Chromatin Proteins and Transcription Factors as Therapeutic Targets

Chapter One: Targeting Chromatin Remodeling in Inflammation and Fibrosis

• Abstract
• 1 Inflammation Initiation in Mucosal Surfaces
• 2 Central Role of NFκB in Regulating the Innate Immune Response
• 3 Mechanisms of Inducible Gene Expression
• 4 Transcriptional Elongation in Rapid Inflammatory Responses
• 5 Mechanisms Linking Chronic Inflammation to Mesenchymal Transition and Airway Fibrosis
• 6 The RelA–BRD4 Pathway Links Inflammation, Fibrosis, and Airway Remodeling
• 7 Effects of the Mesenchymal Cell-State Change on Innate Responses
• 8 Therapeutic Targets in the RelA-Triggered Innate/Fibrotic Pathway
• 9 Discussion and Outlook
• Acknowledgments

Chapter Two: HMGB1 Protein: A Therapeutic Target Inside and Outside the Cell

• Abstract
• 1 Introduction
• 2 HMGB1—General Overview
• 3 HMGB1 in the Nucleus—An Architectural Factor
• 4 HMGB1 Outside the Cell
• 5 HMGB1 as a Therapeutic Target
• 6 HMGB1 as a Target of miRs
• 7 Concluding Remarks

Chapter Three: Targeting IKK and NF-κB for Therapy

• Abstract
• 1 IKK and NF-κB Signaling
• 2 NF-κB Target Gene Specificity
• 3 NF-κB in Inflammation, Survival, and Proliferation
• 4 IKK and NF-κB Signaling in Disease
• 5 Targeting IKK and NF-κB Signaling
• 6 IKK/NF-κB and Anticancer Drug Resistance
• 7 Clinical Trials
• 8 Concluding Remarks
• Acknowledgments

Chapter Four: NF-κB as a Therapeutic Target in Inflammatory-Associated Bone Diseases

• Abstract
• 1 Introduction
• 2 Inflammation and Bone Disorders
• 3 Inflammation and NF-κB Signaling
• 4 NF-κB and Bone Remodeling
• 5 Pharmaceutical Approaches to Modulate NF-κB Activity
• 6 Drug Delivery Strategies in Bone Disorders
• 7 Conclusion

Chapter Five: The Functional Stability of FOXP3 and RORγt in Treg and Th17 and Their Therapeutic Applications

• Abstract
• 1 Introduction
• 2 Regulation of FOXP3 Function in Tregs
• 3 Regulation of RORγt Function in Th17
• 4 Plasticity of Treg and Th17 in Health and Diseases
• 5 Plasticity of Treg and Th17 Cell Lineages
• 6 Concluding Remarks
• Acknowledgments

Chapter Six: The Complex Role of the ZNF224 Transcription Factor in Cancer

• Abstract
• 1 Introduction
• 2 ZNF224 Interacts With Distinct Partners to Elicit Differential Regulatory Pathways
• 3 Multiple Roles of KRAB-ZFPS in Cancer
• 4 ZNF224 as a New Therapeutic Target in Cancer
• 5 Conclusions

Chapter Seven: Transcription Factors in Breast Cancer—Lessons From Recent Genomic Analyses and Therapeutic Implications

• Abstract
• 1 Introduction
• 2 Features of Oncogenic Alterations in TFs
• 3 Altered TFs Involved in Super-Enhancers and Positive Transcriptional Elongation
• 4 Induction of TFs Through Mutations in DNA-Binding Sites and Altered Chromatin Conformation
• 5 Additional TFs Implicated in BC but Not Identified by Recent Genomic Analyses
• 6 Therapeutic Implications
• 7 Approaches to Target-Specific Genetic Alterations in TFs
• 8 Targeting Frequently Altered TFs in BC
• 9 Concluding Remarks
• Acknowledgments

Chapter Eight: Transcription Factors as a Target for Vaccination Against Ticks and Mites

• Abstract
• 1 Introduction
• 2 Targets From Mites and Ticks
• 3 Targeting Pathogens and Symbionts
• 4 Conclusions
• Acknowledgments

Chapter Nine: Elucidating the Mutational Landscape in Hepatocyte Nuclear Factor 1β (HNF1B) by Computational Approach

• Abstract
• 1 Introduction
• 2 Materials and Methods
• 3 Results
• 4 Discussion
• 5 Conclusion
• Acknowledgment