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Cell Press Reviews: Cancer Therapeutics
- 1st Edition - December 10, 2013
- Editor: Cell Press
- Language: English
- Paperback ISBN:9 7 8 - 0 - 1 2 - 4 2 0 1 9 2 - 7
- eBook ISBN:9 7 8 - 0 - 1 2 - 7 9 9 9 1 7 - 3
Cell Press Reviews: Cancer Therapeutics informs, inspires, and connects cancer researchers at all stages in their careers with timely, comprehensive reviews written by leaders i… Read more
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Request a sales quoteCell Press Reviews: Cancer Therapeutics informs, inspires, and connects cancer researchers at all stages in their careers with timely, comprehensive reviews written by leaders in the field and curated by Cell Press editors. The publicatio offers a broad view of some of the most compelling topics in cancer therapeutics including:
- Genetic approaches for personal oncology
- Targeting epigenetic dysregulation and protein interaction networks
- Vaccines and antibodies in cancer immunotherapy
- Tumor heterogeneity and chemotherapy resistance
- Tumor associated macrophages in anticancer treatment
Contributions come from leading voices in the field, including:
- Daniel A. Haber, Director of Massachusetts General Hospital Cancer Center and Professor at Harvard Medical School
- Tony Kouzarides, Professor at the University of Cambridge, Deputy Director of the Wellcome Trust/Cancer Research UK Gurdon Institute, and a founder of the cancer drug discovery company Chroma Therapeutics
- Charles L. Sawyers, Chair of the Human Oncology and Pathogenesis Program at Memorial Sloan Kettering Cancer Center, President of the American Association for Cancer Research, member of the presidentially appointed National Cancer Advisory Board, and recipient of the 2013 Breakthrough Prize in Life Sciences
Cell Press Reviews: Cancer Therapeutics is part of the Cell Press Reviews series, which features reviews published in Cell Press primary research and Trends reviews journals.
- Provides timely, comprehensive articles on a wide range of topics in cancer therapeutics
- Offers insight from experts on genetic, molecular, and cellular aspects of cancer therapy
- Features reviews on basic science advances translated into drug discovery and therapeutic approaches
- Includes articles originally published in Cell, Cancer Cell, Trends in Genetics, Trends in Molecular Medicine, and Trends in Pharmacological Sciences
Academic, medical researchers, and students in cancer biology, and cancer prevention/therapeutics, including cell biologists, biological chemists, geneticists, pharmacologists, oncologists, and radiation oncologists.
About Cell Press
Contributors
Preface
Chapter 1. The Evolving War on Cancer
Acknowledgments
Summary
Introduction
Breaking the Cancer War Stalemate
Drawing from Somatic Cancer Genetics to Find Therapeutic Targets
Challenging Medicinal Chemistry to Design New Classes of Inhibitors
Redesigning Cancer Clinical Trials: Genotype First, Monitor in Real Time
The Next Steps in the War on Cancer
References
Chapter 2. Can We Deconstruct Cancer, One Patient at a Time?
Acknowledgments
Summary
Cancer Treatment in the Age of Omics
Cancer as a Black Box
Deconstructing Cancer, One Patient at a Time
The Road Ahead
Concluding Remarks
References
Chapter 3. The Genetic Basis for Cancer Treatment Decisions
Acknowledgments
Summary
Introduction
Framework Requirements for Evaluating the Genetic Basis for Cancer Treatment
Patient Recruitment and Informed Consent
Tissue Requirements: Quantity, Quality, Processing, and Timing
Genomic Technologies and Data Management
Reporting Data to Clinicians and Patients
Monitoring and Evaluating the Utility of Clinical Genomics
Data Sharing
Implications for Drug Development
Implications for Regulatory Bodies
Implications for Patients, Healthcare Providers, and Payers
Conclusions
References
Chapter 4. Cancer Epigenetics: From Mechanism to Therapy
Acknowledgments
Summary
Introduction
Characterizing the Epigenome
Epigenetics and the Cancer Connection
Epigenetic Pathways Connected to Cancer
Perspective and Conclusions
References
