
Chitosan-Based Nanoparticles for Biomedical Applications
- 1st Edition - October 30, 2024
- Imprint: Woodhead Publishing
- Editors: Charles Oluwaseun Adetunji, Michael K Danquah, Jaison Jeevanandam, Daniel Ingo Hefft, Sharadwata Pan, Tabassum Asif Khan
- Language: English
- Paperback ISBN:9 7 8 - 0 - 4 4 3 - 1 3 9 9 7 - 0
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 1 3 9 9 8 - 7
Chitosan-Based Nanoparticles for Biomedical Applications explores the use of chitosan-based nanoparticles as a sustainable solution for the development of improved therapeut… Read more

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Request a sales quoteChitosan-Based Nanoparticles for Biomedical Applications explores the use of chitosan-based nanoparticles as a sustainable solution for the development of improved therapeutic and diagnostic techniques. A range of biomedical applications is reviewed, including treatment against highly resistant bacteria and parasites; tissue regeneration; drug delivery, and more. Moreover, the application of chitosan-based nanoparticles for the effective delivery of hormones, vaccines, phytochemicals, nutraceuticals, and their application in immobilization of enzymes is also discussed in detail. This book provides a state-of-the-art overview for materials scientists, pharmaceutical scientists, and researchers with an interest in the development of novel materials for therapeutics.
- Provides a comprehensive overview of chitosan-based nanoparticles, from extraction, synthesis and characterization to biomedical applications, clinical trials and toxicological considerations
- Covers a range of biomedical applications, including nutraceuticals, wound healing, antimicrobial treatment, cancer therapeutics, and more
- Utilizes an interdisciplinary approach, combining materials science, biochemistry, and bioscience inputs to appeal to a broad audience
- Title of Book
- Cover image
- Title page
- Table of Contents
- Copyright
- List of contributors
- Chapter 1. Extraction, properties, and modification of chitosan-based nanoparticles
- Abstract
- 1.1 Introduction
- 1.2 Preparation of chitosan
- 1.3 Extraction of Chitosan-based nanoparticles
- 1.4 Properties of chitosan
- 1.5 Properties of chitosan-based nanoparticles
- 1.6 Uses of chitosan-based nanoparticles
- 1.7 Modification of chitosan-based nanoparticles
- 1.8 Recent reports on chitosan-based nanoparticles
- 1.9 Conclusion
- References
- Chapter 2. Bioinformatics, instrumentation, and control for modeling, synthesis, and characterization of chitosan based nanoparticles
- Abstract
- 2.1 Introduction
- 2.2 Bioinformatics and its role in chitosan-based nanoparticle synthesis
- 2.3 Integration of biological and chemical data
- 2.4 Examples of bioinformatics tools and databases for nanoparticle research
- 2.5 Instrumentation for nanoparticle synthesis
- 2.6 Modeling the synthesis of nanoparticle-based on chitosan
- 2.7 Integration of bioinformatics, instrumentation, and modeling
- 2.8 Integration of bioinformatics and instrumentation in nanoparticle research
- 2.9 Characterization of chitosan nanoparticles
- 2.10 Predictive modeling and design of chitosan nanoparticles
- 2.11 Targeted delivery systems
- 2.12 Computational modeling techniques
- 2.13 Bioinformatics tools for molecular modeling
- 2.14 Conclusion
- References
- Chapter 3. Biosynthesized and natural chitosan-based nanoparticles for biomedical applications
- Abstract
- 3.1 Introduction
- 3.2 Properties of chitosans
- 3.3 Synthesis and characterization of biosynthesized and natural chitosan-based nanoparticles
- 3.4 Natural chitosan-based nanoparticles
- 3.5 Natural sources of chitosans
- 3.6 Extraction techniques for chitosan from natural sources
