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Cellular, Molecular, Physiological, and Behavioral Aspects of Spinal Cord Injury

  • 1st Edition - May 10, 2022
  • Latest edition
  • Editors: Rajkumar Rajendram, Victor R. Preedy, Colin R. Martin
  • Language: English

Spinal injury affects about 10 million people annually worldwide, impacting on the family unit and causing lifelong disabilities, with varied symptoms including paresthesia, sp… Read more

Description

Spinal injury affects about 10 million people annually worldwide, impacting on the family unit and causing lifelong disabilities, with varied symptoms including paresthesia, spasticity, loss of motor control, and often severe pain. Cellular, Molecular, Physiological, and Behavioral Aspects of Spinal Cord Injury will enhance readers’ understanding of the biological and psychological effects of spinal cord injury. Featuring chapters on gene expression, metabolic effects, and behavior, this volume discusses in detail the impact of spinal cord injury to better understand the underlying pathways and processes. The book has applicability for neuroscientists, neurologists, clinicians, and anyone working to better understand these injuries.

Key features

  • Summarizes the neuroscience of spinal cord injury, including cellular and molecular biology
  • Contains chapter abstracts, key facts, dictionary, and summary points to aid in understanding
  • Features chapters on signaling and hormonal events
  • Includes plasticity and gene expression
  • Examines health and stress behaviors after spinal cord injury

Readership

Neuroscientists, neurologists, clinicians, health scientists, public health workers, doctors, and research scientists. Academic libraries that covers the domains of neurology and health sciences. Undergraduates, postgraduate, lecturers and academic professors

Table of contents

I. Setting The Scene and Introductory Chapters

1. Causes of spinal injury: motor vehicle accidents and beyond
Joji Inamasu

2. MRI findings in spinal cord injury during acute and chronic phases
Syed Ather Enam, Kiran Aftab, Namrah Aziz, Batool Mujtaba, Asma Akbar Ladak and Fatima Mubarak

3. Exercise programs in spinal cord injury
Jeongmin Lee, Dong-il Kim and J. Jeon

4. Use of anodal transcranial direct current stimulation: features, facets and applications to incomplete spinal cord injury
Amanda Vitória Lacerda de Araujo

5. Neuromodulation and restoration of motor responses after severe spinal cord injury
G. Taccola

6. Rehabilitation and wheelchair users after spinal cord injury: an overview
Marcelo Riberto, Ligia Jia Lin Wu and Daniel Rubio de Souza

II. Cellular and Molecular Aspects of Spinal Injury



7. Gene expression, bone loss and spinal cord injury
A. Zamarioli

8. Sperm DNA fragmentation and its relevance to men with spinal cord injury
S. Johnston

9. Cytokines and spinal cord injury
Jesús Amo-Aparicio and Clara Penas

10. Interleukin-10, vascular pathology in traumatic cervical Spinal cord injury
Michael G. Fehlings

11. Protein Degradome in Spinal Cord Injury
S. Bsat, Hani Chanbour, Ali Amine, Charbel Moussalem, Mohamad Nabih El Housheimy, Sarah Kawtharani, Adham Halaoui, Firas H. Kobaissy, Safwan Alomari and Ibrahim Omeis

12. Proteomics of Pressure Ulcers in Spinal cord injury
M. Barderas

13. Innate immune responses of glia and inflammatory cells in spinal cord injury
Stella Elkabes, Lun Li, Cigdem Acioglu and Robert Heary

14. The role of oxidative stress in spinal cord injury animal models: a focus on nuclear factor erythroid-2 related factor 2
Fernando da Silva Fiorin, Caroline Cunha do Espírito-Santo and L.F.F. Royes

15. Novel agent ONO-2506 suppresses astrocytic activation and attenuates post-spinal cord injury pain
Hiroyuki Ishiguro and Takashi Kaito

16. Histology, neural tissue loss and compression-induced spinal cord injury
Jaroslav Pavel

17. Remodeling mitochondrial transport and cellular energetics in axonal regeneration and spinal cord injury
Ning Huang and Zu-Hang Sheng

18. Neurotrophins and their Role in Axonal Outgrowth Following Spinal Cord Injury
Darren Svirskis, Anusha Dravid and Simon O'Carroll

19. The neuroscience of transient receptor potential vanilloid type 4 (TRPV4) and spinal cord injury
I. Han and Hemant Kumar