Chapter 5. Converting Cancer Therapies into Cures: Lessons from Infectious Diseases
Acknowledgments
Summary
Introduction
Mutational Mechanisms of Resistance
Nonmutational Resistance Mechanisms
Overcoming Resistance
Exceptions: Examples of Successful Monotherapy
Precision Diagnostics: Essential for Targeted Cancer Drugs, Missed Opportunity for Antibacterials
Conclusions and Challenges
References
Chapter 6. Antibody-Based Immunotherapy of Cancer
Acknowledgments
Summary
Introduction
Manipulating Antibody Structure
Stimulating Persistent Immunity
Modulating the Amplitude of Immune Responses
Immunoconjugates: Targeting Cytotoxic Agents
A Longer-Term View
Supplemental Information
Web Resources
References
Chapter 7. Macrophage Regulation of Tumor Responses to Anticancer Therapies
Acknowledgments
Summary
Introduction
Tumor-Associated Macrophages
Macrophage Involvement in Tumor Responses to Therapy
Concluding Remarks: Implications for Cancer Treatment
References
Chapter 8. Recombinant Viral Vaccines for Cancer
Acknowledgments
Summary
Cancer Immunity
Recombinant Viral Vaccines Expressing TAAs
Recombinant Viral Vaccines Expressing Tumour-Associated Antigens and Immunomodulatory Molecules
IT Vaccination to Enhance Immune Activation
Oncolytic Viral Vaccines
Granulocyte Macrophage Colony Stimulating Factor
Modulating the Tumour Immune Microenvironment
Implications for the Future of Cancer Vaccines
References
Chapter 9. Dynamics of Targeted Cancer Therapy
Summary
Targeted Cancer Therapy
Modeling the Evolution of Resistance to Cancer Therapy
Effects of Density Dependence on the Evolution of Resistance
Applications and Extensions
Concluding Remarks and Future Perspectives
Appendix A Supplementary Material
References
Chapter 10. Targeting Protein–Protein Interactions as an Anticancer Strategy
Acknowledgment
Summary
Rising Interest in Targeting PPIs
PPI interfaces Constitute Basic Units in Oncogenic Signaling Networks
OVERCOMING CHALLENGES and Current Strategies for Targeting of PPIs
Clinical Validation of PPI Targeting in Cancer
Emerging Opportunities for Targeting of PPIs
Concluding Remarks
References
Chapter 11. Targeting the RAS Pathway in Melanoma
Acknowledgments
Summary
Current Therapies for Melanoma
The Central Melanoma Axis and Therapeutic Targets
Concluding Remarks
References
Chapter 12. Targeting Tumor Cell Motility as a Strategy against Invasion and Metastasis
Acknowledgments
Summary
Basic Mechanisms of Tumor Dissemination
Motility Cascade
Extracellular Regulators of Migration
Potential Interventional Opportunities
Concluding Remarks
References
Chapter 13. The Valley of Death in Anticancer Drug Development: A Reassessment
Acknowledgments
Summary
The Valley of Death
The Tumor Microenvironment
The Impact of Exposure Time
Choice of Preclinical Model
Drug Delivery to Tumors
Changing Clinical Practice
Some Paths Forward
Concluding Remarks
References
Chapter 14. Metformin and Cancer: From the Old Medicine Cabinet to Pharmacological Pitfalls and Prospects
Acknowledgments
Summary
The Past and Present of Metformin
Rationale for Cancer Prevention with Metformin
Role of Metformin in Gluconeogenesis and its Link to Chemoprevention
Influence of Metformin Disposition on Cancer Prevention
Concluding Remarks
References
Chapter 15. Curing APL through PML/RARA Degradation by As2O3
Acknowledgments
Summary
Both Poison and Cure
APL Response to Therapies
A Key Role of PML/RARA Degradation in Therapy Response
How does Arsenic Induce Degradation of PML and PML/RARA?
How does Arsenic Trigger PML Sumoylation?
What is the Role for PML NBs in APL Therapy?
Are there Other Arsenic-Sensitive Diseases?
Concluding Remarks
References
Glossary
Chapter 16. A Snapshot of Chemoresistance to PARP Inhibitors
Acknowledgments
Summary
Exploiting Synthetic Lethality for Targeted Therapy
PIR: Experimental and Clinical Evidence
Restoration of BRCA Function: an Inevitable Drawback of PARPi?
P-Glycoprotein Upregulation: Auto-Defeating Effects of PARPi
Further Considerations
Concluding Remarks
References
Index
- No. of pages: 322
- Language: English
- Edition: 1
- Published: December 10, 2013
- Imprint: AP Cell
- Paperback ISBN: 9780124201927
- eBook ISBN: 9780127999173