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Elsevier

Cellular, Molecular, Physiological, and Behavioral Aspects of Spinal Cord Injury

  • 1st Edition - May 10, 2022
  • Latest edition
  • Editors: Rajkumar Rajendram, Victor R. Preedy, Colin R. Martin
  • Language: English

Spinal injury affects about 10 million people annually worldwide, impacting on the family unit and causing lifelong disabilities, with varied symptoms including paresthesia, sp… Read more

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Description

Spinal injury affects about 10 million people annually worldwide, impacting on the family unit and causing lifelong disabilities, with varied symptoms including paresthesia, spasticity, loss of motor control, and often severe pain. Cellular, Molecular, Physiological, and Behavioral Aspects of Spinal Cord Injury will enhance readers’ understanding of the biological and psychological effects of spinal cord injury. Featuring chapters on gene expression, metabolic effects, and behavior, this volume discusses in detail the impact of spinal cord injury to better understand the underlying pathways and processes. The book has applicability for neuroscientists, neurologists, clinicians, and anyone working to better understand these injuries.

Key features

  • Summarizes the neuroscience of spinal cord injury, including cellular and molecular biology
  • Contains chapter abstracts, key facts, dictionary, and summary points to aid in understanding
  • Features chapters on signaling and hormonal events
  • Includes plasticity and gene expression
  • Examines health and stress behaviors after spinal cord injury

Readership

Neuroscientists, neurologists, clinicians, health scientists, public health workers, doctors, and research scientists. Academic libraries that covers the domains of neurology and health sciences. Undergraduates, postgraduate, lecturers and academic professors

Table of contents

I. Setting The Scene and Introductory Chapters

1. Causes of spinal injury: motor vehicle accidents and beyond
Joji Inamasu

2. MRI findings in spinal cord injury during acute and chronic phases
Syed Ather Enam, Kiran Aftab, Namrah Aziz, Batool Mujtaba, Asma Akbar Ladak and Fatima Mubarak

3. Exercise programs in spinal cord injury
Jeongmin Lee, Dong-il Kim and J. Jeon

4. Use of anodal transcranial direct current stimulation: features, facets and applications to incomplete spinal cord injury
Amanda Vitória Lacerda de Araujo

5. Neuromodulation and restoration of motor responses after severe spinal cord injury
G. Taccola

6. Rehabilitation and wheelchair users after spinal cord injury: an overview
Marcelo Riberto, Ligia Jia Lin Wu and Daniel Rubio de Souza

II. Cellular and Molecular Aspects of Spinal Injury



7. Gene expression, bone loss and spinal cord injury
A. Zamarioli

8. Sperm DNA fragmentation and its relevance to men with spinal cord injury
S. Johnston

9. Cytokines and spinal cord injury
Jesús Amo-Aparicio and Clara Penas

10. Interleukin-10, vascular pathology in traumatic cervical Spinal cord injury
Michael G. Fehlings

11. Protein Degradome in Spinal Cord Injury
S. Bsat, Hani Chanbour, Ali Amine, Charbel Moussalem, Mohamad Nabih El Housheimy, Sarah Kawtharani, Adham Halaoui, Firas H. Kobaissy, Safwan Alomari and Ibrahim Omeis

12. Proteomics of Pressure Ulcers in Spinal cord injury
M. Barderas

13. Innate immune responses of glia and inflammatory cells in spinal cord injury
Stella Elkabes, Lun Li, Cigdem Acioglu and Robert Heary

14. The role of oxidative stress in spinal cord injury animal models: a focus on nuclear factor erythroid-2 related factor 2
Fernando da Silva Fiorin, Caroline Cunha do Espírito-Santo and L.F.F. Royes

15. Novel agent ONO-2506 suppresses astrocytic activation and attenuates post-spinal cord injury pain
Hiroyuki Ishiguro and Takashi Kaito

16. Histology, neural tissue loss and compression-induced spinal cord injury
Jaroslav Pavel

17. Remodeling mitochondrial transport and cellular energetics in axonal regeneration and spinal cord injury
Ning Huang and Zu-Hang Sheng

18. Neurotrophins and their Role in Axonal Outgrowth Following Spinal Cord Injury
Darren Svirskis, Anusha Dravid and Simon O'Carroll

19. The neuroscience of transient receptor potential vanilloid type 4 (TRPV4) and spinal cord injury
I. Han and Hemant Kumar

20. Autoantibodies in spinal cord injury
Daniel Garcia-Ovejero, Lukas Grassner, Eduardo Molina-Holgado and Angel Arevalo-Martin