20. Autoantibodies in spinal cord injury
Daniel Garcia-Ovejero, Lukas Grassner, Eduardo Molina-Holgado and Angel Arevalo-Martin

21. Calpain role in the pathophysiology of spasticity after spinal cord injury
Frédéric Brocard

22. Targeting mTOR Signaling to Promote Autophagy for Functional Recovery after Spinal Cord Injury
Nadia Al-Sammarraie and Swapan K. Ray

23. Tertiary damage: Hippocampal and brain changes after spinal cord injury
Florencia Labombarda

III. Physiological and Metabolic Effects



24. Hormonal events and spinal cord injury: a focus on vasopressin and natriuretic peptide
Charles Hubscher

25. Linking sensorimotor plasticity, the motor cortex and spinal cord injury
R. Nardone

26. Bone mass and spinal cord injury: risk of fracture
Ifaz T. Haider, Narina Simonian, Thomas Schnitzer and W. Brent Edwards

27. Functional and morphological re-organization of the brain following spinal cord injury : Insights from MRI
Maria M. D'Souza, Jeanne D'Souza, Prabhjot Kaur and Pawan Kumar

28. Cardiometabolic changes and upper extremity exercise as an augmentative strategy in spinal cord injury
Benjamin Scoblionko, Patricia Orme, James Pendleton, Roger Liu and James J. Bresnahan

29. Electrophysiological outcome measures in spinal cord injury: a new narrative
Radha Korupolu, Argyrios Stampas, Sudha Tallavajhula and Lumy Sawaki

30. Features and Physiology of Spinal Stretch Reflex Pathways in People with Chronic Spinal Cord Injury
Aiko K. Thompson and Thomas Sinkjær

31. Metabolic syndrome iin spinal cord injury: impact on health
Arcangelo Barbonetti, Chiara Castellini, Sandro Francavilla, Felice Francavilla and Settmio D’Andrea

32. Body composition and spinal cord injury
Katherine Jane Desneves, Nicole Kiss, Robin Daly and Leigh Ward

33. Energy requirements and spinal cord injury
Katherine Jane Desneves, Nicole Kiss, Robin Daly and Leigh Ward

34. Virtual walking and spinal cord injury neuropathic pain
Elizabeth Richardson and Zina Trost

35. Cervical spinal cord injury and thermoregulatory processes: a new narrative
Ibrahim Omeis

36. Spinal cord injury and the gut microbiota
Phillip G. Popovich and Kristina A. Kigerl

IV. Behavioural and Psychological Effects



37. Risk factors and predictors of depression after spinal cord injury: emphasis on the inflammatory process
Caroline Cunha do Espírito-Santo, Fernando da Silva Fiorin and L.F.F. Royes

38. Spirituality, hope, and resilience in the recovery and adaptation process following spinal cord injury
Kate Jones and Grahame Simpson

39. Wellness intervention for spinal cord injuries
Stephanie L. Silveira, Emma Richardson and Robert W. Motl

40. Sexual satisfaction and spinal cord injury
Seçil Taylan

41. Depressive symptoms in rehabilitation, spinal cord injury
Swati Mehta

42. Self-Harm behaviors in Patients with Spinal Cord Injuries: From Nonadherence to Suicide
Maggi Budd, Herb Ames and John Bradley

Product details

  • Edition: 1
  • Latest edition
  • Published: May 10, 2022
  • Language: English

About the editors

RR

Rajkumar Rajendram

Dr Rajkumar Rajendram is a clinician-scientist with expertise in internal medicine, anaesthesia, intensive care and peri-operative medicine. He graduated with distinctions from Guy’s, King’s and St Thomas’ Medical School, King’s College London, in 2001, where he received several prizes, merits and distinctions in pre-clinical and clinical subjects.

Dr Rajendram completed specialist training in acute and general medicine in Oxford and subsequently held a Consultant appointment in Acute General Medicine at the John Radcliffe Hospital, Oxford. He also trained in anaesthesia and intensive care in London, including advanced training in regional anaesthesia and intensive care, and subsequently held a Consultant appointment in Intensive Care, Anaesthesia and Peri-operative Medicine at the Royal Free London Hospitals.

His postgraduate training has spanned internal medicine, anaesthesia, intensive care and point-of-care ultrasound (POCUS). He was awarded Fellowship of the Royal College of Anaesthetists in 2009, Fellowship of the Faculty of Intensive Care Medicine in 2013, and the European Diploma in Intensive Care Medicine in 2014. He is a Fellow of both the Royal College of Physicians of Edinburgh and the Royal College of Physicians of London.

