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Cellular, Molecular, Physiological, and Behavioral Aspects of Traumatic Brain Injury

  • 1st Edition - May 10, 2022
  • Latest edition
  • Editors: Rajkumar Rajendram, Victor R. Preedy, Colin R. Martin
  • Language: English

Traumatic brain injury has complex etiology and may arise as a consequence of physical abuse, violence, war, vehicle collisions, working in the construction industry, and sp… Read more

Description

Traumatic brain injury has complex etiology and may arise as a consequence of physical abuse, violence, war, vehicle collisions, working in the construction industry, and sports. Cellular, Molecular, Physiological, and Behavioral Aspects of Traumatic Brain Injury will improve readers’ understanding of the detailed processes arising from traumatic brain injury. Featuring chapters on neuroinflammation, metabolism, and psychology, this volume discusses the impact of these injuries on neurological and body systems to better understand underlying pathways. This book will be relevant for neuroscientists, neurologists, clinicians, and anyone working to better understand traumatic brain injury.

Key features

  • Summarizes the neuroscience of traumatic brain injury, including cellular and molecular biology
  • Contains chapter abstracts, key facts, dictionary, and summary points to aid in understanding
  • Features chapters on signaling and hormonal events
  • Includes plasticity and gene expression
  • Examines health and stress behaviors after traumatic brain injury

Readership

Neuroscientists, neurologists, clinicians, health scientists, public health workers, doctors, and research scientists. Undergraduates, postgraduate, lecturers and academic professors

Table of contents

I. Setting The Scene and Introductory Chapters

1. Fall-related traumatic brain injuries: The role of the neck
Jacob Sosnoff and Tobia Zanotto

2. The implications of sex and gender in traumatic brain injury
Tatyana Mollayeva

3. Concussion and sports injuries the role of repetitive head injury exposure
Brian D. Stemper

4. Traumatic brain injury and molecular biology: a new narrative
Asma Akbar Ladak, Sarosh Irfan Madhani, Fatima Gauhar, Kiran Aftab, Fatima Mubarak and Syed Ather Enam

5. Features of Decompressive Craniectomy in Traumatic Brain Injury: History, Effects, Management and New Trends
Zefferino Rossini

6. Management of Traumatic Brain Injury in Accordance With Contemporary Guidelines: Treatment, Monitorization and Thresholds
Gregory W.J. Hawryluk and Buse Sarigul

II. Cellular and Molecular Aspects of Traumatic Brain Injury



7. Neuroinflammatory responses in traumatic brain injury
J Narayanan, T. Tamilanban, V. Chitra and M.K Kathiravan

8. Seizures in traumatic brain injury: a focus on cellular aspects
Thara Tunthanathip

9. Linking traumatic brain injury, neural stem and progenitor cells
Li Cai

10. The microglia in traumatic brain injury
Ramesh Raghupathi, Dana Lengel and JIMMY HUH

11. Dendritic spine plasticity and traumatic brain injury
Ye Xiong, Asim Mahmood and Michael Chopp

12. Immune response and traumatic brain injury
Sandy Shultz and Mujun Sun

13. The adaptive immune system in traumatic brain injury: a focus on T and B lymphocytes
Maria Daglas, Robert Medcalf and Maithili Sashindranath

14. Regulatory T cells and traumatic brain injury
Michael K.E. Schäfer

15. The role of prokineticin 2 in traumatic brain injury
Marimelia A. Porcionatto

16. Na+/K+- ATPase activity and traumatic brain injury
L.F.F. Royes

17. Pyruvate dehydrogenase complex enzymes, metabolic enzymes and energy derangement in traumatic brain injury
Giacomo Lazzarino, Patrick O’Halloran, Valentina Di Pietro, Renata Mangione, Barbara Tavazzi, Angela Maria Amorini, giuseppe lazzarino and Stefano Signoretti

18. Angiopoietin-1/Tie-2 and traumatic brain injury
Yutaka Koyama and Shotaro Michinaga

19. Brain microdialysis and applications to drug therapy in severe traumatic brain injury
N. Ketharanathan, U. Rohlwink, A. Figaji, Enno Wildschut, D. Tibboel and Elizabeth Cunera maria de Lange

20. Comparing radiation and traumatic brain injuries: new narrative
Steve Kornguth

21. Electrolytes and traumatic brain injury: a focus on sodium
Yvonne Lui and Hemal Grover

22. WNT genes and their role in traumatic brain injury
Linyi Chen, Min-Zong Liang and Chu-Yuan Chang

III. Physiological and Metabolic Effects



23. Circuit Reorganization After Diffuse Axonal Injury: Utility of the Whisker Barrel Circuit
Theresa Currier Thomas and Gokul Krishna

