Chemistry, Biology, and Medicine of Neurohypophyseal Hormones and Their Analogs
The Peptides Analysis, Synthesis, Biology, Vol. 8
- 1st Edition - November 14, 2013
- Editors: Sidney Udenfriend, Johannes Meienhofer, Clark W. Smith
- Language: English
- Paperback ISBN:9 7 8 - 1 - 4 8 3 2 - 0 4 5 8 - 1
- eBook ISBN:9 7 8 - 1 - 4 8 3 2 - 1 8 0 1 - 4
Chemistry, Biology, and Medicine of Neurohypophyseal Hormones and Their Analogs, Volume 8 covers the advances in methods to study peptide hormone action at the molecular level. The… Read more
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Chemistry, Biology, and Medicine of Neurohypophyseal Hormones and Their Analogs, Volume 8 covers the advances in methods to study peptide hormone action at the molecular level. The book discusses the anatomy, physiology, and clinical disorders of the neurohypophysis; the biosynthesis of neurohypophyseal peptides; and the structure-activity relationships of neurohypophyseal peptides, with an emphasis on the role of conformational features. The text also describes conformational studies of neurohypophyseal hormones by physical chemical techniques; the central nervous system effects of neurohypophyseal peptides; and the effects of neurohypophyseal hormones on the kidney. The effects of neurohypophyseal hormones on the cardiovascular systems are also considered. Chemists, neurobiologists, and people involved in the study of neurohypophyseal hormones will find the book invaluable.
Preface IX
Chapter 1 Clinical Disorders of the Neurohypophysis
I Anatomy
II Synaptic Input
III Physiology
IV Pathophysiologic Mechanisms
V Hypofunction of the Neurohypophysis: Diabetes Insipidus
VI Hyperfunction of the Posterior Pituitary—Syndrome of Inappropriate Secretion of Antidiuretic Hormone
References
Chapter 2 The Other Neurohypophyseal Peptides
I Introduction
II Opioid Peptides
III Hypothalamic Releasing and Release-Inhibiting Factors
IV Gastrointestinal Peptides
V Other Peptides
VI Physiological Significance of Other Neurohypophyseal Peptides
References
Chapter 3 Biochemistry and Biology of Vasopressin, Oxytocin, and Their Corresponding Neurophysins
I Introduction
II Structural Aspects—Polyproteins
III Vasopressin and Oxytocin—Functional Aspects
IV Gene Structure
V Comparison of the Bovine and Rat Genes
VI Transcriptional Control
VII Precursor Structure
VIII Processing and Modifications
IX Genetic Defect—Diabetes Insipidus
X Expression in Peripheral Tissues
XI Perspectives
References
Chapter 4 Structure-Activity Relationships of Neurohypophyseal Peptides
I. Introduction
II. Naturally Occurring Neurohypophyseal Hormones—An Overview
III. Structure-Activity Relationships of Oxytocin Agonists
IV. Structure-Activity Relationships of Antagonist Analogs of the Neurohypophyseal Hormones That Competitively Block the Actions of the Native Hormone at Receptors for Oxytocin
V. Structure-Activity Relationships of Vasopressin Agonists
VI. Antagonist Analogs of the Neurohypophyseal Hormones That Competitively Block the Action(s) of the Native Hormones at Receptors for Vasopressin
VII. Concluding Remarks
References
Chapter 5 The Conformation of Neurohypophyseal Hormones
I Introduction
II Theories Relating Conformation to Activity
III Conformational Assignments
IV Energy-Based Molecular Modelling
V Summary and Conclusions
Chapter 6 Central Nervous System Effects of Neurohypophyseal Peptides
I Introduction
II Animal Studies
III Human Studies—Neurohypophyseal Peptides and Memory
IV Neurohypophyseal Peptides and Drug Tolerance and Dependence
V Effects of Oxytocin in the CNS
VI CNS Effects of Neurohypophyseal Peptides Not Related to Learning or Memory
VII Possible Sites and Mechanisms of Action of Neurohypophyseal Peptides in the CNS
VIII Conclusions
References
Chapter 7 Renal Effects and Hormonal Interaction with the Neurohypophyseal Hormone, Vasopressin
I Introduction
II Nephron Sites of AVP Action
III Cellular Action of Hydroosmotic Action of AVP
IV Modulating Factors of AVP Action
V Interactions of Other Hormones and AVP
VI Role of AVP in Pathophysiological States
VII Effect of AVP on Chloride and Other Electrolyte Transport
VIII Effect of AVP on Renal Hemodynamics
IX Effect of AVP on Renin Secretion
X Other Renal Effects and Metabolism
XI AVP Antagonists
References
Chapter 8 Cardiovascular Effects of Neurotiypophyseal Peptides
I Effects on Cells
II Local Effects on Regional Vascular Tissues
III Integrated Hemodynamic Effects
IV Effects of Vasopressin on Neural Control of Circulation
V Agonists and Antagonists Used to Study Cardiovascular Effects
VI Summary
References
Index
- Edition: 1
- Published: November 14, 2013
- Language: English
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