21. Calpain role in the pathophysiology of spasticity after spinal cord injury
Frédéric Brocard

22. Targeting mTOR Signaling to Promote Autophagy for Functional Recovery after Spinal Cord Injury
Nadia Al-Sammarraie and Swapan K. Ray

23. Tertiary damage: Hippocampal and brain changes after spinal cord injury
Florencia Labombarda

III. Physiological and Metabolic Effects



24. Hormonal events and spinal cord injury: a focus on vasopressin and natriuretic peptide
Charles Hubscher

25. Linking sensorimotor plasticity, the motor cortex and spinal cord injury
R. Nardone

26. Bone mass and spinal cord injury: risk of fracture
Ifaz T. Haider, Narina Simonian, Thomas Schnitzer and W. Brent Edwards

27. Functional and morphological re-organization of the brain following spinal cord injury : Insights from MRI
Maria M. D'Souza, Jeanne D'Souza, Prabhjot Kaur and Pawan Kumar

28. Cardiometabolic changes and upper extremity exercise as an augmentative strategy in spinal cord injury
Benjamin Scoblionko, Patricia Orme, James Pendleton, Roger Liu and James J. Bresnahan

29. Electrophysiological outcome measures in spinal cord injury: a new narrative
Radha Korupolu, Argyrios Stampas, Sudha Tallavajhula and Lumy Sawaki

30. Features and Physiology of Spinal Stretch Reflex Pathways in People with Chronic Spinal Cord Injury
Aiko K. Thompson and Thomas Sinkjær

31. Metabolic syndrome iin spinal cord injury: impact on health
Arcangelo Barbonetti, Chiara Castellini, Sandro Francavilla, Felice Francavilla and Settmio D’Andrea

32. Body composition and spinal cord injury
Katherine Jane Desneves, Nicole Kiss, Robin Daly and Leigh Ward

33. Energy requirements and spinal cord injury
Katherine Jane Desneves, Nicole Kiss, Robin Daly and Leigh Ward

34. Virtual walking and spinal cord injury neuropathic pain
Elizabeth Richardson and Zina Trost

35. Cervical spinal cord injury and thermoregulatory processes: a new narrative
Ibrahim Omeis

36. Spinal cord injury and the gut microbiota
Phillip G. Popovich and Kristina A. Kigerl

IV. Behavioural and Psychological Effects



37. Risk factors and predictors of depression after spinal cord injury: emphasis on the inflammatory process
Caroline Cunha do Espírito-Santo, Fernando da Silva Fiorin and L.F.F. Royes

38. Spirituality, hope, and resilience in the recovery and adaptation process following spinal cord injury
Kate Jones and Grahame Simpson

39. Wellness intervention for spinal cord injuries
Stephanie L. Silveira, Emma Richardson and Robert W. Motl

40. Sexual satisfaction and spinal cord injury
Seçil Taylan

41. Depressive symptoms in rehabilitation, spinal cord injury
Swati Mehta

42. Self-Harm behaviors in Patients with Spinal Cord Injuries: From Nonadherence to Suicide
Maggi Budd, Herb Ames and John Bradley

Product details

  • Edition: 1
  • Latest edition
  • Published: August 18, 2022
  • Language: English

About the editors

RR

Rajkumar Rajendram

Dr Rajkumar Rajendram is a clinician scientist with a focus on internal medicine, anaesthesia, intensive care and peri-operative medicine. He graduated with distinctions from Guy’s, King’s and St. Thomas Medical School, King’s College London in 2001. As an undergraduate he was awarded several prizes, merits and distinctions in pre-clinical and clinical subjects.

Dr Rajendram began his post-graduate medical training in general medicine and intensive care in Oxford. He attained membership of the Royal College of Physicians (MRCP) in 2004 and completed specialist training in acute and general medicine in Oxford in 2010. Dr Rajendram subsequently practiced as a Consultant in Acute General Medicine at the John Radcliffe Hospital, Oxford.

Dr Rajendram also trained in anaesthesia and intensive care in London and was awarded a fellowship of the Royal College of Anaesthetists (FRCA) in 2009. He completed advanced training in regional anaesthesia and intensive care. He was awarded a fellowship of the Faculty of Intensive Care Medicine (FFICM) in 2013 and obtained the European diploma of intensive care medicine (EDIC) in 2014. He then moved to the Royal Free London Hospitals as a Consultant in Intensive Care, Anaesthesia and Peri-operative Medicine. He has been a fellow of the Royal College of Physicians of Edinburgh (FRCP Edin) and the Royal College of Physicians of London (FRCP Lond) since 2017 and 2019 respectively. He is currently a Consultant in Internal Medicine at King Abdulaziz Medical City, National Guard Heath Affairs, Riyadh, Saudi Arabia.

