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Carbonic Anhydrases
Biochemistry and Pharmacology of an Evergreen Pharmaceutical Target
- 1st Edition - July 17, 2019
- Editors: Claudiu T. Supuran, Alessio Nocentini
- Language: English
- Paperback ISBN:9 7 8 - 0 - 1 2 - 8 1 6 4 7 6 - 1
- eBook ISBN:9 7 8 - 0 - 1 2 - 8 1 6 7 4 5 - 8
Carbonic Anhydrases provides an interdisciplinary review of the burgeoning carbonic anhydrase (CA) research area, spanning from CAs classification (biochemical and structura… Read more
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Request a sales quoteCarbonic Anhydrases provides an interdisciplinary review of the burgeoning carbonic anhydrase (CA) research area, spanning from CAs classification (biochemical and structural features) to drug design and pharmacology of CA inhibitors and activators, finally touching on the biotechnological applications of these metalloenzymes. The book adopts a clear step-by-step approach and introduction to this intricate and highly interdisciplinary field. A diverse range of chapters from international experts speak to CA classification and distribution, the mechanisms of action and drug design of inhibitors and activators, the druggability of the various isoforms in the treatment of a multitude of diseases, and threats to human health.
Carbonic Anhydrases provides biology, biochemistry, and medicinal chemistry students and researchers a thorough discussion and update on the evergreen and expanding research area of CAs.
- Offers a full overview of CAs’ biochemical and structural features, as well as drug design and pharmacology of inhibitors and activators
- Provides a thorough update on the newly identified isoforms, modulating chemotypes, and innovative biomedical applications
- Describes the current biotechnological applications of CAs, including processes for CO2 capture
- Features chapter contributions from international leaders in CA biology, medicinal chemistry, and pharmacology
Active researchers and students in biochemistry, molecular biology, pharmaceutical science, cellular biology, applied microbiology, and biotechnology; medical chemists; clinician scientists
- No. of pages: 560
- Language: English
- Edition: 1
- Published: July 17, 2019
- Imprint: Academic Press
- Paperback ISBN: 9780128164761
- eBook ISBN: 9780128167458
CS
Claudiu T. Supuran
Dr. Claudiu T. Supuran received his BSc in chemistry from the Polytechnic University of Bucharest, Romania (1987) and PhD in chemistry at the same university in 1991. In 1990, he became Assistant and then Associate Professor of Chemistry at the University of Bucharest. He was Visiting Scholar at the University of Florida, Gainesville, United States, at Griffith University, Brisbane, Australia, and Visiting Professor at University of La Plata, Argentina. In 1995 he moved to the University of Florence, Italy, where he is currently Full Professor in the Department of Neuroscience, Psychology, Medicine and Child Health. His main research interests include design of enzyme inhibitors and activators, heterocyclic chemistry, chemistry of sulfonamides, sulfamates, and sulfamides, biologically active organo-element derivatives, QSAR studies, X-ray crystallography of metallo-enzymes, metal complexes with biologically active ligands (metal-based drugs), carbonic anhydrases, cyclooxygenases, serine proteases, matrix metalloproteinases, bacterial proteases, and amino acid derivatives among others. He has published more than 1900 papers in these fields.
Affiliations and expertise
Full Professor, University of Florence, Neuroscience, Psychology, Medicine and Child Health, Florence, ItalyAN
Alessio Nocentini
Dr. Alessio Nocentini currently works at the Department of Neuroscience, University of Florence, Italy. He recently concluded his PhD thesis, which dealt with several aspects of carbonic anhydrase, spanning from drug-design, synthesis of inhibitors, and molecular modeling to biological evaluations of carbonic anhydrase modulators. He is now a post-doctoral researcher in Professor Supuran’s research team.
Affiliations and expertise
Post-doc Researcher, Department of Neuroscience, University of Florence, Italy