plant Immunity

• Abstract
• 1 Introduction
• 2 Snf2 Proteins and ATP-Dependent Chromatin Remodeling
• 3 Classification, Subunit Composition, and Functions of Plant Snf2 Proteins
• 4 Snf2 Proteins Involved in Plant Immunity
• 5 Concluding Remarks