Cardiovascular Pathology

4th Edition - November 11, 2015
Editors: L. Maximilian Buja, Jagdish Butany
Language: English
Hardback ISBN:
9 7 8 - 0 - 1 2 - 4 2 0 2 1 9 - 1
eBook ISBN:
9 7 8 - 0 - 1 2 - 8 0 0 4 5 9 - 3
eBook ISBN:
9 7 8 - 0 - 1 2 - 8 0 4 0 4 9 - 2

Cardiovascular Pathology, Fourth Edition, provides users with a comprehensive overview that encompasses its examination, cardiac structure, both normal and physiolog… Read more

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Cardiovascular Pathology, Fourth Edition, provides users with a comprehensive overview that encompasses its examination, cardiac structure, both normal and physiologically altered, and a multitude of abnormalities. This updated edition offers current views on interventions, both medical and surgical, and the pathology related to them.

Congenital heart disease and its pathobiology are covered in some depth, as are vasculitis and neoplasias. Each section has been revised to reflect new discoveries in clinical and molecular pathology, with new chapters updated and written with a practical approach, especially with regards to the discussion of pathophysiology. New chapters reflect recent technological advances with cardiac devices, transplants, genetics, and immunology. Each chapter is highly illustrated and covers contemporary aspects of the disease processes, including a section on the role of molecular diagnostics and cytogenetics as specifically related to cardiovascular pathology.