24. Neuroendocrine Abnormalities Following Traumatic Brain Injury
Jehane Dagher and Benjamin Green

25. Thyroid hormone actions in the setting of traumatic brain injury
Adomas Bunevicius

26. Testosterone: features and role in treating traumatic brain injury
L. Portela

27. The rate of empty sella (ES) in traumatic brain injury: links with endocrine profiles
Fausto Fama, Alessandro Sindoni, Ulla Feldt-Rasmussen, Salvatore Benvenga and Marianne Klose

28. Traumatic brain injury. Interrelationship with sleep
Rachel Rowe

29. Pubety and traumatic brain injury
Rachel Rowe

30. Role of endocannabinoids in the escalation of alcohol use following traumatic brain injury
Patricia E. Molina, Zachary Stielper, Scott Edwards and Nicholas Gilpin

31. Imaging connectivity and functional brain networks in mild traumatic brain injury
Maria M. D'Souza, Mukesh Kumar, Jeanne D'Souza, Prabhjot Kaur and Pawan Kumar

32. Multi-shell diffusion MR imaging and brain microstructure after mild traumatic brain injury: A focus on working memory
Sohae Chung, Els Fieremans, Joseph Rath and Yvonne Lui

33. Monitoring real-time changes in physiology: impact of pediatric traumatic brain injury
Brian Appavu

34. Blood gasses, arterial and end-tidal carbon dioxide in traumatic brain injury
Jen-Ting Yang, Chun-Yu Wu, and David R. Wright

35. Disturbances of cerebral microcirculation in traumatic brain injury: the role of changes in microcirculatory biomarkers
Alexey O. Trofimov

IV. Behavioural and Psychological Effects



36. Social cognition in traumatic brain injury
Philippe Allain

37. Physical exercise: effects on cognitive function after traumatic brain injury
Margalida Coll, Laura Amorós-Aguilar, David Costa-Miserachs, Isabel Portell-Cortés and Meritxell Torras-Garcia

38. Linking cognitive function, diffuse traumatic brain injury and dementia
Lyndsey Collins-Praino

39. Neuropsychological Functioning of Children and Youth after Traumatic Brain Injury
Paula Karina Perez-Delgadillo, Daniela Ramos-Usuga, Nini Lucia Muñoz-Perez and Juan Arango Arango-Lasprilla

40. Behavioral effects of traumatic brain injury: use of guanosine
Felix Alexandre Antunes Soares and Fernando Dobrachinski

41. Recognizing emotions and effects of traumatic brain injury
Alessia Celeghin, Ylenia Camassa Nahi, Blanca Tasso and Olga Dal Monte

42. Cognitive Communication Connections and Higher-Level Language with Traumatic Brain Injured Population
J. Koebli

43. Self-awareness after severe traumatic brain injury: from impairment of Self-awareness to psychological adjustment
U. Bivona, Susanna Lucatello and Alberto Costa

44. Disentangling antecedents from consequences of traumatic brain injury: The need for prospective longitudinal studies
Sheilagh Hodgins and G. Guberman

45. Linking sleeping patterns and quality of life in childhood traumatic brain injury
Edith Botchway

 

Product details

  • Edition: 1
  • Latest edition
  • Published: August 18, 2022
  • Language: English

About the editors

Rajkumar Rajendram

Editor

Dr Rajkumar Rajendram is a clinician-scientist with expertise in internal medicine, anaesthesia, intensive care and peri-operative medicine. He graduated with distinctions from Guy’s, King’s and St Thomas’ Medical School, King’s College London, in 2001, where he received several prizes, merits and distinctions in pre-clinical and clinical subjects.

Dr Rajendram completed specialist training in acute and general medicine in Oxford and subsequently held a Consultant appointment in Acute General Medicine at the John Radcliffe Hospital, Oxford. He also trained in anaesthesia and intensive care in London, including advanced training in regional anaesthesia and intensive care, and subsequently held a Consultant appointment in Intensive Care, Anaesthesia and Peri-operative Medicine at the Royal Free London Hospitals.

His postgraduate training has spanned internal medicine, anaesthesia, intensive care and point-of-care ultrasound (POCUS). He was awarded Fellowship of the Royal College of Anaesthetists in 2009, Fellowship of the Faculty of Intensive Care Medicine in 2013, and the European Diploma in Intensive Care Medicine in 2014. He is a Fellow of both the Royal College of Physicians of Edinburgh and the Royal College of Physicians of London.