Dr Rajendram’s focus on improving outcomes from Coronavirus Disease 2019 (COVID-19) has involved research on point of care ultrasound and phenotypes of COVID-19. Dr Rajendram also recognises that nutritional support is a fundamental aspect of medical care. This is particularly important for patients with COVID-19. As a clinician scientist he has therefore devoted significant time and effort into nutritional science research and education. He is an affiliated member of the Nutritional Sciences Research Division of King’s College London and has published over 400 textbook chapters, review articles, peer-reviewed papers and abstracts.

Affiliations and expertise
Consultant, Medical Protocol Department, King Abdulaziz Medical City, Ministry of National Guard Heath Affairs, Riyadh, Saudi Arabia

VP

Victor R. Preedy

Victor R. Preedy BSc, PhD, DSc, FRSB, FRSPH, FRSC, FRCPath graduated with an Honours Degree in Biology and Physiology with Pharmacology. After gaining his University of London PhD, he received his Membership of the Royal College of Pathologists. He was later awarded his second doctorate (DSc), for his contribution to protein metabolism in health and disease. He is Professor of Clinical Biochemistry (Hon) at King’s College Hospital and Emeritus Professor of Nutritional Biochemistry at King’s College London. He has Honorary Professorships at the University of Hull, and the University of Suffolk. Professor Preedy was the Founding Director and then long-term Director of the Genomics Centre at King’s College London from 2006 to 2020. Professor Preedy has been awarded fellowships of the Royal Society of Biology, the Royal College of Pathologists, the Royal Society for the Promotion of Health, the Royal Institute of Public Health, the Royal Society for Public Health, the Royal Society of Chemistry and the Royal Society of Medicine. He carried out research when attached to the National Heart Hospital (part of Imperial College London), The School of Pharmacy (now part of University College London) and the MRC Centre at Northwick Park Hospital. He has collaborated with international research groups in Finland, Japan, Australia, USA, and Germany. To his credit, Professor Preedy has published over 750 articles, which includes peer-reviewed manuscripts based on original research, abstracts and symposium presentations, reviews and edited books.
Affiliations and expertise
Professor, Department of Clinical Biochemistry, King’s College Hospital, London, UK; Emeritus Professor, Faculty of Life Sciences and Medicine, King’s College London, UK; Visiting Professor, University of Hull, UK

CM

Colin R. Martin

Colin R. Martin RN, BSc, MSc, PhD, MBA, YCAP, FHEA, C.Psychol, AFBPsS, C.Sci is Professor of Clinical Psychobiology and Applied Psychoneuroimmunology and Clinical Director of the Institute of Health and Wellbeing at the University of Suffolk, UK. He is a Chartered Health Psychologist and a Chartered Scientist. He also trained in analytical biochemistry, this aspect reflecting the psychobiological focus of much of his research within mental health. He has published or has in press well over 300 research papers and book chapters. He is a keen book author and editor having written and/or edited more than 50 books. These outputs include the prophetic insight into the treatment of neurological disease, Handbook of Behavior, Food and Nutrition (2011), Nanomedicine and the Nervous System (2012), Oxidative Stress and Dietary Antioxidants in Neurological Disease (2020), Zika Virus Impact, Diagnosis, Control and Models (2021), Factors Affecting Neurodevelopment: Genetics, Neurology, Behavior and Diet (2021), Diagnosis and Treatment of Spinal Cord Injury (2022), The Neurobiology, Physiology, and Psychology of Pain (2022) and The Handbook of Lifespan Cognitive Behavioral Therapy: Childhood, Adolescence, Pregnancy, Adulthood, and Aging (2023). Professor Martin is particularly interested in all aspects of the relationship between underlying physiological substrates and behavior, particularly in how these relationships manifest in both acute and chronic psychiatric disorder. He has published original research germane to significant mental health disorders including the areas of schizophrenia, anxiety, depression, self-esteem, alcohol and drug dependency, high secure forensic mental health and personality disorder. He has a keen interest in the impact of postviral illness and is actively involved in clinical research post-Covid pandemic and in particular, the impact of Long Covid on psychological, neurological, physiological and social functioning. He is involved in collaborative International research with many European and Non-European countries.
Affiliations and expertise
Visiting Professor of Perinatal Wellbeing, Institute for Health and Wellbeing, University of Suffolk, Ipswich, UK

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