Cellular, Molecular, and Environmental Contribution in Cardiac Remodeling

From Lab Bench Work to its Clinical Perspective

1st Edition - April 16, 2024
Imprint: Academic Press
Authors: Asim K. Duttaroy, Rahul Mallick
Language: English
Paperback ISBN:
9 7 8 - 0 - 3 2 3 - 9 9 5 7 0 - 2
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 9 9 5 7 1 - 9

Cellular, Molecular and Environmental Contribution in Cardiac Remodeling consolidates the most recent research advances on cellular, molecular, biochemical, and heterogen… Read more

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Cellular, Molecular and Environmental Contribution in Cardiac Remodeling consolidates the most recent research advances on cellular, molecular, biochemical, and heterogeneous factors contributing to the physiological and pathological cardiac remodeling, elucidating their mechanisms of action and the clinical outcomes of cardiac remodeling. The book extensively covers the factors determining cardiac remodeling, including cardiomyocyte regeneration, cardiac stem cells and their therapeutic potential, cardiac resident pericytes, the role of natural bioactive compounds in cardiac remodeling, chronic cardiac adaptations to exercise, and more.

It provides basic science researchers and clinical investigators in cardiology with a current and comprehensive resource on molecular mechanisms and contributing factors to cardiac remodeling, along with its effects and impacts on heart health. New research areas for the future, aimed at preventing, limiting, and reversing bad remodeling, are also discussed.