Dr Rajendram is currently a Consultant at King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia, and holds a joint appointment as Associate Professor in the Research Unit, Department of Medical Education, at King Saud bin Abdulaziz University for Health Sciences.

His multidisciplinary clinical background has informed his research interests in nutrition, fluid management and fluid balance in health and disease, particularly in acutely and critically ill patients. His research has also addressed POCUS, COVID-19 phenotypes and nutritional support in illness. Dr Rajendram has contributed extensively to medical research and education and has authored more than 400 textbook chapters, review articles, peer-reviewed papers and conference abstracts.

Affiliations and expertise
Consultant, Medical Protocol Department, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia & Joint Appointment Associate Professor, Research Unit, Department of Medical Education, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia

Victor R. Preedy

Editor

Victor R. Preedy, BSc, PhD, DSc, FRSB, FRSPH, FRCPath, FRSC, FRSM, is Professor of Clinical Biochemistry (Hon) at King’s College Hospital and Emeritus Professor of Nutritional Biochemistry at King’s College London. He also holds an Honorary Professorship at the University of Suffolk and served as the long‑term Director of the Genomics Centre at King’s College London from 2006 to 2020. Professor Preedy graduated with an Honours Degree in Biology and Physiology with Pharmacology and later obtained his PhD from the University of London. He subsequently received Membership of the Royal College of Pathologists and later earned his second doctorate (DSc) in recognition of his contributions to protein metabolism. He is a Fellow of the Royal Society of Medicine, the Royal Society of Biology, the Royal College of Pathologists, the Royal Society for the Promotion of Health, the Royal Institute of Public Health and Hygiene, the Royal Society for Public Health, and the Royal Society of Chemistry. Professor Preedy has conducted research while affiliated with Imperial College London, the School of Pharmacy (now part of University College London), and the MRC Centre at Northwick Park Hospital. He has collaborated widely with international research groups in Finland, Japan, Australia, the USA, and Germany. His longstanding academic interests include health and well‑being. He has published more than 750 works, including peer‑reviewed research articles, abstracts, symposium presentations, reviews, and edited books.

Affiliations and expertise
Professor, Department of Clinical Biochemistry, King’s College Hospital, London, UK; Emeritus Professor, Faculty of Life Sciences and Medicine, King’s College London, UK; Visiting Professor, University of Hull, UK

Colin R. Martin

Editor
Colin R. Martin RN, BSc, MSc, PhD, MBA, YCAP, FHEA, C.Psychol, AFBPsS, C.Sci is Professor of Clinical Psychobiology and Applied Psychoneuroimmunology and Clinical Director of the Institute of Health and Wellbeing at the University of Suffolk, UK. He is a Chartered Health Psychologist and a Chartered Scientist. He also trained in analytical biochemistry, this aspect reflecting the psychobiological focus of much of his research within mental health. He has published or has in press well over 300 research papers and book chapters. He is a keen book author and editor having written and/or edited more than 50 books. These outputs include the prophetic insight into the treatment of neurological disease, Handbook of Behavior, Food and Nutrition (2011), Nanomedicine and the Nervous System (2012), Oxidative Stress and Dietary Antioxidants in Neurological Disease (2020), Zika Virus Impact, Diagnosis, Control and Models (2021), Factors Affecting Neurodevelopment: Genetics, Neurology, Behavior and Diet (2021), Diagnosis and Treatment of Spinal Cord Injury (2022), The Neurobiology, Physiology, and Psychology of Pain (2022) and The Handbook of Lifespan Cognitive Behavioral Therapy: Childhood, Adolescence, Pregnancy, Adulthood, and Aging (2023). Professor Martin is particularly interested in all aspects of the relationship between underlying physiological substrates and behavior, particularly in how these relationships manifest in both acute and chronic psychiatric disorder. He has published original research germane to significant mental health disorders including the areas of schizophrenia, anxiety, depression, self-esteem, alcohol and drug dependency, high secure forensic mental health and personality disorder. He has a keen interest in the impact of postviral illness and is actively involved in clinical research post-Covid pandemic and in particular, the impact of Long Covid on psychological, neurological, physiological and social functioning. He is involved in collaborative International research with many European and Non-European countries.
Affiliations and expertise
Visiting Professor of Perinatal Wellbeing, Institute for Health and Wellbeing, University of Suffolk, Ipswich, UK

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