- 3.7 Characterization of natural chitosan-based nanoparticles
- 3.8 Biomedical applications of biosynthesized and natural chitosan-based nanoparticles
- 3.9 Toxicity and biocompatibility issues
- 3.10 In vivo studies of chitosan-based nanoparticles
- 3.11 Regulatory and ethical considerations
- 3.12 Emerging trends in chitosan-based nanoparticle
- 3.13 Future direction for research and development
- 3.14 Conclusion
- References
- Chapter 4. Chitosan-based nanoformulation of phytochemicals for biomedical applications
- Abstract
- 4.1 Introduction
- 4.2 Application of chitosan-based nanoparticles in biomedical industries
- 4.3 Application of chitosan-based nanoparticle in bacterial infection treatment
- References
- Chapter 5. Chitosan-based nanoformulation of metal and metal oxide nanoparticles
- Abstract
- 5.1 Introduction
- 5.2 Production and characterization of metal oxide and metal nanoparticles
- 5.3 Characterization techniques of nanoparticles
- 5.4 Utility of chitosan-based nanoformulations in biomedical and environmental field
- 5.5 Utility of chitosan-based nanoformulations in biomedical imaging and diagnosis
- 5.6 Industrial and environmental applications
- 5.7 Challenges and future directions associated with natural chitosan-based nanoparticles
- 5.8 Conclusion
- References
- Chapter 6. Application of chitosan-based nanoparticles in the treatment of cancer
- Abstract
- 6.1 Introduction
- 6.2 Challenges in current cancer treatment approaches
- 6.3 Properties of chitosan
- 6.4 Advantages of chitosan-based nanoparticles for cancer therapy in the delivery of drugs
- 6.5 Synthesis of chitosan-based nanoparticles
- 6.6 Importance of controlled synthesis of chitosan nanoparticles
- 6.7 Chemotherapeutic agents
- 6.8 Cell culture studies demonstrating nanoparticles effectiveness
- 6.9 Assessment of cytotoxicity and biocompatibility
- 6.10 Animal model in evaluation of therapeutic outcomes
- References
- Chapter 7. Chitosan-based nanoparticles for insulin delivery and diabetes treatment
- Abstract
- 7.1 Introduction
- 7.2 Glucose and its regulation
- 7.3 Insulin
- 7.4 Mechanism of action of insulin
- 7.5 Management of diabetes
- 7.6 Nanotechnology and uses in biomedicine
- 7.7 Use of nanoparticles in food technology
- 7.8 Application of nanoparticles in cosmetology
- 7.9 Nanoparticles in medicine
- 7.10 Chitosan
- 7.11 Chitosan as nanoparticle for insulin delivery
- 7.12 Conclusion
- References
- Chapter 8. Enhanced chitosan-based nanoformulation for antifungal applications
- Abstract
- 8.1 Introduction
- 8.2 Chitosan
- 8.3 Chitosan-based nanoformulations
- 8.4 Chitosan-based nanoformulations and applications
- 8.5 Chitosan-based nanoformulations and antifungal activity
- 8.6 Target parts of fungi
- 8.7 Going forward: how to further improve the antifungal activity
- 8.8 Conclusion
- References
- Chapter 9. Application of chitosan-based nanoparticles as an effective antibacterial agent
- Abstract
- 9.1 Introduction
- 9.2 Chitosan-based nanoparticles as antibacterial agents
- 9.3 Mode of action of chitosan-based nanoparticles on bacteria
- 9.4 Factors influencing the bacterial efficacy of chitosan-based nanoparticles
- 9.5 Applications of the antibacterial efficacy of chitosan-embedded nanoparticles
- 9.6 Conclusion
- References
- Chapter 10. Chitosan-based nanoparticles to treat highly resistant microorganisms and pathogenic parasites
- Abstract
- 10.1 Introduction
- 10.2 General overview of highly resistant microorganisms and pathogenic parasites
- 10.3 General overview of parasites with specific examples
- 10.4 Mechanisms of chitosan-based nanoparticles against highly resistant microorganisms and pathogenic parasites
- 10.5 Bacteriostatic or bactericidal?
- 10.6 Membrane destruction or disruption?