Dr Rajendram is currently a Consultant at King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia, and holds a joint appointment as Associate Professor in the Research Unit, Department of Medical Education, at King Saud bin Abdulaziz University for Health Sciences.

His multidisciplinary clinical background has informed his research interests in nutrition, fluid management and fluid balance in health and disease, particularly in acutely and critically ill patients. His research has also addressed POCUS, COVID-19 phenotypes and nutritional support in illness. Dr Rajendram has contributed extensively to medical research and education and has authored more than 400 textbook chapters, review articles, peer-reviewed papers and conference abstracts.

Affiliations and expertise
Consultant, Medical Protocol Department, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia & Joint Appointment Associate Professor, Research Unit, Department of Medical Education, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia

VP

Victor R. Preedy

Victor R. Preedy, BSc, PhD, DSc, FRSB, FRSPH, FRCPath, FRSC, FRSM, is Professor of Clinical Biochemistry (Hon) at King’s College Hospital and Emeritus Professor of Nutritional Biochemistry at King’s College London. He also holds an Honorary Professorship at the University of Suffolk and served as the long‑term Director of the Genomics Centre at King’s College London from 2006 to 2020. Professor Preedy graduated with an Honours Degree in Biology and Physiology with Pharmacology and later obtained his PhD from the University of London. He subsequently received Membership of the Royal College of Pathologists and later earned his second doctorate (DSc) in recognition of his contributions to protein metabolism. He is a Fellow of the Royal Society of Medicine, the Royal Society of Biology, the Royal College of Pathologists, the Royal Society for the Promotion of Health, the Royal Institute of Public Health and Hygiene, the Royal Society for Public Health, and the Royal Society of Chemistry. Professor Preedy has conducted research while affiliated with Imperial College London, the School of Pharmacy (now part of University College London), and the MRC Centre at Northwick Park Hospital. He has collaborated widely with international research groups in Finland, Japan, Australia, the USA, and Germany. His longstanding academic interests include health and well‑being. He has published more than 750 works, including peer‑reviewed research articles, abstracts, symposium presentations, reviews, and edited books.

Affiliations and expertise
Professor, Department of Clinical Biochemistry, King’s College Hospital, London, UK; Emeritus Professor, Faculty of Life Sciences and Medicine, King’s College London, UK; Visiting Professor, University of Hull, UK

CM

Colin R. Martin

Colin R. Martin RN, BSc, MSc, PhD, MBA, YCAP, FHEA, C.Psychol, AFBPsS, C.Sci is Professor of Clinical Psychobiology and Applied Psychoneuroimmunology and Clinical Director of the Institute of Health and Wellbeing at the University of Suffolk, UK. He is a Chartered Health Psychologist and a Chartered Scientist. He also trained in analytical biochemistry, this aspect reflecting the psychobiological focus of much of his research within mental health. He has published or has in press well over 300 research papers and book chapters. He is a keen book author and editor having written and/or edited more than 50 books. These outputs include the prophetic insight into the treatment of neurological disease, Handbook of Behavior, Food and Nutrition (2011), Nanomedicine and the Nervous System (2012), Oxidative Stress and Dietary Antioxidants in Neurological Disease (2020), Zika Virus Impact, Diagnosis, Control and Models (2021), Factors Affecting Neurodevelopment: Genetics, Neurology, Behavior and Diet (2021), Diagnosis and Treatment of Spinal Cord Injury (2022), The Neurobiology, Physiology, and Psychology of Pain (2022) and The Handbook of Lifespan Cognitive Behavioral Therapy: Childhood, Adolescence, Pregnancy, Adulthood, and Aging (2023). Professor Martin is particularly interested in all aspects of the relationship between underlying physiological substrates and behavior, particularly in how these relationships manifest in both acute and chronic psychiatric disorder. He has published original research germane to significant mental health disorders including the areas of schizophrenia, anxiety, depression, self-esteem, alcohol and drug dependency, high secure forensic mental health and personality disorder. He has a keen interest in the impact of postviral illness and is actively involved in clinical research post-Covid pandemic and in particular, the impact of Long Covid on psychological, neurological, physiological and social functioning. He is involved in collaborative International research with many European and Non-European countries.
Affiliations and expertise
Visiting Professor of Perinatal Wellbeing, Institute for Health and Wellbeing, University of Suffolk, Ipswich, UK

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