Cover image
Title page
Table of Contents
Copyright
Preface
Chapter 1. Cardiac remodeling: Impacts on cardiac health and disease
1. Introduction
2. Physiological cardiac remodeling
3. Exercise-induced cardiac remodeling
4. Pregnancy-induced cardiac remodeling
5. Pathological cardiac remodeling
6. Hypertensive left ventricular remodeling
7. Atrophic cardiac remodeling
8. Ventricular remodeling in myocardial infarction
9. Metabolic remodeling of the heart
10. Diagnosis
11. Consequences
12. Congestive heart failure
13. Therapeutic targets
14. Fibrosis
15. Cardiomyocyte hypertrophy
16. Cardiomyocyte death
17. Vascular remodeling
18. Metabolic remodeling
19. Conclusion
Chapter 2. Physiological cardiac modeling: Effects of exercise and other physical activities
1. Introduction
2. Effects of exercise and cardiovascular system
3. Effects of exercise on the cardiac remodeling
4. Effects of exercise on the left and right ventricles
5. Determinants of exercise-induced cardiac remodeling magnitude
6. Cellular and molecular mechanism of mechanisms of EICR
7. Energy metabolism, exercise, and cardiac remodeling
8. Cellular signaling system, exercise, and cardiac remodeling
9. Conclusions
Chapter 3. Prognostic elements of unfavorable cardiac remodeling
1. Introduction
2. Left ventricular ejection fraction
3. Myocardial infarction
4. Ventricular dilatation
5. Wall thickness
6. Biomarkers
7. Hypertrophy
8. Fibrosis
9. Hemodynamic changes
10. Functional impairment
11. Symptom severity
12. Comorbidities
13. Response to treatment
14. Summary
Chapter 4. Neurohormones in cardiac remodeling and function
1. Introduction
2. Neurohormonal activation
3. The adrenergic nervous system in the heart
4. RAAS perturbation
5. RAAS in cardiac remodeling
6. Conclusion
Chapter 5. Cardiokines and cardiac remodeling
1. Introduction
2. The heart as an endocrine organ
3. Cardiokines in cardiac stress
4. Autocrine/paracrine signaling of cardiokines
5. Endocrine activities of cardiokines
6. Cardiokines as cardiac disorders biomarkers
7. Conclusion
Chapter 6. Comparative effects of fatty acid and glucose in cardiac remodeling
1. Introduction
2. Cardiac hypertrophy impacting fatty acids and glucose metabolism
3. Glucose and cardiac remodeling
4. Fats and cardiac remodeling
5. Conclusions
Chapter 7. Vitamins, minerals, and nutraceuticals: Their cardioprotective functions
1. Introduction
2. Cardiac protection by vitamins
3. Minerals and cardiac remodeling
4. Phenolic compounds and cardiac remodeling
5. Conclusions
Chapter 8. Junctional adhesion molecules: Their roles in integrity and functionality of the heart
1. Introduction
2. Interactions and signaling pathways
3. Major functions
4. Role of junctional adhesion molecules in cardiovascular diseases
5. Conclusion and perspective
Chapter 9. Composition and function of ion channels and their effects on cardiac remodeling
1. Introduction
2. Electrocardiogram: Sensitive and specific technique to measure cardiac electrical activity
3. Overview of cardiac action potential
4. Cardiac action potential regulating ion channels and transporters
5. Trafficking machinery of cardiomyocytes
6. Proarrhythmogenic mechanisms
7. Electrical remodeling in disease conditions
8. Conclusion
Chapter 10. Notch signaling molecules: A driver of cardiac function
1. Introduction
2. Notch signaling pathway
3. Notch signaling in the endocardium during cardiac regeneration
4. Hemodynamic alterations stimulate endocardial Notch signaling
5. Notch signaling in the diseased heart
6. Conclusion
Chapter 11. Neuregulin-1: Can it be useful to treat heart failure?
1. Introduction
2. NRG-1β signaling in the heart
3. Cardiac stress adaptive role of NRG-1β
4. Can NRG-1β be considered as the cardiovascular health marker?
5. Therapeutic potential of NRG-1β
6. Conclusion
Chapter 12. Does endoplasmic reticulum stress break the heart?
1. Introduction
2. Endoplasmic reticulum functions and stress
3. Endoplasmic reticulum stress in cardiac pathology
4. ER stress targeting therapy
5. Conclusion
Chapter 13. Role of pattern recognition receptors in cardiac remodeling
1. Introduction
2. Ligands of pattern recognition receptors
3. Signaling pathways of pattern recognition receptors
4. Pattern recognition receptor–related cardiovascular diseases
5. Targeting pattern recognition receptor–related pathways to treat cardiovascular diseases
6. Conclusion
Chapter 14. Myocardial contractile proteins: Role in disease progression and drug discovery
1. Introduction
2. Cardiac α-actin and cardiomyopathy
3. Myosin in the morphogenesis of the heart
4. Regulation of myosin
5. Actin-myosin structural transition in heart diseases
6. Cardiac troponin: Biomarker of cardiac damage
7. Conclusion
Chapter 15. Growth and proliferation of cardiomyocytes: Roles of energy metabolism, cell death, oxidative stress, and metabolites
1. Introduction
2. Microanatomy
3. Development of the heart
4. Cardiomyocyte cell cycle and regeneration potential
5. Cardiomyocyte senescence in adult heart
6. Cross-talk between cardiomyocytes and cardiac resident other cells during cardiac remodeling
7. Clinical perspective
8. Conclusion
Chapter 16. Cardiac endothelial cells and their cross-talks with neighboring cells in cardiac remodeling
1. Introduction
2. Cardiac endothelial cell transcriptome
3. Functional significance of endothelial cells during cardiac remodeling
4. Maintenance of vascular tone
5. Hemostasis
6. Role in neovascularization
7. Act as conditional immune cells
8. Interaction with cardiomyocytes
9. Cross-talk with leukocytes
10. Differentiation into mesenchymal cells
11. Contribute to cardiac fibrosis
12. Recruitment of endothelial progenitor cells
13. Conclusion
Chapter 17. Pathophysiology of cardiac fibroblasts and impacts on the severity of the cardiac disease
1. Cardiac fibroblasts
2. Cardiac-resident fibroblast activation
3. Origins and characterization of cardiac fibroblasts
4. Fibroblast responses to microenvironmental stimuli
5. Prime regulator of extracellular matrix turnover
6. Electrophysiology of cardiac fibroblasts
7. Contribution to cardiac fibrosis
8. Conclusion
Chapter 18. Involvement of cardiac stem cells in cardiac remodeling or myocardial regeneration
1. Introduction
2. Self-renewal cells in the heart
3. Embryological origin of cardiac stem cells
4. Endogenous cardiac stem and progenitor cells
5. The regenerative capacity of cardiac stem and progenitor cells
6. Metabolism of cardiac stem cells
7. Paracrine role of cardiac stem cells following cardiac injury
8. Cross-talk between cardiac stem cells and other cells
9. Clinical prospect
Chapter 19. Cardiac pericytes and cardiac remodeling
1. Introduction
2. Properties of cardiac pericytes
3. Pericyte secretome
4. Contribution to cardiac homeostasis
5. Contribution to the cardiac remodeling process
6. Are cardiac pericytes and cardiac stem cells similar
7. Therapeutic potential of cardiac pericytes
8. Conclusion
Chapter 20. Macrophages in the remodeling of diseased heart
1. Introduction
2. Identification of cardiac macrophages
3. Origin of cardiac macrophages
4. Role of macrophages during cardiac remodeling
5. Mechanism of macrophage polarization
6. Role of macrophages in ventricular arrhythmia
7. Conclusion
Chapter 21. Inflammatory role of neutrophils in cardiac remodeling: Damage versus resolution
1. Introduction
2. Phenotypic heterogeneity of neutrophils
3. Contribution in adaptive immunity
4. Does circadian oscillation affect the neutrophil counts: Prognostic factor of disease outcome?
5. Dual role of neutrophil infiltration kinetics in cardiac remodeling: Damage versus resolution?
6. NETosis
7. Secreted extracellular vesicle–mediated effects in the heart
8. Provoking granulopoiesis during myocardial infarction
9. Production of specialized proresolving mediators
10. Angiogenic properties
11. Sexual dimorphism in postmyocardial infarction inflammatory responses
12. Conclusion
Chapter 22. Extracellular vesicle in cardiac remodeling
1. Introduction
2. Biophysical properties of extracellular vesicles
3. Role of extracellular vesicles in heart disease
4. Extracellular vesicles in cardiovascular therapeutics
5. Engineering the extracellular vesicles
6. Conclusions
Chapter 23. Long noncoding RNAs and miRNAs: Emerging regulatory roles in cardiac disease research
1. Introduction
2. Functions of long noncoding RNAs
3. Long noncoding RNAs in cardiovascular diseases
4. microRNAs: Potential therapeutic targets for cardiovascular disease
5. Conclusion
Index

Life Sciences

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Health

Cellular, Molecular, and Environmental Contribution in Cardiac Remodeling

From Lab Bench Work to its Clinical Perspective

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Asim K. Duttaroy

Rahul Mallick

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