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Chromatin Remodeling Complexes and Transcriptional Coregulators
- 1st Edition, Volume 53 - September 22, 2023
- Editors: Laurie S. Kaguni, David Arnosti
- Language: English
- Hardback ISBN:9 7 8 - 0 - 4 4 3 - 1 6 0 0 7 - 3
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 1 6 0 0 8 - 0
Chromatin Remodeling Complexes and Transcriptional Coregulators, Volume 53, the latest release in The Enzymes series highlights new advances in the field, with interesting n… Read more
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Request a sales quoteChromatin Remodeling Complexes and Transcriptional Coregulators, Volume 53, the latest release in The Enzymes series highlights new advances in the field, with interesting new chapters that cover Perspectives on Chromatin Remodeling, The functions of ISWI-type remodelers in yeast, Conserved mechanisms of NuRD function in hematopoietic gene expression, The SIN3 complex as a metabolic epigenetic regulator, Soft repression and chromatin modification by conserved transcriptional corepressors, The NPAC-LSD2 complex in nucleosome demethylation, Role of intrinsically disordered domains in transcriptional regulation, and Regulation of the Recovery of Cancer from Therapy Exposure by Noncoding RNAs.
- Provides the authority and expertise of leading contributors from an international board of authors
- Updated release includes the latest information on Chromatin remodeling complexes and transcriptional coregulators
- Presents the latest release in The Enzymes series
Researchers, students, and professors interested in chromatin remodeling, ISWI-type remodelers, hematopoetic gene expression, SIN3 complex, NPAC-LSD2 complex, soft repression and chromatin modification, noncoding RNAs
- Cover image
- Title page
- Table of Contents
- Series Page
- Copyright
- Contributors
- Preface
- Chapter One: Perspectives on ATP-dependent chromatin remodeling
- Abstract
- 1: The many facets of chromatin biology
- 2: Nucleosomes are intrinsically immobile
- 3: Early studies of chromatin assembly
- 4: Discovery of chromatin remodeling factors
- 5: The Snf2-like family of motor proteins
- 6: Mechanism of function of molecular motors
- 7: Regulation of the activity of chromatin remodeling factors
- 8: Future perspectives
- Acknowledgments
- References
- Chapter Two: Conserved mechanisms of NuRD function in hematopoetic gene expression
- Abstract
- 1: Regulation of gene transcription during differentiation
- 2: The NuRD complex
- 3: Vertebrate hematopoiesis
- 4: NuRD guides lineage decisions during hematopoiesis
- 5: NuRD teams up with hematopoietic transcription factors
- 6: NuRD and FOG1—a well-studied liaison
- 7: NuRD and γ-globin silencing
- 8: Hematopoiesis and NuRD in invertebrates
- 9: Conservation of the Ush/FOG-NuRD axis
- 10: Open questions
- 11: Concluding remarks
- Acknowledgments
- References
- Chapter Three: Coordination of cross-talk between metabolism and epigenetic regulation by the SIN3 complex
- Abstract
- 1: Introduction
- 2: Feedback between metabolite level and epigenetic regulation
- 3: Epigenetic regulators are sensitive to metabolite levels
- 4: Metabolic enzymes that affect gene expression through activity in the nucleus
- 5: The SIN3 histone modifying complex at the nexus between epigenetics and metabolism
- 6: Metabolic diseases affected by epigenetic regulators
- 7: Conclusions
- Acknowledgments
- References
- Chapter Four: Soft repression and chromatin modification by conserved transcriptional corepressors
- Abstract
- 1: Introduction: Microbial antecedents and insights into transcriptional repression
- 2: Transcriptional repression revealed through developmental studies
- 3: Genomic approaches to understand properties of eukaryotic transcriptional repressors and corepressors
- 4: Evidence for conservation of eukaryotic transcriptional repressors and corepressors
- 5: Mechanisms of repressors and corepressors
- 6: Histone remodeling and modifying complexes in repression
- 7: Repressor and corepressor interactions with the basal transcriptional machinery and nuclear environment
- 8: Soft repression: A mechanism for dynamic control of widely expressed metabolic genes
- 9: Soft repression, or a continuum of repression activities
- 10: Mechanistic studies to understand soft repression effects
- 11: Impact of studying soft repression
- Acknowledgments
- References
- Chapter Five: The NPAC-LSD2 complex in nucleosome demethylation
- Abstract
- 1: Introduction
- 2: NPAC as an epigenetic reader and nucleosome binder
- 3: The tetrameric dehydrogenase domain of NPAC
- 4: The LSD2-binding site on NPAC
- 5: LSD2 associated complex in transcriptional elongation
- Acknowledgments
- References
- Chapter Six: Regulatory miRNAs in cancer cell recovery from therapy exposure and its implications as a novel therapeutic strategy for preventing disease recurrence
- Abstract
- 1: Introduction
- 2: A short primer on miRNAs
- 3: The limited success of miRNA based therapies in treating cancer
- 4: A proposed novel use for miRNA-targeted therapies
- 5: Cell stress states that promote recovery from therapy exposure
- 6: Strategies to prevent recovery from therapy exposure
- 7: Future directions
- Acknowledgments
- References
- No. of pages: 282
- Language: English
- Edition: 1
- Volume: 53
- Published: September 22, 2023
- Imprint: Academic Press
- Hardback ISBN: 9780443160073
- eBook ISBN: 9780443160080
LK
Laurie S. Kaguni
Laurie S. Kaguni is at Michigan State University, MI, USA
Affiliations and expertise
Michigan State University, MI, USADA
David Arnosti
Dr. Arnosti completed his Ph.D. at the University of California, Berkeley. He is interested in research on metazoan transcriptional regulation's fundamental mechanisms in the context of development.
Affiliations and expertise
Professor, Department of Biochemistry and Molecular Biology, Michigan State University, USARead Chromatin Remodeling Complexes and Transcriptional Coregulators on ScienceDirect