- 10.7 Oxidative stress
- 10.8 Immune system modulation
- 10.9 Factors affecting antibacterial activity
- 10.10 Bacterial species type
- 10.11 Bacterial growth stage
- 10.12 Zeta potential
- 10.13 pH
- 10.14 Concentrations
- 10.15 Effect of molecular weight and acetylation level
- 10.16 Advantages and limitations in medical aspects
- 10.17 Limitations
- 10.18 Conclusion
- References
- Chapter 11. Healthcare application of chitosan-based nanoparticles incorporated with antimicrobial textile
- Abstract
- 11.1 Introduction
- 11.2 Sources and chemical composition of chitosan
- 11.3 Improving the efficacy of chitosan
- 11.4 Chitosan characteristics
- 11.5 Physical properties of chitosan
- 11.6 Solubility of chitosan
- 11.7 Chemical properties of chitosan
- 11.8 Biodegradability of chitosan
- 11.9 Toxicity of chitosan nanoparticles
- 11.10 Modification of chitosan
- 11.11 Antimicrobial properties of chitosan
- 11.12 Biomedical application of chitosan as nanoparticulate polymer formulations
- 11.13 Nanoparticles as spray-drying preparation
- 11.14 Nanoparticles loaded electrospun nanofibers
- 11.15 D-nanofibrous scaffold
- 11.16 Halloysite nanotube-based nanocomposite films
- 11.17 Freeze-dried biocompatible nanocomposite carboxymethyl cellulose
- 11.18 Nanotechnology in textile applications
- 11.19 Nanofilament and chitosan-based filament
- 11.20 Chitosan-textile finishing and its applications
- 11.21 Chitosan as a microbial inhibitor in textile-finishing
- 11.22 Antimicrobial mechanisms of chitosan nanoparticles
- 11.23 Chitosan advantages as a microbicidal agent incorporated in textiles
- 11.24 Drawbacks of chitosan as a textile microbicidal agent
- 11.25 Summary
- 11.26 Conclusion
- References
- Chapter 12. Application of chitosan-based nanoparticles for the treatment of kidney diseases
- Abstract
- 12.1 Introduction
- 12.2 Chitosan-based nanoparticles
- 12.3 Kidney diseases
- 12.4 Effective application of chitosan-based nanoparticles for the treatment of kidney diseases
- 12.5 Current scenario and future perspectives
- 12.6 Conclusion
- References
- Chapter 13. Application of chitosan-based nanoparticles for the treatment of liver diseases
- Abstract
- 13.1 Introduction
- 13.2 Chitosan
- 13.3 Nanochitosan preparation
- 13.4 Toxicity of chitosan nanoparticles
- 13.5 Benefits derived from nanochitosan
- 13.6 Conclusion
- References
- Chapter 14. Chitosan-based nanoparticles for the treatment of neurological disorders
- Abstract
- 14.1 Introduction
- 14.2 Chitosan
- 14.3 Potential use of nanoparticles as drug carriers
- 14.4 Chitosan based nanoparticles
- 14.5 Challenges in neurological disorder treatments
- 14.6 Application of chitosan based nanoparticles in neuronal disorders
- 14.7 Application of chitosan-based nanoparticles in treatment of Alzheimer’s disease
- 14.8 Application of chitosan based nanoparticles in treatment of Parkinson’s disease
- 14.9 Application of chitosan based nanoparticles in treatment of epilepsy
- 14.10 Application of chitosan based nanoparticles in treatment of multiple sclerosis
- 14.11 Application of chitosan based nanoparticles in treatment of strokes
- 14.12 Limitations associated with the use of chitosan based nanoparticles for the treatment of neurological disorders
- 14.13 Conclusion
- References
- Chapter 15. Chitosan based nanoparticles for the treatment of rare genetic diseases
- Abstract
- 15.1 Introduction
- 15.2 Rare genetic diseases: prevalence and impact on patients and families
- 15.3 Chitosan-based nanoparticles: harnessing biocompatibility, biodegradability, and non-toxicity for advanced drug delivery systems
- 15.4 Drug delivery potential of chitosan-based nanoparticles: enhancing therapeutic outcomes
- 15.5 Significance of chitosan-based nanoparticles in rare genetic diseases
- 15.6 Applications of chitosan-based nanoparticles in the treatment of rare genetic diseases: unveiling therapeutic possibilities through advanced drug delivery
- 15.7 Recent studies and their relevance to the global economy
- 15.8 Challenges and future directions in the utilization of chitosan-based nanoparticles for treating rare genetic diseases
- 15.9 Conclusion
- References
- Chapter 16. Chitosan-based nanoformulations for alopecia treatment
- Abstract
- 16.1 Introduction
- 16.2 Minoxidil topical administration methods
- 16.3 Nanomaterials for androgenetic alopecia drug delivery
- 16.4 Problems with toxicity
- 16.5 Regulatory affairs
- 16.6 Conclusion and future perspectives
- References