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Dedication
Preface
Acknowledgments
Chapter 1: Anatomic Considerations and Examination of Cardiovascular Specimens (Excluding Devices)
- Abstract
- Gross Examination of the Heart
- Examination of Surgical Cardiovascular Specimens
- Microscopic Examination of the Blood Vessels and Heart
Chapter 2: Age-related Cardiovascular Changes and Diseases
- Abstract
- Nonspecific Cardiovascular Changes of Aging
- Changes in the Conduction System
- Changes in Arteries
- Age-related Diseases
- Disorders of Premature Aging
- Telomere
Chapter 3: Vascular Pathobiology: Atherosclerosis and Large Vessel Disease
- Abstract
- Introduction to Atherosclerosis
- Epidemiology and Risk Factors
- Gross and Microscopic Morphology of the Fibroinflammatory Lipid Plaque
- Steps in Atherosclerotic Plaque Formation and Complications
- Cellular Function and Pathways in Atherogenesis
- Nonatherosclerotic Diseases of the Aorta
Chapter 4: Diseases of Small and Medium-sized Blood Vessels
- Abstract
- Introduction
- Vascular Activation and Common Vascular Pathologic Changes
- Congenital Vascular Diseases
- Genetic Vascular Disorders
- Endocrine/Metabolic Vascular Disorders
- Vasculitis
- Infection
- Toxic Vasculopathies
- Coagulopathic Disorders
- Hypertension
- Vascular Deposition Disorders
- Intimal Proliferative Diseases
- Arterial Dissections
- Miscellaneous Conditions
- Disorders of Veins
Chapter 5: Aneurysms of the Aorta: Ascending, Thoracic and Abdominal and Their Management
- Abstract
- Introduction
- Normal Anatomy and Histology of the Aorta
- Aging Changes of the Aorta
- Thoracic Aortic Aneurysms
- Etiology and Pathologic Findings
- Clinical Presentation and Natural History
- Abdominal Aortic Aneurysm
- Aortic Dissection
- Management
Chapter 6: Fundamental Principles in Cardiovascular Genetics
- Abstract
- Genetic Variation
- Modern Molecular Diagnostics
- Identifying the Genetic Basis of Cardiovascular Disease
- Representative Genetic Cardiovascular Conditions
- Molecular Diagnostics in Cardiovascular Pathology Practice
Chapter 7: Myocardial Ischemia and Its Complications
- Abstract
- Definition and History
- Clinical Manifestations
- Epidemiology
- Biochemical Changes with Ischemia and Biochemical Markers
- Ultrastructural Evolution of Acute Ischemic Injury
- Cellular and Subcellular Mechanisms of Myocardial Injury
- Microscopic Evolution of Acute Ischemic Injury
- Morphology of Coronary Arteries and Plaques
- Tako-Tsubo Cardiomyopathy
- Gross Evolution of Acute Ischemic Injury
- Patterns of MI
- Phenomena Associated with Ischemic Injury
- Reperfusion of Ischemic Myocardium
- Complications of MI
- Recognition and Quantification of Acute Ischemic Injury
- Pathology of Interventions
- Pathophysiological and Pharmacological Interventions
- Molecular Biology of Myocardial Ischemia
Chapter 8: Pathophysiology of Heart Failure and an Overview of Therapies
- Abstract
- Overview of Heart Failure
- Pathophysiology of HF
- Neurohormonal Alterations in HF
- Signaling Responses to Various Stimuli During HF
- HF-related Alterations in Cellular Function and Biochemical Pathways
- Metabolic Remodeling in HF
- Summary of HF
- Therapeutic Management of HF
Chapter 9: Myocarditis
- Abstract
- Definition of Myocarditis
- Diagnosis of Myocarditis
- Histopathologic Patterns of Myocarditis
- Etiologies of Myocarditis
- Treatment of Myocarditis
Chapter 10: Pathology of Sudden Death, Cardiac Arrhythmias and Conduction System
- Abstract
- Acknowledgments
- Sudden Death
- Cardiac Conduction System
- Atrial Fibrillation
- Appendix Guidelines for Postmortem Study of Sudden Death
Chapter 11: Cardiomyopathies
- Abstract
- Definition and Classification of Cardiomyopathies
- Dilated Cardiomyopathy
- Hypertrophic Cardiomyopathy
- Arrhythmogenic Cardiomyopathy
- Restrictive Cardiomyopathy
- Others
Chapter 12: Valvular Heart Disease
- Abstract
- Introduction
- Functional Anatomy
- Types of Valvular Dysfunction
Chapter 13: Cardiac Valve Replacement and Related Interventions
- Abstract
- General Considerations
- Valve-related Complications: Clinical Importance, Morphology, Secondary Effects, and Pathogenesis
- Other Tissue Valve Substitutes
- Catheter-based Valve Implantation
- Valve Repair and Valve Sparing Procedures
- New Developments and Future Considerations
- Pathologic Considerations in Analysis of Heart Valve Substitutes
- Disclosure
- Appendix
Chapter 14: The Pathology of Cardiovascular Interventions and Devices for Coronary Artery Disease, Vascular Disease, Heart Failure, and Arrhythmias
- Abstract
- Endovascular Therapies and Myocardial Revascularization
- Aortic and Peripheral Vascular Replacement and Reconstruction
- Cardiac Assist and Replacement
- Arrhythmia Control
Chapter 15: Congenital Heart Disease: Pathology, Natural History, and Interventions
- Abstract
- Introduction
- Epidemiology and Etiology
- Embryology of the Cardiovascular System
- Clinical Features and Consequences
- Specific Forms of CHD
- Surgical and Nonsurgical Interventions for Treatment of CHD
- CHD in the Adult
- Natural History of CHD Without and with Interventions
Chapter 16: The Pericardium and Its Diseases
- Abstract
- Anatomy
- Physiology
- Histology
- Echocardiography
- Pericardiocentesis and Biopsy
- Congenital Abnormalities
- Pericardial Effusion After Cardiac Surgery
- Pneumopericardium
- Early Postmyocardial Infarction Pericarditis and Dressler Syndrome
- Iatrogenic and Traumatic Pericarditis
Chapter 17: Pathology of Cardiac Transplantation
- Abstract
- General Clinicopathologic Considerations
- Pathology of the Explanted Recipient Heart
- Pathology of the Donor Heart
- Pathology of the Allograft
- Heart Transplantation in Combination with Other Organs
- Pathological Review of an EMB
- Approach to the Examination of a Failed Allograft
- Future Considerations
Chapter 18: Toxins and the Heart
- Abstract
- Introduction
- Endocardium
- Myocardium
- Pericarditis
- Primary Conduction System Abnormalities
- Coronary Artery Lesions
- Cocaine-Other Drug Interactions
- Drugs to Treat Attention Deficit-Hyperactivity Disorders
- Antipsychotic Medications
- Nonsteroidal Anti-inflammatory Drugs
- Myocardial Toxins as a Cause of Death
Chapter 19: Tumors of the Cardiovascular System: Heart and Blood Vessels
- Abstract
- Incidence and Classification
- Clinical Symptoms
- Reactive Cardiac Masses and Pseudotumors
- Ectopias
- Hamartomas and Benign Neoplasms
- Hamartomas of Cardiac Muscle
- Benign Fatty Tumors
- Benign Tumors of Myofibroblastic Tissue
- Miscellaneous Benign Fibrous Tumors
- Cardiac Myxoma
- Benign Neural Neoplasms
- Malignant Tumors
- Metastatic Tumors
- Sarcomas of the Great Vessels
Chapter 20: Forensic Aspects of Cardiovascular Pathology
- Abstract
- Investigative Information
- General Changes
- Primary Diseases/Injuries of the Heart
- Cardiomyopathies, Myocarditis, and Genetic Causes of SCD
- Anomalies and Diseases of the Aorta and Coronary Arteries
- Diseases of the Cardiac Valves
- Ancillary Studies
- Sudden Death Following Surgery and Medical Procedures
- Organ and Tissue Harvesting
- Cardiovascular Pathology Consultation
- Summary
Index

