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Challenges and Opportunities of Next-Generation Sequencing for Biomedical Research
1st Edition, Volume 89 - October 4, 2012
Editor: Mark Rees
Hardback ISBN:9780123942876
9 7 8 - 0 - 1 2 - 3 9 4 2 8 7 - 6
eBook ISBN:9780123982735
9 7 8 - 0 - 1 2 - 3 9 8 2 7 3 - 5
Published continuously since 1944, the Advances in Protein Chemistry and Structural Biology serial has been a continuous, essential resource for protein chemists. Covering reviews… Read more
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Published continuously since 1944, the Advances in Protein Chemistry and Structural Biology serial has been a continuous, essential resource for protein chemists. Covering reviews of methodology and research in all aspects of protein chemistry, including purification/expression, proteomics, modeling and structural determination and design, each volume brings forth new information about protocols and analysis of proteins while presenting the most recent findings from leading experts in a broad range of protein-related topics. This volume features articles on Challenges and Opportunities of Next-Generation Sequencing for Biomedical Research.
Covers reviews of methodology and research in all aspects of protein chemistry
Brings forth new information about protocols and analysis of proteins while presenting the most recent findings from leading experts in a broad range of protein-related topics
Biochemists, biophysicists, cell biologists, protein chemists, structural geneticists, and structural biologists
Preface
Chapter One Next Generation Sequencing Methodologies - An Overview
1 Introduction/NGS
2 Sample Submission Strategies
3 Phenotyping Challenges and Strategies
4 Development of NGS Technologies
5 Application of NGS
6 Bioinformatics
Chapter Two Next Generation Sequencing in the Clinical Domain: Clinical Advantages, Practical, and Ethical Challenges
1 Introduction
2 What is NGS?
3 Explosion of Exome Sequencing Papers
4 The Successes of Exome Sequencing
5 The Successes of Genome Sequencing
6 Ethics of WES
7 NGS in Routine Clinical Practice?
Chapter Three Opportunities and Challenges for Genome Sequencing in the Clinic
1 Introduction
2 Milestones in the Development of Genetic Mapping
3 Strategies for the Application of Next-Generation Sequencing in Genetic Mapping
4 Consequence of Gene Discovery in Research Programs
5 Challenges Around Incorporating Sequencing to the Clinic
Chapter Four Polymorphisms in Neuropsychiatric and Neuroinflammatory Disorders and the Role of Next Generation Sequencing in Early Diagnosis and Treatment
1 Polymorphisms in Major Depressive Disorders
2 Polymorphisms in ADHD
3 Polymorphisms in Neuroinflammatory Diseases
4 Multiple Sclerosis
5 Alzheimer’s Disease
6 Parkinson’s Disease
7 Role of the NGS in Early Diagnostic and Treatment
8 Conclusions
Chapter Five Structural Modelling Pipelines in Next Generation Sequencing Projects