- Chapter 17. Chitosan-based nanoformulation as nebulizer for nasal drug delivery in cystic fibrosis treatment
- Abstract
- 17.1 Introduction
- 17.2 Cystic fibrosis
- 17.3 Chitosan-based nanoformulations
- 17.4 Conclusion
- References
- Chapter 18. Chitosan-based nanoparticles as an antihypercholesterol agent
- Abstract
- 18.1 Introduction
- 18.2 Pathogenesis of hypercholesterolemia
- 18.3 Chitosan-based nanoparticles
- 18.4 Chitosan-based nanoparticles as an anti-hypercholesterol agent
- 18.5 Summary and future perspectives
- References
- Chapter 19. Chitosan based nanocarriers for delivery of therapeutic agents
- Abstract
- 19.1 Introduction
- 19.2 Chitosan nanoparticles
- 19.3 Recent in vivo/in vitro investigation of chitosan-based nanoparticles as therapeutic agent
- 19.4 Future challenges and opportunities
- 19.5 Conclusion
- References
- Chapter 20. Chitosan-based nanoparticles as an effective hormone delivery agent
- Abstract
- 20.1 Introduction
- 20.2 The fundamentals of chitosan
- 20.3 Chitosan-based nanomaterials for controlled bioactive agents release
- 20.4 Chitosan-based nanoparticles for hormone delivery
- 20.5 Delivery of estradiol
- 20.6 Delivery of progesterone
- 20.7 Delivery of human chorionic gonadotropin
- 20.8 Delivery of follicle-stimulating hormone
- 20.9 Delivery of luteinizing hormone-releasing hormone
- 20.10 Delivery of oxytocin
- 20.11 Delivery of insulin
- 20.12 Delivery of thyroxin
- 20.13 Delivery of testosterone
- 20.14 Delivery of growth hormone-releasing hormone
- 20.15 Conclusion
- References
- Chapter 21. Chitosan-based nanoparticles for tissue engineering and wound healing application
- Abstract
- 21.1 Introduction
- 21.2 Chitosan-based nanoparticles in tissue engineering
- 21.3 Bone regeneration using chitosan-based nanoparticles
- 21.4 Dental regeneration using chitosan-based nanoparticles
- 21.5 Cartilage regeneration using chitosan-based nanoparticles
- 21.6 Cardiac and nervous tissues regeneration using chitosan-based biomaterials
- 21.7 Wound healing
- 21.8 Chitosan-based biomaterials for wound healing and skin regeneration
- 21.9 Chitosan-based membranes for wound healing and skin regeneration
- 21.10 Chitosan-based hydrogels for wound healing and skin regeneration
- 21.11 Conclusion
- References
- Chapter 22. Nutraceutical applications of chitosan-based nanoparticles
- Abstract
- 22.1 Introduction
- 22.2 Natural products
- 22.3 Preparation of chitosan nanoparticles
- 22.4 Synthesis of nanoparticles from biological samples of plants
- 22.5 Nutraceutical applications of chitosan-based nanoparticles
- 22.6 Conclusion
- References
- Chapter 23. Machine learning models in clinical trials of chitosan-based nanoparticles potency
- Abstract
- 23.1 Introduction
- 23.2 The significance of artificial intelligence and machine learning techniques
- 23.3 Machine learning techniques
- 23.4 Nanoinformatics and machine learning
- 23.5 Challenges in the domains of machine learning and nanoinformatics
- 23.6 Clinical trials for nanomedicine
- 23.7 Clinical trials using machine learning for nanoparticles based on chitosan
- 23.8 The machine learning models in different clinical trials of chitosan-based nanoparticles
- 23.9 Biosafety and efficacy evaluation
- 23.10 Knowledge discovery and data integration
- 23.11 Drug delivery optimization
- 23.12 Personalized treatment strategies
- 23.13 Toxicity prediction
- 23.14 Examples of artificial intelligence and machine learning applications in nanosecurity
- 23.15 Conclusion
- Reference
- Chapter 24. Toxicology of nanoengineered chitosan
- Abstract
- 24.1 Introduction
- 24.2 Physicochemical properties of chitosan-based nanoparticles
- 24.3 Toxicology of nanoengineered chitosans
- 24.4 Nanochitosan biodegradation
- 24.5 Biodistribution of nanoengineered chitosan
- 24.6 Conclusion
- References
- Chapter 25. Chitosan-based nanoparticles in the management of cardiovascular disease
- Abstract
- 25.1 Introduction
- 25.2 Delivery of microRNAs by chitosan nanoparticles to functionally alter macrophage cholesterol efflux in vitro and in vivo
- 25.3 Challenges and future directions
- 25.4 Nanoparticles for the treatment of ischemic heart diseases
- 25.5 Novel approaches and combinations
- 25.6 Addressing insufficient local drug deposit
- 25.7 Chitosan and curcumin nanoformulations against potential cardiac risks associated with hydroxyapatite nanoparticles in Wistar male rats
- 25.8 Conclusion
- References
- Chapter 26. Chitin and chitosan: evolving application landscape in tissue engineering, wound healing, and drug delivery