L. Maximilian Buja

Professor of Pathology and Laboratory Medicine, Medical School, The University of Texas Health Science Center at Houston (UTHealth); Distinguished Teaching Professor, The University of Texas System; Executive Director, The TMC Library; Editor-in-Chief, Cardiovascular Pathology (the official journal of the Society for Cardiovscular Pathology) Dr. Buja MD is a Professor of Pathology and Laboratory Medicine at the University of Texas Health Science Center at Houston. His subspecialty interest is cardiovascular pathology with research interests in myocardial cell injury, myocardial ischemia, atherosclerosis and cardiomyopathies. Dr. Buja teaches medical students, medical residents, clinical fellows, graduate students and research post-doctoral fellows. He also conducts a clinical practice in cardiovascular pathology providing staffing of autopsy cases and surgical pathology consultation of cardiac and vascular cases and interpretation of myocardial biopsies from referrals. He directs a cardiovascular pathology fellowship approved by the Texas Medical Board. He is the editor-in-chief of Cardiovascular Pathology, the official journal of the Society for Cardiovascular Pathology. He also serves as the Executive Director of The Texas Medical Center Library located adjacent to the medical school.

Affiliations and expertise

Professor of Pathology and Laboratory Medicine at the University of Texas Health Science Center, Houston, TX, USA

Jagdish Butany

Consultant Cardiovascular Pathologist/Director Autopsy Services Co-Editor-in-Chief, Cardiovascular Pathology, Guest Editor, Seminars in Diagnostic Pathology Secretary-Treasurer, WASPaLM, Professor, University of Toronto & Director, Division of Pathology,Dept. of Laboratory Medicine and Pathobiology, University Health Network / Laboratory Medicine Program Toronto General Hospital,Toronto, Ontario, Canada. Dr. Butany is Professor in the Department of Laboratory Medicine and Pathobiology at the University of Toronto, Canada and Director of the Division of Pathology in the Department. He is a Staff Cardiovascular Pathologist at the University Health Network (Toronto General Hospital Site), and Director of Autopsy Services. His investigative work has primarily been based on clinical investigations and outcomes and collaboration with clinical colleagues in basic and applied research. His major interest has been prosthetic heart valves. Dr. Butany has been involved in teaching at the undergraduate and post-graduate levels, including medical students, pathology residents, cardiology residents and cardiac surgery residents and fellows. He is a founding member of the Society for Cardiovascular Pathology and served as the president from 2007-2009). He has been Co-Editor-in-Chief of Cardiovascular Pathology, the official journal of the Society of Cardiovascular Pathology and continues to serve on its Editorial Board.

Affiliations and expertise

Professor, University of Toronto and Director, Division of Pathology, Deptartment of Laboratory Medicine and Pathobiology, University Health Network / Laboratory Medicine Program Toronto General Hospital, Canada

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