- Abstract
- Highlights
- 26.1 Introduction
- 26.2 Chitin and chitosan in bone tissue engineering application
- 26.3 Wound healing application
- 26.4 Chitosan in drug delivery
- 26.5 Conclusion
- 26.6 Future prospects
- Author contributions
- Conflicts of interest
- References
- Chapter 27. Recent advances in the application of next-generation chitosan-based nanoparticles applied in the management of numerous kidney diseases and its complications
- Abstract
- 27.1 Introduction
- 27.2 Properties of chitosan-based nanoparticles
- 27.3 Application of chitosan-based nanoparticles
- 27.4 Chitosan-based nanoparticles for kidney therapy
- 27.5 Advances in chitosan-based nanoparticles for drug delivery
- 27.6 Conclusion and future trends on chitosan-based nanoparticles for the treatment of kidney disease
- References
- Chapter 28. Current trends in the utilization of next-generation chitosan-based for sustainable treatment of liver diseases
- Abstract
- 28.1 Introduction
- 28.2 Pathophysiology of liver disease
- 28.3 Chitosan-based nanoparticles for the treatment of liver disease
- 28.4 Conclusion
- References
- Chapter 29. Recent applications of chitosan-based nanoformulated metal and metal oxide nanoparticles
- Abstract
- 29.1 Introduction
- 29.2 Techniques of processing chitosan-based nanoformulation of metal oxide and metal nanoparticles
- 29.3 Recent advance in chitosan-based nanoformulation of metal oxide and metal nanoparticles
- 29.4 Significance importance of chitosan-based nanoformulation of metal oxide and metal nanoparticles
- 29.5 Conclusion and future trends
- 29.6 Future trends
- References
- Chapter 30. Application of nanochitosan for detection and diagnosis of diseases
- Abstract
- 30.1 Introduction
- 30.2 Utilization of nanochitosan for detection and diagnosis of diseases: useful considerations
- 30.3 Role of nanochitosan in the detection and diagnosis of infertility
- 30.4 Application of nanochitosan as adjuvant nanodiagnostic for heavy metal–induced diseases
- 30.5 Nanochitosan for other diagnostic purposes
- 30.6 Discussion
- 30.7 Conclusion
- References
- Index
- Edition: 1
- Published: October 30, 2024
- Imprint: Woodhead Publishing
- No. of pages: 656
- Language: English
- Paperback ISBN: 9780443139970
- eBook ISBN: 9780443139987
CA
Charles Oluwaseun Adetunji
Prof. Charles Oluwaseun Adetunji is a full Professor at the Department of Microbiology, Faculty of Sciences and the Director of Research and Innovation, Edo State University Uzairue (EDSU), Edo State, Nigeria. He formerly served as the Acting Director of Intellectual Property and Technology Transfer, Head of the Department of Microbiology, and Sub Dean of the Faculty of Science. Currently, he holds the positions of Chairman of the Grant Committee and Dean of the Faculty of Science at EDSU.
Prof. Adetunji is a Fellow of the Royal Society of Biology in the UK. Additionally, he serves as a Visiting Professor and the Executive Director of the Center for Biotechnology at Precious Cornerstone University, Nigeria. His research centers on applying biological techniques and microbial bioprocesses to achieve Sustainable Development Goals (SDGs) and contribute to advancements in agriculture.
MK
Michael K Danquah
JJ
Jaison Jeevanandam
DH
Daniel Ingo Hefft
SP
Sharadwata Pan
Dr. Sharadwata Pan obtained his tertiary education (Bachelors and Masters in Technology, 2002-2007) in Biotechnology in India. Following this, he obtained his PhD degree in 2015, working in an interdisciplinary area transcending molecular biotechnology and polymer physics, via a unique, dual-badged programme between Indian Institute of Technology Bombay, India and Monash University, Australia. Since 2016, he is working in Germany, first as a scientific staff at the Technical University of Munich (2016-2023), and currently (2023-to date), in the same capacity at the Friedrich-Alexander University of Erlangen-Nuremberg. For the past 6 years or so, his main expertise encompass developing the next generation of patentable healthcare, cosmetics and biomedical products, partnering with German SMEs and raising third party research grants (> 1M €) to carry out cutting edge and application oriented research, primarily targeted towards industrial product development. His main focus lies on generating sustainable solutions and specializes in benchmarking existing commercial products and conceptualization of innovative techniques to tune novel prototypes.
TK